Supplementary Table 1. Patient Characteristics of AML and MDS Samples Analyzed
Supplementary table 1. Patient characteristics of AML and MDS samples analyzed
Sample Number / Diagnosis / Age / Gender / FAB subtype / Immunophenotype / Karyotype1 / AML / 53 / Female / M0 AML / CD34,45,13,33,11b,7 / 46,xx
2 / AML / 26 / Female / M0 AML / CD34,45,HLA-DR,13,33,117 / 45,xx der(3)t(1;3)(q21;q21)inv(5)(q13q33),add(6)(q25),[14]
3 / AML / 63 / Male / M0AML / CD45,HLA-DR,CD13,CD34,CD4 / 46,xy,del(9)(q13q22),del(20)(q11.2)[cp9}/46,idem,del(4)(q?21q?27)[cp11]
4 / AML / 62 / Female / M1 AML / CD34,33,5,7,13,11b / 45,xx,der(7)t(7;12)(q10;q10),-12[18]/46,xx[2]
5 / AML / 71 / Female / M1 AML / CD34,45,13,11b,33 / post 46,xx,del(7)(q22)[19]/46,idem,del(2)(q33),der(6)ins(6;?)(p12;?),add(21)(q11.2)[9]/46,xx[2]
6 / AML / 75 / female / M1 AML / CD45,CD13,CD33 / 46,xx
7 / AML / 66 / Male / M1 AML / CD34,45,13,33 / 46,x,?t(y;12)(q12;p13),t(6;9)(p23;q34)
8 / AML / 46 / Female / M1 AML / CD45,33,11b,13 / 46,xx
9 / AML / 20 / Male / M1 AML / CD34,HLA-DR,CD13,CD33,CD7 / 46,xy
10 / AML / 31 / Male / M1 AML / CD34,CD45,HLA-DR,CD33,CD7,CD5,CD3 / 46,xy,del(11)(q21q22).ish11q23(MLLx2)
11 / AML / 19 / Male / M1 AML / CD34,CD45,HLA-DR,CD7,CD13,CD33 / 46,xy
12 / AML / 50 / Female / M1 AML / CD34,CD45,HLA-DR,CD7,CD13,CD33 / 46,xx,del(9)(q13q32)[18]/46,xx[2]
13 / AML / 35 / Female / M1 AML / CD45,CD13,CD33 / 46,xx
14 / AML / 72 / Male / M1 AML / CD13,CD33, / 46,xy
15 / AML / 80 / Male / M1 AML / CD45,CD34,HLA-DR,CD13,CD33 / 46,xy
16 / AML / 64 / Male / M1 AML / CD34,CD45,HLA-DR,CD13 / 46,xy
17 / AML / 65 / Male / M1 AML / 34,45,HLA-DR,7,13,117 / 46,xy
18 / AML / 47 / Female / M1 AML / CD45,HLA-DR,CD13,CD117,CD33 / n/a
19 / AML / 53 / Female / M1 AML / CD34,45,HLA-DR,117,13,33 / 46,xx,+(5;11)(q35;q13-14)[2]/46,xx
20 / AML / 29 / Female / M1 AML / CD34,45,HLADR,7,117,13,33 / 46xx
21 / AML / 49 / Female / M1 AML / CD33,13,7,34,HLA-DR,117 / 47,xx,+11[19]/46,xx[2]
22 / AML / 59 / Female / M1 AML / CD45,HLA-DR,117 / 46,xx
23 / AML / 59 / Female / M1 AML / CD45,13,33 / 46,xx
24 / AML / 71 / Male / M1 AML / CD45,HLA-DR,CD117,33,13,11b / 46,xy
25 / AML / 62 / Male / M1AML / CD45,CD13,CD33,CD14,CD11b / 49,xy,add91)(p32),+5,-6,der(6)(p32;q23),+8,+8,+mar[cp11]/46,xy[10]0
26 / AML / 46 / Female / M1AML / CD45,CD13,CD33 / 46,xx
27 / AML / 63 / Male / M2 AML / CD45,CD13,33 / 45,x,-y[19]/46,xy[1]
28 / AML / 56 / Male / M2 AML / CD34,13,33 / 43-44,xy,der(1;12)(p10;q10),-2,-5,der960t(2;6)(q21;p25),del(7)(q11),der(9)t(5;9)(q11;p22),-12,der913)t(1;13)(q12;p11),-14,add(16)(p13),-17,-18,-19,-20,+2-3r,+3-4mar[cp8]
29 / AML / 64 / Male / M2 AML / CD34,45,13,33,CD7 / 46,xy,add(20)(p13).ish(wcp20+,tel20p+)
30 / AML / 29 / Female / M2 AML / CD34,45,13,33,11b / 46,xx,t(3;5)(q21;q31)
31 / AML / 51 / Male / M2 AML / CD34,45,13,33 / 46,xy
32 / AML / 36 / Female / M2 AML / CD34,45,13,33 / 49,xx,add(2)(p16),del(5)(q?22q?34)+9,+11,-17,-18,+21,+2mar[7]/46,xx[5].nucish5p15.2(d5s721/d5s23x2),5q31(egr1x1)
33 / AML / 74 / Male / M2 AML / CD34,45,13,33 / 46,xy,t(4;14)(q21;q11)[19]/46,xy[3]
34 / AML / 57 / Male / M2 AML / CD34,CD45,CD13,CD33,HLA-DR / 43,xy,der(2)add(2)(p11)del(2)(q?33q?35),inv(3)(p21q29),der(5;22)(p10;q10),del(12)(p12.1),-16,-17,add(17)(q21),der(20)t(?11;20)(q13;q12)[cp16]/46,xy[4]
35 / AML / 76 / Female / M2 AML / CD34,CD45,HLA-DR,CD33,CD7,CD5,CD3 / 46,xx,del(11)(q21q23).ish11q23(MLLx2)
36 / AML / 56 / Male / M2 AML / CD45,CD13,CD33 / 46,xy
37 / AML / 55 / Male / M2 AML / n/a
38 / AML / 45 / Male / M2 AML / CD45,CD34,CD13,CD33 / 46,xy
39 / AML / 58 / Male / M2 AML / CD34,CD45,HLA-DR,CD13,CD33 / 45,x,-y,t(8;21)(q22;q22),del(9)(q13q32)
40 / AML / 51 / Female / M2 AML / CD34,CD45,HLA-DR,CD13,CD33 / n/a
41 / AML / 65 / Male / M2 AML / CD34,45,HLA-DR,CD13,CD33,CD117 / 46,xynuc8q22,22q22
42 / AML / 67 / Female / M2 AML / CD34,45,HLA-DR,13,33,117 / 43-44,xy,del(3)(p21),del(5)(q22q33),-11,-15,-17
43 / AML / 74 / Male / M2 AML / CD34,45,HLA-DR, CD13,CD33 / 46,xy
44 / AML / 54 / Male / M2 AML / CD34,CD20,CD3 / 46,xy
45 / AML / 68 / Female / M2 AML / CD34,45,HLA-DR,13,117,CD19 / 47,xx,+6
46 / AML / 70 / Male / M2 AML / CD45 / n/a
47 / AML / 73 / Male / M3 AML / CD45,CD13,CD33,CD5,CD23,CD19,CD20 / 46,xy t915;17)(q22;q11)
48 / AML / 21 / Female / M3 AML / CD34,45,13,33 / 46,xx,t(15;17)(q22;q21)
49 / AML / 26 / Male / M3 AML / CD45,13,33,56 / 46,xy,t(15;17)(q22;q21)
50 / AML / 19 / Female / M3 AML / CD45,13,33 / 46,x,?add(x)(q25),t(3;18)(p14;q22),der(7)ins(7;?)(q22;?),y(15;17)(q22;q21[18]/46,xx{2}
51 / AML / 39 / Male / M3 AML / CD45,13,33 / 46,xy,t(15;17)(q22;q21)
52 / AML / 42 / Female / M3 AML / CD45,34,117,CD13,CD33 / 46,xx+(15;17)(q22;q4)[14],xx(6)
53 / AML / 42 / Male / M3 AML / CD45,13,33,117 / 46,xy,t(15;17)(q22;q21)[15]/46,xyder(15)t(15;17)(q22;q21),der(17)
54 / AML / 39 / Female / M3 AML / CD45,13,33,117 / 46,xx,t(6;15)(q13;q22)[19]/46,xx[1].ishder(6)der17
55 / AML / 65 / Male / M3v AML / CD45,13,33 / 46,xy,t(15;17)(q22;q21)
56 / AML / 52 / Male / M4 AML / CD34,CD45,CD13,CD33 / 46xy,+(6;9)(p23;q34)
57 / AML / 58 / Male / M4 AML / n/a / n/a
58 / AML / 44 / Male / M4 AML / n/a / 46, xy,16q22(cbfbx2)
59 / AML / 67 / Male / M4 eos / CD45,HLADR,CD34,CD14,CD11b,CD13,CD33 / 46,xy,inv(16)(p13q22)
60 / AML / 35 / Female / M4 eos / CD34,45,HLA-DR,CD13,CD33 / 46,xy,inv(16)(p13q22)
61 / AML / 35 / Male / M4 eos / CD34,45,HLA-DR,13,117,33 / 46,xy,inv(16)
62 / AML / 59 / Male / M4AML / CD45,CD13,CD33 / 46,xy
63 / AML / 36 / Male / M4Eo / CD34,CD45,HLA-DR,CD13,CD33 / 46,xy,inv(9)c,inv(16)(p13q22)[18]/46,xy,inv(9)c[2]
64 / AML / 77 / Male / M4eo AML / CD34,CD45,CD13,CD33 / 46,x,der(y)?inv(y)(p11q12),del(9)(q12q22),add(17)(q24)[18]/46,xy[3]inv[16](cbfbx2)(cbfbspx1)
65 / AML / 63 / Female / M5 AML / CD4,13,CD33,56,71 / 46,xx
66 / AML / 54 / Male / M5 AML / CD34,CD45,HLA-DR,CD13,CD33,CD11b / unsuccessful
67 / AML / 73 / Male / M5a AML / n/a / 45,x,-y[5]/46,xy[16]
68 / AML / 42 / Male / M5b AML / CD34,CD45,CD13,CD33 / 47,xy,+8[16]/46,xy[4]
69 / AML / 42 / Male / M5bAML / CD45,HLA-DR,CD13,CD33,CD11b / 46,xy
70 / AML / 34 / Female / M6 AML / 45,33,13,11b / 46,xx
71 / AML / 81 / Male / M6 AML / 45,13,33,34117 / 46,xy
72 / AML / 78 / Male / M7AML / CD45,HLA-DR,CD13,CD33,CD41,CD42b / 48,xy,+8,+8,der(18)t(2;18)(q21;p11.3),del(20)(q12q14)[15]/48,idem,del(13)(q12q14)[4]/46,xy[1]
73 / AML / 73 / Male / Mast Cell Leukemia / CD34 / 46,xy
76 / MDS / 63 / Male / CMML / CD13, CD33, CD11b / 47,xy,del(2)(p13p21),+mar.ishdel(2)(p12p21)(wcp2x)
77 / MDS / 59 / Male / RA / n/a / 46 xy with last marrow
78 / MDS / 93 / Male / RA / n/a / 46,xy
79 / MDS / 81 / Female / RAEB / n/a / cyto pre sample:-45-48,xx,del(5)(q13q22)[11],del(5)(q13q22)x2[2],del(6)(q21)[9],der(7)t(7;12)(q22;q12)[11],-12[12]add(16)(q24)[9],-18[3],-20[11],+21[11]+21,+21[2],+22{11]/{cp13]/46,xx{2}
80 / MDS / 53 / Female / RAEB / n/a / 44,xx,-3,der(4)t(4;15)(q12;q22),del(5)(q13q33),add(7)(p15),add(8)(p21),del(10)(q11.2),add(12)(p11.2),del(15)(q22),der(16)t(3;16)(q12;q24)-20[cp13]/45,xx,-3,del(5),add(7),add(8),del(10)add(12),der(16),-20,+mar[7]
81 / MDS / 79 / Male / RAEB / n/a / 46,xy
82 / MDS / 62 / Male / RAEB / CD34,45,13,33 / 47,xy,+8[19]/46,xy[1]
83 / MDS / 61 / Female / RAEB / CD34,CD45,HLA-DR,CD13,CD33 / n/a
84 / MDS / 69 / Male / RAEB / n/a / 45,xy,-7,del(12)(p11.2)[13]/46,idem,+21[3]/45,xy,-7[1]/46,xy,t(1;3)(p34;q21)[1]
85 / MDS / 74 / Male / RAEB / CD34,CD45,HLA-DR,CD13,CD33 / 45,xy,-7
86 / MDS / 68 / Male / RAEB / CD34,CD45,HLA-DR,CD13,CD33 / 55,xy,+1,del(5)(q13q33),+6,+8,+11,+14,-15 add(15)(p12),-17,+19,+21,+22,+2,-3mar
87 / MDS / 75 / Female / RAEB / CD45,CD34,CD13,CD33,HLA-DR / 46,xx,-7,+(9;12)(p12-13),+mar[cp19].nuc ish 9q34(ABLx2),22q11.2 bcrx2
88 / MDS / 66 / Female / RAEB / CD34,CD45,HLA-DR,CD13,CD117 / 48,xx,+1,der(1;19_(q10;q10),+8[cp19]/46,xx[1]
89 / MDS / 53 / Female / RAEB / n/a / 45,xx,-5,t(5;11;7)(q12;q23;p15)[14]46,xx[6]
90 / MDS / 32 / Female / RAEB / CD34,45,HLA-DR,CD13,CD33 / 46,xx
91 / MDS / 58 / Female / RAEB / CD34,45,HLA-DR,CD13,CD33 / unsuccessful
92 / MDS / 67 / Male / RAEB / CD34,45,HLA-DR,CD13,CD117,CD33 / 46,xy,del(6)(q23q26),(17)(q10)
93 / MDS / 64 / Male / RAEB / CD34,45,13,117,33 / 47,xy,+11,add(11)(q13),x[1]/47,xy,t(7;12)(q22;q24),+11,add(11)(q13)[6]
94 / MDS / 64 / Female / RAEB / n/a / 47,xx,-3,-5,-13,der(19)t(5;19)(p11;p13.1),add(21)(p11)+4-5mar[cp5]/46,xx,-3,-5,+2 mar[cp3]/46,xx[7]
95 / MDS / 79 / Female / RAEBT / n/a / unsuccessful
96 / MDS / 82 / Male / RAEB-T / CD34,CD45,CD13,CD33,HLA-DR / 46,xy,?del(11)(q23)[2]/46,xy[2].nuc ish 11q23(mllx2)
97 / MDS / 87 / Male / RAEB-T / CD19,CD20,FMC-7 / 46,xy.nuc ish 5q31(egr1x2),14q32.2(IGHx2)
98 / AML / 37 / Male / n/a / CD13,CD7,CD34,CD10,HLADR,CD117 / 46,xy,-2,der(5)t(5;?;14)(p15;?;q21),del(14)(q21),+mar
99 / AML / 19 / Female / n/a / CD34,CD45,HLA-DR,CD13,CD33,CD7 / 46,xx,t(2;9)(q21;q21.2),t(11;18)(p11;q11)[3]/46,xx,del(9)(p13)[cp2]/46,xx,nonclonal
100 / AML / 81 / Female / n/a / CD45,CD34,HLA-DR,CD13,CD33,CD7 / 46,xx
101 / AML / 62 / Male / n/a / CD34,CD45,HLA-DR,CD11b,CD13,CD33 / 45,xy,del(5)(q13q31),add(7)(q?22),?del(7)(q11),+10,der(10)t(7;10)(q11;q11),add(12)(p13),-16(13),-17,-18,add(21)(q22),+mar
102 / AML / 87 / Male / n/a / CD33,CD13,CD11b / 46xy
103 / AML / 81 / Female / n/a / n/a / 46xx
104 / AML / 60 / Female / n/a / CD13,15,33,64,4,11b,14,56,117,34 / n/a
105 / AML / 59 / Male / n/a / CD34,45,13,7 / 46,xy
106 / AML / 38 / Female / n/a / CD34,45,13,33 / n/a
107 / AML / 64 / Male / n/a / CD34,45,13,33 / 46,xy
108 / AML / Female / n/a / n/a / n/a
109 / AML / 65 / Male / n/a / n/a / 46,xy,-2,-3,del(4)(q21q27),del(4)(q21q27),del(5),-7,-11,add(11)(p14,-12,+5mar[13]
110 / AML / 50 / Male / n/a / CD13,CD33,CD34 / 46,xy
111 / AML / Female / n/a / n/a / n/a
112 / AML / 77 / Male / n/a / CD34,45,HLA-DR,CD13,CD33 / 46,xy
113 / AML / n/a / n/a / n/a
114 / AML / 64 / Female / n/a / CD4,CD11,CD13,CD33,CD64,CD117,HLA-DR,CD34 / 46,xx
115 / AML / 35 / Male / n/a / CD34,45,HLA-DR,CD13,CD33,CD117 / n/a
116 / AML / 48 / Female / n/a / n/a / n/a
117 / AML / n/a / n/a / n/a
118 / AML / 78 / Female / n/a / n/a / 46,xx
119 / AML / 65 / Female / n/a / n/a / n/a
120 / AML / 80 / Male / n/a / CD45+CD13+CD33+-34 / n/a
121 / MDS / 65 / Female / n/a / CD45,CD33 / 46,xx