Hand Bone Loss in RA

Hand Bone Loss in RA

Table S2. The association between bone loss at whole hand and at various regions around MCP joints and mean disease variables and MRI scores for synovitis and MRI bone marrow edema, adjusted for treatment group.

2A.Bone loss between baseline and three months.

Mean both hands / Dominant hand / Mean metacarpal heads MCP 2-5 / Mean whole proximal phalang digit 2-5 / Mean partial proximal phalang digit 2-5 / Partial proximal phalang digit 2 / Partial proximal phalang digit 3 / Partial proximal phalang digit 4 / Partial proximal phalang digit 5
HAQ / Beta=-0.345
P=0.028 / Beta=-0.302
P=0.060 / Beta=-0.269
P=0.089 / Beta=-0.442
P=0.002 / Beta=-0.342
P=0.018 / Beta=-0.105
P=0.51 / Beta=-0.291
P=0.042 / Beta=-0.130
P=0.42 / Beta=-0.403
P=0.010
Swollen joints (0-56) / Beta=-0.216
P=0.20 / Beta=-0.171
P=0.31 / Beta=-0.240
P=0.15 / Beta=-0.235
P=0.14 / Beta=-0.192
P=0.22 / Beta=-0.030
P=0.86 / Beta=-0.026
P=0.87 / Beta=-0.129
P=0.44 / Beta=-0.353
P=0.033
CRP (mg/liter) / Beta=-0.658
P0.001 / Beta=-0.419
P=0.009 / Beta=-0.287
P=0.077 / Beta=-0.356
P=0.020 / Beta=-0.370
P=0.013 / Beta=-0.181
P=0.26 / Beta=-0.532
P0.001 / Beta=0.047
P=0.78 / Beta=-0.392
P=0.015
RAMRIS MCP2-5 / Beta=-0.358
P=0.024 / Beta=-0.337
P=0.036 / Beta=-0.323
P=0.041 / Beta=-0.225
P=0.14 / Beta=-0.142
P=0.35 / Beta=-0.167
P=0.29 / Beta=-0.062
P=0.68 / Beta=-0.016
P=0.92 / Beta=-0.151
P=0.36
RAMRIS MCP2 / Beta=-0.253
P=0.13 / Beta=-0.102
P=0.55 / Beta=-0.157
P=0.35 / Beta=-0.197
P=0.22 / Beta=-0.212
P=0.17 / Beta=-0.157
P=0.34 / Beta=-0.258
P=0.085 / Beta=-0.024
P=0.88 / Beta=-0.217
P=0.20
RAMRIS MCP3 / Beta=-0.355
P=0.024 / Beta=-0.372
P=0.018 / Beta=-0.251
P=0.11 / Beta=-0.246
P=0.11 / Beta=-0.192
P=0.20 / Beta=-0.204
P=0.19 / Beta=-0.015
P=0.92 / Beta=-0.054
P=0.74 / Beta=-0.245
P=0.13
RAMRIS MCP4 / Beta=-0.326
P=0.039 / Beta=-0.350
P=0.027 / Beta=-0.207
P=0.19 / Beta=-0.210
P=0.17 / Beta=-0.045
P=0.77 / Beta=-0.190
P=0.22 / Beta=-0.005
P=0.97 / Beta=0.051
P=0.75 / Beta=-0.000
P=1.00
RAMRIS MCP5 / Beta=-0.195
P=0.25 / Beta=0.254
P=0.13 / Beta=-0.420
P=0.009 / Beta=-0.050
P=0.76 / Beta=0.024
P=0.88 / Beta=0.031
P=0.85 / Beta=0.106
P=0.49 / Beta=-0.069
P=0.68 / Beta=-0.017
P=0.921
MRI BME MCP2-5 / Beta=-0.307
P=0.053 / Beta=-0.318
P=0.046 / Beta=-0.111
P=0.49 / Beta=-0.305
P=0.042 / Beta=-0.414
P=0.003 / Beta=-0.467
P=0.001 / Beta=-0.325
P=0.022 / Beta=-0.195
P=0.22 / Beta=-0.188
P=0.24
MRI BME MCP2 / Beta=-0.302
P=0.056 / Beta=-0.327
P=0.039 / Beta=-0.052
P=0.75 / Beta=-0.364
P=0.014 / Beta=-0.477
P=0.001 / Beta=-0.449
P=0.002 / Beta=-0.276
P=0.054 / Beta=-0.257
P=0.10 / Beta=-0.337
P=0.033
MRI BME MCP3 / Beta=-0.235
P=0.144 / Beta=-0.200
P=0.220 / Beta=-0.061
P=0.704 / Beta=-0.133
P=0.392 / Beta=-0.198
P=0.183 / Beta=-0.292
P=0.058 / Beta=-0.292
P=0.042 / Beta=0.001
P=0.993 / Beta=-0.018
P=0.912
MRI BME MCP4 / Beta=-0.026
P=0.873 / Beta=0.035
P=0.830 / Beta=-0.195
P=0.223 / Beta=-0.155
P=0.314 / Beta=-0.280
P=0.056 / Beta=-0.350
P=0.021 / Beta=-0.290
P=0.043 / Beta=-0.098
P=0.542 / Beta=-0.075
P=0.645
MRI BME MCP5 / Beta=-0.188
P=0.243 / Beta=-0.248
P=0.123 / Beta=-0.120
P=0.455 / Beta=-0.189
P=0.217 / Beta=-0.213
P=0.150 / Beta=-0.256
P=0.096 / Beta=-0.042
P=0.773 / Beta=-0.247
P=0.118 / Beta=-0.035
P=0.829

2B. Bone loss between baseline and 12 months.

Mean both hands / Dominant hand / Mean metacarpal heads MCP2-5 / Mean whole proximal phalang digit2-5 / Mean partial proximal phalang digit2-5 / Partial proximal phalang digit2 / Partial proximal phalang digit3 / Partial proximal phalang digit4 / Partial proximal phalang digit5
HAQ / Beta=-0.450
P=0.004 / Beta=-0.412
P=0.007 / Beta=-0.449
P=0.003 / Beta=-0.448
P=0.003 / Beta=-0.466
P=0.002 / Beta=-0.509
P=0.001 / Beta=-0.504
P=0.001 / Beta=-0.329
P=0.036 / Beta=-0.289
P=0.072
Swollen joints (0-56) / Beta=-0.338
P=0.035 / Beta=-0.276
P=0.080 / Beta=-0.326
P=0.036 / Beta=-0.284
P=0.075 / Beta=-0.341
P=0.030 / Beta=-0.350
P=0.027 / Beta=-0.276
P=0.083 / Beta=-0.459
P=0.003 / Beta=-0.121
P=0.46
CRP (mg/liter) / Beta=-0.641
P<0.001 / Beta=-0.637
P<0.001 / Beta=-0.664
P<0.001 / Beta=-0.640
P<0.001 / Beta=-0.704
P<0.001 / Beta=-0.619
P<0.001 / Beta=-0.682
P<0.001 / Beta=-0.553
P<0.001 / Beta=-0.584
P<0.001
RAMRIS MCP2-5 / Beta=-0.300
P=0.065 / Beta=-0.307
P=0.052 / Beta=-0.291
P=0.064 / Beta=-0.309
P=0.053 / Beta=-0.309
P=0.053 / Beta=-0.262
P=0.10 / Beta=-0.239
P=0.14 / Beta=-0.343
P=0.030 / Beta=-0.230
P=0.16
RAMRIS MCP2 / Beta=-0.301
P=0.072 / Beta=-0.249
P=0.13 / Beta=-0.266
P=0.10 / Beta=-0.314
P=0.055 / Beta=-0.337
P=0.039 / Beta=-0.278
P=0.094 / Beta=-0.303
P=0.066 / Beta=-0.338
P=0.039 / Beta=-0.252
P=0.14
RAMRIS MCP3 / Beta=-0.175
P=0.28 / Beta=-0.211
P=0.18 / Beta=-0.213
P=0.17 / Beta=-0.205
P=0.20 / Beta=-0.203
P=0.20 / Beta=-0.175
P=0.28 / Beta=-0.086
P=0.60 / Beta=-0.280
P=0.076 / Beta=-0.165
P=0.31
RAMRIS MCP4 / Beta=-0.372
P=0.020 / Beta=-0.363
P=0.019 / Beta=-0.217
P=0.17 / Beta=-0.303
P=0.057 / Beta=-0.270
P=0.089 / Beta=-0.312
P=0.049 / Beta=-0.226
P=0.16 / Beta=-0.252
P=0.11 / Beta=-0.158
P=0.34
RAMRIS MCP5 / Beta=-0.094
P=0.59 / Beta=-0.153
P=0.37 / Beta=-0.226
P=0.17 / Beta=-0.144
P=0.40 / Beta=-0.165
P=0.33 / Beta=-0.061
P=0.72 / Beta=-0.146
P=0.39 / Beta=-0.208
P=0.22 / Beta=-0.149
P=0.39
MRI BME MCP2-5 / Beta=-0.390
P=0.014 / Beta=-0.467
P=0.002 / Beta=-0.234
P=0.13 / Beta=-0.330
P=0.036 / Beta=-0.338
P=0.030 / Beta=-0.329
P=0.036 / Beta=-0.241
P=0.13 / Beta=-0.359
P=0.021 / Beta=-0.249
P=0.12
MRI BME MCP2 / Beta=-0.362
P=0.023 / Beta=-0.428
P=0.005 / Beta=-0.183
P=0.24 / Beta=-0.315
P=0.046 / Beta=-0.364
P=0.019 / Beta=-0.318
P=0.043 / Beta=-0.155
P=0.34 / Beta=-0.384
P=0.013 / Beta=-0.393
P=0.012
MRI BME MCP3 / Beta=-0.336
P=0.037 / Beta=-0.397
P=0.010 / Beta=-0.247
P=0.12 / Beta=-0.324
P=0.041 / Beta=-0.280
P=0.077 / Beta=-0.317
P=0.045 / Beta=-0.339
P=0.031 / Beta=-0.239
P=0.14 / Beta=-0.098
P=0.55
MRI BME MCP4 / Beta=-0.149
P=0.36 / Beta=-0.227
P=0.15 / Beta=-0.165
P=0.29 / Beta=-0.124
P=0.44 / Beta=-0.190
P=0.23 / Beta=-0.203
P=0.21 / Beta=-0.147
P=0.361 / Beta=-0.112
P=0.49 / Beta=-0.193
P=0.23
MRI BME MCP5 / Beta=-0.051
P=0.76 / Beta=-0.061
P=0.70 / Beta=-0.056
P=0.73 / Beta=-0.074
P=0.65 / Beta=-0.080
P=0.62 / Beta=-0.119
P=0.46 / Beta=-0.179
P=0.26 / Beta=-0.130
P=0.42 / Beta=-0.106
P=0.52

MCP: Metacarpophalangeal joints. HAQ: Health assessment questionnaire. CRP: C-reactive protein. MRI: Magnetic resonance imaging. RAMRIS: Rheumatoid arthritis MRI scoring system. BME: Bone marrow edema. Bold if P values are <0.05.

1

Top View