Natalia Tretyakova

Natalia Y. Tretyakova

University of Minnesota

Box 806 Mayo

420 Delaware Street SE

Minneapolis, MN 55455

Tel: (612) 626-3432; e-mail:

Education

1993 – 1997Ph.D. University of North Carolina, Chapel Hill, NC, Dept. of Environmental Sciences and Engineering. Thesis: "Identification and quantitation of 1,3-butadiene-induced DNA adducts using mass spectrometry"

1985 – 1990B.S., M.S. in Chemistry, Moscow State University, Moscow, Russia

Work experience

June 2005 – presentUniversity of Minnesota, Minneapolis, MN
Department of Medicinal Chemistry and Cancer Center
Associate Professor

May 2000 – 2005University of Minnesota, Minneapolis, MN
Department of Medicinal Chemistry and Cancer Center
Assistant Professor

1997 – 2000 Massachusetts Institute of Technology, Cambridge, MA
Division of Bioengineering and Environmental Health
Postdoctoral Research Associate

research interests

 The chemistry of DNA damage with exogenous and endogenous carcinogens

 Sequence effects on chemical reactivity of DNA nucleobases

 DNA-DNA and DNA-protein cross-linking by antitumor drugs and bifunctional carcinogens

awards

2003-2005McKnight-Land Grant professorship, University of Minnesota

1997Student Award, North Carolina Society of Toxicology

1996 Student Award, North Carolina Society of Toxicology

1995Student Travel Award, International Congress of Toxicology, Seattle, WA

1995Student Travel Award, International Symposium on Butadiene and Isoprene Health Risks, Blaine, WA

1994Weiss Award, University of North Carolina

professional memberships

American Association for Cancer Research

American Chemical Society

American Society for Mass Spectrometry

American Association of the Colleges of Pharmacy

editorial duties

Ad hoc Reviewer for Analytical Biochemistry, Biochemistry, Cancer Research, Carcinogenesis, Chemical Research in Toxicology, Chemico-Biological Interactions, Chemistry and Biology, Journal of Mass Spectrometry, Journal of Medicinal Chemistry, Journal of Organic Chemistry, Journal of the American Chemical Society, Journal of the American Society for Mass Spectrometry, Nature Chemical Biology, Nucleic Acids Research

INVITED SEMINARS

Annual Butadiene Research Review: Santa Fe, NM Sept 4-6, 2007. Identification and quantitatve analysis of bifunctional DNA adducts of 1,2,3,4-diepoxybutane

Departmental seminar (Dept. of Chemistry) at Washington University, St. Louis, MS: April 19, 2007. Bifunctional DNA-DNA and DNA-Protein Lesions of 1,2,3,4-diepoxybutane

Departmental seminar (Cancer Center) at University of North Carolina, Chapel Hill: May 2, 2007. Bifunctional DNA-DNA and DNA-Protein Lesions of 1,2,3,4-diepoxybutane

Washington University-St. Louis Department of Chemistry: Bifunctional DNA-DNA and DNA-protein lesions of diepoxybutane. April 19, 2007

Chemistry and Cancer research: a Vital Partnership. A joint AARC-ACS conference: San Diego, CA, Feb, 4-7, 2007. Bifunctional DNA-DNA and DNA-protein adduct of diepoxybutane.

95th annual meeting ofthe American Association for Cancer Research: Washington, DC April 1-4, 2006Sequence specificity for DNA modification by Chemical Carcinogens

Annual Butadiene Research Review: Sarasota, FL: October 22, 2004 DNA-DNA and DNA-protein cross-linking by diepoxybutane: the role of stereochemistry

University of Minnesota Chemical Biology Symposium: May 25, 2004 DNA-DNA and DNA-protein cross-linking by bifunctional electrophiles

University of Minnesota Department of Biochemistry, Molecular, and Cellular Biology Seminar Series: May 25, 2004 Mass spectrometry of chemically modified DNA

Annual Butadiene Research Review: Sarasota, FL: October 22, 2003 DNA-DNA cross-links of diepoxybutane

U.S. Environmental Protection Agency, Duluth, MN: October 15, 2003 Studies of DNA covalent modifications by mass spectrometry

Mutagenesis and Carcinogenesis Monthly Seminars, Univ. of Minnesota Cancer Center: September 25, 2003: Sequence effects on the formation of DNA-carcinogen adducts

226th National Meeting of the American Chemical Society, New York, NY, Sept. 7-11, 2003: Stable isotope labeling-mass spectrometry to map the reactivity of DNA bases towards carcinogens and antitumor agents

51st Annual Conference on Mass Spectrometry and Related Topics, Montreal, Canada, June 8 - 12, 2003: Probing the reactivity of specific positions within DNA towards carcinogens and drugs by stable isotope labeling HPLC-ESI-MS/MS

Carleton College, Dept. of Chemistry: Feb 21, 2003: Mass Spectrometry of Chemically modified DNA

2nd Engebreston Symposium on Drug Design, Mayo Clinic, Sept. 11, 2002 Sequence Selectivity for DNA Modification with Carcinogens and Drugs

Mutagenesis and Carcinogenesis Gordon Research Conference March 3 - March 8, 2002, in Ventura, California. Mapping nucleobase adducts within DNA sequences with electrospray and MALDI mass spectrometry

34th Great Lakes Regional Meeting of the American Chemical Society June 2-4, 2002 Minneapolis, MN. Mass Spectrometry of Chemically modified DNA

Univ. of Minnesota Cancer Center Seminar Series: May 15, 2001 Mapping carcinogen-induced nucleobase lesions within DNA sequences by mass spectrometry.

Univ. Of Minnesota Chemical Biology Colloquium: October 17, 2001 Mass Spectrometry of Chemically Modified DNA

Minnesota Mass Spectrometry Discussion Group: October 9, 2000 Mass Spectral Analysis of the Distribution of Carcinogen-modified DNA Nucleobases within DNA Sequences

14th Montreux LC-MS Symposium. Cornell University, Ithaca, NY, July 21-25, 1997. LC-ESI MS/MS in analysis of 1,3-butadiene-induced DNA adducts.

Publications

  1. Goggin, M., Anderson, C., Park, S., Walker, V., and Tretyakova, N.(2008) Quantitative HPLC-ESI+ MS/MS analysis of adenine-guanine cross-links of 1,2,3,4-diepoxybutane in vitro and in vivo. Submitted.
  2. Seneviratne, U., Antsypovich, S., Quirk Dorr, D., Guza, R., and Tretyakova, N. (2008) Exocyclic deoxyadenosine adducts of 1,3-butadiene: synthesis, structural elucidation, and effects of DNA structure. Submitted.
  3. Loeber, R., Michaelson, E., Fang, Q., Campbell, C., Pegg, A.E., and Tretyakova, N. (2008) Cross-linking of the DNA repair protein O6-alkylguanine DNA alkyltransferase to DNA in the presence of antitumor nitrogen mustards. Chem. Res. Toxicol. In press.
  4. Antsypovich, S., Quirk Dorr, D., Pitts, C., and Tretyakova, N. (2007) Site specific N6-(2-hydroxy-3,4-epoxybut-1-yl)adenine oligodeoxynucleotide adducts of 1,2,3,4 diepoxybutane: synthesis and stability at physiological pH. Chem. Res. Toxicol.20, 641-649.
  5. Goggin, M., Loeber, R., Park, S., Walker, V., Wickliffe, J., and Tretyakova, N. (2007) HPLC-ESI+-MS/MS analysis of N7-guanine-N7-guanine DNA cross-links in tissues of mice exposed to 1,3-butadiene. Chem. Res. Toxicol.20, 839-847.
  6. Kim, M.Y., Park, S., Tretyakova, N., and Wogan, G. (2007) Mutagenesis of the supF gene by stereoisomers of 1,2,3,4-diepoxybutane. Chem. Res. Toxicol.20, 790-797.
  7. Matter, B., Guza, R., Zhao, J., Li, Z., Jones, R., and Tretyakova, N. (2007) Sequence distribution of acetaldehyde-derived N2-ethyl-dG adducts along duplex DNA. Chem. Res. Toxicol.20, 1379-1387.
  8. Miksa, B., Chinnapann, R., Dang, N.C., Reppert, M., Matter, B., Tretyakova, N., Grubor, N., and Jankowiak, R. (2007) Spectral differentiation and immunoaffinity capillary electrophoresis separation of enantiomeric benzo(a)pyrene diol epoxide-derived DNA adducts. Chem. Res. Toxicol.20, 1192-1199.
  9. Quirk-Dorr, D., Murphy, K., and Tretyakova, N. (2007) Synthesis of DNA oligodeoxynucleotides containing structurally defined N6-(2'-hydroxy-3',4'-buten-1'-yl)-adenine adducts of 3,4-epoxy-1-butene. Chemico-Biol. Interact.166, 104-111.
  10. Tretyakova, N., Livshits, A., Park, S., Bisht, B., and Goggin, M. (2007) Structural elucidation of a novel DNA-DNA cross-link of 1,2,3,4-diepoxybutane. Chem. Res. Toxicol.20, 284-289.
  11. Guza, R., Rajesh, M., Fang, Q., Pegg, A.E., and Tretyakova, N. (2006) Kinetics of O6-methyl-2'-deoxyguanosine repair by O6-alkylguanine DNA alkyltransferase within K-ras gene-derived DNA sequences. Chem. Res. Toxicol.19, 531-538.
  12. Loeber, R., Rajesh, M., Fang, Q., Pegg, A.E., and Tretyakova, N. (2006) Cross-linking of the human DNA repair protein O6-alkylguanine DNA alkyltransferase to DNA in the presence of 1,2,3,4-diepoxybutane. Chem. Res. Toxicol.19, 645-654.
  13. Malejka-Giganti, M. and Tretyakova, N. (2006) Molecular mechanisms of carcinogenesis. In Carcinogenic and anticarcinogenic food components. (Baer-Dubowska, W., Bartoszek, A., and Malejka-Giganti, D. Eds.), pp 13-36, CRC Press, Boca Raton, FL.
  14. Matter, B., Malejka-Giganti D., Csallany, A.S., and Tretyakova, N. (2006) Quantitative analysis of the oxidative DNA lesion, 2,2-diamino-4-(2-deoxy--D-erythro-pentofuranosyl)amino]-5(2H)-oxazolone (oxazolone), in vitro and in vivo by isotope dilution-capillary HPLC-ESI-MS/MS. Nuc. Acids. Res.34, 5449-5460.
  15. Millard, J.T., Hanly, T.C., Murphy, K., and Tretyakova, N. (2006) The 5'-GNC Site for DNA Interstrand Cross-Linking is Conserved for Diepoxybutane Stereoisomers. Chem. Res. Toxicol.19, 16-19.
  16. Park, S., Anderson, C.,Wang. G, Jones, R., and Tretyakova, N. (2005) Interstrand and intrastrand DNA-DNA cross-linking by 1,2,3,4-diepoxybutane: role of stereochemistry. J. Am. Chem. Soc., 127, 14355-14365.
  17. Rajesh, M., Wang, G., Jones, R., Tretyakova, N. (2005) Stable Isotope Labeling-Mass Spectrometry Analysis of Methyl- and Pyridyloxobutyl-Guanine Adducts of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone in p53-Derived DNA Sequences. Biochemistry,44, 2197-2207.
  18. Kim, J., Park S., Tretyakova, N., Wagner, C.R. (2004) A method for quantitating the intracellular metabolism of AZT amino acid phosphoramidate pronucleotides by capillary high-performance liquid chromatography-electrospray ionization mass spectrometry. Mol. Pharm.2, 233-241.
  19. Park, S., Hodge, J., Anderson, C., Tretyakova, N. (2004) Guanine-adenine DNA cross-linking by 1,2,3,4-diepoxybutane: potential basis for biological activity. Chem. Res. Toxicol.17, 1638-1651.
  20. Thomson, N.M., Mijal, R.S., Ziegel, R., Fleischer, N.L., Pegg, A.E., Tretyakova, N., and Peterson, L.A. (2004) Development of a quantitative liquid chromatography/electrospray mass spectrometric assay for a mutagenic tobacco specific nitrosamine-derived DNA adduct, O6-[4-oxo-4-(3-pyridyl)butyl]-2'-deoxyguanosine. Chem. Res. Toxicol.17, 1600-1606.
  21. Balcome, S., Park, S., Quirk-Dorr, D.R., Hafner, L., Phillips, L., Tretyakova, N. (2004) Adenine-containing DNA-DNA cross-links of antitumor nitrogen mustards. Chem. Res. Toxicol.17, 950-962.
  22. Matter, B., Wang, G., Jones, R., Tretyakova, N. (2004) Formation of diastereomeric benzo[a]pyrene diol epoxide-guanine adducts in p53 gene-derived DNA sequences. Chem. Res. Toxicol.17, 731-741.
  23. Park, S., Tretyakova, N. (2004) Structural characterization of the major DNA-DNA cross-link of 1,2,3,4-diepoxybutane. Chem. Res. Toxicol.17, 129-136.
  24. Ziegel, R., Shallop, A., Upadhyaya, P., Jones, R., Tretyakova, N. (2004) Endogenous 5-methylcytosine protects neighboring guanines from N7 and O6-methylation and O6-pyridyloxobutylation by the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Biochemistry,43, 540-549.
  25. Park, S., Seethraman, M., Ogdie, A., Ferguson, D., Tretyakova, N. (2003) 3'-Exonuclease resistance of DNA oligodeoxynucleotides containing O6-[4-oxo-4-(3-pyridyl)butyl]guanine. Nucleic Acids Res.31, 1984-1994.
  26. Ziegel, R., Shallop, A., Jones, R., Tretyakova, N. (2003) K-ras gene sequence effects on the formation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-DNA adducts. Chem. Res. Toxicol.16, 541-550.
  27. Upadhyaya, P., Sturla, S.J., Tretyakova, N., Ziegel, R., Villalta, P.W., Wang, M., Hecht, S.S. (2003) Identification of adducts produced by the reaction of 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanol with deoxyguanosine and DNA. Chem. Res. Toxicol.16, 180-190.
  28. Pfeifer, G.P., Denissenko, M.F., Olivier, M., Tretyakova, N., Hecht, S.S., Hainaut, P. (2002) Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers. Oncogene,21, 7435-7451.
  29. Tretyakova, N., Matter, B., Jones, R., Shallop, A. (2002) Formation of benzo[a]pyrene diol epoxide-DNA adducts at specific guanines within K-ras and p53 gene sequences: stable isotope-labeling mass spectrometry approach. Biochemistry, 41, 9535-9544.
  30. Tretyakova, N., Matter, B., Ogdie, A., Wishnok, J.S., and Tannenbaum, S.R. (2001) Locating nucleobase lesions within DNA sequences by MALDI-TOF mass spectral analysis of exonuclease ladders. Chem. Res. Toxicol.14, 1058-1070.
  1. Swenberg, J.A., Ham, A., Koc, H., Morinello, E., Ranasinghe, A., Tretyakova, N., Upton, P.B., Wu, K.Y. (2000) DNA adducts: effects of low exposure to ethylene oxide, vinyl chloride and butadiene. Mutat. Res.464, 77-86
  2. Tretyakova, N., Burney, S., Pamir, B., Wishnok, J.S., Dedon, P.C., Wogan, G.N., and Tannenbaum, S.R. (2000) Peroxynitrite-induced DNA damage in the supF gene: correlation with the mutational spectrum. Mutation Res.447, 287-303.
  3. Tretyakova, N., Wishnok, J.S., and Tannenbaum, S.R. (2000) Peroxynitrite-induced secondary oxidative lesions at guanine nucleobases: chemical stability and recognition by the Fpg repair enzyme. Chem. Res. Toxicol.13, 658-664.
  4. Vatsadze, S.Z., Lebedev, A.T., Zyk, N.V., Zefirov, N.S., Tretyakova, N., Hass, J.R. (2000) Fragmentation of 3,7-dialkyl-1,5-diphenyl-3,7-diazabicyclo[3.3.1]nonan-9-ones under electron ionization. Rapid Commun. Mass Spectrom. 14, 1949-1953.
  5. Koc, H., Tretyakova, N., Walker, V.E., Henderson, R.F., and Swenberg, J.A. (1999) Molecular dosimetry of N-7-guanine adduct formation in mice and rats exposed to 1,3-butadiene. Chem. Res. Toxicol. 12, 566-574.
  6. Tretyakova, N., Niles, J., Burney, S., Wishnok, J.S. and Tannenbaum, S.R. (1999) Peroxynitrite-induced reactions of synthetic oligonucleotides containing 8-oxoguanine. Chem. Res. Toxicol.12, 459-466.
  7. Tretyakova, N., Chiang, S-Y., Walker, V. and Swenberg, J.A. (1998) Quantitative analysis of 1,3-butadiene-induced DNA adducts in vivo and in vitro using liquid chromatography-electrospray ionization tandem mass spectrometry, J. Mass Spectrom.33, 363-376.
  8. Lebedev, A.T., Karakhanova, N.K., Sipyaguin, A.M., Efremov,I.V., Tretyakova, N., and Hass, J.R. (1997) Comparative study of the cyclization of dithiocarbamate derivatives of polyhalopyridines induced by electron impact and carried out in solution. J. Mass Spectrom. 32, 728-738.
  9. Lebedev, A.T., Predein, E., Bakulev, V., Tretyakova, N., Hass, J.R. (1997) Isomerization of thioamidomethylpyridine ylides and isoquinoline ylides under electron impact. European J. Mass Spectrom. 3, 217-223.
  10. Sangaiah, R., Christova-Georgieva, N.I., Ranasighe, A., Tretyakova, N., Gold, A., Ball, L.M., and Swenberg, J.A. (1997) Synthesis of perdeuterated analogues of the epoxide metabolites of butadiene: 1,2-epoxybut-3-ene-d6 and 1,2,3,4-diepoxybutane-d6. J. Labelled. Compd. Rad.39, 731-739.
  11. Tretyakova, N., Lin, Y-P, Sangaiah, R., Upton, P.B. and Swenberg, J.A. (1997) Identification and quantification of DNA adducts from calf thymus DNA exposed to 3,4-epoxy-1-butene. Carcinogenesis 18, 137-147.
  12. Tretyakova, N., Sangaiah, R., Yen, T-Y. and Swenberg, J.A. (1997) Adenine adducts with diepoxybutane: isolation and analysis in exposed calf thymus DNA. Chem. Res. Toxicol. 10, 1171-1179.
  1. Tretyakova, N., Sangaiah, R., Yen, T-Y. and Swenberg, J.A. (1997) Synthesis, characterization and in vitro quantitation of N-7-guanine adducts of diepoxybutane. Chem. Res. Toxicol.10, 779-785.
  2. Tretyakova, N., Hass, J.R., Saginova, L.G. and Lebedev, A.T. (1997) Decomposition of 3,5-diaryl-oxathiolane-2-oxides under the electron impact. Int.J. Mass Spectrom. 165/166, 595-607.
  3. Tretyakova, N., Lin, Y-P, Upton, P.B., Sangaiah, R. and Swenberg, J.A. (1996) Macromolecular adducts of butadiene. Toxicology 113, 70-76.
  4. Tretyakova, N., Lebedev, A.T. and Petrosyan, V.S.(1994)Degradative pathways of the aqueous chlorination of orcinol. Environ. Sci. Technol. 28, 606-613.

Abstracts

234nd National Meeting of the American Chemical Society: Boston, MA Aug. 19-23, 2007 Identification and quantitative analysis of bifunctional DNA adducts of 1,2,3,4-diepoxybutane

55th Meeting of the American Association for Mass Spectrometry: Indianapolis, IN June 3-7, 2007. Stable isotope labeling-HPLC-MS/MS analysis of sequence preferences for DNA adduct formation HPLC- ESI-MS/MS method for kinetic Analysis of O6-alkylguanine DNA alkyltransferase mediated repair of carcinogen induced O6-alkyldeoxyguanosine lesions

Rachel Loeber, Colin Campbell, and Natalia Tretyakova. Nitrogen Mustard-Induced Cross-Linking of the Human DNA Repair Protein O6-Alkylguanine DNA Alkyltransferase to Its DNA Substrate. Poster presentation at the 234th National Meeting of the American Chemical Society: Boston, MA Aug. 19-23, 2007

Uthpala Seneviratne and Natalia Tretyakova. Synthesis of the optically pure exocyclic 2'-deoxyadenosine adducts of 1,2,3,4-diepoxybutane. Poster presentation at the University of Minnesota NIH Training Grant Symposium Chemical Biology: A Catalyst for Discovery: Wednesday, May 30, 2007

Rebecca Guza and Natalia Tretyakova. O6-Alkylguanine DNA Alkyltransferase Mediated Repair of Carcinogen Induced O6-alkyl-deoxyguanosine Lesions. Poster presentation at the University of Minnesota NIH Training Grant Symposium Chemical Biology: A Catalyst for Discovery: Wednesday, May 30, 2007

Kris Murphy and Natalia Tretyakova Mechanisms of 5-methylciytosine induced effects on reactivity of neighboring guanine bases toward tobacco carcinogens. Poster presentation at the University of Minnesota NIH Training Grant Symposium Chemical Biology:A Catalyst for Discovery: Wednesday, May 30, 2007

Tretyakova, Natalia; Seneviratne, Uthpala; Goggin, Melissa. Identification and quantitative analysis of bifunctional DNA adducts of 1,2,3,4-diepoxybutane. Oral presentation at the 234th ACS National Meeting, Boston, MA, United States, August 19-23, 2007

Loeber, Rachel L.; Goggin, Melissa; Quirk Dorr, Danae R.; Pegg, Anthony E.; Tretyakova, Natalia. Nitrogen mustard-induced cross-linking of the human DNA repair protein O6-alkylguanine DNA alkyltransferase to its DNA substrate. Poster presentation at the 234th ACS National Meeting, Boston, MA, United States, August 19-23, 2007

Antsypovich, Sergey; Guza, Rebecca; Quirk Dorr, Danae; Pitts, Crystal; Matter, Brock; Tretyakova, Natalia. Novel exocyclic dA adducts of 1,2,3,4-diepoxybutane. Abstracts of Papers, 232nd ACS National Meeting, San Francisco, CA, United States, Sept. 10-14, 2006

Natalia Tretyakova. Cross-linking of the human DNA repair protein O6-alkylguanine DNA alkyltransferase to DNA in the presence of 1,2,3,4-diepoxybutane Oral presentation at the Biological Reactive Intermediates Conference (BRIVII): Tucson, AZ January 2006

Natalia Tretyakova. Distribution of structurally defined oxidative guanine lesions along K-ras and p53 derived DNA sequences: Oral presentation at the 232nd Meeting of the American Chemical Society: San Francisco, CA Sept. 10-14, 2006

Rachel Loeber and Natalia Tretyakova. Cross-linking of the human DNA repair protein O6-alkylguanine transferase to its DNA substrate in the presence of 1,2,3,4-diepoxybutane. Poster presentation at the 95th Annual meeting of the American Association for Cancer Research: Washington, DC April 1-4, 2006

Quirk-Dorr, D. and Tretyakova, N. Synthesis of DNA oligodeoxynucleotides containing structurally defined N6-(2'-hydroxy-3',4'-epoxybut-1'-yl)adenine adducts of 1,2,3,4-diepoxybutane. 3rd Annual Symposium Chemical Biology: Unlocking Nature's Secrets - June 2006

Brock Matter, Mathur Rajesh and Natalia Tretyakova. Endogenous cytosine methylation controls the reactivity of neighboring guanine nucleobases towards tobacco carcinogens. Poster presentation at the 95th annual meeting of the American Association for Cancer Research: DC March 31-April 4, 2006, Washington, DC

Tretyakova, N., Matter, B., Rajesh, M., Shallop, A., Gaffner, B., and Jones, R. Stable isotope labeling as a tool to investigate sequence selectivity for DNA modification by carcinogens and drugs. Poster presentation at the XVI International Roundtable on Nucleotides and Nucleic Acids, September 12-16, 2004, Minneapolis, MN.
Tretyakova, N. DNA-DNA and DNA-protein cross-linking by 1,2,3,4-diepoxybutane. Oral presentation at the National Meeting of the American Chemical Society, August 22-26, 2004, Philadelphia, PA

Park, S. and Tretyakova, N. Structural characterization of the asymmetric DNA-DNA cross-links of diepoxybutane. Poster presentation at the National Meeting of the American Chemical Society, August 22-26, 2004, Philadelphia, PA

Rajesh, M., Wang, G, Jones, R., and Tretyakova, N. Stable isotope labeling – HPLC-MS/MS study of sequence selective guanine alkylation by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Poster presentation at the Poster presentation at the 52ndannual meeting of the American Society for Mass Spectrometry; May 23 - 27, 2004, Nashville, Tennessee.

Tretyakova, N., Park, S., and Hodge, J. Structural characterization of the guanine-adenine cross-links of diepoxybutane. Gordon Research Conference on Mutagenesis and Carcinogenesis: Ventura, CA (March 2004)

Loeber, R. and Tretyakova, N. DNA-DNA and DNA-GSH cross-linking by meso-1,2,3,4-diepoxybutane. 42nd Annual Medicinal Chemistry meeting-in-miniature (MIKI), Iowa City. Iowa April 16-18, 2004

Quirk-Dorr, D. and Tretyakova, N. Structural characterization of novel DNA-DNA cross-links of mechlorethamine. 42nd Annual Medicinal Chemistry meeting-in-miniature (MIKI), Iowa City. Iowa April 16-18, 2004

Ziegel, B. and Tretyakova, N. Effects of gene sequence and endogenous methylation on DNA adduct formation by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Poster presentation at the 94th annual meeting of the American Association for Cancer Research. July 2003, Washington, D.C.

Ziegel, B. and Tretyakova, N. Effects of gene sequence and endogenous methylation on DNA adduct formation by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Poster presentation at the annual 41st Annual Medicinal Chemistry meeting-in-miniature (MIKI), April 2003

Park, S. and Tretyakova, N. Structural characterization and quantitative analysis of 1,2,3,4-diepoxybutane-induced DNA-DNA cross-links. Poster presentation at the 51stannual meeting of the American Society for Mass Spectrometry: Montreal, Canada June 8 - 12, 2003