Waters® Xevo® TQD
Installation Checklist
Introduction
WARNING:There are various hazards associated with the installation and operation of this equipment. The precautions detailed in the Waters Xevo® TQD Operator’s Overview and Maintenance Guide (Documentation CD p/n715002944) must be observed when following procedures listed in this checklist.
The Xevo TQD Installation Checklist is completed by a Waters field service engineer (FSE) during the installation of a standalone instrument and any purchased Xevo TQD options. The purpose of the document is:
- To ensure that all the necessary steps are followed during the installation.
- To provide proof of installation by a qualified Waters engineer.
- To demonstrate operation of the Xevo TQD instrument to the customer.
- To ensure that the customer is trained to a level to enable basic operation of the system.
NOTE:If the customer has purchased a qualification, then the FSE does not need to fill out this entire checklist, but does need to complete the "Customer Training" section.
The FSE must fill out the summary tables, and complete, sign and date the "Installation Confirmation" section. The FSE then leaves a signed copy of the checklist with the customer to document installation and testing, and also retains an electronic or printed copy of the checklist to either send or fax to the regional office.
Notice
The information in this document is subject to change without notice and should not be construed as a commitment by Waters Corporation. Waters Corporation assumes no responsibility for any errors that may appear in this document. This checklist is believed to be complete and accurate at the time of publication. In no event shall Waters Corporation be liable for incidental or consequential damages in connection with or arising from the use of this document.
©2013 WATERS CORPORATION. PRINTED IN THE UNITED STATES OF AMERICA. ALL RIGHTS RESERVED. THIS BOOK OR PARTS THEREOF MAY NOT BE REPRODUCED IN ANY FORM WITHOUT THE WRITTEN PERMISSION OF THE PUBLISHER.
Waters, The Science of What's Possible, Xevo, TRIZAIC, Waters Quality Parts,MassLynx, and Connections INSIGHT are registered trademarks of Waters Corporation.
iRequest, IntelliStart, and TargetLynx are trademarks of Waters Corporation.
All other trademarks are the sole property of their respective owners.
Xevo TQD Unpacking
The shipping containers or unpacked items have been inspected for damage; any damage
found has been reported to Waters.
Yes No N/A
The components required for the installation have been assessed; any discrepancies found
have been reported to Waters.
Yes No N/A
The system is positioned in the final location.
Yes No N/A
The instrument lifting straps are removed from the instrument once in position.
Yes No N/A
The test samples are available.
Yes No N/A
Sample kit part number:Lot number:
Expiry date:
Suitable solvents for sample preparation and installation are available.
Yes No N/A
For detail on the setup of any of the system components, refer to the following documentation:
• Xevo TQD Installation Manual (p/n 715003191)
• Xevo TQD Operator’s Overview and Maintenance Guide (Documentation CD p/n 715002944)
Also, for detail on using the software refer to the user documentation. Refer to the Ethernet Instrument Getting Started Guide (p/n 71500074403)for detail on setup and control of Waters Ethernet instruments.
Xevo TQD Setup
The rotary / scroll pump lines are connected.
Yes No N/A
The rotary / scroll pump exhaust is connected to a suitable air extraction system (separatefrom the source exhaust).
Yes No N/A
The rotary pump (where supplied) is filled with oil to the upper level mark.
Yes No N/A
The pump control cable has been connected to the pump and control port on the rear panel of the instrument.
Yes No N/A
The instrument and the rotary / scroll pump are connected to the laboratory power supply.
Yes No N/A
The source exhaust tube is connected to the exhaust trap bottle.
Yes No N/A
The source exhaust outlet is connected to a suitable air extraction system (separate from the vacuum pump exhaust).
Yes No N/A
The exhaust trap bottle valve control cable is connected to the rear panel.
Yes No N/A
The liquid waste line is connected to a suitable waste container.
Yes No N/A
The fluidics wash line tube is placed in a reservoir bottle containing 70:30 acetonitrile/water.
Yes No N/A
The nitrogen generator is installed, functioning, and the forms are returned to the manufacturer.
Yes No N/A
The nitrogen gas supply is connected to the rear panel, the pressure on the regulatoris set to 6.7±0.2 bar (97 ±3 psi) and there are no leaks.
Yes No N/A
CAUTION:Where the APGC source is supplied, nitrogen purity must be >99.999%.
The nitrogen pressure is:The argon collision gas supply (>99.997% purity) is connected to the rear panel, the pressure on the regulator is set to 0.5 ±0.1 bar (7 ±2 psi) and there are no leaks.
Yes No N/A
The argon pressure is:Event cables are connected between the detector and the LC inlet (if an LC inlet is installed).
Yes No N/A
The stop flow (gas fail) cable is connected between the instrument and the LC inlet.
Yes No N/A
The host PC is connected to a suitable power supply.
Yes No N/A
The electrospray probe is installed.
Yes No N/A
APGC and 7890 GC Oven Setup
This section applies/does not apply to this configuration.
Applies Does Not Apply
GC plinth assembly and instrument have been secured using the location plate.
Yes No N/A
7890 GC oven assembly has been placed on plinth and travel assembly functions correctly.
Yes No N/A
The helium supply is connected and is leak free.
Yes No N/A
The helium supply pressure is:The nitrogen supply is connected and is leak free.
Yes No N/A
The supplied moisture trap is fitted on the nitrogen gas supply to the 7890 GC oven using metal tubing and fittings.
Yes No N/A
The nitrogen supply pressure is:CAUTION:Where the APGC source is supplied, nitrogen purity must be >99.999%.
The electrical connections have been made.
Yes No N/A
The heated transfer line is connected to the 7890 GC oven.
Yes No N/A
The network and communications configuration for the 7890 GC oven and MS are set up.
Yes No N/A
Analytical column has been fitted and configured.
Yes No N/A
Auxillary EPC has been configured.
Yes No N/A
Heated transfer line has been configured internally to the 7890 GC oven.
Yes No N/A
Xevo TQD Checks
The MassLynx™ PC boots up successfully.
Yes No N/A
MassLynx is installed and any software updates are loaded.
Yes No N/A
The MassLynx software version is:The following updates are present:
TargetLynx and OpenLynx application managers are installed.
Yes No N/A
The following application managers are present:The Connections INSIGHT software is installed, setup and registered.
Yes No N/A
The instrument switches on and the embedded PC boots up successfully.
Yes No N/A
The host PC communicates with the instrument.
Yes No N/A
The software starts successfully.
Yes No N/A
The instrument pumps down successfully and the turbo speeds reach 100%.
Yes No N/A
The instrument switches into Operate.
Yes No N/A
All instrument cooling fans are working.
Yes No N/A
The Tune page readbacks are correct.
Yes No N/A
The fluidics are under software control.
Yes No N/A
The RF generators have been aligned to optimal values.
Yes No N/A
The collision cell pressure with the gas switched on is between 3.5E-3 and 4.0E-3 mbar.
Yes No N/A
The collision cell pressure:An ion beam is visible in the Tune page.
Yes No N/A
Mass scale and resolution is set up correctly, and the relevant spectra and Tune pages have been recorded.
Yes No N/A
Ion energy and DC balance are optimized.
Yes No N/A
Both quadrupoles have been calibrated through IntelliStart™ in unit mass analysis type, and any other analysis type required by the user.
Yes No N/A
Xevo TQD Verification Tests
Before performing the following tests, ensure that the mass spectrometer has been in Operate for at least 30minutes and the status LEDs display continuous green.
Refer to the Xevo TQD Installation Manual (p/n 715003191) for test procedures.
High Mass Resolution, Positive Ion, MS1 and MS2
Resolution is measured using a 10 µL/min infusion of setup solution QP. The valley between the 2034.63 Da and 2035.63 Da peaks is ≤12% of the average height of the two peaks.
MS1 resolution:MS2 resolution:
The MS1 and MS2 valleys are≤12% of the average height of the two peaks.
Yes No N/A
Xevo TQD Sensitivity Tests
This section applies/does not apply to this configuration.
Applies Does Not Apply
Before performing the following tests, ensure that the mass spectrometer has been in Operate for at least 30minutes and the status LEDs display continuous green.
Refer to the Xevo TQD Installation Manual (p/n 715003191) for test procedures.
ESI Positive Ion Sensitivity
Five sample infusions of 1 pg/µL reserpine (in 70:30 acetonitrile/water) and three blank infusions (70:30 acetonitrile/water) are made into a flow of 200 µL/min 70:30 acetonitrile/water, using the system fluidics.
Signal-to-RMS noise:The average signal-to-noise ratio of the sample peaks (RMS with no extra processing)is ≥1000:1.
Yes No N/A
The %RSD for the five sample peak heights is ≤10%.
Yes No N/A
The average blank intensity is ≤10% of the average sample intensity.
Yes No N/A
ESI Negative Ion Sensitivity
Five sample infusions of 0.5 pg/µL chloramphenicol (in 70:30 acetonitrile/water) and three blank infusions (70:30 acetonitrile/water) are made into a flow of 200 µL/min 70:30 acetonitrile/water, using the fluidics.
Signal-to-RMS noise:The average signal-to-noise ratio of the sample peaks (RMS with no extra processing)is ≥250:1.
Yes No N/A
The %RSD for the five sample peak heights is ≤10%.
Yes No N/A
The average blank intensity is ≤10% of the average sample intensity.
Yes No N/A
Source Options Tests
APCI Positive Ion Sensitivity
This section applies/does not apply to this configuration.
Applies Does Not Apply
Five sample infusions of 10 pg/µL 17--hydroxyprogesterone (in 70:30 acetonitrile/water) and three blank infusions (70:30 acetonitrile/water) are made into a flow of 1 mL/min 70:30 acetonitrile/water, using the system fluidics.
Signal-to-RMS noise:The average signal-to-noise ratio of the sample peaks (RMS with no extra processing)is ≥100:1.
Yes No N/A
The %RSD for the five sample peak heights is ≤10%.
Yes No N/A
The average blank intensity is ≤10% of the average sample intensity.
Yes No N/A
APPI Positive Ion Sensitivity
This section applies/does not apply to this configuration.
Applies Does Not Apply
Five sample infusions of 100 pg/µL naphthalene (in 100% methanol) and three blank infusions
(100% methanol) are made into a flow of 200 µL/min 100% methanol, using the system fluidics.
The average signal-to-noise ratio of the sample peaks (RMS with no extra processing)is ≥40:1.
Yes No N/A
The %RSD for the five sample peak heights is ≤10%.
Yes No N/A
The blank intensity is≤10% of the average sample intensity.
Yes No N/A
NanoFlow Positive Ion Sensitivity
This section applies/does not apply to this configuration.
Applies Does Not Apply
A direct infusion of 100 fmol/µL [Glu1]-fibrinopeptide B (in 50:50 acetonitrile/water +1% formic acid) at 400 nL/min is made using an external syringe pumpwith a 100 µL gas tight LC syringe. MS full scan spectra are acquired, 700 to 900 Da at 2sec/scan.
Peak Intensity:The peak intensity of the peak at m/z 785.8 (six scans combined) is ≥5E5.
Yes No N/A
The %RSD for the six sample peak heights is ≤10%.
Yes No N/A
APGC Positive Ion Mode MS Specification
This section applies/does not apply to this configuration.
Applies Does Not Apply
Using six consecutive injections of 1 µL of 10 pg/µL hexachlorobenzene in hexane, the signal intensity has a signal-to-noise of 2000:1 RMS.
Yes No N/A
On the chromatographic peak shape, the ratio of the hexachlorobenzene peak at 5% baseline (defined as B/A) is ≤1.5.
Yes No N/A
NOTE:A is the time difference between the front edge of the peak and the peak center, and B is the time difference between the tail edge of the peak and peak center at 5% baseline.
Signal intensity of the MRM trace on the six analyte peaks >1E4 and %RSD <10%.
Yes No N/A
%RSD <10% on the blank peaks.
Yes No N/A
NOTE:Blank peaks must be <10% the height of the smallest analyte peak.
Blank injections / Injection 1 / Injection 2 / Injection 3%RSD
Analyte injections / Injection 4 / Injection 5 / Injection 6 / Injection 7 / Injection 8 / Injection 9
Signal-to-noise
Signal intensity
Peak symmetry
Xevo TQD Installation Completion
The instrument covers are in place.
Yes No N/A
The Tune page is in the basic tuning view and contains the correct settings for all ion modes.
Yes No N/A
Installation projects copied to DVD.
Yes No N/A
The Service Reminder section in Xevo TQD console has been completed.
Yes No N/A
NOTE:Copies of this Installation Checklist and all printouts of installation data must be sent to the local Waters office and left with the customer.
Customer Training
The Waters engineer will introduce the following topics while demonstrating the system performance specifications. Waters intends only to provide familiarization with the basic operation and maintenance of the system, and does not attempt to provide comprehensive training during installation.
For full details of training courses available, please contact your Waters representative.
Safety
Review the safety sections of the Xevo TQD Operator’s Overview and Maintenance Guide(Documentation CD p/n 715002944).
Yes No N/A
Routine Maintenance
Review the maintenance chapters of the relevant operator’s guides.
Yes No N/A
Overview
Instrument description.
Yes No N/A
Vacuum system.
Yes No N/A
Status panel LEDs.
Yes No N/A
Location of gas and electrical connections.
Yes No N/A
Modes of operation.
Yes No N/A
MassLynx
Host PC user name and password.
Yes No N/A
Opening MassLynx.
Yes No N/A
MS Console page, Sample List, Inlet and MS Method editors.
Yes No N/A
Basic Operation
Switching the instrument on and off.
Yes No N/A
Pumping and venting the instrument.
Yes No N/A
Vacuum Monitoring window.
Yes No N/A
Switching into Operate and Standby.
Yes No N/A
Rebooting the embedded PC.
Yes No N/A
Diagnostics window.
Yes No N/A
Maintaining the utilities.
Yes No N/A
Ion Source(s)
Overview.
Yes No N/A
Installation.
Yes No N/A
Setting temperatures and voltages.
Yes No N/A
Adjusting the probe position.
Yes No N/A
Basic operation.
Yes No N/A
Dual-mode ionization operation.
Yes No N/A
Routine Operation
Calibration using IntelliStart.
Yes No N/A
Sample tuning using IntelliStart.
Yes No N/A
Optimization of probe position using the IntelliStart Manual Tune window.
Yes No N/A
Creation of a sample list for quantification.
Yes No N/A
SystemQC function.
Yes No N/A
Processing quantification data using TargetLynx™.
Yes No N/A
APGC
This section applies/does not apply to this configuration.
Applies Does Not Apply
Review the safety sections of the Atmospheric Pressure GC Operator’s Overview and Maintenance Guide Supplement (p/n 715001804).
Yes No N/A
Setting up/dismantling APGC.
Yes No N/A
Gas connections and their functions.
Yes No N/A
Setting temperatures and voltages.
Yes No N/A
Checking for a beam.
Yes No N/A
Optimizing sensitivity.
Yes No N/A
Calibration.
Yes No N/A
Demonstrate the functionality of APGC source.
Yes No N/A
Maintenance.
Yes No N/A
Customer Familiarization
Review workflow on the Xevo TQD Operator’s Quick Reference Card(p/n 715002946).
Yes No N/A
Additional Resources
Support information (
Yes No N/A
Education and training (
Yes No N/A
Obtaining spares (
Yes No N/A
Use of Connections INSIGHT and submitting requests (if connected).
Yes No N/A
Use of iRequest™ to submit online service requests.
Yes No N/A
The benefits of Total Assurance Warranty (TAW).
Yes No N/A
The benefits of Waters Analytical Standards and Reagents for supplying certified samples (
Yes No N/A
Obtaining technical, software and spares support locally.
Yes No N/A
Waters Global Services
Waters Global Services focuses on optimizing Waters products with superior service, support, upgrades, training, and Waters Quality Parts®. For more information, go to .
Summary
Customer Information
Company: / Customer Name:Address 1: / Telephone:
Address 2: / Engineer Name:
City: / SAP Order:
State/Prov/ Region: / Installation Date:
Postal Code:
Country:
Component Information
Sample manager: / Solvent Manager:Sample organizer : / Autosampler:
Pump #1 Model No: / Pump #1 Serial No:
Pump #2 Model No: / Pump #2 Serial No:
Pump #3 Model No: / Pump #3 Serial No:
Detector #1 Model No: / Detector #1 Serial No:
Detector #2 Model No: / Detector #2 Serial No:
Detector #3 Model No: / Detector #3 Serial No:
Detector #4 Model No: / Detector #4 Serial No:
Mass Spec Model No: / Mass Spec Serial No:
Separations System: / Roughing/Dry Pump:
Column Manager: / Column Heater/Cooler:
30-cm Column Heater/Cooler: / High-Temp Column Heater:
Software Model: / Software Serial No:
Host PC: / Other 1:
Other 2: / Other 3:
Other 4: / Other 5:
Installation Confirmation
The installation and setup have been performed and acknowledged by marking each step in this checklist.
Yes No N/A
All tests pertinent to this installation have been performed and have met the defined specification criteria.
Yes No N/A
The customer has been trained in all aspects of instrument operation listed in this checklist.
Yes No N/A
I confirm on behalf ofCompany Name
that the instrument has been installed in accordance with the procedures detailed in this installation checklist, and that instrument operation has been demonstrated by conducting all tests relevant to this installation. The test specifications defined in this installation checklist have been achieved.
Signed: / / Date:
Customer
Type Name
I certify that the installation has been successfully completed.
Signed: / / Date:
Waters Engineer
Type Name
Comments:
Attachments
Use the space below to add any necessary attachments (screen captures, chromatograms, scans, etc) to this Installation Checklist.
All attachments are included below.
Yes No N/A
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