Agenda for Annual Review Meeting 2011

14/01/11

AGENDA FOR ANNUAL REVIEW MEETING 2011

UNIVERSITY OF NAIROBI STD/AIDS COLLABORATIVE GROUP

MAYFAIR COURT SOUTHERN SUN, NAIROBI

Monday, January 17, 2011

8:00 – 9:00 Registration

9:00 – 9:25 OPENING CEREMONIES

Chair: Omu Anzala

Opening remarks – Prof. I. Kibwage – Principal, College of Health Sciences, Univ. Nairobi

Official opening – Prof. G. Magoha – Vice-Chancellor, Univ. Nairobi (To be confirmed)

Close the Gap Program – presentation to UNITID – Lou Dierick

Session I: Special Presentations: The Year’s Highlights

Co-Chairs: Omu Anzala

Joanne Embree

9:25 – 9:50 Good news for microbicides: The CAPRISA 004 trial, the MDP trial of Pro2000

and Buffergel – Isaac Malonza

9:50 – 10:10 Back with a vengeance? Emerging antimicrobial resistance in Neisseria gonorrheoae isolates from Coast, Nairobi and Kisumu regions – Philippe Lagace-Wiens

10:10 – 10:30 Once-daily Truvada lowers risk for HIV acquisition: summary of iPrEx results and updates on oral PreP clinical trials - Nelly Mugo

10:30- 11:00 Coffee / tea

Session II: Epidemiology, Transmission, Risk Factors I

Co-Chairs: Julie Overbaugh

Stephen Moses

11:15 – 11:30 Identifying individuals at high risk for acquiring HIV infection in Kisumu: formative study and initiation of a novel targeted-recruitment incidence cohort (Arthur Ogendo – CDC / KEMRI)

11:30 – 11:45 HIV epidemiology, risk behaviour and the impact of HIV services in the KEMRI-CDC Health and Demographic Surveillance Survey (DHS) area (Frederick Odongo – CDC / KEMRI)

11:45- 12:00 Sexual behaviour, partnership characteristics and HIV infection among adolescent women in Nairobi (Anne Rositch – Univ. N. Carolina / Univ. Washington / Univ. Nairobi)

12:00 – 12:15 Disproportionate HIV and HSV-2 prevalence and incidence among women and adolescent girls in Western Kenya: Preparation for female-centred prevention trials (Fred Otieno – CDC / KEMRI)

12:15 – 12:30 Preliminary findings of an integrated bio-behavioural surveillance survey among migrant female sex workers in Nairobi (Greg Irving, Joshua Kimani – Intl. Org. for Migration / Univ. Manitoba / Univ. Nairobi)

12:30 – 12:45 Substance abuse among sex workers in the Nairobi SWOP Clinic (Charles Wachihi – Univ. Manitoba / Univ. Nairobi)

12:45- 1:00 HIV prevalence and characteristics of sex work among female sex workers in Hargeisa, Somaliland (Jason Theede – Intl. Org. for Migration)

1:00 – 2:00 Lunch

Session III: Interventions I

Co-Chairs: Elizabeth Ngugi

Carey Farquhar

2:00 – 2:20 Moving toward evidence-based HIV prevention behavioural interventions for Kenya (Jennifer Galbraith, Helgar Mutua – CDC / NASCOP)

2:20 – 2:35 Use of post-exposure prophylaxis for sexual exposure (PEPSE) in an urban `population of female sex workers in Nairobi (Preston Izulla – Univ. Manitoba / Univ. Nairobi)

2:35– 2:50 The HAART Cell Phone Randomised Controlled Trial: final results (Sarah Karanja –Univ. Manitoba / Univ. Nairobi)

2:50 – 3:00 The PMTCT Cell Phone trial – study design (Mary Gichuhi – Univ. Manitoba / Univ. Nairobi)

3:00 – 3:15 Preventing clinical trials co-enrollment through biometric participant identification: the experience of three HIV prevention trials in Nyanza Province (Lisa Mills – CDC / KEMRI)

3:15 – 3:25 Comparison of two visit reminder strategies to ensure retention of participants in an HIV prevention preparedness study in Kisumu: preliminary analysis (Monicah Nyambura – CDC / KEMRI)

3:25 – 3:35 Pregnancy among screened and enrolled participants in the Kisumu Incidence Cohort Study: implications for HIV prevention (Victor Akelo – CDC / KEMRI)

3:35 – 3:45 Preliminary findings of a response analysis of combination prevention along transport corridors in Kenya (Timothy Abuya – Intl Organisation for Migration)

3:45 – 4:00 Coffee / tea

Session IV: Family Planning and Reproductive Health

Co-Chairs: Nelly Mugo

Marleen Temmerman

4:00 – 4:10 Non-barrier family planning use among HIV-positive women enrolled in Lumumba HIV Clinic with integrated FP services (Dan Okumu – FACES / KEMRI / UCSF)

4:10 – 4:20 Contraceptive use and receptivity to integration of family planning services into HIV care among HIV-infected men and women in Nyanza Province (Goretty Ong’udi – FACES / KEMRI / UCSF)

4:20 – 4:30 Effects of anticipated stigma and subsequent disclosure on utilization of labour and delivery services among women in Nyanza Province (Maricianah Onono – FACES / KEMRI / UCSF)

4:30 – 4:45 Voluntary medical male circumcision: is this an opportunity to involve men in family planning? (Beatrice Ochieng – Family Health International / Univ. N. Carolina)

4:45 – 5:00 Gender-based violence/sex work / HIV in women and girls (Elizabeth Ngugi – Univ. Nairobi / Univ. Washington / Univ. Victoria)

5:00 – 5:15 Unveiling Sexual and Gender-based violence in Kenya – A multimedia project (Elizabeth Aroka – ICRH / Univ. Ghent / Univ. Nairobi)

6:00 – 9:30 Cocktail party and reception – Mayfair Court Hotel poolside – all participants invited

Tuesday, January 18, 2011

Session V: Perinatal transmission and HIV/AIDS in children

Co-Chairs: Ruth Nduati

Grace John-Stewart

8:30 – 8:45 HIV acquisition during and after pregnancy (John Kinuthia – Univ. Washington / Univ. Nairobi)

8:45 – 9:00 Lipid changes in HIV-1 infected infants initiating highly active antiretroviral therapy (HAART) at less than one year of age (Agnes Langat – Univ. Washington / Univ. Nairobi)

9:00 – 9:15 CD4 C868T polymorphism and HIV-1 progression or mortality among mothers (Robert Choi - Univ. Washington / Univ. Nairobi)

9:15 – 9:30 Maternal anaemia in HIV+ pregnant women in the Kisumu Breastfeeding Study (KiBS) (Collins Odhiambo – CDC/ KEMRI)

9:30 – 9:45 Nevirapine-associated hepatotoxicity and rash are not predicted by a CD4 cell count ≥ 250 cells/µL among HIV-infected pregnant women in Western Kenya (Frank Angira – CDC/KEMRI)

9:45 – 10:00 Breast milk cellular HIV-1 specific interferon-gamma responses are associated with protection from early breast milk HIV-1 transmission (Barbara Lohman-Payne – Univ. Washington / Univ. Nairobi)

10:00 – 10:15 Neutralising antibodies and vertical transmission of HIV-1 (Jennifer Mabuka-Maroa – Univ. Washington / Univ. Nairobi)

10:15 – 10:30 Improving access to prevention of parent to child transmission (PPCT) services through mobile outreach antenatal care (ANC) clinics (Peter Manwari – FACES / KEMRI / UCSF)

10:30 – 11:00 Coffee / tea

Session VI: Epidemiology, Transmission, Risk Factors II – Men Who Have Sex With Men (MSMs)

Co-Chairs: Nicolas Muraguri

Eduard Sanders

11:00 – 11:15 MSM respondent driven survey (RDS) in Nairobi (Scott Geibel – Pop Council / Univ. Nairobi)

11:15 – 11:30 MSM respondent driven survey (RDS) in Kisumu (Robert Bailey – Univ. Illinois Chicago / Univ. Nairobi)

11:30 - 11:45 Data and experience from 275+ male sex workers registered at the Nairobi SWOP Clinic (Joshua Kimani – Univ. Manitoba / Univ. Nairobi)

11:45 – 12:00 Risk factors for HIV-incidence in high risk men in coastal Kenya (Haile Selassie Okulu – KEMRI)

12:00 – 12:15 Disentangling HIV-1 transmission networks among MSM in Kenya from sequence data (Daniela Bezemer – SHM/AMC, the Netherlands)

12:15 – 12:30 www.marps-africa.org - Online health worker training on MSM behaviour in Kenya (Nicolas Muraguri – NASCOP Kenya)

12:30 – 12:40 Challenges in adherence during a PrEP trial among MSM and FSW in Kilifi (Elisabeth van der Elst (KEMRI)

12:40 – 12:50 Behavioural interventions to prevent HIV for MSM: are strategies from the USA applicable to Kenya? (Don Operario – Brown Univ.)

12:50 – 1:00 Men who have sex with men – sex workers and law enforcement in Mombasa – is sexual and gender-based violence an issue? (M. Syengo – ICRH / Univ. Ghent / Pop Council)

1:00 – 2:00 Lunch

Session VII: Treatment and Care I

Co-Chairs: Elizabeth Bukusi

Lisa Mills

2:00 – 2:15 PEPFAR 2010 – Annual update (Katherine Perry – PEPFAR Country Coordinator, U.S. State Dept.)

2:15 – 2:30 Perceived barriers and facilitators to ART adherence in Mombasa: findings from a qualitative study (Anisa Baghazal – Coast General Hospital / ICRH / NASCOP)

2:30 – 2:45 Factors influencing antiretroviral treatment switch among HIV/AIDS patients receiving care at New Nyanza General Hospital, Kisumu (Elizabeth Matey – KEMRI / Univ. Manitoba / Univ. Nairobi)

2:45 – 3:00 A pilot HIV viral load screening program in Nyanza Province – lessons learned (Eric Opiyo – CDC / KEMRI)

3:00 – 3:15 “We are adolescents and we live with HIV”: perceptions and challenges towards life with HIV among HIV-positive adolescents in Kenya and Uganda – Daniel Adipo (Inst. of Trop. Med / KEMRI)

3:15 – 3:30 Increased capacity for integrated HIV/TB services in Kenyan prisons (Ulo Benson – Intl. Medical Corps / CDC / KEMRI)

3:30 – 3:45 Family model of HIV care and treatment - building on family strengths (Patrick Oyaro – FACES / KEMRI / UCSF)

3:45 – 4:00 Univ. Manitoba/Nairobi ART and Care Project: Progress to date (Charles Wachihi – Univ. Manitoba / Univ. Nairobi)

4:00 – 4:15 Coffee / tea

Session VIII: Molecular epidemiology

Co-Chairs: Julius Oyugi

Keith Fowke

4:15 – 4:30 Detection and characterization of early HIV infections: methodologies and new studies (Lisa Mills, Clement Zeh – CDC / KEMRI)

4:30 – 4:45 HIV-1 drug resistant mutation pattern in Kenyan women on first-line anti-retroviral therapy (Juma Shafi – Univ. Washington / Univ. Nairobi)

4:45 – 5:00 Molecular epidemiology of recent and long-term HIV infections in rural Western Kenya (Clement Zeh – CDC / KEMRI)

5:00 – 5:15 Relationship between plasma and female genital HIV-1 RNA concentrations before and after initiation of antiretroviral therapy (Vernon Mochache – Univ. Washington / Univ. Nairobi)

Wednesday, January 19, 2011

Session IX: Resistance and Susceptibility to HIV Infection and Disease

Co-chairs: Frank Plummer

Barbara Lohman-Payne

8:30 – 8:45 Correlates of protection against HIV – studies of HIV exposed seronegative subjects (HESN) (Blake Ball – Univ. Manitoba / Univ. Nairobi)

8:45 – 9:00 Sex work and immune activation: does abstinence make the immune system grow fonder? (Keith Fowke – Univ. Manitoba / Univ.Nairobi)

9:00 – 9:15 Are Serpin antiproteases playing a protective role against HIV infection? Evidence from proteomic studies of HIV –highly exposed yet uninfected women of the Pumwani sex worker cohort (Adam Burgener (Univ. Manitoba / Univ. Nairobi)

9:15 – 9:30 HIV-exposed seronegative people express lower levels of IFN-γ inductible chemokine in their cervico-vaginal lavages (Julie Lavoie – Univ. Manitoba / Univ. Nairobi)

9:30 – 9:45 Characteristics of Th17 cells from the female genital tract (Lyle McKinnon – Univ. Toronto / Univ. Nairobi)

9:45 – 10:00 A blunted IL-17 response and HIV-specific IL-10 production are associated with prolonged commercial sex work without HIV acquisition in Kenyan female sex workers (Rupert Kaul – Univ. Toronto / Univ. Nairobi)

10:00 – 10:15 Viral fitness implication of variation within an immunodominant CD8+ T-cell epitope of HIV-1 (Kelly MacDonald – Univ. Toronto)

10:15 – 10:30 Prevalence of HIV-1 specific IFN-γ responses detected by overlapping peptide pools is similar in HIV-1 exposed seronegative and HIV-1 unexposed individuals (Barbara Lohman-Payne – Univ. Washingrton / Univ. Nairobi)

10:30 – 10:45 Comparison of polyfunctional CD4+ and CD8+ responses and memory markers subtypes in HIV-1 highly exposed seronegarive and HIV-infected female sex workers (James Mwanjewe – Univ. Manitoba / Univ. Nairobi)

10:45 – 11:15 Coffee / tea

Session X: Vaccine Studies

Co-Chairs: Walter Jaoko

James Mwanjewe

11:15 – 11:30 Preventing HIV-1 infection, more epitopes might not be better: systemic analysis of HIV-1 gag epitopes of two HLA Class I alleles associated with different outcomes of HIV-1 infection in the Pumwani sex cohort (Ma Luo – Public Health Agency of Canada / Univ. Manitoba / Univ. Nairobi)

11:30 – 11:45 Assessment of the feasibility of a different HIV vaccine approach (Rupert Capina – National Public Health Agency of Canada / Univ. Manitoba / Univ. Nairobi)

11:45 – 12:00 Mucosal specimen collection in Africa: preliminary results of a pilot study for use in future vaccine trials (Gloria Omosa-Manyonyi – KAVI / Univ. Nairobi)

12:00 - 12:15 Multi Low-dose Mucosal SIVmac239 challenge of cynomolgus macaques immunized with “hyper-attenuated” SIV vaccine constructs (Kelly MacDonald – Univ. Toronto)

12:15 – 12:30 Varicella zoster virus as a vector for mucosal SIV vaccine followed by multi-low dose SIVmac239 intra rectal challenge (Kelly MacDonald – Univ. Toronto)

12:30 – 12:45 Characterising influenza cytokine and T-lymphocyte responses among HIV-exposed unifected commercial sex workers after administration of live attenuated influenza vaccine (Yoav Keynan – Univ. Manitoba / Univ. Nairobi)

12:45 – 1:00 Pre-clinical and clinical development of a vaccine for Respiratory syncytial virus (RSV) (Julia Hurwitz - St. Jude Children’s Research Hospital)

1:00 – 2:00 Lunch

Session XI: Other Infectious Diseases

Co-Chairs: Allan Ronald

Sabine Mall

2:00 – 2:15 Comparison of clinical aspects, risk and epidemiologic factors of community-acquired methicillin-susceptible versus methicillin-resistant Staphylococcus aureus at a Canadian paediatric hospital (Sergio Fanella – Univ. Manitoba)

2:15 – 2:30 Quinolone resistance of N. gonorrhoeae in Kenya: using surveillance to strengthen links between research and policy (Sarah Duncan – Oxford Univ./ KEMRI)

2:30 – 2:45 Routine cryptococcal screening and treatment in Nyanza Province (Caroline Kendl – FACES /KEMRI / UCSF)

2:45 – 3:00 Feasibility of decentralized scale-up of routine cryptococcal screening for patients with CD4 ≤100 cells in Kenya (Noel Odhiambo – FACES / KEMRI / UCSF)

3:00 – 3:15 Understanding the diversity and pathogenesis of enteric viruses (Stacey Schultz-Cherry – St. Jude Children’s Research Hospital)

3:15 – 3:40 Understanding mortality during the H1N1 epidemic (Jonathan McCullers - St.

Jude Children’s Research Hospital)

3:40 – 4:00 Coffee / tea

Session XII: Treatment and Care II

Co-Chairs: Lisa Avery

James Blanchard

4:00 – 4:10 Providing prevention and health care services to MARPS: lessons learned from the SWOP clinic (Gloria Kimani – Univ. Manitoba / Univ. Nairobi)

4:10 – 4:20 Post-exposure prophylaxis among MARPS: are the exposed really exposed? (Jane Njeri – Univ. Manitoba / Univ. Nairobi)

4:20 – 4:35 HIV infection and cognitive impairment (Allan Ronald – Univ. Manitoba / Makerere Infectious Disease Inst)

4:35 – 5:15 The HIV Neurology in Kenya (THINK) study – update (Judith Kwasa – KEMRI / UCSF)

·  Measuring antiretroviral adherence in HIV-infected individuals with and without cognitive impairment in Western Kenya

·  Diagnostic tools and culturally-specific norms for the diagnosis of HIV-associated cognitive impairment in Western Kenya

·  Neuropsychological performance amongst Kenyan adults

·  Utility of quantitative sensory testing and neuropathy screening tools in identifying HIV-associated peripheral neuropathy in Western Kenya