Abstract Number: 1

BRIDGING SAFETY PHARMACOLOGY TO CHINA

Yi Yang.

Frontage Laboratories, Inc. Princeton, NJ, USA

Abstract Number: 2

NONCLINICAL SAFETY PHARMACOLOGY STUDY SUBMISSION - DATA STANDARDS AND STATISTICAL ANALYSES

Wherly Hoffman, Mary Jeanne Kallman.

Eli Lilly & Company, Greenfield, IN, USA

Abstract Number: 3

PREDICTIVE VALUE OF THE RAT TELEMETRY MODEL FOR PRECLINICAL EVALUATION OF HEMODYNAMIC LIABILITIES: COMPARISON OF HEMODYNAMIC PROFILES OF TWO PRESSOR AGENTS IN RATS, BEAGLE DOGS AND RHESUS MONKEYS

Patrick A. Fanelli, Kimbery Hoagland.

Merck & Co., Inc., West Point, PA, USA

Abstract Number: 4

THE INFLUENCE OF ANTIEPILEPTIC DRUGS ON THE EEG PATTERNS IN EPILEPTIC PATIENTS (CARBAMAZEPINE)

Irma Khachidze.

Beritashvili Institute of Physiology, Tbilisi, Republic of Georgia

Abstract Number: 5

CORRELATION BETWEEN dP/dtmax AND QA INTERVAL, TWO CARDIAC CONTRACTILITY PARAMETERS, IN THE ANESTHETIZED RAT

Jacqueline Ngo.

UCB Pharma, Braine L’Alleud, Belgium

Abstract Number: 6

EFFECT OF VAGOTOMY ON THE CARDIOVASCULAR FUNCTION IN PENTOBARBITAL ANESTHETIZED DOGS

Richard Woltmann, Pierre Morissette.

Merck & Co., Inc., West Point, PA, USA

Abstract Number: 7

FAST, EFFORTLESS AND ACCURATE MEASUREMENT OF GLOMERULAR FILTRATION RATE IN CONSCIOUS MONKEYS

Alain Stricker-Krongrad1, Paul A. Zavorskas1, Carlos Rabito2, Susan Van Tongeren3, John Robb4, Garner T. Haupert Jr.5

1Charles River Laboratories, Shrewsbury, MA, USA;

2Radiology, Massachusetts General Hospital, Boston, MA, USA,

3Boehringer Ingelheim, Ridgefield, CT, USA;

4Appropriate Technology Co. Newburyport, MA,

5Nephrology Division, Medical Services, Massachusetts General Hospital, Boston, MA

Abstract Number: 8

URODYNAMICS TELEMETRY: A TOOL FOR INVESTIGATING THE URINARY BLADDER FUNCTION IN CONSCIOUS CYNOMOLGUS MONKEY

Stéphane Milano1, O. Boucheix1, E. Chalencon1, P. Lege1, C. Bory1, S. Baudet1, C. Botteron1, I. Williamson2, D. Westbrook2, D. Newgreen2.

1MDS Pharma Services, Lyon, France

2Pfizer Inc., Sandwich, UK.

Abstract Number: 9

MOUSE: MORE SENSITIVE THAN RAT OR GUINEA PIG FOR ASSESSING RESPIRATORY DEPRESSANT POTENTIAL OF DRUGS

Sandra Picard.

Porsolt and Partners Pharmacology, Boulogne-Billancourt, France

Abstract Number: 10

THE SMARTPILL FOR GASTROINTESTINAL MONITORING IN DOGS.

Kevin Norton, Helen Penton.

Charles River Laboratories Preclinical Services, Montreal, Quebec, Canada

Abstract Number: 11

SURVEY OF INDUSTRY: IDENTIFYING CONSORTIA PROJECTS ADDRESSING SIGNIFICANT PUBLIC HEALTH CONCERNS

Niels Christian Ganderup.

Ellegaard Göttingen Minipigs, Dalmose, Denmark

Abstract Number: 12

THE GÖTTINGEN MINIPIG IN CARDIOVASCULAR SAFETY PHARMACOLOGY - A CONSORTIA PROJECT PRELIMINARY REPORT

Niels Christian Ganderup.

Ellegaard Göttingen Minipigs, Dalmose, Denmark

Abstract Number: 13

INHIBITION OF COUGH REFLEX INDUCED BY VARIOUS DRUGS IN CONSCIOUS DOGS

Tadashi Tsubouchi.

Dainippon Sumitomo Pharma Co., Ltd, Osaka, Japan

Abstract Number: 14

INTRODUCTION OF FOB AND AMBULATORY ELECTROCARDIOGRAPHY IN THE EXTENDED SINGLE-DOSE TOXICITY STUDY IN RATS

Yasuki Akie.

Fuji Biomedix Co., Ltd., Hokuto-shi, Yamanashi-pref., Japan

Abstract Number: 15

COMPREHENSIVE EVALUATION OF SAFETY PHARMACOLOGY CORE BATTERY FOR MONKEY IN A NOVEL CHAMBER OF WHOLE-BODY PLETHYSMOGRAPHY

K. Sasaki.

Mitsubishi Chemical Safety Institute Ltd., Uto, Kumamoto, Japan

Abstract Number: 16

EFFECTS OF TUBE RESTRAINT ON HEART RATE, BLOOD PRESSURE AND RESPIRATORY PARAMETERS IN RATS

Steven Behringer, Brian M. Roche, Mathew Ellinger, Vedat Yildiz, Alecia Peppers, Jessica Wise, Craig Hassler.

Battelle Memorial Institute, Columbus, OH, USA

Abstract Number: 17

COMPARISON OF RESPIRATORY FUNCTIONAL ASSESSMENT TOOLS USING PNEUMOTACHOGRAPH AND RESPIRATORY INDCUTANCE PLETHYSMOGRAPHY

Kenneth R. Kearney.

WIL Research Laboratories, LLC, Ashland, OH, USA

Abstract Number: 18

EF50: A NON-INVASIVE MEASURE OF BRONCHOCONSTRICTION IN RATS?

Lorna Ewart, Jean-Pierre Valentin.

AstraZeneca R&D Alderley Park, Macclesfield, UK

Abstract Number: 19

PULMONARY FUNCTION IN RATS MONITORED BY BUXCO® WHOLE-BODY PLETHYSMOGRAPHY

David V. Gauvin, Ph.D., Jill A. Dalton, Ph.D., D.A.B.T., Theodore J. Baird, Ph.D.

Safety Pharmacology & Neurobehavioral Sciences,MPI Research, Mattawan, MI,USA

Abstract Number: 20

EVALUATION OF EFFECTS ON RESPIRATION IN CONSCIOUS MARMOSET (CALLITHRIX JACCHUS) USING WHOLE BODY PLETHYSMOGRAPHY

Sola-Puyravel Marie Laure, Champeroux Pascal.

CERB, Baugy, France

Abstract Number: 21

THE USE OF REFERENCE COMPOUNDS IN THE FREELY MOVING RAT PLETHYSMOGRAPHY SYSTEM

Philippa Priestley, A. Esmail

Covance Laboratories Ltd., Harrogate, UK

Abstract Number: 22

BRONCHOCONSTRICTION MODEL DEVELOPMENT - EFFECT OF APNEA ON PULMONARY RESISTANCE IN ANESTHETIZED SPRAGUE-DAWLEY, SPONTANEOUS HYPERTENSIVE, AND WISTAR-KYOTO RATS

Chin-hu Huang.

Pfizer, Inc, Groton, CT, USA

Abstract Number: 23

WHOLE BODY PLETHYSMOGRAPHY VIA IV INFUSIONS, WITHOUT THE NEED FOR SURGICAL PREPARATION

Helen Prior, Jean-Pierre Valentin.

AstraZeneca UK Ltd, Macclesfield, Cheshire, UK

Abstract Number: 24

ASSESSMENT OF THE VARIABLES AFFECTING RODENT RESPIRATORY STUDY DESIGN AND DATA INTERPRETATION

Philip Atterson.

WIL Research Laboratories, LLC, Ashland, OH, USA

Abstract Number: 25

INHALATION SAFETY PHARMACOLOGY IN THE MINIPIG: VALIDATION OF PROCEDURES

Ken Meecham, Stuart Purbrick.

Huntingdon Life Sciences Ltd, Alconbury, Cambs, UK

Abstract Number: 26

EVALUATION OF RESPIRATORY INDUCTIVE PLETHYSMOGRAPHY AS A METHOD FOR MEASURING VENTILATORY PARAMETERS IN CONSCIOUS, NON-RESTRAINED DOGS

Jonathan Renninger, Daniel Schramek and Dennis Murphy.

GlaxoSmithKline, King of Prussia, PA, USA

Abstract Number: 27

EEG TELEMETRY MODELS IN THE RODENT AND NON-HUMAN PRIMATE

Erik DeBoer, Gregory Friedrichs.

Schering-Plough Research Institute, Lafayette NJ, USA

Abstract Number: 28

VIDEO-ELECTROENCEPHALOGRAPHY IN CONSCIOUS MONKEYS USING TELEMETRY AND COMPUTER ANALYSIS: REFINEMENT OF A SAFETY PHARMACOLOGY MODEL

Simon Authier.

LAB Research Inc., Laval, Quebec, Canada

Abstract Number: 29

TELEMETERED ACTIVITY OF THE RESPIRATORY MUSCLES IN THE FERRET: A RELEVANT APPROACH FOR MONITORING THE EMETIC REFLEX

Stéphane Milano1, P. Lege1, E. Chalencon1, V. Roger1, S. Baudet1, E. Rieux2, S. Caradec2, H. Michelau2.

1MDS Pharma Services, Lyon, France

2Data Science International, St Paul, MN, USA.

Abstract Number: 30

PHARMACOKINETIC/PHARMACODYNAMIC (PK/PD) MODELING FOR THE RESPIRATORY EFFECT OF AMINOPHYLLINE IN RATS

Angela C. Jenkins, Sun Ku Lee, R. Dustan Sarazan.

Covance Laboratories Inc., Madison, WI, USA

Abstract Number: 31

SAFETY PHARMACOLOGICAL STUDIES ON THE AMORPHOUS FORMULATION OF CELECOXIB

Shyam S Sharma.

National Centre for Safety Pharmacology, National Inst. of Pharm. Edu. & Res., S.A.S. Nagar, India

Abstract Number: 32

IN VITRO PHARMACOLOGICAL PROFILES OF KINASE INHIBITORS: COMPARISON WITH OTHER PHARMACEUTICALS

Mike Rolf..

AstraZeneca UK Ltd, Macclesfield, UK

Abstract Number: 33

ROLE OF HYPERBARIC OXYGEN THERAPY ON SURVIVAL AND ENGRAFTMENT OF STEM CELLS IN THE INFARCT HEART

Mahmood Khan, Periannan Kuppusamy, Robert L Hamlin.

The Ohio State University, Columbus, OH, USA

Abstract Number: 34

EFFECTS OF ISOPRENALINE ON HUMAN STEM CELL DERIVED CARDIOMYOCYTES

Simon Bryant,1, Wyllie, C.1, Palmer, R.1, Heal, R.1, Demmon, J.1, Nicol, S.1, Anson, B.2, Rudy-Reil, D.2, Ma, J.2

1VivoMedica (UK) Ltd, Kent, UK

2Cellular Dynamics International Inc, Madison, WI, USA

Abstract Number: 35

A HIGH THROUGHPUT METHOD FOR THE ENUMERATION OF MICROBIAL COLONIES

Thomas Hattier.

Cellular Technology Limited, Shaker Heights, OH, USA

Abstract Number: 36

EFFECTS OF TEGASEROD ON HUMAN ISOLATED SMALL AND LARGE CORONARY ARTERIES

Kathryn Bagot, Mozam Ali, Lee Dawson, Sandy Williams, Bob Sheldrick.

Asterand UK Ltd, Royston, Hertfordshire, UK.

Abstract Number: 37

ALTERNATIVE MECHANISMS OF DRUG-INDUCED QT PROLONGATION: hERG AND BEYOND

Jean-Pierre Valentin.

AstraZeneca UK Ltd, Macclesfield, UK.

Abstract Number: 38

RELEVANCE OF KINETIC PARAMETERS IN hERG-BASED LQT PREDICTION

Julie Cayer.

IPS Therapeutique Inc., Sherbrooke, Quebec, Canada

Abstract Number: 39

TRANSLATION BETWEEN IN VITRO INHIBITION OF THE CARDIAC NAV1.5 CHANNEL AND PRECLINICAL AND CLINICAL QRS WIDENING

Jill V. Steidl, Martin Sanders, Jason Cordes.

Pfizer Inc., Groton CT, USA

Abstract Number: 40

TRANSLATION OF IN VITRO AND IN VIVO EFFECTS ON CARDIAC SODIUM CHANNELS

Doe CP, Ballini E, Cui Y, Stankus G, Graham S, Heath B, McMahon N.
GlaxoSmithKline, The Frythe, Welwyn, Hertfordshire, UK

Abstract Number: 41

EFFECTS OF CA-CHANNEL ANTAGONISTS ON L-TYPE CA CHANNEL IN THE HH-8 CELLS---A TOOL FOR SCREENING OF NEW COMPOUNDS

Wenge Yu.

Mitsubishi Chemical Safety Institute Ltd., Uto, Kumamoto, Japan

Abstract Number: 42

THROMBIN-INDUCED INCREASES IN VASCULAR PERMEABILITY IN PRESSURISED HUMAN SUBCUTANEOUS ARTERIES: A NOVEL OPTICAL METHOD FOR ISOLATED TISSUES

Emma J Moss, Derek Smith, David C Bunton.

Biopta Ltd, Glasgow, UK

Abstract Number: 43

METHOD VALIDATION AND BACKGROUND DATA FOR AN IN VITRO hERG ASSAY.

Helen Penton.

Charles River Laboratories, Preclinical Services Montreal, Quebec, Canada

Abstract Number: 44

CARDIAC CHANNEL PANELTM: A CRITICAL PATH TOOL FOR UNDERSTANDING CARDIAC RISK

Arthur M. Brown.

ChanTest Corporation, Cleveland, OH, USA

Abstract Number: 45

AUTOMATED PATCH CLAMP FOR hERG SAFETY SCREENING

Alison Haythornthwaite, Andrea Brueggemann, Cecilia Farre, Sonja Stoelzle, Claudia Haarmann, Michael George, Niels Fertig.

Nanion Technologies, Munich, Germany

Abstract Number: 46

SCREENING OF hERG BLOCKERS BY AUTOMATED PATCH CLAMP SYSTEM: QPATCH 16

Yong Zhao.

Cerep, Inc, Redmond, WA, USA

Abstract Number: 47

EFFECT OF COMPOUND PLATE COMPOSITION ON MEASUREMENT OF hERG CURRENT IC50 USING PATCHXPRESS

Zun-Li Mo.

Pfizer Inc, St. Louis, MO, USA

Abstract Number: 48

INCIDENCE AND SPECIFICITY OF DRUG-INDUCED TRAFFICKING INHIBITION OF CARDIAC ION CHANNELS

Barbara A. Wible.

ChanTest Corporation, Cleveland, OH, USA

Abstract Number: 49

OVERVIEW OF THE JOINT PHRMA-FDA DIALOGUE SESSION ON ABUSE POTENTIAL ASSESSMENT

Carrie G. Markgraf1, Mary Jeanne Kallman2.

1Schering Plough Research Institute, Lafayette, NJ, USA

2Eli Lilly & Company, Greenfield, IN, USA

Abstract Number: 50

STRATEGY TO REDUCE SEIZURE LIABILITY IN DRUG DISCOVERY

M. Elizabeth Bell, Russell Bialecki.

AstraZeneca, Wilmington, DE, USA

Abstract Number: 51

EVALUATION OF MORPHINE WITHDRAWAL EFFECTS USING TELEMETRY

Paul Moser.

Porsolt & Partners Pharmacology, Boulogne-Billancourt, France

Abstract Number: 52

GLP-COMPLIANT DRUG SELF-ADMINISTRATION IN THE NON-HUMAN PRIMATE

David V. Gauvin, Ph.D., Robert A. Code, B.S., Margaret M. McComb, B.S., Christina D. Selent, B.S., Bryna A. Shannon, B.A., Theodore J. Baird, Ph.D.

Safety Pharmacology & Neurobehavioral Sciences, MPI Research, Matawan, MI, USA

Abstract Number: 53

CORRELATION BETWEEN EJECTION FRACTION AND DP/DT+ IN CONSCIOUS TELEMETERED DOGS DOSED WITH ATENOLOL

Helen Prior, Jean-Pierre Valentin.

AstraZeneca UK Ltd, Cheshire, UK

Abstract Number: 54

USE OF EMBRYONIC STEM CELL DERIVED CARDIOMYOCYTES FOR DETERMINATION OF CARDIAC CYTOTOXICITY

Silke Schwengberg.

Axiogenesis AG, Cologne, Germany

Abstract Number: 55

APEX-TO-BASE DISPERSION IS GREATER THAN TRANSMURAL DISPERSION OF REPOLARIZATION IN AN INTACT ISOLATED RABBIT HEART MODEL
Nicolas Guérard, Martin Traebert, Willi Suter, Bérengère Dumotier.

Novartis Pharma AG, Basel, Switzerland

Abstract Number: 56

DIFFERENCES IN ECG INTERVALS AND RESTITUTION PARAMETERS IN THE CONSCIOUS SLING-TRAINED CANINE MODEL OF SHORT QT SYNDROME

Anusak Kijtawornrat, Robert L. Hamlin.

QTest Labs, LLC/The Ohio State University, Columbus, OH, USA

Abstract Number: 57

APPLICATION OF MAGNETIC RESONANCE IMAGING (MRI) IN A STUDY OF CARDIAC FUNCTION AND MORPHOLOGY IN MICE

Yee H Looi, Bela Patel, Kumar Changani, Kelly Keddie, Jim Ridings, Nick McMahon. GlaxoSmithKline, The Frythe, Welwyn, Hertfordshire, UK

Abstract Number: 58

EVALUATION OF THE PRO-THROMBOTIC EFFECT OF COX-2 INHIBITOR ROFECOXIB IN DOG MODEL OF ARTERIAL THROMBOSIS

Aliaksandr Bulhak.

AstraZeneca R&D Sdertlje, Sweden

Abstract Number: 59

IKS: ANOTHER CARDIOVASCULAR LIABILITY BESIDES hERG, AND USE OF A NOVEL IKS BLOCKER TO SCREEN FOR IKS BLOCKADE

Rob Towart.

Johnson & Johnson PRD, Beerse, Belgium

Abstract Number: 60

A HESI CONSORTIUM APPROACH TO ASSESS THE HUMAN PREDICTIVE VALUE OF NON-CLINICAL REPOLARISATION ASSAYS

Jean-Pierre Valentin, Syril Pettit.

HESI, Washington, DC, USA

Abstract Number: 61

TOLERANCE AND SPONTANEOUS WITHDRAWAL ASSESSMENT IN THE RAT

Anne Maurin, Champeroux Pascal.

CERB, Baugy, France

Abstract Number: 62

EVALUATION OF THE EFFECTS OF OPIATE DEPENDENCY ON CARDIOVASCULAR PARAMETERS IN RATS

Hamid Daneshvar.

WIL Research Laboratories, LLC, Ashland. OH, USA

Abstract Number: 63

CARDIOVASCULAR EFFECTS OF CONTINGENT (ACTIVE) VERSUS NON-CONTINGENT (PASSIVE) COCAINE ADMINISTRATIONS IN CYNOMOLGUS MONKEYS

David V. Gauvin, Ph.D. Robert A. Code, B.S., Margaret M. McComb, B.S., Christina D. Selent, B.S., Bryna A. Shannon, B.A., Theodore J. Baird, Ph.D.

Safety Pharmacology & Neurobehavioral Sciences, MPI Research, Matawan. MI USA

Abstract Number: 64

DETERMINATION OF SEXUAL CYCLE PHASES AND EVALUATION OF OVULATION INHIBITORY ACTIVITY IN THE FEMALE RAT

Champeroux Pascal, Bracq Emmanuel.

CERB, Baugy, France

Abstract Number: 65

CLINICAL INVESTIGATION OF SILYBUN MARIANUM SEED (SILYMARIN) SEED EXTRACT IN TREATMENT OF TYPE-II DIABETIC PATIENTS

Wael Mohamed Yousef.

Pennsylvania State University, State College, PA, USA

Abstract Number: 66

EFFECT OF SOME CALCIUM CHANNEL BLOCKERS IN EXPERIMENTALLY INDUCED DIABETIC NEPHROPATHY IN RATS

Wael Mohamed Yousef.

Pennsylvania State University, State College, PA, USA

Abstract Number: 67

DIETARY-INDUCED INSULIN RESISTANCE IN NON-HUMAN PRIMATES: A MODEL FOR EFFICACY AND SAFETY ASSESSMENTS

Alain Stricker-Krongrad, Joan Flanagan, Sera Murray.

Charles River Laboratories, Shrewsbury, MA,USA

Abstract Number: 68

ELECTRORETINOGRAPHY: COMPARISON OF SINGLE FLASH WITH AVERAGED TRACINGS USING A STANDARDIZED TESTING PROTOCOL FOR DRUG SAFETY EVALUATIONS

Simon Authier.

LAB Research Inc., Laval, Quebec, Canada

Abstract Number: 69

DIFFERENCES IN ELECTROGRAPHIC ICTAL ACTIVITY BETWEEN C57BL/6 AND BALB/C MOUSE STRAINS

M. Elizabeth Bell, Russell Bialecki.

AstraZeneca, Wilmington, DE, USA

Abstract Number: 70

VEHICLE SELECTION IN THE GASTROINTESTINAL TRANSIT SCREEN

Richard Noy.

Covance Laboratories Ltd., Harrogate, UK

Abstract Number: 71

THE EVALUATION OF AN IN VITRO MOTILITY ASSAY FOR ITS POTENTIAL TO PREDICT GASTROINTESTINAL ADVERSE DRUG REACTIONS

Christopher Keating1, Vicente Martinez1, Jean Pierre Valentin1, David Grundy2.

1AstraZeneca, Alderley Park, UK

2University of Sheffield, Sheffield, UK

Abstract Number: 72

PHARMACOLOGICAL COMPARISON OF PERISTALTIC EFFECTS IN RODENTS

Thomas K.Shaughnessy, K.J.Larson, J.S.Polakowski.

Abbott Laboratories, Abbott Park, IL, USA

Abstract Number: 73

EVALUATION OF THE EFFECTS OF DOSAGE AND DOSE VOLUME ON INDICES OF NEOMYCIN OTOTOXICITY IN THE ALBINO GUINEA PIG

Theodore J. Baird, Ph.D1., Rachel L. Tapp, B.S.1, David D. Dolan, Ph.D.2, Richard A. Altschuler, Ph.D.2, Michael Eliel, B.S.1, David V. Gauvin, Ph.D.1

1Safety Pharmacology & Neurobehavioral Sciences,MPI Research, Inc., Matawan, MI,USA

2KHRI, University of Michigan, Ann Arbor, MI, USA

Abstract Number: 74

COMPARISON OF PIGMENTED AND ALBINO GUINEA PIGS FOR USE IN OTOTOXICITY MODELING

Rachel L. Tapp, B.S.1, Michael Eliel, B.S.1, David D. Dolan, Ph.D.2, Richard A. Altschuler, Ph.D.2, David V. Gauvin, Ph.D.1, Theodore J. Baird, Ph.D.1

1Safety Pharmacology & Neurobehavioral Sciences, MPI Research, Mattawan, MI, USA

2KHRI, University of Michigan, Ann Arbor, MI, USA

Abstract Number: 75

EVALUATION OF DOSE, TIME, AND FREQUENCY DEPENDENT OTOTOXIC RESPONSE TO CISPLATIN ADMINISTRATION IN THE ALBINO GUINEA PIG

Theodore J. Baird, Ph.D.1, Jeffrey W-D Foy, Ph.D., D.A.B.T.2, David D. Dolan, Ph.D.3, Theron Wall, B.S.1, Tara Posthumus, B.S.1, Michael Eliel, B.S.1, Rachel L. Tapp, B.S.1, David V. Gauvin, Ph.D.1

1Safety Pharmacology & Neurobehavioral Sciences, MPI Research, Mattawan, MIUSA

2 Quark Pharmaceuticals, Boulder, CO, USA

3KHRI, University of Michigan, Ann Arbor, MI, USA

Abstract Number: 76

A PRIMARY “ICH S7A CNS CORE” NEUROBEHAVIORAL SCREEN FOR EARLY PHASE DRUG DISCOVERY

Donald B Hodges Jr.

Vertex Pharmaceuticals, Cambridge, MA, USA

Abstract Number: 77

EVALUATION OF EFFECT ON CENTRAL NERVOUS SYSTEM BY FOB AND CARIOVASUCULAR SYSTEM BY TELEMETRY FOR CPZ IN DOGS

Kiyotaka Hoshiai.

Kobuchisawa Research Laboratory, Fuji Biomedix, kobuchisawa, Hokuto, Yamanashi, Japan

Abstract Number: 78

SHORT-TERM EEG RECORDING IN CONSCIOUS GÖTTINGEN MINIPIGS AS AN ALTERNATIVE TO NON-HUMAN PRIMATES AND DOGS

Mark Vezina.

Charles River Laboratories Preclinical Services Montreal, Quebec, Canada

Abstract Number: 79

FUNCTIONAL MOTOR ASSESSMENTS ASSOCIATED WITH SKELETAL MUSCLE NECROSIS

Mary Jeanne Kallman, Deah Modlin, Mario Sgro.

Eli Lilly & Co., Greenfield, IN, USA

Abstract Number: 80

CAN LOCOMOTOR SCREENING BE UTILIZED AS A FIRST-TIERED APPROACH FOR PRECLINICAL CNS/NEUROBEHAVIORAL SAFETY TESTING?

James J. Lynch III, Scott W. Mittelstadt

Abbott Laboratories, Abbott Park, IL, USA

Abstract Number: 81

EVALUATION OF PROPOFOL EFFECT IN ALTERING PENTYLENETETRAZOL INDUCED SEIZURE THRESHOLD IN PERIPHERAL INFLAMMATORY MODELS IN RATS

Bikash Medhi, Ajay Prakash, Prasad Byrav D S.

Department of Pharmacology, PGIMER, Chandigarh, India

Abstract Number: 82

ENGINEERED TISSUES: A NOVEL PARADIGM FOR HIGH THROUGHPUT QUANTITATION OF TISSUE BIOLOGICAL AND MECHANICAL TOXICITIES

Vy Lam.

Biotechnology and Bioengineering Center, Medical College of Wisconsin, Milwaukee, WI, USA

Abstract Number: 83

WHOLE ZEBRAFISH CYTOCHROME P450 MICROPLATE ASSAYS FOR ASSESSING DRUG METABOLISM AND DRUG SAFETY

Chunqi Li.

Phylonix Pharmaceuticals, Inc., Cambridge, MA, USA

Abstract Number: 84

ALTERED CARDIOMYOCYTE Ca2+ HANDLING AS A PREDICTOR OF CARDIOTOXICITY AND ARRHYTHMOGENESIS OF DRUG CANDIDATES

Jian-Yong Qian, Liang Guo.

Hoffmann-La Roche, Inc., NJ, USA

Abstract Number: 85

IN VITRO AND IN VIVO ELECTROPHYSIOLOGICAL CORRELATES IN NICOTINE AND KAINIC ACID-INDUCED SEIZURES

Alison Easter.

AstraZeneca Pharmaceuticals, Wilmington DE, USA

Abstract Number: 86

SAFETY AGAINST MAXIMAL ELECTROSHOCK (MES) INDUCED SEIZURE BY ACONITUM VIOLACEUM

Muhammad Liaquat Raza.

HEJ, ICCBS, Neuropharmacology Unit, University of Karachi, Karachi, Pakistan

Abstract Number: 87

SAFETY AND EFFICACY OF CONCOMITANT USE OF NEWER AND OLDER ANTIEPILEPTIC DRUGS IN TERTIARY CARE CENTRE OF NORTH INDIA: A PROSPECTIVE COHORT STUDY

Ajay Prakash, Bansal D, Medhi B.

Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

Abstract Number: 88

THE COMBINATION OF DSI RAT TELEMETRY AND THE CULEX AUTOMATED BLOOD SAMPLER (ABS) FOR MULTIPARAMETER SAFETY PHARMACOLOGY SCREENING

David Lengel..

AstraZeneca Pharmaceuticals, Wilmington, DE, USA

Abstract Number: 89

NON-INVASIVE BLOOD PRESSURE DETERMINATION IN MACACA FASCICULARIS AND CALLITHRIX JACCHUS BY HIGH DEFINITION OSCILLOMETRY

Barthel Schmelting.

Covance Laboratories, Muenster, Germany

Abstract Number: 90

A CARDIOVASCULAR SAFETY ASSESSMENT PARADIGM FOR THE EARLY IDENTIFICATION OF PROARRHYTHMIC AND TORSADAGENIC COMPOUNDS

Dinah L Misner1, C. Frantz1, E. Meierhenry, M. Fielden, L. Guo2, J. Ly, H. Uppal, D. Rotstein, M. Gralinski3, P. Senese3, M. Albassam, Sushmita Chanda1, Stefan Platz1, and K. Kolaja.

1Roche Palo Alto, Palo Alto, CA; USA,

2Hoffman La-Roche Inc., Nutley, NJ, USA

3CorDynamics Inc., Chicago, IL, USA

Abstract Number: 91

A NOVEL IMPLANTABLE BLOOD PRESSURE TELEMETRY DEVICE; COMPARISON BETWEEN DATA SCIENCES AND TELEMETRY RESEARCH SYSTEMS

Simon Malpas.

Telemetry Research Ltd., Auckland, New Zealand

Abstract Number: 92

NORMAL PREVALENCE OF CARDIAC ARRHYTHMIAS IN 24 H ECG RECORDINGS OF CHRONICALLY TELEMETERED, HEALTHY, FREELY MOVING BEAGLE DOGS

Frank Cools, David Gallacher..

Johnson & Johnson PRD, Beerse, Belgium

Abstract Number: 93

EVALUATION OF TEST ARTICLE-RELATED VENTRICULAR PREMATURE COMPLEXES IN CONSCIOUS TELEMETERED DOGS

Haisong Ju, Xuejun Wu, Jason Payseur, Jon Renninger, Dennis Murphy.

GlaxoSmithKline, King of Prussia, PA, USA

Abstract Number: 94

AN IN VITRO METHOD FOR DETECTING POTENTIAL PROARRHYTHMIC PROPERTIES OF CARDIOMYOCYTES GROWN ON MICROELECTRODE ARRAYS

Simon Bryant, Wyllie, C., Palmer, R., Heal, R., Demmon, J., Nicol, S.