Supplementary Table 1: Results from global gene expression studies

Gene Symbol / Gene name / Study / Type / Tissue / Cell line / Antipsychotic / Dose / Exposure / Fold change / Reported P
value
ABCA1 / ATP-binding cassette, sub-family A (ABC1), member 1 / Vik-Mo, 200919 / Replication / Brain (Glia) / GaMg / Haloperidol / 10 µM / 6 hrs / 0.6 ± 0.06 / <0.01
ABCA1 / ATP-binding cassette, sub-family A (ABC1), member 1 / Vik-Mo, 200919 / Replication / Brain (Glia) / GaMg / Haloperidol / 10 µM / 12 hrs / 0.3 ± 0.03 / <0.01
ABCA1 / ATP-binding cassette, sub-family A (ABC1), member 1 / Vik-Mo, 200919 / Replication / Brain (Glia) / GaMg / Haloperidol / 10 µM / 18 hrs / 0.3 ± 0.03 / <0.01
ABCA1 / ATP-binding cassette, sub-family A (ABC1), member 1 / Vik-Mo, 200919 / Replication / Brain (Glia) / GaMg / Haloperidol / 10 µM / 24 hrs / 0.3 ± 0.04 / <0.01
ABCA1 / ATP-binding cassette, sub-family A (ABC1), member 1 / Vik-Mo, 200919 / Replication / Liver / HepG2 / Haloperidol / 25 uM / 24 hrs / 2.0 ± 0.13 / <.05
ABCA1 / ATP-binding cassette, sub-family A (ABC1), member 1 / Vik-Mo, 200919 / Replication / Brain (Glia) / GaMg / Clozapine / 25 µM / 6 hrs / 1.0 ± 0.02
ABCA1 / ATP-binding cassette, sub-family A (ABC1), member 1 / Vik-Mo, 200919 / Replication / Brain (Glia) / GaMg / Clozapine / 25 µM / 12 hrs / 1.5 ± 0.1
ABCA1 / ATP-binding cassette, sub-family A (ABC1), member 1 / Vik-Mo, 200919 / Replication / Brain (Glia) / GaMg / Clozapine / 25 µM / 18 hrs / 1.2 ± 0.2
ABCA1 / ATP-binding cassette, sub-family A (ABC1), member 1 / Vik-Mo, 200919 / Replication / Brain (Glia) / GaMg / Clozapine / 25 µM / 24 hrs / 2.6 ± 0.2 / <0.01
ABCA1 / ATP-binding cassette, sub-family A (ABC1), member 1 / Vik-Mo, 200919 / Replication / Liver / HepG2 / Clozapine / 25 uM / 24 hrs / 1.9 ± 0.16
ABCA1 / ATP-binding cassette, sub-family A (ABC1), member 1 / Vik-Mo, 200919 / Replication / Brain (Glia) / GaMg / Olanzapine / 10 µM / 6 hrs / 0.9 ± 0.2
ABCA1 / ATP-binding cassette, sub-family A (ABC1), member 1 / Vik-Mo, 200919 / Replication / Brain (Glia) / GaMg / Olanzapine / 10 µM / 12 hrs / 0.9 ± 0.1
ABCA1 / ATP-binding cassette, sub-family A (ABC1), member 1 / Vik-Mo, 200919 / Replication / Brain (Glia) / GaMg / Olanzapine / 10 µM / 18 hrs / 1.4 ± 0.06 / <0.01
ABCA1 / ATP-binding cassette, sub-family A (ABC1), member 1 / Vik-Mo, 200919 / Replication / Brain (Glia) / GaMg / Olanzapine / 10 µM / 24 hrs / 1.2 ± 0.02 / <0.01
ABCA1 / ATP-binding cassette, sub-family A (ABC1), member 1 / Vik-Mo, 200919 / Replication / Liver / HepG2 / Olanzapine / 25 uM / 24 hrs / 1.3 ± 0.12
ACAT2 / Acetyl-CoA acetyltransferase 2 / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Clozapine / 1 µM / 24 hrs / 1.1 ± 0.07
ACAT2 / Acetyl-CoA acetyltransferase 2 / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Clozapine / 10 µM / 24 hrs / 1.7 ± 0.17
ACAT2 / Acetyl-CoA acetyltransferase 2 / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Clozapine / 25 µM / 24 hrs / 3.3 ± 0.37
ACAT2 / Acetyl-CoA acetyltransferase 2 / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Clozapine / 50 µM / 24 hrs / 3.0 ± 0.66 / 0.00009
ACAT2 / Acetyl-CoA acetyltransferase 2 / Polymeropoulos, 200916 / Global / Eye, Neuronal Model / ARPE-19 / Common AP signature / 10 µM / 24 hrs / In top 20 ranked gene probe sets
APOE / Apolipoprotein E / Vik-Mo, 200919 / Replication / Brain (Glia) / GaMg / Haloperidol / 10 µM / 6 hrs / 1.2 ± 0.1
APOE / Apolipoprotein E / Vik-Mo, 200919 / Replication / Brain (Glia) / GaMg / Haloperidol / 10 µM / 12 hrs / 1.5 ± 0.2
APOE / Apolipoprotein E / Vik-Mo, 200919 / Replication / Brain (Glia) / GaMg / Haloperidol / 10 µM / 18 hrs / 2.3 ± 0.2 / <0.01
APOE / Apolipoprotein E / Vik-Mo, 200919 / Replication / Brain (Glia) / GaMg / Haloperidol / 10 µM / 24 hrs / 2.4 ± 0.2 / <0.01
APOE / Apolipoprotein E / Vik-Mo, 200919 / Replication / Brain (Glia) / GaMg / Haloperidol / 1 uM / 24 hrs / 1.3 ± 0.13 / <.05
APOE / Apolipoprotein E / Vik-Mo, 200919 / Replication / Brain (Glia) / GaMg / Haloperidol / 10 uM / 24 hrs / 2.0 ± 0.24 / <.05
APOE / Apolipoprotein E / Vik-Mo, 200919 / Replication / Brain (Glia) / GaMg / Haloperidol / 25 uM / 24 hrs / 2.2 ± 0.24 / <.05
APOE / Apolipoprotein E / Vik-Mo, 200919 / Replication / Brain (Glia) / CFF-STGG1 / Haloperidol / 25 uM / 24 hrs / 2.6 ± 0.20 / <.05
APOE / Apolipoprotein E / Vik-Mo, 200919 / Replication / Liver / HepG2 / Haloperidol / 25 uM / 24 hrs / 3.0 ± 0.47 / <.05
APOE / Apolipoprotein E / Vik-Mo, 200919 / Replication / Brain (Glia) / GaMg / Clozapine / 25 µM / 6 hrs / 1.2 ± 0.1
APOE / Apolipoprotein E / Vik-Mo, 200919 / Replication / Brain (Glia) / GaMg / Clozapine / 25 µM / 12 hrs / 1.8 ± 0.1 / <0.01
APOE / Apolipoprotein E / Vik-Mo, 200919 / Replication / Brain (Glia) / GaMg / Clozapine / 25 µM / 18 hrs / 2.2 ± 0.2 / <0.01
APOE / Apolipoprotein E / Vik-Mo, 200919 / Replication / Brain (Glia) / GaMg / Clozapine / 25 µM / 24 hrs / 4.5 ± 0.1 / <0.01
APOE / Apolipoprotein E / Vik-Mo, 200919 / Replication / Brain (Glia) / GaMg / Clozapine / 1 uM / 24 hrs / 1.1 ± 0.13
APOE / Apolipoprotein E / Vik-Mo, 200919 / Replication / Brain (Glia) / GaMg / Clozapine / 10 uM / 24 hrs / 2.8 ± 0.58 / <0.01
APOE / Apolipoprotein E / Vik-Mo, 200919 / Replication / Brain (Glia) / GaMg / Clozapine / 25 uM / 24 hrs / 4.1 ± 0.71 / <0.01
APOE / Apolipoprotein E / Vik-Mo, 200919 / Replication / Brain (Glia) / CFF-STGG1 / Clozapine / 25 uM / 24 hrs / 2.4 ± 0.06 / <0.01
APOE / Apolipoprotein E / Vik-Mo, 200919 / Replication / Liver / HepG2 / Clozapine / 25 uM / 24 hrs / 2.9 ± 0.47 / <.05
APOE / Apolipoprotein E / Vik-Mo, 200919 / Replication / Brain (Glia) / GaMg / Olanzapine / 10 µM / 6 hrs / 1.2 ± 0.1
APOE / Apolipoprotein E / Vik-Mo, 200919 / Replication / Brain (Glia) / GaMg / Olanzapine / 10 µM / 12 hrs / 1.1 ± 0.1
APOE / Apolipoprotein E / Vik-Mo, 200919 / Replication / Brain (Glia) / GaMg / Olanzapine / 10 µM / 18 hrs / 1.5 ± 0.4
APOE / Apolipoprotein E / Vik-Mo, 200919 / Replication / Brain (Glia) / GaMg / Olanzapine / 10 µM / 24 hrs / 1.5 ± 0.1 / <.05
APOE / Apolipoprotein E / Vik-Mo, 200919 / Replication / Brain (Glia) / GaMg / Olanzapine / 1 uM / 24 hrs / 1.5 ± 0.03 / <.05
APOE / Apolipoprotein E / Vik-Mo, 200919 / Replication / Brain (Glia) / GaMg / Olanzapine / 10 uM / 24 hrs / 1.6 ± 0.03 / <.05
APOE / Apolipoprotein E / Vik-Mo, 200919 / Replication / Brain (Glia) / GaMg / Olanzapine / 25 uM / 24 hrs / 1.8 ± 0.19 / <.05
APOE / Apolipoprotein E / Vik-Mo, 200919 / Replication / Liver / HepG2 / Olanzapine / 25 uM / 24 hrs / 2.9 ± 0.42 / <.05
CYP51A1 / Cytochrome P450, family 51, subfamily A, polypeptide 1 / Fernø, 200515 / Global / Brain (Glia) / GaMg / Haloperidol / 10 µM / 24 hrs / ND
CYP51A1 / Cytochrome P450, family 51, subfamily A, polypeptide 1 / Fernø, 200515 / Global / Brain (Glia) / GaMg / Clozapine / 30 µM / 24 hrs / 2.7
CYP51A1 / Cytochrome P450, family 51, subfamily A, polypeptide 1 / Polymeropoulos, 200916 / Global / Brain (Glia) / H4 / Common AP signature / 10 µM / 24 hrs / In top 20 ranked gene probe sets
CYP51A1 / Cytochrome P450, family 51, subfamily A, polypeptide 1 / Polymeropoulos, 200916 / Global / Eye, Neuronal Model / ARPE-19 / Common AP signature / 10 µM / 24 hrs / In top 20 ranked gene probe sets
DDR2 / Discoidin domain receptor tyrosine kinase 2 / Polymeropoulos, 200916 / Global / Brain (Glia) / H4 / Common AP signature / 10 µM / 24 hrs / In top 20 ranked gene probe sets
DHCR7 / 7-dehydrocholesterol reductase / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Clozapine / 1 µM / 24 hrs / 1.2 ± 0.25
DHCR7 / 7-dehydrocholesterol reductase / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Clozapine / 10 µM / 24 hrs / 2.3 ± 0.15
DHCR7 / 7-dehydrocholesterol reductase / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Clozapine / 25 µM / 24 hrs / 3.2 ± 0.19
DHCR7 / 7-dehydrocholesterol reductase / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Clozapine / 50 µM / 24 hrs / 4.3 ± 0.15 / 0.000008
DHCR7 / 7-dehydrocholesterol reductase / Polymeropoulos, 200916 / Global / Eye, Neuronal Model / ARPE-19 / Common AP signature / 10 µM / 24 hrs / In top 20 ranked gene probe sets
EBP / Emopamil binding protein (sterol isomerase) / Polymeropoulos, 200916 / Global / Eye, Neuronal Model / ARPE-19 / Common AP signature / 10 µM / 24 hrs / In top 20 ranked gene probe sets
FADS1 / Fatty acid desaturase 1 / Fernø, 200515 / Global / Brain (Glia) / GaMg / Haloperidol / 10 µM / 24 hrs / 3.2
FADS1 / Fatty acid desaturase 1 / Fernø, 200515 / Global / Brain (Glia) / GaMg / Clozapine / 30 µM / 24 hrs / 1.7
FADS1 / Fatty acid desaturase 1 / Polymeropoulos, 200916 / Global / Brain (Glia) / H4 / Common AP signature / 10 µM / 24 hrs / In top 20 ranked gene probe sets
FADS1 / Fatty acid desaturase 1 / Polymeropoulos, 200916 / Global / Eye, Neuronal Model / ARPE-19 / Common AP signature / 10 µM / 24 hrs / In top 20 ranked gene probe sets
FADS2 / Fatty acid desaturase 2 / Fernø, 200515 / Global / Brain (Glia) / GaMg / Haloperidol / 10 µM / 24 hrs / ND
FADS2 / Fatty acid desaturase 2 / Fernø, 200515 / Global / Brain (Glia) / GaMg / Clozapine / 30 µM / 24 hrs / 2.3
FADS2 / Fatty acid desaturase 2 / Polymeropoulos, 200916 / Global / Eye, Neuronal Model / ARPE-19 / Common AP signature / 10 µM / 24 hrs / In top 20 ranked gene probe sets
FAM117A / Family with sequence similarity 117, member A / Polymeropoulos, 200916 / Global / Brain (Glia) / H4 / Common AP signature / 10 µM / 24 hrs / In top 20 ranked gene probe sets
FASN / Fatty acid synthase / Fernø, 200515 / Global / Brain (Glia) / GaMg / Haloperidol / 10 µM / 24 hrs / 2.2
FASN / Fatty acid synthase / Fernø, 200515 / Global / Brain (Glia) / GaMg / Clozapine / 30 µM / 24 hrs / 3.1
FASN / Fatty acid synthase / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Clozapine / 1 µM / 24 hrs / 1.7 ± 0.38
FASN / Fatty acid synthase / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Clozapine / 10 µM / 24 hrs / 2.4 ± 0.10
FASN / Fatty acid synthase / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Clozapine / 25 µM / 24 hrs / 3.8 ± 0.50
FASN / Fatty acid synthase / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Clozapine / 50 µM / 24 hrs / 5.4 ± 0.27 / 0.000008
FASN / Fatty acid synthase / Polymeropoulos, 200916 / Global / Eye, Neuronal Model / ARPE-19 / Common AP signature / 10 µM / 24 hrs / In top 20 ranked gene probe sets
FDFT1 / Farnesyl-diphosphate farnesyltransferase 1 / Fernø, 200515 / Global / Brain (Glia) / GaMg / Haloperidol / 10 µM / 24 hrs / 2
FDFT1 / Farnesyl-diphosphate farnesyltransferase 1 / Fernø, 200515 / Global / Brain (Glia) / GaMg / Clozapine / 30 µM / 24 hrs / ND
FDFT1 / Farnesyl-diphosphate farnesyltransferase 1 / Polymeropoulos, 200916 / Global / Eye, Neuronal Model / ARPE-19 / Common AP signature / 10 µM / 24 hrs / In top 20 ranked gene probe sets
FDPS / Farnesyl pyrophosphate synthetase / Fernø, 200515 / Global / Brain (Glia) / GaMg / Haloperidol / 10 µM / 24 hrs / 3.3
FDPS / Farnesyl pyrophosphate synthetase / Fernø, 200515 / Global / Brain (Glia) / GaMg / Clozapine / 30 µM / 24 hrs / 1.8
FDPS / Farnesyl pyrophosphate synthetase / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Clozapine / 1 µM / 24 hrs / 1.1 ± 0.20
FDPS / Farnesyl pyrophosphate synthetase / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Clozapine / 10 µM / 24 hrs / 1.8 ± 0.08
FDPS / Farnesyl pyrophosphate synthetase / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Clozapine / 25 µM / 24 hrs / 2.2 ± 0.19
FDPS / Farnesyl pyrophosphate synthetase / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Clozapine / 50 µM / 24 hrs / 2.8 ± 0.21 / 0.000009
FDPS / Farnesyl pyrophosphate synthetase / Polymeropoulos, 200916 / Global / Eye, Neuronal Model / ARPE-19 / Common AP signature / 10 µM / 24 hrs / In top 20 ranked gene probe sets
GPNMB / Glycoprotein (transmembrame) nmb / Polymeropoulos, 200916 / Global / Brain (Glia) / H4 / Common AP signature / 10 µM / 24 hrs / In top 20 ranked gene probe sets
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Chlorpromazine / 0.1 µM / 24 hrs / 0.8 ± 0.1
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Chlorpromazine / 1.0 µM / 24 hrs / 1.2 ± 0.1
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Chlorpromazine / 10 µM / 24 hrs / 2.3 ± 0.03 / <.001
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Chlorpromazine / 25 µM / 24 hrs / 2.6 ± 0.2 / <.001
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Fernø, 200515 / Global / Brain (Glia) / GaMg / Haloperidol / 10 µM / 24 hrs / 2.4
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Fernø, 200618 / Replication / Brain (Glia) / CCF-STTG1 / Haloperidol / 10 µM / 24 hrs / 5.3 ± 0.6 / <0.01
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Fernø, 200618 / Replication / Brain (Glia) / CCF-STTG1 / Haloperidol / 25 µM / 24 hrs / 9.3 ± 0.4 / <.001
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Haloperidol / 0.1 µM / 24 hrs / 1.0 ± 0.06
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Haloperidol / 1.0 µM / 24 hrs / 1.3 ± 0.2
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Haloperidol / 10 µM / 24 hrs / 2.7 ± 0.2
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Haloperidol / 25 µM / 24 hrs / 3.2 ± 0.3
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Vik-Mo, 200919 / Replication / Brain (Glia) / GaMg / Haloperidol / 10 µM / 6 hrs / 2.1 ± 0.2 / <0.01
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Vik-Mo, 200919 / Replication / Brain (Glia) / GaMg / Haloperidol / 10 µM / 12 hrs / 2.1 ± 0.1 / <0.01
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Vik-Mo, 200919 / Replication / Brain (Glia) / GaMg / Haloperidol / 10 µM / 18 hrs / 2.2 ± 0.04 / <0.01
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Vik-Mo, 200919 / Replication / Brain (Glia) / GaMg / Haloperidol / 10 µM / 24 hrs / 1.8 ± 0.01 / <0.01
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Fernø, 200618 / Replication / Brain (Neuron) / SH-SY5Y / Haloperidol / 10 µM / 24 hrs / 1.3 ± 0.06 / <.05
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Fernø, 200618 / Replication / Brain (Neuron) / SH-SY5Y / Haloperidol / 25 µM / 24 hrs / 1.5 ± 0.1 / <.05
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Fernø, 200618 / Replication / Brain (Neuron) / HCN2 / Haloperidol / 10 µM / 24 hrs / 1.2 ± 0.03 / <.05
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Fernø, 200618 / Replication / Brain (Neuron) / HCN2 / Haloperidol / 25 µM / 24 hrs / ND
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Fernø, 200515 / Global / Brain (Glia) / GaMg / Clozapine / 30 µM / 24 hrs / 1.8
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Fernø, 200618 / Replication / Brain (Glia) / CCF-STTG1 / Clozapine / 10 µM / 24 hrs / 1.5 ± 0.2 / <.05
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Fernø, 200618 / Replication / Brain (Glia) / CCF-STTG1 / Clozapine / 25 µM / 24 hrs / 5.0 ± 0.2 / <.001
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Clozapine / 0.1 µM / 24 hrs / 1.1 ± 0.06
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Clozapine / 1.0 µM / 24 hrs / 1.2 ± 0.1
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Clozapine / 10 µM / 24 hrs / 1.8 ± 0.3
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Clozapine / 25 µM / 24 hrs / 2.5 ± 0.1
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Vik-Mo, 200919 / Replication / Brain (Glia) / GaMg / Clozapine / 25 µM / 6 hrs / 2.4 ± 0.1 / <0.01
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Vik-Mo, 200919 / Replication / Brain (Glia) / GaMg / Clozapine / 25 µM / 12 hrs / 2.2 ± 0.1 / <0.01
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Vik-Mo, 200919 / Replication / Brain (Glia) / GaMg / Clozapine / 25 µM / 18 hrs / 2.1 ± 0.1 / <0.01
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Vik-Mo, 200919 / Replication / Brain (Glia) / GaMg / Clozapine / 25 µM / 24 hrs / 2.2 ± 0.1 / <0.01
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Clozapine / 1 µM / 24 hrs / 1.2 ± 0.13
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Clozapine / 10 µM / 24 hrs / 1.8 ± 0.31
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Clozapine / 25 µM / 24 hrs / 2.5 ± 0.14
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Clozapine / 50 µM / 24 hrs / 3.1 ± 0.17 / 0.00001
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Fernø, 200618 / Replication / Brain (Neuron) / SH-SY5Y / Clozapine / 10 µM / 24 hrs / 0.9 ± 0.02
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Fernø, 200618 / Replication / Brain (Neuron) / SH-SY5Y / Clozapine / 25 µM / 24 hrs / 1.4 ± 0.1 / <.05
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Fernø, 200618 / Replication / Brain (Neuron) / HCN2 / Clozapine / 10 µM / 24 hrs / ND
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Fernø, 200618 / Replication / Brain (Neuron) / HCN2 / Clozapine / 25 µM / 24 hrs / 2.4 ± 0.2 / <0.01
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Olanzapine / 0.1 µM / 24 hrs / 0.9 ± 0.03
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Olanzapine / 1.0 µM / 24 hrs / 1.0 ± 0.1
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Olanzapine / 10 µM / 24 hrs / 1.2 ± 0.1
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Olanzapine / 25 µM / 24 hrs / 2.5 ± 0.3 / <.05
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Vik-Mo, 200919 / Replication / Brain (Glia) / GaMg / Olanzapine / 10 µM / 6 hrs / 1.8 ± 0.3 / <.05
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Vik-Mo, 200919 / Replication / Brain (Glia) / GaMg / Olanzapine / 10 µM / 12 hrs / 1.3 ± 0.05 / <0.01
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Vik-Mo, 200919 / Replication / Brain (Glia) / GaMg / Olanzapine / 10 µM / 18 hrs / 1.4 ± 0.06 / <0.01
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Vik-Mo, 200919 / Replication / Brain (Glia) / GaMg / Olanzapine / 10 µM / 24 hrs / 1.1 ± 0.05 / <.05
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Risperidone / 0.1 µM / 24 hrs / 0.8 ± 0.05
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Risperidone / 1.0 µM / 24 hrs / 0.9 ± 0.1
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Risperidone / 10 µM / 24 hrs / 1.2 ± 0.07
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Risperidone / 25 µM / 24 hrs / 1.7 ± 0.09 / <0.01
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Ziprasidone / 0.1 µM / 24 hrs / 1.1 ± 0.02
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Ziprasidone / 1.0 µM / 24 hrs / 1.1 ± 0.02
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Ziprasidone / 10 µM / 24 hrs / 1.4 ± 0.04
/ <.05
HMGCR / 3-hydroxy-3-methylglutaryl-CoA reductase / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Ziprasidone / 25 µM / 24 hrs / 1.5 ± 0.08 / <.05
HMGCS1 / 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Chlorpromazine / 0.1 µM / 24 hrs / 1.0 ± 0.1
HMGCS1 / 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Chlorpromazine / 1.0 µM / 24 hrs / 1.8 ± 0.2 / <.05
HMGCS1 / 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Chlorpromazine / 10 µM / 24 hrs / 3.5 ± 0.3 / <.001
HMGCS1 / 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Chlorpromazine / 25 µM / 24 hrs / 2.3 ± 0.1 / <0.01
HMGCS1 / 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) / Fernø, 200515 / Global / Brain (Glia) / GaMg / Haloperidol / 10 µM / 24 hrs / 2.2
HMGCS1 / 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Haloperidol / 0.1 µM / 24 hrs / 1.1 ± 0.1
HMGCS1 / 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Haloperidol / 1.0 µM / 24 hrs / 1.7 ± 0.3
HMGCS1 / 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Haloperidol / 10 µM / 24 hrs / 4.1 ± 0.5 / <0.01
HMGCS1 / 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Haloperidol / 25 µM / 24 hrs / 3.8 ± 0.8 / <.05
HMGCS1 / 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) / Fernø, 200515 / Global / Brain (Glia) / GaMg / Clozapine / 30 µM / 24 hrs / 2.2
HMGCS1 / 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Clozapine / 0.1 µM / 24 hrs / 1.1 ± 0.03
HMGCS1 / 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Clozapine / 1.0 µM / 24 hrs / 1.0 ± 0.01
HMGCS1 / 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Clozapine / 10 µM / 24 hrs / 3.3 ± 0.2 / <.001
HMGCS1 / 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Clozapine / 25 µM / 24 hrs / 5.2 ± 0.6 / <.001
HMGCS1 / 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Clozapine / 1 µM / 24 hrs / 1.0 ± 0.02
HMGCS1 / 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Clozapine / 10 µM / 24 hrs / 3.3 ± 0.25
HMGCS1 / 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Clozapine / 25 µM / 24 hrs / 5.2 ± 0.63
HMGCS1 / 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Clozapine / 50 µM / 24 hrs / 5.6 ± 0.45 / 0.000009
HMGCS1 / 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Olanzapine / 0.1 µM / 24 hrs / 0.9 ± 0.09
HMGCS1 / 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Olanzapine / 1.0 µM / 24 hrs / 1.6 ± 0.3
HMGCS1 / 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Olanzapine / 10 µM / 24 hrs / 1.7 ± 0.2
HMGCS1 / 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Olanzapine / 25 µM / 24 hrs / 3.6 ± 0.04 / <.001
HMGCS1 / 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Risperidone / 0.1 µM / 24 hrs / 0.9 ± 0.1
HMGCS1 / 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Risperidone / 1.0 µM / 24 hrs / 1.0 ± 0.1
HMGCS1 / 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Risperidone / 10 µM / 24 hrs / 1.2 ± 0.05
HMGCS1 / 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Risperidone / 25 µM / 24 hrs / 1.8 ± 0.09
HMGCS1 / 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Ziprasidone / 0.1 µM / 24 hrs / 1.1 ± 0.05
HMGCS1 / 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Ziprasidone / 1.0 µM / 24 hrs / 1.1 ± 0.1
HMGCS1 / 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Ziprasidone / 10 µM / 24 hrs / 1.5 ± 0.05 / <.05
HMGCS1 / 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Ziprasidone / 25 µM / 24 hrs / 1.3 ± 0.08 / <.05
IDI1 / isopentenyl-diphosphate delta isomerase 1 / Fernø, 200515 / Global / Brain (Glia) / GaMg / Haloperidol / 10 µM / 24 hrs / 2.2
IDI1 / isopentenyl-diphosphate delta isomerase 1 / Fernø, 200515 / Global / Brain (Glia) / GaMg / Clozapine / 30 µM / 24 hrs / 2.1
INSIG1 / Insulin induced gene 1 / Polymeropoulos, 200916 / Global / Brain (Glia) / H4 / Common AP signature / 10 µM / 24 hrs / In top 20 ranked gene probe sets
INSIG1 / Insulin induced gene 1 / Polymeropoulos, 200916 / Global / Eye, Neuronal Model / ARPE-19 / Common AP signature / 10 µM / 24 hrs / In top 20 ranked gene probe sets
LDLR / Low density lipoprotein receptor / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Chlorpromazine / 0.1 µM / 24 hrs / 1.0 ± 0.05
LDLR / Low density lipoprotein receptor / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Chlorpromazine / 1.0 µM / 24 hrs / 1.7 ± 0.3 / <.05
LDLR / Low density lipoprotein receptor / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Chlorpromazine / 10 µM / 24 hrs / 1.3 ± 0.05 / <.05
LDLR / Low density lipoprotein receptor / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Chlorpromazine / 25 µM / 24 hrs / 1.0 ± 0.3
LDLR / Low density lipoprotein receptor / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Haloperidol / 0.1 µM / 24 hrs / 1.1 ± 0.03
LDLR / Low density lipoprotein receptor / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Haloperidol / 1.0 µM / 24 hrs / 1.5 ± 0.1
LDLR / Low density lipoprotein receptor / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Haloperidol / 10 µM / 24 hrs / 2.3 ± 0.2 / <.001
LDLR / Low density lipoprotein receptor / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Haloperidol / 25 µM / 24 hrs / 2.8 ± 0.3 / <.001
LDLR / Low density lipoprotein receptor / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Clozapine / 0.1 µM / 24 hrs / 1.1 ± 0.02
LDLR / Low density lipoprotein receptor / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Clozapine / 1.0 µM / 24 hrs / 1.2 ± 0.08
LDLR / Low density lipoprotein receptor / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Clozapine / 10 µM / 24 hrs / 1.7 ± 0.2 / <0.01
LDLR / Low density lipoprotein receptor / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Clozapine / 25 µM / 24 hrs / 2.3 ± 0.3 / <.001
LDLR / Low density lipoprotein receptor / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Clozapine / 1 µM / 24 hrs / 1.1 ± 0.08
LDLR / Low density lipoprotein receptor / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Clozapine / 10 µM / 24 hrs / 1.9 ± 0.21
LDLR / Low density lipoprotein receptor / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Clozapine / 25 µM / 24 hrs / 2.7 ± 0.32
LDLR / Low density lipoprotein receptor / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Clozapine / 50 µM / 24 hrs / 2.8 ± 0.14 / 0.00001
LDLR / Low density lipoprotein receptor / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Olanzapine / 0.1 µM / 24 hrs / 1.0 ± 0.1
LDLR / Low density lipoprotein receptor / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Olanzapine / 1.0 µM / 24 hrs / 1.0 ± 0.05
LDLR / Low density lipoprotein receptor / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Olanzapine / 10 µM / 24 hrs / 1.3 ± 0.1
LDLR / Low density lipoprotein receptor / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Olanzapine / 25 µM / 24 hrs / 2.2 ± 0.3 / <0.01
LDLR / Low density lipoprotein receptor / Yang, 200720 / Replication / liver / HEPG2 / Olanzapine / 1 µM / 24 hrs / 0.9 ± 0.03
LDLR / Low density lipoprotein receptor / Yang, 200720 / Replication / liver / HEPG2 / Olanzapine / 10 µM / 24 hrs / 1.7 ± 0.45 / p<0.05
LDLR / Low density lipoprotein receptor / Yang, 200720 / Replication / liver / HEPG2 / Olanzapine / 50 µM / 24 hrs / 3.8 ± 0.60 / p<0.05
LDLR / Low density lipoprotein receptor / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Risperidone / 0.1 µM / 24 hrs / 0.9 ± 0.05
LDLR / Low density lipoprotein receptor / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Risperidone / 1.0 µM / 24 hrs / 1.0 ± 0.08
LDLR / Low density lipoprotein receptor / Fernø, 200618 / Replication / Brain (Glia) / GaMg / Risperidone / 10 µM / 24 hrs / 1.2 ± 0.1