Supplementary Tables S1-S12

Supplementary Table S1. Study group characteristics

A. Distribution of gender in the study groups.

Study groups / N cases / Frequency male cases / N controls / Frequency male controls
Caucasians combined / 1494 / 0.80 / 1769 / 0.61
Hungary / 226 / 0.63 / 76 / 0.74
Germany combined / 1268 / 0.83 / 1693 / 0.61
East Germany / 216 / 0.86 / 212 / 0.84
West Germany combined / 1052 / 0.83 / 1481 / 0.57
West Germany – ongoing / 619 / 0.77 / 517 / 0.70
West Germany - industrial / 433 / 0.91 / 964 / 0.51
DO-hospital / 91 / 0.85
DO-occupational / 342 / 0.93
Non Caucasian study groups
Pakistan / 106 / 0.88 / 61 / 0.85
Venezuela / 112 / 0.71 / 190 / 0.41
All combined / 1712 / 0.80 / 2020 / 0.60

B. Distribution of age at diagnosis (cases) and at examination (controls), respectively, in the study groups.

Study groups / Status / N / Min / Max / Median / Mean / Standard deviation
Caucasians combined / Cases / 1494 / 20.10 / 95.20 / 67.70 / 66.66 / 11.38
Controls / 1769 / 20.10 / 100.00 / 66.90 / 63.41 / 15.30
Hungary / Cases / 226 / 37.70 / 95.10 / 70.50 / 69.23 / 10.82
Controls / 76 / 30.00 / 81.20 / 63.45 / 63.59 / 12.78
Germany combined / Cases / 1268 / 20.10 / 95.20 / 67.25 / 66.20 / 11.42
Controls / 1693 / 20.10 / 100.00 / 67.00 / 63.40 / 15.41
East Germany / Cases / 216 / 20.10 / 91.30 / 65.60 / 64.90 / 11.26
Controls / 212 / 29.40 / 91.20 / 67.70 / 67.68 / 10.05
West Germany combined / Cases / 1052 / 26.10 / 95.20 / 67.60 / 66.47 / 11.44
Controls / 1481 / 20.10 / 100.00 / 66.90 / 62.79 / 15.94
W. Germany - ongoing / Cases / 619 / 26.10 / 95.20 / 71.40 / 69.91 / 10.88
Controls / 517 / 20.50 / 100.00 / 61.90 / 59.43 / 18.52
W. Germany - industrial / Cases / 433 / 32.10 / 83.90 / 61.40 / 61.55 / 10.40
Controls / 964 / 20.10 / 93.90 / 67.80 / 64.59 / 14.05
DO-hospital / Cases / 91 / 44.80 / 83.90 / 67.30 / 66.76 / 9.20
DO-occupational / Cases / 342 / 32.10 / 83.30 / 60.40 / 60.16 / 10.25
Non Caucasian study groups
Pakistan / Cases / 106 / 24.00 / 82.00 / 61.50 / 59.34 / 13.05
Controls / 61 / 27.00 / 77.00 / 56.00 / 53.34 / 14.05
Venezuela / Cases / 112 / 29.30 / 87.10 / 59.05 / 60.16 / 11.82
Controls / 190 / 20.00 / 90.50 / 30.60 / 36.14 / 15.59
All combined / Cases / 1712 / 20.10 / 95.20 / 67.00 / 65.78 / 11.74
Controls / 2020 / 20.00 / 100.00 / 65.10 / 60.54 / 17.27

C. Frequency of non-smokers, former smokers and current smokers in the study groups.

Study groups / Status / N / Non-smokers / Former smokers / Current smokers
Caucasians combined / Cases / 1482 / 0.21 / 0.50 / 0.29
Controls / 1747 / 0.44 / 0.38 / 0.18
Hungary / Cases / 226 / 0.27 / 0.36 / 0.37
Controls / 76 / 0.46 / 0.34 / 0.20
Germany combined / Cases / 1256 / 0.20 / 0.52 / 0.28
Controls / 1671 / 0.44 / 0.38 / 0.17
East Germany / Cases / 215 / 0.23 / 0.48 / 0.29
Controls / 200 / 0.47 / 0.44 / 0.10
West Germany combined / Cases / 1041 / 0.20 / 0.53 / 0.27
Controls / 1471 / 0.43 / 0.38 / 0.19
W. Germany - ongoing / Cases / 613 / 0.19 / 0.57 / 0.24
Controls / 513 / 0.38 / 0.38 / 0.23
W. Germany - industrial / Cases / 430 / 0.21 / 0.47 / 0.33
Controls / 961 / 0.46 / 0.37 / 0.17
DO-hospital / Cases / 91 / 0.18 / 0.26 / 0.56
DO-occupational / Cases / 337 / 0.22 / 0.52 / 0.26
Non Caucasian study groups
Pakistan / Cases / 106 / 0.35 / 0.00 / 0.65
Controls / 61 / 0.15 / 0.00 / 0.85
Venezuela / Cases / 112 / 0.12 / 0.38 / 0.51
Controls / 190 / 0.63 / 0.18 / 0.19
All combined / Cases / 1700 / 0.22 / 0.46 / 0.33
Controls / 2000 / 0.45 / 0.35 / 0.20
For 34 subjects smoking habits were unknown.

Supplementary Table S2. Results of the chi-squared test of Hardy-Weinberg equilibrium (HWE) for the seven NAT2 SNPs and the NAT2 tagSNP rs1495741.

Study groups / Status / N NAT2 / N TagSNP / P value (HWE test)
G191A / C282T / T341C / C481T / G50A / A803G / G857A / TagSNP
Caucasians combined: / Cases / 1474 / 1487 / 1.0000 / 0.0977 / 0.9273 / 0.6579 / 0.0971 / 0.4616 / 0.6429 / 0.3114
Controls / 1748 / 1707 / 1.0000 / 0.7105 / 0.3166 / 0.0995 / 0.6716 / 0.9619 / 0.4219 / 0.0984
Hungary / Cases / 225 / 224 / 1.0000 / 0.8999 / 0.4556 / 0.6153 / 0.4689 / 0.3887 / 0.8126 / 0.9606
Controls / 72 / 76 / 1.0000 / 0.9186 / 0.7686 / 0.5947 / 0.9233 / 0.6032 / 0.8567 / 0.5954
Germany combined: / Cases / 1249 / 1263 / 1.0000 / 0.0601 / 0.6478 / 0.4662 / 0.0310 / 0.6927 / 0.6224 / 0.3072
Controls / 1676 / 1631 / 1.0000 / 0.7140 / 0.2510 / 0.0632 / 0.7002 / 0.8271 / 0.4057 / 0.1273
East Germany / Cases / 215 / 215 / 1.0000 / 0.8792 / 0.9313 / 0.9432 / 0.3268 / 0.3609 / 0.1175 / 0.6297
Controls / 212 / 211 / 1.0000 / 0.0632 / 0.0790 / 0.1166 / 0.1064 / 0.0901 / 0.1891 / 0.0910
W. Germany combined: / Cases / 1034 / 1048 / 1.0000 / 0.0516 / 0.5625 / 0.4409 / 0.0652 / 0.9807 / 0.6366 / 0.1589
Controls / 1464 / 1420 / 1.0000 / 0.7798 / 0.5875 / 0.1683 / 0.8717 / 0.7314 / 0.3575 / 0.3580
W. Germany - ongoing / Cases / 609 / 617 / 1.0000 / 0.0380 / 0.2697 / 0.2848 / 0.0962 / 0.3045 / 0.9173 / 0.2446
Controls / 505 / 515 / 1.0000 / 0.9668 / 0.1534 / 0.0479 / 0.6606 / 0.7339 / 0.4209 / 0.6336
W. Germany - industrial / Cases / 425 / 431 / 1.0000 / 0.6361 / 0.6501 / 0.8964 / 0.4282 / 0.1689 / 0.8629 / 0.4665
Controls / 959 / 905 / 1.0000 / 0.7194 / 0.7567 / 0.8155 / 0.5915 / 0.4721 / 0.8985 / 0.1164
DO-hospital / Cases / 87 / 91 / 1.0000 / 0.2114 / 0.8937 / 0.8049 / 0.2014 / 0.9440 / 0.8700 / 0.9415
DO-occupational / Cases / 338 / 340 / 1.0000 / 0.9734 / 0.5935 / 0.7249 / 0.9087 / 0.1394 / 0.8540 / 0.4868
Non Caucasian study groups
Pakistan / Cases / 106 / 103 / 1.0000 / 0.0282 / 0.8241 / 0.9297 / 0.2059 / 0.8836 / 0.9006 / 0.8538
Controls / 61 / 60 / 1.0000 / 0.1362 / 0.9404 / 0.5696 / 0.5379 / 0.9404 / 0.8439 / 0.9165
Venezuela / Cases / 112 / 112 / 0.2354 / 0.1383 / 0.8265 / 0.9296 / 0.2242 / 0.8880 / 0.9104 / 0.2894
Controls / 186 / 190 / 0.9117 / 0.3915 / 0.1506 / 0.1068 / 0.4459 / 0.4173 / 0.8537 / 0.4609
All combined / Cases / 1692 / 1702 / 0.9320 / 0.0061 / 0.8013 / 0.6063 / 0.0187 / 0.5294 / 0.3229 / 0.2685
Controls / 1995 / 1957 / 0.9732 / 0.7475 / 0.1871 / 0.0484 / 0.9826 / 0.7516 / 0.2051 / 0.0984
For 45 subjects NAT2 could not be determined, for 73 subjects rs1495741 genotypes could not be determined.

Supplementary Table S3.Distribution of the 7-SNP genotype, unadjusted and adjusted P values, ORs and 95% CIs stratified and not stratified for smoking habits (supplement to Table 1).

A. Distribution of the 7-SNP genotype, unadjusted and adjusted P values, ORs and 95% CIs

Study groups / Status / N / Genotypes / Unadjusted / Adjusted
slow / intermediate / rapid / P value / OR
95% CI / P value / OR
95% CI
Caucasians combined / Cases / 1474 / 0.60 / 0.35 / 0.05 / 0.8824 / 0.99
0.85-1.151 / 0.6195 / 0.96
0.82-1.12
Controls / 1748 / 0.59 / 0.36 / 0.05
Hungary / Cases / 225 / 0.60 / 0.34 / 0.06 / 0.9666 / 1.01
0.59-1.74 / 0.9271 / 0.97
0.54-1.75
Controls / 72 / 0.60 / 0.38 / 0.03
Germany combined / Cases / 1249 / 0.60 / 0.36 / 0.04 / 0.8685 / 0.99
0.85-1.152 / 0.6616 / 0.96
0.82-1.14
Controls / 1676 / 0.59 / 0.36 / 0.05
East Germany / Cases / 215 / 0.61 / 0.33 / 0.06 / 0.4181 / 1.17
0.80-1.73 / 0.4134 / 1.19
0.79-1.80
Controls / 212 / 0.57 / 0.39 / 0.04
West Germany combined / Cases / 1034 / 0.60 / 0.36 / 0.04 / 0.5947 / 0.96
0.81-1.133 / 0.4497 / 0.93
0.78-1.12
Controls / 1464 / 0.59 / 0.36 / 0.05
W. Germany - ongoing / Cases / 609 / 0.61 / 0.35 / 0.03 / 0.4209 / 0.90
0.70-1.164 / 0.3620 / 0.88
0.67-1.16
Controls / 505 / 0.64 / 0.31 / 0.05
W. Germany - industrial / Cases / 425 / 0.57 / 0.37 / 0.05 / 0.9331 / 1.01
0.80-1.27 / 0.8594 / 1.02
0.79-1.33
Controlsa / 959 / 0.57 / 0.38 / 0.05
DO-hospitala / Cases / 87 / 0.57 / 0.36 / 0.07 / 0.9228 / 1.02
0.66-1.59 / 0.8097 / 1.06
0.66-1.71
DO-occupationala / Cases / 338 / 0.57 / 0.38 / 0.05 / 0.9577 / 1.01
0.78-1.29 / 0.8865 / 1.02
0.77-1.35
Non Caucasian study groups
Pakistan / Cases / 106 / 0.67 / 0.27 / 0.06 / 0.1476 / 1.61
0.84-3.08 / 0.0583 / 2.02
0.98-4.20
Controls / 61 / 0.56 / 0.38 / 0.07
Venezuela / Cases / 112 / 0.50 / 0.44 / 0.06 / 0.7190 / 1.09
0.68-1.74 / 0.8475 / 1.07
0.54-2.12
Controls / 186 / 0.48 / 0.45 / 0.08
All combined / Cases / 1692 / 0.60 / 0.35 / 0.05 / 0.7844 / 1.02
0.89-1.175 / 0.7732 / 0.98
0.85-1.13
Controls / 1995 / 0.58 / 0.37 / 0.05
OR odds ratio, 95% CI 95% confidence interval
a Controls were the Dortmund control group
Asymptotic P values of the chi-squared test and confidence limits are given, combined study groups were adjusted for region according to the method of Mantel-Haenszel
Adjusted P values, ORs and 95% CIs were estimated by logistic regression models adjusting for age, gender, smoking habits and – in case of combined study groups – for region.
1 Breslow-Day test P=0.7087
2 Breslow-Day test P=0.5017
3 Breslow-Day test P=0.4939
4 Breslow-Day test P=0.9751
5 Breslow-Day test P=0.6148

B. Non-smokers: Distribution of the 7-SNP genotype, unadjusted and adjusted P values, ORs and 95% CIs.

Study groups / Status / N / Genotypes / Unadjusted / Adjusted
slow / intermediate / rapid / P value / OR
95% CI / P value / OR
95% CI
Caucasians combined / Cases / 315 / 0.56 / 0.41 / 0.04 / 0.7993 / 0.96
0.73-1.271 / 0.6231 / 0.93
0.70-1.24
Controls / 759 / 0.55 / 0.40 / 0.05
Hungary / Cases / 60 / 0.53 / 0.40 / 0.07 / 0.6941 / 0.84
0.36-1.98 / 0.5661 / 0.77
0.31-1.91
Controls / 33 / 0.58 / 0.42 / 0.00
Germany combined / Cases / 255 / 0.56 / 0.41 / 0.03 / 0.8940 / 0.98
0.73-1.322 / 0.6902 / 0.94
0.70-1.27
Controls / 726 / 0.55 / 0.40 / 0.05
East Germany / Cases / 49 / 0.59 / 0.37 / 0.04 / 0.8013 / 1.09
0.54-2.21 / 0.6883 / 1.17
0.55-2.48
Controls / 93 / 0.57 / 0.40 / 0.03
West Germany combined / Cases / 206 / 0.55 / 0.42 / 0.03 / 0.7918 / 0.96
0.69-1.333 / 0.5935 / 0.91
0.65- 1.28
Controls / 633 / 0.55 / 0.40 / 0.05
W. Germany - ongoing / Cases / 117 / 0.54 / 0.43 / 0.03 / 0.24654 / 0.75
0.47-1.214 / 0.1522 / 0.68
0.40-1.15
Controls / 193 / 0.61 / 0.34 / 0.05
W. Germany - industrial / Cases / 89 / 0.57 / 0.40 / 0.02 / 0.3858 / 1.23
0.77-1.94 / 0.1238 / 1.47
0.90-2.39
Controlsa / 440 / 0.52 / 0.42 / 0.05
DO-hospitala / Cases / 16 / 0.50 / 0.38 / 0.13 / 0.8581 / 0.91
0.34-2.48 / 0.9503 / 0.97
0.35-2.66
DO-occupationala / Cases / 73 / 0.59 / 0.41 / 0.00 / 0.2930 / 1.31
0.79-2.16 / 0.0834 / 1.61
0.94-2.75
Non Caucasian study groups
Pakistan / Cases / 37 / 0.51 / 0.41 / 0.08 / 0.1506 / 3.69
0.58-40.00 / 0.4293 / 2.11
0.33-13.34
Controls / 9 / 0.22 / 0.56 / 0.22
Venezuela / Cases / 13 / 0.38 / 0.46 / 0.15 / 0.4130 / 0.61
0.19-1.99 / 0.2446 / 0.42
0.10-1.81
Controls / 117 / 0.50 / 0.42 / 0.08
All combined / Cases / 365 / 0.55 / 0.41 / 0.05 / 0.8835 / 0.98
0.75-1.285 / 0.5974 / 0.93
0.71-1.22
Controls / 885 / 0.54 / 0.40 / 0.05
OR odds ratio, 95% CI 95% confidence interval
a Controls were the Dortmund control group
Unadjusted P values ORs and 95% CIs were estimated using the asymptotic chi-squared test and confidence limits in case of single study groups, the exact P value and 95% CI were used in case of Pakistan, for combined study groups the method of Mantel-Haenszel was used. Adjusted P values, ORs and 95% CIs were estimated by logistic regression models adjusting for age, gender, smoking habits and study groups.
1 Breslow-Day test P= 0.4758
2 Breslow-Day test P= 0.3026
3 Breslow-Day test P= 0.1316
4 Breslow-Day test P= 0.7076
5 Breslow-Day test P= 0.3380

C. Former smokers: Distribution of the 7-SNP genotype, unadjusted and adjusted P values, ORs and 95% CIs.

Study groups / Status / N / Genotypes / Unadjusted / Adjusted
slow / intermediate / rapid / P value / OR
95% CI / P value / OR
95% CI
Caucasians combined / Cases / 725 / 0.60 / 0.35 / 0.04 / 0.4077 / 0.91
0.73-1.141 / 0.7199 / 0.96
0.76-1.21
Controls / 658 / 0.62 / 0.34 / 0.05
Hungary / Cases / 82 / 0.65 / 0.32 / 0.04 / 0.5727 / 0.75
0.28-2.02 / 0.5463 / 0.73
0.26-2.03
Controls / 24 / 0.71 / 0.29 / 0.00
Germany combined / Cases / 643 / 0.60 / 0.36 / 0.05 / 0.4742 / 0.92
0.73-1.162 / 0.8963 / 0.98
0.77-1.25
Controls / 634 / 0.61 / 0.34 / 0.05
East Germany / Cases / 103 / 0.59 / 0.37 / 0.04 / 0.7370 / 1.10
0.62-1.96 / 0.8394 / 1.06
0.59-1.90
Controls / 88 / 0.57 / 0.40 / 0.03
West Germany combined / Cases / 540 / 0.60 / 0.36 / 0.05 / 0.3522 / 0.89
0.69-1.143 / 0.7545 / 0.96
0.74-1.25
Controls / 546 / 0.62 / 0.33 / 0.05
W. Germany - ongoing / Cases / 344 / 0.62 / 0.34 / 0.04 / 0.7378 / 1.06
0.74-1.544 / 0.4389 / 1.17
0.79-1.72
Controls / 192 / 0.60 / 0.35 / 0.05
W. Germany - industrial / Cases / 196 / 0.56 / 0.39 / 0.06 / 0.0782 / 0.73
0.51-1.04 / 0.1343 / 0.74
0.49-1.10
Controlsa / 354 / 0.63 / 0.31 / 0.05
DO-hospitala / Cases / 23 / 0.57 / 0.43 / 0.00 / 0.5159 / 0.75
0.32-1.77 / 0.5544 / 0.77
0.33-1.826
DO-occupationala / Cases / 173 / 0.55 / 0.38 / 0.06 / 0.0857 / 0.72
0.50-1.05 / 0.1509 / 0.73
0.48-1.12
Non Caucasian study groups
Pakistan / Cases / 0 / - / - / - / - / - / - / -
Controls / 0 / - / - / -
Venezuela / Cases / 42 / 0.62 / 0.38 / 0.00 / 0.0065 / 3.74
1.42-9.85 / 0.0433 / 3.58
1.04-12.32
Controls / 33 / 0.30 / 0.58 / 0.12
All combined / Cases / 767 / 0.60 / 0.36 / 0.04 / 0.7056 / 1.08
0.72-1.635 / 0.7689 / 1.03
0.83-1.30
Controls / 691 / 0.60 / 0.35 / 0.05
OR odds ratio, 95% CI 95% confidence interval
a Controls were the Dortmund control group
Unadjusted P values ORs and 95% CIs were estimated using the asymptotic chi-squared test and confidence limits in case of single study groups, for combined study groups the method of Mantel-Haenszel was used, if not indicated otherwise. Adjusted P values, ORs and 95% CIs were estimated by logistic regression models adjusting for age, gender, smoking habits and study groups.
1 Breslow-Day test P= 0.3833
2 Breslow-Day test P= 0.2338
3 Breslow-Day test P= 0.1182
4 Breslow-Day test P= 0.7322
5 Breslow-Day test P= 0.0253, estimates of the random effects model
6not adjusted for gender due to lack of female cases in the subgroups of former smokers

D. Current smokers: Distribution of the 7-SNP genotype, unadjusted and adjusted P values, ORs and 95% CIs.

Study groups / Status / N / Genotypes / Unadjusted / Adjusted
slow / intermediate / rapid / P value / OR
95% CI / P value / OR
95% CI
Caucasians combined / Cases / 422 / 0.62 / 0.32 / 0.06 / 0.7711 / 1.05
0.76-1.441 / 0.7431 / 1.06
0.76-1.47
Controls / 309 / 0.61 / 0.35 / 0.04
Hungary / Cases / 83 / 0.60 / 0.31 / 0.08 / 0.3267 / 1.73
0.57- 5.23 / 0.2112 / 2.23
0.63-7.85
Controls / 15 / 0.47 / 0.40 / 0.13
Germany combined / Cases / 339 / 0.63 / 0.32 / 0.06 / 0.9898 / 1.00
0.72-1.392 / 0.9891 / 1.00
0.71-1.42
Controls / 294 / 0.62 / 0.34 / 0.04
East Germany / Cases / 62 / 0.65 / 0.26 / 0.10 / 0.3511 / 1.64
0.58-4.63 / 0.5958 / 1.35
0.45-4.06
Controls / 19 / 0.53 / 0.42 / 0.05
West Germany combined / Cases / 277 / 0.62 / 0.33 / 0.05 / 0.7691 / 0.95
0.67-1.353 / 0.8833 / 0.97
0.68-1.40
Controls / 275 / 0.63 / 0.34 / 0.04
W. Germany - ongoing / Cases / 142 / 0.65 / 0.32 / 0.02 / 0.3482 / 0.77
0.44-1.334 / 0.4263 / 0.76
0.39-1.48
Controls / 116 / 0.73 / 0.22 / 0.04
W. Germany - industrial / Cases / 135 / 0.59 / 0.33 / 0.07 / 0.4333 / 1.20
0.76-1.91 / 0.6050 / 1.14
0.69-1.88
Controlsa / 159 / 0.55 / 0.42 / 0.03
DO-hospitala / Cases / 48 / 0.60 / 0.31 / 0.08 / 0.4856 / 1.26
0.65-2.44 / 0.5494 / 1.23
0.62-2.45
DO-occupationala / Cases / 87 / 0.59 / 0.34 / 0.07 / 0.5553 / 1.17
0.69-1.99 / 0.7666 / 1.09
0.62-1.94
Non Caucasian study groups
Pakistan / Cases / 69 / 0.75 / 0.20 / 0.04 / 0.1023 / 1.91
0.87-4.18 / 0.10896 / 1.92
0.87-4.246
Controls / 52 / 0.62 / 0.35 / 0.04
Venezuela / Cases / 57 / 0.44 / 0.47 / 0.09 / 0.2716 / 0.63
0.27-1.45 / 0.6923 / 0.80
0.27-2.39
Controls / 36 / 0.56 / 0.42 / 0.03
All combined / Cases / 548 / 0.62 / 0.32 / 0.06 / 0.6395 / 1.07
0.81-1.415 / 0.5509 / 1.09
0.82-1.46
Controls / 397 / 0.61 / 0.35 / 0.04
OR odds ratio, 95% CI 95% confidence interval
a Controls were the Dortmund control group
Unadjusted P values ORs and 95% CIs were estimated using the asymptotic chi-squared test and confidence limits in case of single study groups, for combined study groups the method of Mantel-Haenszel was used. Adjusted P values, ORs and 95% CIs were estimated by logistic regression models adjusting for age, gender, smoking habits and study groups.
1 Breslow-Day test P= 0.2451
2 Breslow-Day test P= 0.1930
3 Breslow-Day test P= 0.1262
4 Breslow-Day test P= 0.2240
5 Breslow-Day test P= 0.1625
6 not adjusted for gender due to the lack of female cases in the subgroup of current smokers

Supplementary Table S4. Distribution of the tagSNP rs1495741, unadjusted and adjusted P values, ORs and 95% CIs stratified and not stratified for smoking habits (supplement to Table 1).

A. Distribution of the tagSNP, unadjusted and adjusted P values, ORs and 95% CIs.

Study groups / Status / N / Genotypes / Unadjusted / Adjusted
slow / intermediate / rapid / P value / OR
95% CI / P value / OR
95% CI
Caucasians combined / Cases / 1487 / 0.62 / 0.34 / 0.04 / 0.5693 / 1.04
0.90-1.211 / 0.8139 / 1.02
0.87-1.19
Controls / 1707 / 0.60 / 0.36 / 0.04
Hungary / Cases / 224 / 0.63 / 0.33 / 0.04 / 0.8634 / 1.05
0.61-1.79 / 0.9555 / 1.02
0.57-1.82
Controls / 76 / 0.62 / 0.36 / 0.03
Germany combined / Cases / 1263 / 0.61 / 0.35 / 0.04 / 0.5872 / 1.04
0.89-1.222 / 0.7338 / 1.03
0.87-1.21
Controls / 1631 / 0.59 / 0.36 / 0.04
East Germany / Cases / 215 / 0.63 / 0.32 / 0.05 / 0.2510 / 1.26
0.85-1.85 / 0.1448 / 1.37
0.90-2.07
Controls / 211 / 0.58 / 0.39 / 0.03
West Germany combined / Cases / 1048 / 0.61 / 0.35 / 0.04 / 0.9233 / 1.01
0.85-1.193 / 0.8488 / 0.98
0.82-1.18
Controls / 1420 / 0.60 / 0.36 / 0.05
W. Germany - ongoing / Cases / 617 / 0.62 / 0.34 / 0.03 / 0.7567 / 0.96
0.75-1.234 / 0.4328 / 0.90
0.68-1.18
Controls / 515 / 0.63 / 0.32 / 0.05
W. Germany - industrial / Cases / 431 / 0.59 / 0.36 / 0.04 / 0.5806 / 1.07
0.85-1.35 / 0.6310 / 1.07
0.82-1.38
Controlsa / 905 / 0.58 / 0.38 / 0.05
DO-hospitala / Cases / 91 / 0.60 / 0.35 / 0.04 / 0.5971 / 1.13
0.72-1.75 / 0.7063 / 1.10
0.68-1.76
DO-occupationala / Cases / 340 / 0.59 / 0.37 / 0.04 / 0.6896 / 1.05
0.82-1.36 / 0.7069 / 1.06
0.80-1.40
Non Caucasian study groups
Pakistan / Cases / 103 / 0.68 / 0.28 / 0.04 / 0.2156 / 1.52
0.78-2.93 / 0.1110 / 1.81
0.87-3.76
Controls / 60 / 0.58 / 0.35 / 0.07
Venezuela / Cases / 112 / 0.47 / 0.46 / 0.06 / 0.8534 / 0.96
0.60-1.53 / 0.8275 / 0.93
0.47-1.82
Controls / 190 / 0.48 / 0.44 / 0.07
All combined / Cases / 1702 / 0.61 / 0.35 / 0.04 / 0.4636 / 1.05
0.92-1.215 / 0.8114 / 1.02
0.88-1.18
Controls / 1957 / 0.58 / 0.37 / 0.05
OR odds ratio, 95% CI 95% confidence interval
a Controls were the Dortmund control group
Unadjusted P values ORs and 95% CIs were estimated using the asymptotic chi-squared test and confidence limits in case of single study groups, for combined study groups the method of Mantel-Haenszel was used. Adjusted P values, ORs and 95% CIs were estimated by logistic regression models adjusting for age, gender, smoking habits and study groups.
1 Breslow-Day test P= 0.6780
2 Breslow-Day test P= 0.4681
3 Breslow-Day test P= 0.4855
4 Breslow-Day test P= 0.9718
5 Breslow-Day test P= 0.7205

B. Non-smokers: Distribution of the tagSNP, unadjusted and adjusted P values, ORs and 95% CIs.

Study groups / Status / N / Genotypes / Unadjusted / Adjusted
slow / intermediate / rapid / P value / OR
95% CI / P value / OR
95% CI
Caucasians combined / Cases / 317 / 0.58 / 0.38 / 0.03 / 0.6441 / 1.07
0.81-1.411 / 0.7694 / 1.04
0.79-1.39
Controls / 739 / 0.56 / 0.40 / 0.04
Hungary / Cases / 60 / 0.55 / 0.40 / 0.05 / 0.8392 / 0.92
0.40-2.12 / 0.7608 / 0.87
0.36-2.13
Controls / 35 / 0.57 / 0.43 / 0.00
Germany combined / Cases / 257 / 0.59 / 0.38 / 0.03 / 0.5744 / 1.09
0.81-1.472 / 0.7119 / 1.06
0.78-1.43
Controls / 704 / 0.56 / 0.40 / 0.04
East Germany / Cases / 49 / 0.65 / 0.31 / 0.04 / 0.4012 / 1.36
0.66-2.79 / 0.3090 / 1.49
0.69-3.21
Controls / 93 / 0.58 / 0.40 / 0.02
West Germany combined / Cases / 208 / 0.58 / 0.39 / 0.03 / 0.8163 / 1.04
0.75-1.443 / 0.9350 / 1.01
0.73-1.42
Controls / 611 / 0.56 / 0.40 / 0.04
W. Germany - ongoing / Cases / 119 / 0.55 / 0.41 / 0.03 / 0.4587 / 0.83
0.52-1.344 / 0.2984 / 0.76
0.45-1.28
Controls / 196 / 0.60 / 0.35 / 0.05
W. Germany - industrial / Cases / 89 / 0.61 / 0.37 / 0.02 / 0.2489 / 1.32
0.82-2.10 / 0.0614 / 1.61
0.98-2.65
Controlsa / 415 / 0.54 / 0.42 / 0.04
DO-hospitala / Cases / 16 / 0.50 / 0.38 / 0.13 / 0.7543 / 0.85
0.31-2.32 / 0.8846 / 0.93
0.34-2.56
DO-occupationala / Cases / 73 / 0.63 / 0.37 / 0.00 / 0.1520 / 1.45
0.87-2.43 / 0.0318 / 1.83
1.05-3.16
Non Caucasian study groups
Pakistan / Cases / 35 / 0.57 / 0.37 / 0.06 / 0.1324 / 4.67
0.72-50.57 / 0.2923 / 2.70
0.43-17.15
Controls / 9 / 0.22 / 0.56 / 0.22
Venezuela / Cases / 13 / 0.31 / 0.54 / 0.15 / 0.1973 / 0.45
0.13-1.55 / 0.1350 / 0.32
0.07-1.43
Controls / 119 / 0.50 / 0.44 / 0.07
All combined / Cases / 365 / 0.57 / 0.39 / 0.04 / 0.6303 / 1.07
0.82-1.395 / 0.8538 / 1.03
0.78-1.35
Controls / 867 / 0.55 / 0.40 / 0.04
OR odds ratio, 95% CI 95% confidence interval
a Controls were the Dortmund control group
Unadjusted P values ORs and 95% CIs were estimated using the asymptotic chi-squared test and confidence limits in case of single study groups, the exact P value and 95% CI were used in case of Pakistan, for combined study groups the method of Mantel-Haenszel was used. Adjusted P values, ORs and 95% CIs were estimated by logistic regression models adjusting for age, gender, smoking habits and study groups.
1 Breslow-Day test P= 0.4652
2 Breslow-Day test P= 0.2988
3 Breslow-Day test P= 0.1610
4 Breslow-Day test P= 0.6635
5 Breslow-Day test P= 0.1741

C. Former smokers: Distribution of the tagSNP, unadjusted and adjusted P values, ORs and 95% CIs.

Study groups / Status / N / Genotypes / Unadjusted / Adjusted
slow / intermediate / rapid / P value / OR
95% CI / P value / OR
95% CI
Caucasians combined / Cases / 731 / 0.62 / 0.34 / 0.04 / 0.7050 / 0.96
0.76-1.201 / 0.9945 / 1.00
0.79-1.26
Controls / 644 / 0.62 / 0.34 / 0.05
Hungary / Cases / 81 / 0.69 / 0.28 / 0.02 / 0.4463 / 0.67
0.24-1.88 / 0.4035 / 0.64
0.22-1.83
Controls / 26 / 0.77 / 0.23 / 0.00
Germany combined / Cases / 650 / 0.61 / 0.35 / 0.04 / 0.8358 / 0.98
0.77-1.232 / 0.7759 / 1.04
0.82-1.32
Controls / 618 / 0.61 / 0.34 / 0.05
East Germany / Cases / 103 / 0.61 / 0.35 / 0.04 / 0.4431 / 1.25
0.70-2.23 / 0.5283 / 1.21
0.67-2.16
Controls / 88 / 0.56 / 0.41 / 0.03
West Germany combined / Cases / 547 / 0.61 / 0.35 / 0.05 / 0.5725 / 0.93
0.72-1.203 / 0.9514 / 0.99
0.76-1.29
Controls / 530 / 0.62 / 0.33 / 0.05
W. Germany - ongoing / Cases / 348 / 0.63 / 0.33 / 0.04 / 0.8596 / 1.03
0.72-1.494 / 0.6798 / 1.09
0.74-1.60
Controls / 196 / 0.62 / 0.34 / 0.05
W. Germany - industrial / Cases / 199 / 0.57 / 0.37 / 0.06 / 0.2846 / 0.82
0.58-1.18 / 0.4139 / 0.84
0.56-1.27
Controlsa / 334 / 0.62 / 0.33 / 0.05
DO-hospitala / Cases / 24 / 0.58 / 0.42 / 0.00 / 0.7229 / 0.86
0.37-1.99 / 0.7546 / 0.87
0.38-2.036
DO-occupationala / Cases / 175 / 0.57 / 0.37 / 0.06 / 0.2898 / 0.82
0.56-1.19 / 0.4378 / 0.84
0.55-1.30
Non Caucasian study groups
Pakistan / Cases / 0 / - / - / - / - / - / - / -
Controls / 0 / - / - / -
Venezuela / Cases / 42 / 0.57 / 0.43 / 0.00 / 0.0453 / 2.56
1.01-6.46 / 0.1386 / 2.44
0.75-7.96
Controls / 35 / 0.34 / 0.51 / 0.14
All combined / Cases / 773 / 0.62 / 0.34 / 0.04 / 0.9034 / 1.01
0.81-1.265 / 0.6286 / 1.06
0.84-1.33
Controls / 679 / 0.60 / 0.35 / 0.05
OR odds ratio, 95% CI 95% confidence interval
a Controls were the Dortmund control group
Unadjusted P values ORs and 95% CIs were estimated using the asymptotic chi-squared test and confidence limits in case of single study groups, for combined study groups the method of Mantel-Haenszel was used. Adjusted P values, ORs and 95% CIs were estimated by logistic regression models adjusting for age, gender, smoking habits and study groups.
1 Breslow-Day test P= 0.5221
2 Breslow-Day test P= 0.4136
3 Breslow-Day test P= 0.3425
4 Breslow-Day test P= 0.7208
5 Breslow-Day test P= 0.1725
6 not adjusted for gender due to the lack of female cases in the subgroups of former smokers

D. Current smokers: Distribution of the tagSNP, unadjusted and adjusted P values, ORs and 95% CIs.

Study groups / Status / N / Genotypes / Unadjusted / Adjusted
slow / intermediate / rapid / P value / OR
95% CI / P value / OR
95% CI
Caucasians combined / Cases / 427 / 0.63 / 0.32 / 0.04 / 0.6199 / 1.08
0.79-1.481 / 0.7514 / 1.06
0.76-1.47
Controls / 309 / 0.62 / 0.33 / 0.05
Hungary / Cases / 83 / 0.63 / 0.33 / 0.05 / 0.2445 / 1.92
0.63-5.80 / 0.1529 / 2.52
0.71-8.97
Controls / 15 / 0.47 / 0.40 / 0.13
Germany combined / Cases / 344 / 0.64 / 0.32 / 0.04 / 0.8604 / 1.03
0.74-1.432 / 0.9747 / 0.99
0.71-1.40
Controls / 294 / 0.63 / 0.33 / 0.04
East Germany / Cases / 62 / 0.65 / 0.27 / 0.08 / 0.3511 / 1.64
0.58-4.63 / 0.5958 / 1.35
0.45-4.06
Controls / 19 / 0.53 / 0.42 / 0.05
West Germany combined / Cases / 282 / 0.63 / 0.33 / 0.03 / 0.9041 / 0.98
0.69-1.393 / 0.8373 / 0.96
0.67-1.39
Controls / 275 / 0.63 / 0.32 / 0.04
W. Germany - ongoing / Cases / 144 / 0.66 / 0.32 / 0.02 / 0.7185 / 0.91
0.53-1.554 / 0.5145 / 0.81
0.43-1.53
Controls / 119 / 0.71 / 0.24 / 0.05
W. Germany - industrial / Cases / 138 / 0.61 / 0.35 / 0.04 / 0.5801 / 1.14
0.72-1.82 / 0.9849 / 1.01
0.61-1.66
Controlsa / 156 / 0.58 / 0.38 / 0.04
DO-hospitala / Cases / 51 / 0.65 / 0.31 / 0.04 / 0.3759 / 1.34
0.70-2.59 / 0.5605 / 1.23
0.62-2.44
DO-occupationala / Cases / 87 / 0.59 / 0.37 / 0.05 / 0.8882 / 1.04
0.61-1.77 / 0.6442 / 0.87
0.49-1.56
Non Caucasian study groups
Pakistan / Cases / 68 / 0.74 / 0.24 / 0.03 / 0.2998 / 1.52
0.69-3.33 / 0.2786 / 1.56
0.70-3.486
Controls / 51 / 0.65 / 0.31 / 0.04
Venezuela / Cases / 57 / 0.44 / 0.47 / 0.09 / 0.1739 / 0.56
0.24-1.30 / 0.7862 / 0.86
0.29-2.56
Controls / 36 / 0.58 / 0.39 / 0.03
All combined / Cases / 552 / 0.63 / 0.33 / 0.05 / 0.7291 / 1.05
0.80-1.385 / 0.6915 / 1.06
0.79-1.42
Controls / 396 / 0.62 / 0.34 / 0.05
OR odds ratio, 95% CI 95% confidence interval
a Controls were the Dortmund control group
Unadjusted P values ORs and 95% CIs were estimated using the asymptotic chi-squared test and confidence limits in case of single study groups, for combined study groups the method of Mantel-Haenszel was used. Adjusted P values, ORs and 95% CIs were estimated by logistic regression models adjusting for age, gender, smoking habits and study groups.
1 Breslow-Day test P= 0.4071
2 Breslow-Day test P= 0.4107
3 Breslow-Day test P= 0.3347
4 Breslow-Day test P= 0.2630
5 Breslow-Day test P= 0.3104
6 not adjusted for gender due to the lack of female cases in the subgroup of current smokers

Supplementary Table S5. Distribution of the 2-SNP genotype, unadjusted and adjusted P values, ORs and 95% CIs stratified and not stratified for smoking habits yields the same results as the 7-SNP genotype (supplement to Table 1).

A. Distribution of the 2-SNP genotype, unadjusted and adjusted P values, ORs and 95% CIs.

Study groups / Status / N / Genotypes / Unadjusted / Adjusted
slow / intermediate / rapid / P value / OR
95% CI / P value / OR
95% CI
Caucasians combined / Cases / 1474 / 0.60 / 0.35 / 0.05 / 0.8505 / 0.99
0.85-1.141 / 0.5742 / 0.96
0.82-1.12
Controls / 1748 / 0.59 / 0.36 / 0.05
Hungary / Cases / 225 / 0.60 / 0.34 / 0.06 / 0.9666 / 1.01
0.59-1.74 / 0.9271 / 0.97
0.54-1.75
Controls / 72 / 0.60 / 0.38 / 0.03
Germany combined / Cases / 1249 / 0.60 / 0.35 / 0.04 / 0.8353 / 0.98
0.84-1.152 / 0.6096 / 0.96
0.81-1.13
Controls / 1676 / 0.59 / 0.36 / 0.05
East Germany / Cases / 215 / 0.61 / 0.33 / 0.06 / 0.4181 / 1.17
0.80-1.73 / 0.4134 / 1.19
0.79-1.80
Controls / 212 / 0.57 / 0.39 / 0.04
West Germany combined / Cases / 1034 / 0.60 / 0.36 / 0.04 / 0.5626 / 0.95
0.80-1.133 / 0.4033 / 0.93
0.78-1.11
Controls / 1464 / 0.60 / 0.35 / 0.05
W. Germany - ongoing / Cases / 609 / 0.62 / 0.35 / 0.03 / 0.4224 / 0.90
0.70-1.164 / 0.3692 / 0.88
0.67-1.16
Controls / 505 / 0.65 / 0.31 / 0.05
W. Germany - industrial / Cases / 425 / 0.57 / 0.37 / 0.05 / 0.9907 / 1.00
0.80-1.26 / 0.9250 / 1.01
0.78-1.31
Controlsa / 959 / 0.57 / 0.38 / 0.05
DO-hospitala / Cases / 87 / 0.57 / 0.36 / 0.07 / 0.9527 / 1.01
0.65-1.58 / 0.8607 / 1.04
0.65-1.68
DO-occupationala / Cases / 338 / 0.57 / 0.38 / 0.05 / 0.9892 / 1.00
0.78-1.28 / 0.9448 / 1.01
0.76-1.34
Non Caucasian study groups
Pakistan / Cases / 106 / 0.67 / 0.26 / 0.07 / 0.2146 / 1.51
0.79-2.88 / 0.0655 / 1.99
0.96-4.13
Controls / 61 / 0.57 / 0.36 / 0.07
Venezuela / Cases / 112 / 0.51 / 0.44 / 0.05 / 0.9526 / 1.01
0.63-1.62 / 0.9226 / 0.97
0.49-1.91
Controls / 186 / 0.51 / 0.42 / 0.07
All combined / Cases / 1692 / 0.60 / 0.35 / 0.05 / 0.9176 / 1.01
0.88-1.165 / 0.6616 / 0.97
0.84-1.12
Controls / 1995 / 0.58 / 0.37 / 0.05
OR odds ratio, 95% CI 95% confidence interval
a Controls were the Dortmund control group
Unadjusted P values ORs and 95% CIs were estimated using the asymptotic chi-squared test and confidence limits in case of single study groups, for combined study groups the method of Mantel-Haenszel was used. Adjusted P values, ORs and 95% CIs were estimated by logistic regression models adjusting for age, gender, smoking habits and study groups.
1 Breslow-Day test P= 0.7160
2 Breslow-Day test P= 0.5101
3 Breslow-Day test P= 0.5279
4 Breslow-Day test P= 0.9614
5 Breslow-Day test P= 0.7118

B. Non-smokers: Distribution of the 2-SNP genotype, unadjusted and adjusted P values, ORs and 95% CIs.

Study groups / Status / N / Genotypes / Unadjusted / Adjusted
slow / intermediate / rapid / P value / OR
95% CI / P value / OR
95% CI
Caucasians combined / Cases / 315 / 0.56 / 0.41 / 0.04 / 0.6996 / 0.95
0.72-1.251 / 0.5547 / 0.92
0.69-1.22
Controls / 759 / 0.56 / 0.39 / 0.05
Hungary / Cases / 60 / 0.53 / 0.40 / 0.07 / 0.6941 / 0.84
0.36-1.98 / 0.5661 / 0.77
0.31-1.91
Controls / 33 / 0.58 / 0.42 / 0.00
Germany combined / Cases / 255 / 0.56 / 0.41 / 0.03 / 0.7853 / 0.96
0.71-1.292 / 0.6147 / 0.93
0.69-1.25
Controls / 726 / 0.56 / 0.39 / 0.05
East Germany / Cases / 49 / 0.59 / 0.37 / 0.04 / 0.8013 / 1.09
0.54-2.21 / 0.6883 / 1.17
0.55-2.48
Controls / 93 / 0.57 / 0.40 / 0.03
West Germany combined / Cases / 206 / 0.55 / 0.42 / 0.03 / 0.6760 / 0.93
0.67-1.293 / 0.5250 / 0.90
0.64-1.25
Controls / 633 / 0.55 / 0.39 / 0.05
W. Germany - ongoing / Cases / 117 / 0.54 / 0.43 / 0.03 / 0.1739 / 0.72
0.44-1.164 / 0.1218 / 0.66
0.39-1.12
Controls / 193 / 0.62 / 0.33 / 0.05
W. Germany - industrial / Cases / 89 / 0.57 / 0.40 / 0.02 / 0.4075 / 1.21
0.77-1.92 / 0.1272 / 1.46
0.90-2.39
Controlsa / 440 / 0.53 / 0.42 / 0.05
DO-hospitala / Cases / 16 / 0.50 / 0.38 / 0.13 / 0.8441 / 0.90
0.33-2.45 / 0.9347 / 0.96
0.35-2.64
DO-occupationala / Cases / 73 / 0.59 / 0.41 / 0.00 / 0.3097 / 1.30
0.78-2.14 / 0.0847 / 1.61
0.94-2.75
Non Caucasian study groups
Pakistan / Cases / 37 / 0.51 / 0.41 / 0.08 / 0.1506 / 3.69
0.58-39.99 / 0.4293 / 2.11
0.33-13.34
Controls / 9 / 0.22 / 0.56 / 0.22
Venezuela / Cases / 13 / 0.38 / 0.46 / 0.15 / 0.3805 / 0.59
0.18-1.92 / 0.2425 / 0.42
0.10-1.80
Controls / 117 / 0.51 / 0.41 / 0.08
All combined / Cases / 365 / 0.55 / 0.41 / 0.05 / 0.7751 / 0.96
0.74-1.265 / 0.5346 / 0.92
0.70-1.20
Controls / 885 / 0.55 / 0.40 / 0.05
OR odds ratio, 95% CI 95% confidence interval
a Controls were the Dortmund control group
Unadjusted P values ORs and 95% CIs were estimated using the asymptotic chi-squared test and confidence limits in case of single study groups, the exact P value and 95% CI were used in case of Pakistan, for combined study groups the method of Mantel-Haenszel was used. Adjusted P values, ORs and 95% CIs were estimated by logistic regression models adjusting for age, gender, smoking habits and study groups.
1 Breslow-Day test P= 0.4171
2 Breslow-Day test P= 0.2515
3 Breslow-Day test P= 0.1072
4 Breslow-Day test P= 0.7014
5 Breslow-Day test P= 0.2920

C. Former smokers: Distribution of the 2-SNP genotype, unadjusted and adjusted P values, ORs and 95% CIs.

Study groups / Status / N / Genotypes / Unadjusted / Adjusted
slow / intermediate / rapid / P value / OR
95% CI / P value / OR
95% CI
Caucasians combined / Cases / 725 / 0.61 / 0.35 / 0.04 / 0.4358 / 0.91
0.73-1.151 / 0.7399 / 0.96
0.76-1.21
Controls / 658 / 0.62 / 0.33 / 0.05
Hungary / Cases / 82 / 0.65 / 0.32 / 0.04 / 0.5727 / 0.75
0.28-2.02 / 0.5463 / 0.73
0.26-2.03
Controls / 24 / 0.71 / 0.29 / 0.00
Germany combined / Cases / 643 / 0.60 / 0.36 / 0.04 / 0.5058 / 0.92
0.73-1.172 / 0.9166 / 0.99
0.78-1.26
Controls / 634 / 0.62 / 0.34 / 0.05
East Germany / Cases / 103 / 0.59 / 0.37 / 0.04 / 0.7370 / 1.10
0.62-1.96 / 0.8394 / 1.06
0.59-1.90
Controls / 88 / 0.57 / 0.40 / 0.03
West Germany combined / Cases / 540 / 0.60 / 0.35 / 0.04 / 0.3811 / 0.89
0.69-1.153 / 0.7744 / 0.96
0.74-1.25
Controls / 546 / 0.62 / 0.33 / 0.05
W. Germany - ongoing / Cases / 344 / 0.63 / 0.33 / 0.04 / 0.6742 / 1.08
0.75-1.564 / 0.4090 / 1.18
0.80-1.74
Controls / 192 / 0.60 / 0.35 / 0.05
W. Germany - industrial / Cases / 196 / 0.56 / 0.39 / 0.06 / 0.0782 / 0.73
0.51-1.04 / 0.1343 / 0.74
0.49-1.10
Controlsa / 354 / 0.63 / 0.31 / 0.05
DO-hospitala / Cases / 23 / 0.57 / 0.43 / 0.00 / 0.5159 / 0.75
0.32-1.77 / 0.5544 / 0.77
0.33-1.826
DO-occupationala / Cases / 173 / 0.55 / 0.38 / 0.06 / 0.0857 / 0.72
0.50-1.05 / 0.1509 / 0.73
0.48-1.12
Non Caucasian study groups
Pakistan / Cases / 0 / - / - / - / - / - / - / -
Controls / 0 / - / - / -
Venezuela / Cases / 42 / 0.64 / 0.36 / 0.00 / 0.0591 / 2.44
0.96-6.22 / 0.0903 / 2.89
0.85-9.89
Controls / 33 / 0.42 / 0.48 / 0.09
All combined / Cases / 767 / 0.61 / 0.35 / 0.04 / 0.7613 / 0.97
0.78-1.205 / 0.8351 / 1.02
0.82-1.29
Controls / 691 / 0.61 / 0.34 / 0.05
OR odds ratio, 95% CI 95% confidence interval
a Controls were the Dortmund control group
Unadjusted P values ORs and 95% CIs were estimated using the asymptotic chi-squared test and confidence limits in case of single study groups, for combined study groups the method of Mantel-Haenszel was used. Adjusted P values, ORs and 95% CIs were estimated by logistic regression models adjusting for age, gender, smoking habits and study groups.
1 Breslow-Day test P= 0.3595
2 Breslow-Day test P= 0.2166
3 Breslow-Day test P= 0.1054
4 Breslow-Day test P= 0.6709
5 Breslow-Day test P= 0.1209
6 not adjusted for gender due to the lack of female cases in the subgroup of former smokers

D. Current smokers: Distribution of the 2-SNP genotype, unadjusted and adjusted P values, ORs and 95% CIs.

Study groups / Status / N / Genotypes / Unadjusted / Adjusted
slow / intermediate / rapid / P value / OR
95% CI / P value / OR
95% CI
Caucasians combined / Cases / 422 / 0.55 / 0.23 / 0.04 / 0.7839 / 1.05
0.76-1.441 / 0.7996 / 1.04
0.75-1.45
Controls / 309 / 0.62 / 0.34 / 0.04
Hungary / Cases / 83 / 0.60 / 0.31 / 0.08 / 0.3267 / 1.73
0.57-5.23 / 0.2112 / 2.23
0.63-7.85
Controls / 15 / 0.47 / 0.40 / 0.13
Germany combined / Cases / 339 / 0.53 / 0.21 / 0.03 / 0.9953 / 1.00
0.72-1.392 / 0.9431 / 0.99
0.70-1.40
Controls / 294 / 0.63 / 0.34 / 0.04
East Germany / Cases / 62 / 0.65 / 0.26 / 0.10 / 0.3511 / 1.64
0.58-4.63 / 0.5958 / 1.35
0.45-4.06
Controls / 19 / 0.53 / 0.42 / 0.05
West Germany combined / Cases / 277 / 0.51 / 0.19 / 0.01 / 0.7529 / 0.95
0.67-1.343 / 0.8122 / 0.96
0.66-1.38
Controls / 275 / 0.63 / 0.33 / 0.04
W. Germany - ongoing / Cases / 142 / 0.67 / 0.31 / 0.02 / 0.4131 / 0.79
0.45-1.394 / 0.4563 / 0.77
0.40-1.52
Controls / 116 / 0.74 / 0.22 / 0.04
W. Germany - industrial / Cases / 135 / 0.33 / 0.07 / 0.00 / 0.4992 / 1.17
0.74-1.87 / 0.7098 / 1.10
0.67-1.81
Controlsa / 159 / 0.55 / 0.42 / 0.03
DO-hospitala / Cases / 48 / 0.60 / 0.31 / 0.08 / 0.5345 / 1.23
0.64-2.38 / 0.6100 / 1.20
0.60-2.38
DO-occupationala / Cases / 87 / 0.59 / 0.34 / 0.07 / 0.6204 / 1.14
0.67-1.94 / 0.8772 / 1.05
0.59-1.86
Non Caucasian study groups
Pakistan / Cases / 69 / 0.75 / 0.19 / 0.06 / 0.1563 / 1.76
0.80-3.87 / 0.1483 / 1.80
0.81-4.026
Controls / 52 / 0.63 / 0.33 / 0.04
Venezuela / Cases / 57 / 0.44 / 0.49 / 0.07 / 0.2716 / 0.63
0.27-1.45 / 0.6923 / 0.80
0.27-2.39
Controls / 36 / 0.56 / 0.42 / 0.03
All combined / Cases / 548 / 0.56 / 0.25 / 0.04 / 0.7085 / 1.05
0.80-1.395 / 0.6152 / 1.08
0.81-1.44
Controls / 397 / 0.61 / 0.35 / 0.04
OR odds ratio, 95% CI 95% confidence interval
a Controls were the Dortmund control group
Unadjusted P values ORs and 95% CIs were estimated using the asymptotic chi-squared test and confidence limits in case of single study groups, for combined study groups the method of Mantel-Haenszel was used. Adjusted P values, ORs and 95% CIs were estimated by logistic regression models adjusting for age, gender, smoking habits and study groups.
1 Breslow-Day test P= 0.2841
2 Breslow-Day test P= 0.2319
3 Breslow-Day test P= 0.1618
4 Breslow-Day test P= 0.2195
5 Breslow-Day test P= 0.2248
6 not adjusted for gender due to the lack of female cases in the subgroup of current smokers

Supplementary Table S6. C282T confers higher UBC risks that the NAT2 genotype. Distribution of the C282T genotype, unadjusted and adjusted P values, ORs and 95% CIs stratified and not stratified for smoking habits are given (Supplement to Table 4).