Table E1. Baseline characteristics for the statin cohort subgroups.

Category / Statin Continued on Admission / Statin Discontinued on Admission / p-value
Total number of patients / 35 / 10 / n/a
Age* / 71 (63 - 78) / 62 (54-78) / 0.332
Male# / 21 (60) / 5 (50) / 0.720
Admission ICU
Surgical# / 7 (20) / 4 (40) / 0.356
Medical# / 26 (74) / 6 (60) / --
Mixed# / 2 (6) / 0 (0) / --
APACHE III* / 70 (61 - 92) / 99 (89 - 114) / 0.014
Predicted hospital mortality* / 0.27 (0.16 - 0.50) / 0.59 (0.40 - 0.79) / 0.013
SOFA (Day 1)* / 7 (5 - 8) / 10 (7 - 12) / 0.032
PaO2/FiO2 (Day 1)* / 147 (101 - 204) / 102 (59 - 150) / 0.039
Pulmonary ALI/ARDS# / 25 (71) / 6 (60) / 0.700
Aspiration# / 9 (26) / 0 (0) / 0.173
Sepsis# / 12 (34) / 4 (40) / 0.726
Any Blood Component Transfused# / 7 (20) / 3 (30) / 0.668
Postoperative# / 7 (20) / 4 (40) / 0.228
Comorbidities (preadmission diagnosis)
Hyperlipidemia# / 24 (69) / 4 (40) / 0.143
CAD# / 25 (71) / 4 (40) / 0.131
CHF# / 4 (12) / 3 (30) / 0.322
PVD# / 9 (26) / 4 (40) / 0.441
Chronic Obstructive Pulmonary Disease# / 9 (26) / 1 (10) / 0.410
Chronic Kidney Disease# / 3 (9) / 2 (20) / 0.317
Liver disease# / 1 (3) / 1 (10) / 0.407
Diabetes Mellitus# / 14 (41) / 2 (20) / 0.283
Metastatic Malignancy# / 3 (9) / 1 (10) / 1.000
Chronic Immunosuppression# / 2 (6) / 0 (0) / 1.000
DNR status on ICU admission# / 9 (26) / 2 (20) / 1.000
Ventilatory Parameters
Tidal Volume (ml/kg PBW)(n=23)* / 7 (6 - 8) / 7 (6 - 8) / 0.699
Peak airway pressure (cm H2O)(n=33)* / 25 (18 - 30) / 33 (31 - 35) / 0.002
Plateau airway pressure (cm H2O)(n=18)* / 23 (21 - 26) / 28 (24 - 30) / 0.073
PEEP (cm H2O)(n=41)* / 6 (5 - 8) / 12 (5 - 15) / 0.063

ICU = Intensive Care Unit, APACHE = Acute Physiology and Chronic Health Evaluation survey, SOFA = Sequential Organ Failure Assessment, PaO2 = Partial Pressure of Arterial Oxygen, FiO2 = Fraction of Inspired Oxygen, ALI = acute lung injury, ARDS = acute respiratory distress syndrome, CAD = coronary artery disease, CHF = congestive heart failure, PVD = peripheral vascular disease, DNR = Do Not Resuscitate, PBW = predicted body weight, PEEP = positive end-expiratory pressure.

* = median (IQ range), # = No. (%).