Table 2. Effect of Gonadal Hormones on Disease Progression in Jck Mice

Table 2. Effect of gonadal hormones on disease progression in jck mice

No / Surgery / Treatment / Genotype / N / K/BW ratio (%) / Cyst % / BUN (mg/dL)
1 / sham / Vehicle / jck/jck / 9 / 6.29 / ± / 1.6 / 28.58 / ± / 5.58 / 45.00 / ± / 14.2
2 / castration / Vehicle / jck/jck / 15 / 5.08 / ± / 1 / * / 22.90 / ± / 4.57 / * / 33.13 / ± / 6.81 / *
3 / castration / DHT / jck/jck / 8 / 7.22 / ± / 0.6 / # / 28.24 / ± / 3.71 / # / 64.88 / ± / 15.3 / *#
4 / sham / Vehicle / wt / 6 / 1.62 / ± / 0.1 / N/A / 14.83 / ± / 1.83
5 / castration / Vehicle / wt / 7 / 1.51 / ± / 0.2 / N/A / 16.86 / ± / 3.27
6 / castration / DHT / wt / 4 / 1.78 / ± / 0.2 / N/A / 18.00 / ± / 1
7 / sham / None / jck/jck / 5 / 4.45 / ± / 0.4 / 17.52 / ± / 2.8 / 28.60 / ± / 8.08
8 / Ovariectomy / None / jck/jck / 8 / 6.25 / ± / 1.3 / * / 26.28 / ± / 3.19 / * / 50.14 / ± / 13.6 / *
9 / sham / DHT / jck/jck / 6 / 7.41 / ± / 1.2 / * / 26.53 / ± / 5.01 / * / 49.17 / ± / 14.2
10 / Ovariectomy / DHT / jck/jck / 6 / 6.89 / ± / 1.5 / * / 24.21 / ± / 4.17 / * / 50.00 / ± / 7.33 / *
11 / sham / Vehicle / wt / 7 / 1.36 / ± / 0.1 / N/A / 18.00 / ± / 1.71
12 / sham / DHT / wt / 7 / 1.49 / ± / 0.1 / * / N/A / 21.00 / ± / 3.14
13 / Ovariectomy / DHT / wt / 7 / 2.02 / ± / 0.1 / *# / N/A / 20.71 / ± / 3.02
* indicates P<0.05 vs. sham operated
# indicates P<0.05 vs. castrated/ovariectomized
N/A not applicable