1

Supplementary data Bao&Friedrich 2007

Gblocks 0.91b Results

Processed file: pasted_alignment

Number of sequences: 61

Alignment assumed to be: Protein

New number of positions: 135 (selected positions are underlined in #)

10 20 30 40 50 60

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Dmel_boss VATGLTAAILGLIATLAILVFIVVRISLGDVFEGNPTTSILLLLSLILVFCSFVPYSIEY

Dere_boss VATGLTAAILGLIATLAILVFIVVRISLGDVFEGNPATSILLLLSLILVFCSFVPFSIEY

Dore_boss VATGLTAAILGLIATLAILVFIVVRISLGDVFEGNPATSILLLLSLILVFCSFVPFSIEY

Dpse_boss VATGLTAAILGLIATLAILVFIVVRISVGDVFEGNPVTSILLLLSLILVFCSFVPFSIEY

Dvir_boss VATGLTAAILGLIATLAILVFIVVRISLGDVFEGNPVTSILLLLSLILVFCSFVPFSMEY

Aaeg_boss VAAGLTIASLGILFCLAILIFLIVRVCMDDVLEGNPLSSILLLISLIFQFASFLPFSLEY

Agam_boss VAAGLTVSSLGILLCAAILIFLIVRVCMDDILEGHPLGSILLLISLILQFAAFIPFSLEY

Tcas_boss IFAFLSLSLLGVLFCIAILVFLLVSVCRKNVLEGNPVLTILLLFTVMVMFCSIVPLSLE-

Amel_boss IPIFLTVVVCGTFACGAIAVFIIYRFMVEDVLDGNPMLTIVLILANVFTLQTVLPFCIN-

Mmul_GPRC5B VVEAVAGAGALITLLLMLILLVRLPFIKEKEKKSPVGLHFLFLLGTLGLFGLTFAFIIQE

Mfas_GPRC5B VVEAVAGAGALITLLLMLILLVRLPFIKEKEKKSPVGLHFLFLLGTLGLFGLTFAFIIQE

Hsap_GPRC5B VVEAVAGAGALITLLLMLILLVRLPFIKEKEKKSPVGLHFLFLLGTLGLFGLTFAFIIQE

Ptro_GPRC5B VVEAVAGAGALITLLLMLILLVRLPFIKEKEKKSPVGLHFLFLLGTLGLFGLTFAFIIQE

Ppyg_GPRC5B VVEAVAGAGALITLLLMLILLVRLPFIKEKEKKSPVGLHLLFLLGTLGLFGLTFAFIIQE

Btau_GPRC5B VVEAVAGAGALITLLLMLILLVRLPFIKDKEKKDPVGLHFLFLLGTLGLFGLTFAFIIRE

Cfam_GPRC5B VVEAVAGAGALITLLLMLILLVRLPFIKDKEKKDPVGLHFLFLLGTLGLFGLTFAFIIRE

Mmus_GPRC5B VVEAVAGAGALITLLLMLILLVRLPFIKDKERKRPVCLHFLFLLGTLGLFGLTFAFIIQM

Rnor_GPRC5B VVEAVAGAGALITLLLMLILLVRLPFIKDKERRRPVCLHFLFLLGTLGLFGLTFAFIIRM

Ggal_GPRC5B VVEAVAGAGVLTTLLLMLILLVRLPFIKEKEKKSPLGMHFLFLFGTLGLFGLTFAFIIQE

Tnig_GPRC5B AVESVAAGGVLIAILLALVLLCRLRHVSEAEKRSGVGPVLLLLLGTLGLFGLSFAYLIEQ

Mmus_GPRC5C VSEAVAGAGIITTFVLTIILVASLPFVQDTKKRSLLGTQVFFLLGTLGLFCLVFACVVKP

Rnor_GPRC5C VLEAVAGAGIITTFVLTIILVASLPFVQDTKKRSLLGTQVFFLLGTLGLFCLVFACVVKP

Btau_GPRC5C ILEAVAGAGVVTTFVLTIILVASLPFVQDTKKRSLLGTQVFFLLGTLGLFCLVFACVVKP

Xtro_GPRC5C_1 VLQAITSAGIVSTFILTIVLVASTPFIQNKKKKSLLGTQVFFLLGTLGIFGLVFDMVVKK

Ggal_GPRC5C VLEAAASLGAVTSFVLTIVLVASLPFVQDPQKKSLVATQAFFLLGTFGLFCLTFDFIVGP

Drer_GPRC5C VVEAFAAAGLVASLILLIVLLASLPFINSKNWRSSFGLHTVFLIFTFGLFALTFAFIVGK

Xtro_GPRC5C_2 ILEALAGLGIVCALVLAVIFLALAPSVIRDERKGSLAINFMFLFGVFGLFSLVFAFIIAP

Rnor_GPRC5A ALETLAAVGAVATVALMFALVFLICKVQDSSKRKMLPTQFLFLLGVLGVFGLTFAFIIKL

Mmus_GPRC5A ALETLAAVGAVATVACMFALVFLICKVQDSNKRKMLPAQFLFLLGVLGVFGLTFAFIIKL

Hsap_GPRC5A VLETVATAGVVTSVAFMLTLPILVCKVQDSNRRKMLPTQFLFLLGVLGIFGLTFAFIIGL

Ptro_GPRC5A VLETVATAGVVTSVAFMLALPILVCKVQDSNRRKMLPTQFLFLLGVLGIFGLTFAFIIGL

Mmul_GPRC5A VLETLAAAGVVTSVAFMLALPLLVCKVQDSNRRKMLPTQFLFLLGVLGIFGLTFAFIIRL

Cfam_CPRC5A VLEAVAAVGAVTSMAFMFALLILICKVQDSNRRKVLPTQFLFLLGVLGIFGLTFAFIIQL

Btau_GPRC5A VLEALAGVGAVASVAFMITLLVLICKVQDSNKRKLLPTQFLFLLGVLGIFGLTFAFIITL

Ggal_GPRC5D VLESLAAAGVLVTVFLICSLFFLICKVQDNSKRHMISIYFFFLLGILGIFGITFAFIIRS

Mmus_GPRC5D VLESLAVIGIVVTILLLLAFLFLMRKVQDCSQWNVLPTQFLFLLAVLGLFGLTFAFIIQL

Rnor_GPRC5D VLESLAVIGIVVTILLLLAFLFLMRRVQDCSQWNVLPTQFLFLLAVLGLFALTFAFIIQL

Hsap_GPRC5D ILESLAILGIVVTILLLLAFLFLMRKIQDCSQWNVLPTQLLFLLSVLGLFGLAFAFIIEL

Ptro_GPRC5D ILESLAILGIVVTILLLLAFLFLMRKIQDCSQWNVLPTQLLFLLSVLGLFGLAFAFIIEL

Btau_GPRC5D VLESLAAVGIVVTVMLLLAFLFLMRRVQDCAHWNVLPTQFLFLLGVLGLFGLAFAFIIQL

Xlae_GPRC5D VLETLAAAGIVFSIILILALLIMMPRISDPAKRAVSPVQLIFLIGTFGIFGLTFAFIVEL

Aaeg_CG32447l VVPVLVLACLSMIMMAAFEIFVLCKAWRTSPSRRHLFLGQMLLLGLFSCSGLAAVLTINP

Agam_CG32447l VVPVLVLASLSMLMMAAFEVFVLCKAWRTSPSRRHLFLGQMLLLGLFACSGLAAVLTVNP

Tcas_CG32447l VIPVLTLSAVTMALIIGFEVFVLCKAWRTTPSRRHLFLGQMLLLGLFTCAGLGAVYAAAP

Dmel_CG32447 VVPVLVLATLTMLMMAAFEIFVLFKAWRTSPSRRHLFLGQMLLLGLFACASLGAIITAQP

Amel_CG32447l ALPLAALSAATMLLMAGFEVFVLLKARVTAPNRRHLFLGQALLLGLFLLAGLSAAASLSQ

Cbri_CAE58455 NYVLLALITVLVVVAVAVLVLVLVKLYLR-VVKGNQSLGISLLIGIIILYSTAFFFVFDP

Cele_NP_501400 NYVLLALITVLVVVAIAVLVLVLVKLYLR-VVKGNQSLGISLLIGIIILYSTAFFFVFDP

Rnor_V2R2 GYALVILSIFGALVALAVTVVYVIHRHTPLAKANDQELSFLIQMSLVITVLSSILFIGKP

Mmus_V2R2 GFTLVIISIFGALVVLAVTVVYVIHRHTPLVKANDRELSFLIQMSLGITVLSSMLFIGKP

Mmus_CasR1 GFTLVILSIFGALVLLAVTVVYVIHRHTPLVKANDRELSFLIQMSLVITVLSSLLFIGKP

Trub_BAA26126 GIALLVVSLIGSFLTCAVALVFFYHRTSPIVRANNSDLSFLLLFSLTLCFLCSLTFISPP

Spur_mGluR5 AIAAMCFSCVGILLTVFVTVTFIRHNDTALVKASSRENSYILLAGIYLCFLVTFPFIAKP

Rnor_mGluR1 SIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKP

Rnor_mGluR5 PIAAVVFACLGLLATLFVTVIFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKP

Rnor_mGluR2 AVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKP

Hsap_mGluR2 AVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKP

Rnor_mGluR3 AIGPVTIACLGFLCTCIVITVFIKHNNTPLVKASGRELCYILLFGVSLSYCMTFFFIAKP

Dmel_Glu ALIPMAIAIFGIALTSIVIVLFAKNHDTPLVRASGRELSYTLLFGILVCYCNTFALIAKP

Rnor_mGluR6 AALPLLLAVLGIMATTTIMATFMRHNDTPIVRASGRELSYVLLTGIFLIYAITFLMVAEP

Cele_mgl1 SLVPTILAVFGIIATLFVIVVYVIYNETPVVKASGRELSYILLISMIMCYCMTFVLLSKP

################ ##################

70 80 90 100 110 120

======+======+======+======+======+======+

Dmel_boss VGEQRNSH-VTFEDAQTLNTLCAVRVFIMTLVYCFVFSLLLCRAVMLASIGSEGG-FLS-

Dere_boss VGEQRNSH-VTFEDAQTLNTLCAVRVFIMTLVYCFVFSLLLCRAVMLASIGSEGG-FLS-

Dore_boss VGEQRNSH-VTFEDAQTLNTLCAVRVFIMTLVYCFVFSLLLCRAVMLASIGSEGG-FLS-

Dpse_boss VGEQRNSH-VTFEDAQTLNTLCAVRVFIMSLVYCFVFSLLLCRALMLASTGSEGG-FLS-

Dvir_boss VGEQRNSH-VTFEDVHTLNTLCGVRVFIMTLVYCFVFSLLLCRAVMLASIGSEGG-FLS-

Aaeg_boss TGYMPDLL-HKADTIYTWNTLCTVKIFLLSVCYCTTFSLLLCRAIMLASIGSEGG-FLS-

Agam_boss TGYTTDLAGHRTDTMLTWNAHCTVKIFLVSMCYCMTFSLLLCRAIMLASIGSEGG-FLS-

Tcas_boss ------GNRWAKRSICMARALSITLSFAAAFSLMLSRSIVLATASKEIG-FMS-

Amel_boss ------DDYLGGERLNSRKILATTLAFGLDFSLMLTRAFFLVFS-KGGV-FTA-

Mmul_GPRC5B D------ETICSVRRFLWGVLFALCFSCLLSQAWRVRRLVRHGT-----

Mfas_GPRC5B D------ETICSVRRFLWGVLFALCFSCLLSQAWRVRRLVRHGT-----

Hsap_GPRC5B D------ETICSVRRFLWGVLFALCFSCLLSQAWRVRRLVRHGT-----

Ptro_GPRC5B D------ETICSVRRFLWGVLFALCFSCLLSQAWRVRRLVRHGT-----

Ppyg_GPRC5B D------ETICSVRRFLWGVLFALCFSCLLSQAWRVRRLVRRGT-----

Btau_GPRC5B D------ETICSVRRFLWGVLFALCFSCLLSQAWRVRRLVRHGK-----

Cfam_GPRC5B D------ETICSVRRFLWGVLFALCFSCLLSQAWRVRRLVRHGK-----

Mmus_GPRC5B D------ETICSIRRFLWGVLFALCFSCLLSQAWRVRRLVRQGT-----

Rnor_GPRC5B D------ETICSIRRFLWGVLFALCFSCLLSQAWRVRRLVRQGT-----

Ggal_GPRC5B D------EMVCSTRRFLWGVIFALCFSCLLAQAWRLRRLVRHGK-----

Tnig_GPRC5B D------ESLCLLRRALWGLLFAVCFSCLLVQGVRLRRLGRERR-----

Mmus_GPRC5C D------FSTCASRRFLFGVLFAICFSCLVAHVLSLNFLTRKNH-----

Rnor_GPRC5C D------FSTCASRRFLFGVLFAICFSCLIAHTLSLNFLARKNH-----

Btau_GPRC5C S------FSTCASRRFLFGVLFAICFSCLVAHVLALHFLVRKNH-----

Xtro_GPRC5C_1 D------FATCASRRFLFGLLFAICFACLWVHGVSLNYLIRRNT-----

Ggal_GPRC5C D------FSTCTSRRFLFGVLFALCFSCLLAHAVALNFLARRNR-----

Drer_GPRC5C N------FATCASRRFLFGVLFAGCFSCLLMQAVRLNILARRNS-----

Xtro_GPRC5C_2 N------AAVCEVRRFLFGVLFALCFACLVAHSVRLNYLVLHNR-----

Rnor_GPRC5A D------RATGPTRFFLFGVLFALCFSCLLAHAFNLIKLVRGRK-----

Mmus_GPRC5A D------GATGPTRFFLFGVLFAICFSCLLAHAFNLIKLVRGRK-----

Hsap_GPRC5A D------GSTGPTRFFLFGILFSICFSCLLAHAVSLTKLVRGRK-----

Ptro_GPRC5A D------GSTGPTRFFLFGILFSICFSCLLAHAVSLTQLVRGRK-----

Mmul_GPRC5A D------GSTGPTRFFLFGILFSICFSCLLAHALNLTQLVRGRK-----

Cfam_CPRC5A D------GSTGPTRFFLFGVLFSLCFSCLLAHAFNLTKLVHGRK-----

Btau_GPRC5A D------GGTGPTRFFLFGVLFALCFSCLLVHAFNLTKLVRGRQ-----

Ggal_GPRC5D N------ERIRPTRFFLFGVLFALCFSCLLIHASNLIRLVRGKK-----

Mmus_GPRC5D N------HQTAPVRYFLFGVLFAICFSCLLAHASNLVKLVRGRV-----

Rnor_GPRC5D N------QQTAPVRYFLFGVLFAICFSCLLAHASNLVKLVRGRV-----

Hsap_GPRC5D N------QQTAPVRYFLFGVLFALCFSCLLAHASNLVKLVRGCV-----

Ptro_GPRC5D N------QQTAPVRYFLFGVLFALCFSCLLAHASNLVKLVRGCV-----

Btau_GPRC5D N------QQTAPIRYFLFGVLFALCFSCLLAHASNLVKLVRGRA-----

Xlae_GPRC5D T------EQTCPTRFFLFGVLFAICFSCLLAHASKLVRLVRGGH-----

Aaeg_CG32447l T------ILSCATMRFGAGVAFALVFASLLVKCVFLISLNGG-----V-

Agam_CG32447l T------VLSCATMRFGAGVAFALVFASLLVKCVFLISLNGG-----V-

Tcas_CG32447l T------QLTCAVVRFGTGVAYAVVFASLLVKCVFLISLNGG-----V-

Dmel_CG32447 S------LISCGAIRFGVGVAYALVFAALLVKCVFLISLNGG-----V-

Amel_CG32447l N------PLSCAAFRL-VGLPAALVFAALLVKCVFLLSLNSG-----V-

Cbri_CAE58455 T------DSVCRLRVILHGLGYTICFGVMIAKATQLRNAETLGFGTSI-

Cele_NP_501400 T------DSVCRLRVILHGLGYTICFGVMIAKATQLRNAETLGFGTAI-

Rnor_V2R2 Y------NWTCMARQVTLALGFCLCLSSILGKTISLFFAYRISKSKTR-

Mmus_V2R2 C------NWSCKTRQVTLALGFCLCLSSILGKTVSLFFAYRISISKTR-

Mmus_CasR1 C------NWSCMARQITLALGFCLCLSSILGKTISLFFAYRISVSKTR-

Trub_BAA26126 S------QWSCMLRHTAFGITFVLCISCILGKTIVVLMAFRATLPGSD-

Spur_mGluR5 S------TEVCYFRRIGLGLSFCICYAGLVVRTNRMARILAGSKKKILT

Rnor_mGluR1 T------TTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKICT

Rnor_mGluR5 K------QIYCYLQRIGIGLSPAMSYSALVTKTNRIARILAGSKKKICT

Rnor_mGluR2 S------TAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQ-

Hsap_mGluR2 S------TAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQ-

Rnor_mGluR3 S------PVICALRRLGLGTSFAICYSALLTKTNCIARIFDGVKNGAQ-

Dmel_Glu T------IGSCVLQRFGIGVGFSIIYSALLTKTNRISRIFHSASKSAQ-

Rnor_mGluR6 C------AAICAARRLLLGLGTTLSYSALLTKTNRIYRIFEQGKRSVT-

Cele_mgl1 S------AIVCAIKRTGIGFAFSCLYSAMFVKTNRIFRIFS--TRSAQ-

###############################

130 140 150 160 170 180

======+======+======+======+======+======+

Dmel_boss ----HVNGYIQAVICAFSVVAQVGMSVQLLVVMHVASETVSCEN------

Dere_boss ----HVNGYIQAVICAFSVVAQVGMSVQLLVVMHVASETVSCEN------

Dore_boss ----HVNGYIQAVICAFSVVAQVGMSVQLLVVMHVASETVSCEN------

Dpse_boss ----HVNGYIQAVICAFSVFVQVGMSVQLLVVMHVASEAVSCEN------

Dvir_boss ----HVNGYIQAIICVLSVFVQVGMSVQLLVVMHLASESVSCEN------

Aaeg_boss ----HVNGYLQSVICIFSTLVQLGLSTQLVIVLHASSHNISCNE------

Agam_boss ----HINGYIQSVICGFSTLVQLGLSTQLVIVLHANAHSISCGE------

Tcas_boss ----HVAGPVQSFLCLFIFGVQAALSLQVFN------HCED------

Amel_boss ----HINGHLQGLMVFFMFFVQVAISVMFFALNNHDSAVIMRSL------

Mmul_GPRC5B ----GPAGWQLVGLALCLMLVQVIIAVEWLVLTVLRD------

Mfas_GPRC5B ----GPAGWQLVGLALCLMLVQVIIAVEWLVLTVLRD------

Hsap_GPRC5B ----GPAGWQLVGLALCLMLVQVIIAVEWLVLTVLRD------

Ptro_GPRC5B ----GPAGWQLVGLALCLMLVQVIIAVEWLVLTVLRD------

Ppyg_GPRC5B ----GPAGWQLVGLALCLMLVQVIIAVEWLVLTVLRD------

Btau_GPRC5B ----SPSGWQLVGMALCLMLVQVIIAIEWLVLTVLRD------

Cfam_GPRC5B ----SPSGWQLVGVALCLMLVQVIIAIEWLVLTVLRD------

Mmus_GPRC5B ----SPASWQLVSLALCLMLVQVIIATEWLVLTVLRD------

Rnor_GPRC5B ----SPASWQLVSLALCLMLVQVIIATEWLVLTVLRD------

Ggal_GPRC5B ----SPSGWHLAGVAICLMLVQVIIATEWLILTVVRD------

Tnig_GPRC5B ----GPGGCALTGLALGLSAVQGIIAAEWLLLTVLRE------

Mmus_GPRC5C ----GPRGWVIFTVALLLTLVEVIINTEWLIITLVRGGG-QVSPL------

Rnor_GPRC5C ----GPRGWVIFTVALLLTLVEVIINTEWLIITLVRGGG-QVSTP------

Btau_GPRC5C ----GPRGWVIFLVALLLSLVEVIINTEWLIITLVRGAGTEGDAL------

Xtro_GPRC5C_1 ----QPSGWWIFGLAVCLSLVEAIINTEWLIITIVKTAN------

Ggal_GPRC5C ----GPRGWVTLAVALLLALVEVIINAEWLIITVARQER------

Drer_GPRC5C ----GPRGWVWCLGALGLWLVEVVINTEWLIITIVRYPVN------

Xtro_GPRC5C_2 ----GPGGGLIFLLAIGLFLVEAVINAEWLLITNVRHNL------

Rnor_GPRC5A ----PLSWLVILSLAVGFSLVQDVIAIEFLVLTMNRT------

Mmus_GPRC5A ----PLSWLVILSLAVGFSLVQDVIAIEYLVLTMNRT------

Hsap_GPRC5A ----PLSLLVILGLAVGFSLVQDVIAIEYIVLTMNRT------

Ptro_GPRC5A ----PLSLLVILGLAVGFSLVQDVIAIEYIVLTMNRT------

Mmul_GPRC5A ----PLSLLVILGLAVGFSLVQDVIAIEYIVLTMNRT------

Cfam_CPRC5A ----PLSLMVMLSLAVGLSLVQDIIAAEYIILTMNRT------

Btau_GPRC5A ----PLSMLVMLGLALGFSLVQDIIAIEYVVLTMNRT------

Ggal_GPRC5D ----PFSWPVLLLLIVSFALVQVVINIEYLVTMLVK------

Mmus_GPRC5D ----SFCWTTILFIAIGVSLLQTIIAIEYVTLIMTR------

Rnor_GPRC5D ----SFCWTTILFIAIGVSLLQTIIAIEYVTLIMTR------

Hsap_GPRC5D ----SFSWTTILCIAIGCSLLQIIIATEYVTLIMTR------

Ptro_GPRC5D ----SFSWTTILCIAIGCSLLQIIIAIEYVTLIMTR------

Btau_GPRC5D ----SFSWTTILCIAIGVSLLQTIIAIEYVTLIMTR------

Xlae_GPRC5D ----GICWWMMLLMALFLPLVQVVIAILYIVLGLVRSGT------

Aaeg_CG32447l ----YLPAPYQGLLLLFAVLIQVAVGAQWLLTSPPSVDQVPI------SGGTAVSSRYHL

Agam_CG32447l ----YLPAPYQGLLLLFAVLIQVAVGGQWLLTSPPGVDNVPVGAGLGGAGSTAVSSRYHL

Tcas_CG32447l ----YLPAPYQGLLLLFAILIQVAIGAQWLLTSPPLVDNVTF------EAVPSKHRL

Dmel_CG32447 ----YLPAPYQGLLLLFALLIQVAIGGQWLLTQPPEVYTTSV------PVMGSGFLS

Amel_CG32447l ----YLPAPYQALVLGFAVLVQVAIIGQWFYGEPPMVVQVQN------TGQN---

Cbri_CAE58455 ----HISFWNYWLLLFFIVGVQIALSISWFLEPFMSTIGVIDTN------

Cele_NP_501400 ----HISFWNYWLLLFFIVGVQIALSISWFLEPFMSTIGVIDTN------

Rnor_V2R2 -LISMH-PIFRKLIVLICVVGEIGVCTAYLMLKPPRMVKNIEPQN------

Mmus_V2R2 -LISMH-PIFRKLIVLICVVGEIGVCTAYLVLEPPSLFKNIEPQN------

Mmus_CasR1 -LISMH-PIFRKLIVLICVVGEIGICAAYLVLEPPRMFKNIEIQN------

Trub_BAA26126 -VMKWFGPGKQKAIITFSTLVQVVICTVWLVVAPPTPRQYMPRES------

Spur_mGluR5 RKPRFLGSTAQVVMTFGVISFEIGIIVATLVLERPAAVLDYPDLR------

Rnor_mGluR1 RKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPMPILSYPSIK------

Rnor_mGluR5 KKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPSIR------

Rnor_mGluR2 -RPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPE------

Hsap_mGluR2 -RPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPE------

Rnor_mGluR3 -RPKFISPSSQVFICLGLILVQIVMVSVWLILETPGTRRYTLPE------

Dmel_Glu -RLKYISPQSQVVITTSLIAIQVLITMIWMVVEPPGT-RFYYPD------

Rnor_mGluR6 -PPPFISPTSQLVITFGLTSLQVVGVIAWLGAQPPHSVIDYEEQRT------

Cele_mgl1 -RPRFISPISQVVMTAMLAGVQLIGSLIWLSVVPPGWRHHYPTR------

###########

190 200 210 220 230 240

======+======+======+======+======+======+

Dmel_boss ------IYYGRWLWGLLAYDFALL

Dere_boss ------IYYGRWLWGLLAYDFALL

Dore_boss ------IYYGRWLWGLLAYDFALL

Dpse_boss ------LYYGHWLWGLLSYDFVLL

Dvir_boss ------IYYGRWLWGLLAYDFLLL

Aaeg_boss ------IYYGNWFWATIAYDGILL

Agam_boss ------IYYGHWFWAVIAYDGVLL

Tcas_boss ------IFRGHSFIYILSYNIILL

Amel_boss ------VFIALLGYDIFLL

Mmul_GPRC5B ------TRPACAYEPMDFVMALIYDMVLL

Mfas_GPRC5B ------TRPACAYEPMDFVMALIYDMVLL

Hsap_GPRC5B ------TRPACAYEPMDFVMALIYDMVLL

Ptro_GPRC5B ------TRPACAYEPMDFVMALIYDMVLL

Ppyg_GPRC5B ------TRPACAYEPMDFVMALIYDMVLL

Btau_GPRC5B ------AKPACAYEPMDFAMALIYDMVLL

Cfam_GPRC5B ------AKPACAYEPMDFVMALIYDMVLL

Mmus_GPRC5B ------TKPACAYEPMDFVMALIYDMVLL

Rnor_GPRC5B ------TKPACAYEPMDFVMALIYDMVLL

Ggal_GPRC5B ------NKMACSYEPMDFAMALIYVMFLM

Tnig_GPRC5B ------GRAACQYLPLDFSLACTYVLVLL

Mmus_GPRC5C ------GNVSADSTMTSPCAIANMDFVMALIYVMLLL

Rnor_GPRC5C ------GNGSADWTVTSPCAIANMDFVMALIYVMLLL

Btau_GPRC5C ------GNGSAGWVAVSPCAIANADFVMALIYVMLLL

Xtro_GPRC5C_1 ------PPADPCLIGNADFVMALIYVMFLI

Ggal_GPRC5C ------GPVDPCELADADFVMALIYVMVLL

Drer_GPRC5C ------ITGTIAPVLAIPCNIGNQDFVMALIYVLNLL

Xtro_GPRC5C_2 ------SSTVSVGHPCQIDNQDFVTALVYVMFLI

Rnor_GPRC5A ------NVNVFSQLP-APRRNEDFVMLLIYVLFLM

Mmus_GPRC5A ------NVNVFSELP-APRRNEDFVMLLIYVLVLM

Hsap_GPRC5A ------NVNVFSELS-APRRNEDFVLLLTYVLFLM

Ptro_GPRC5A ------NVNVFSELS-APRRNEDFVLLLIYVLFLM

Mmul_GPRC5A ------NVNVFSELS-APRRNEDFVLLLIYVLFLM

Cfam_CPRC5A ------NVAIFSELS-APRRNEDFVMLLIYVLSLM

Btau_GPRC5A ------NVNIFSELS-PPRRNEDFVMLLIYVLFLM

Ggal_GPRC5D ------DRNTFLNMA-SEEANKDFVMLLIYVLFLM

Mmus_GPRC5D ------GLMFEHMT-PYQLNVDFVCLLIYVLFLM

Rnor_GPRC5D ------GLMFEHMT-PYQLNVDFVCLLIYVLFLM

Hsap_GPRC5D ------GMMFVNMT-PCQLNVDFVVLLVYVLFLM

Ptro_GPRC5D ------GMMFVNMT-PCELNVDFVVLLVYVLFLM

Btau_GPRC5D ------GGMFVHMT-PYQLNVDFVVLLVYVLFLM

Xlae_GPRC5D ------PCTVFNGATNYHQLNQDFVLILIYVFLLM

Aaeg_CG32447l LLTAGDLTHVN------PTIPLCHTTFSELLLSLIYVVFLI

Agam_CG32447l LLTAGDLAATAT------PTIPLCHTPFAELLLSLIYIVFLI

Tcas_CG32447l LVTAEDVAH------PTVLPLCRTAYVDILLSLIYVIFLI

Dmel_CG32447 TTVASQTNYSALFYPTSYTTLDGTPEIYTRIAAVSTVLIPLCKTQFSELLFSLIYIVFLI

Amel_CG32447l ------FTMSCCKTPLGQIVASLGYPGALL

Cbri_CAE58455 ------VQRMMCTMGKVEFVVSNFYVMILI

Cele_NP_501400 ------VQRMMCTMGKVEFVVSNFYVMILI

Rnor_V2R2 ------VKIIFECNEGSIEFLCSIFAFDVL

Mmus_V2R2 ------VKIIFECNEGSIEFLCSIFGFDVL

Mmus_CasR1 ------VKIIFECNEGSIEFLCSIFGFDVL

Trub_BAA26126 ------AIIILLCDEGSTIAFSLVLGYIGV

Spur_mGluR5 ------RVRLICNTTTFGFAAPLG-YDAL

Rnor_mGluR1 ------EVYLICNTSNLGVVAPVG-YNGL

Rnor_mGluR5 ------EVYLICNTTNLGVVTPLG-YNGL

Rnor_mGluR2 ------RREVVTLRCNHRDASMLGSLA-YNVL

Hsap_mGluR2 ------RREVVTLRCNHRDASMLGSLA-YNVL

Rnor_mGluR3 ------KRETVILKCNVKDSSMLISLT-YDVV

Dmel_Glu ------RRE-VILKCKIQDMSFLFSQL-YNMI

Rnor_mGluR6 ------VDPEQARGVLKCDMSDLSLIGCLG-YSLL

Cele_mgl1 ------DQVVLTCNVPDHHFLYSLA-YDGF

#############

250 260 270 280 290 300

======+======+======+======+======+======+

Dmel_boss CCVGALIPSIYR--SQRNYREGILIVIGSVLIMVIWVAWIALSLFGD-EW------RD

Dere_boss CCVGALIPSIYR--SQRNYREGILIVIGSVLIMVIWVAWIALSLFGD-EW------RD

Dore_boss CCVGALIPSIYR--SQRNYREGILIVIGSVLIMVIWVAWIALSLFGD-EW------RD

Dpse_boss CCVAALIPFIYR--SQRNYREGILIVIGAVLILVIWVAWIVLSLFGD-EW------RD

Dvir_boss CSLVSLVPFIYR--SQRNYREGILIVIGAVLILIIWSVWIALSMFGD-EW------RD

Aaeg_boss AALIVLSPYIFR--SQRNYREGMLLVTGSILCLVIWTTWIPLCVFGY-EW------RE

Agam_boss VSLIFLAPFIFR--SQRNYREGLLLVTGSVLCLVIWTVWIPLCMFGY-EW------RE

Tcas_boss LLLLCFCPLIFK--SQRNYREGKYFTFATIITSLLWCFWVPAYLLLGDYY------KD

Amel_boss ITLFVVCFFIFQ--LPRNYREGKCFFGTSIGLLIAWAVWLTCFILVEPEY------RD

Mmul_GPRC5B VVTLGLALFTLCGKFKRWKLNGAFLLITAFLSVLIWVAWMTMYLFGN-VKLQ-QGDAWND

Mfas_GPRC5B VVTLGLALFTLCGKFKRWKLNGAFLLITAFLSVLIWVAWMTMYLFGN-VKLQ-QGDAWND

Hsap_GPRC5B VVTLGLALFTLCGKFKRWKLNGAFLLITAFLSVLIWVAWMTMYLFGN-VKLQ-QGDAWND

Ptro_GPRC5B VVTLGLALFTLCGKFKRWKLNGAFLLITAFLSVLIWVAWMTMYLFGN-VKLQ-QGDAWND

Ppyg_GPRC5B VVTLGLALFTLCGKFKRWKLNGAFLLITAFLSVLIWVAWMTMYLFGN-VKLQ-QGDAWND

Btau_GPRC5B VATLALAFFSLCGKFKKWKQNGVCILVTAFLSVLIWVAWMTMYLFGN-AELR-QGDAWGD

Cfam_GPRC5B VATLGLALFTLCGKFKKWKQNGACILVTAFLSVLIWVAWMTMYLFGN-AELR-QGDAWGD

Mmus_GPRC5B AITLAQSLFTLCGKFKRWKVNGAFILVTTFLSALIWVVWMTMYLFGN-SLIK-QGDAWSD

Rnor_GPRC5B AITLAQSLFTLCGKFKRWKVNGAFILITTFLSVLIWVIWMTMYLFGN-SLIK-RADAWSD

Ggal_GPRC5B VFTMGFSLFTLCGKFKKWKKNGVCLIITLFFSILIWVAWMTMYLFGN-AELK-RRDKWSD

Tnig_GPRC5B LAALTAASLALCGKTRQWRCNAIWLLVTCLLSLLLWVAWVGFYLYGN-DWLG-RSPDWDH

Mmus_GPRC5C LTAFLGAWPTLCGRFKRWRKHGVFVLLTTVISIAIWVVWIVMYTYGN-EQHH-SPT-WDD

Rnor_GPRC5C LAAFLGAWPTLCGRFKRWRKHGVFVLLTTATSIAIWVVWIVMYTYGN-KQHH-SPT-WDD

Btau_GPRC5C LCAFSGAWSALCGRFKRWRKHGVFILLTTTASIAIWVVWIVMYTYGN-RQHN-SPT-WDD

Xtro_GPRC5C_1 LAGFITAWPALCGRYGHWRKHAIFILLTLFLSISIWIVWIVMYVYGN-VQVG-NPLYWDD

Ggal_GPRC5C VAAFGTAWPALCGRYTRWRKHGAFILATSGLSMAIWVAWTAMYLYGN-QHVG-KKPIWDD

Drer_GPRC5C LAVVVASVPIMAGKHKQWRKDGALILVTGLLSVGIWVAWIVMYVSGN-AKNG-GPT-WDD

Xtro_GPRC5C_2 LASLIVPCPVLCGHYLPWKRHGRYIVVTALLSLSIWVTWIVMYVYGN-EKLG-HQNTWDD

Rnor_GPRC5A VLTFVASLLVFCGSFSGWKRHGIHICLTSFLSIAIWVAWIILLLIPD-IDR-----KWDD

Mmus_GPRC5A VLTFFTSFLVFCGSFSGWKRHGFHICFTSFLSIAIWVAWIVLLLIPD-IDR-----KWDD

Hsap_GPRC5A ALTFLMSSFTFCGSFTGWKRHGAHIYLTMLLSIAIWVAWITLLMLPD-FDR-----RWDD

Ptro_GPRC5A ALTFLMSSFTFCGSFTGWKRHGAHIYLTMLLSIAIWVAWITLLMLPD-FDR-----RWDD

Mmul_GPRC5A ALTFLMSSFTFCGSFTGWKRHGAHIYLTMLLSIAIWVAWITLLMLPD-FDR-----RWDD

Cfam_CPRC5A ALTFLMSCFIFCGSFIGWKRHGTHIFLTMLLSIGIWVTWITLLLIST-FGP-----EWDD

Btau_GPRC5A ALTFLTASFSFQGSFTAWKRHGAHIYLTTILSIAIWVAWITLLLVPT-LSP-----QWDD

Ggal_GPRC5D ALTFLVSIFTFCGPYKSWKRHGAHIFVTVLFSIAIWVVWITMLTRGN-QSLGKT--NWDD

Mmus_GPRC5D ALTFFVSKATFCGPCENWKQHGRLIFATVLVSIIIWVVWISMLLRGN-PQLQRQP-HWDD

Rnor_GPRC5D ALTFFVSKATFCGPCENWKQHGRLIFATVLVSIIIWVVWISMLMRGN-PQLQRQP-QWDD

Hsap_GPRC5D ALTFFVSKATFCGPCENWKQHGRLIFITVLFSIIIWVVWISMLLRGN-PQFQRQP-QWDD

Ptro_GPRC5D ALTFFVSKATFCGPCENWKQHGRLIFITVLFSIIIWVVWISMLLRGN-PQFQRQP-QWDD

Btau_GPRC5D ALTFFVSKTTFCGPCENWKQHGRLIFVTVLVSIIIWVVWISMLMRGN-TQLQRQP-QWDD

Xlae_GPRC5D AITFLVSLISLCGPCKYWKRHGAHIYVTMFFSIGIWVAWICMLLRGN-ADLNQGNRTWDD

Aaeg_CG32447l IFVAILAIKSRG--IRDNYREATYIGLAVGGIIPIWLGWTLCGLAVA-DR-H------RD

Agam_CG32447l VFVAILAIKSRG--IRDNYREATYIGLAIGGIIPIWLGWTLCGLAVA-DR-H------RD

Tcas_CG32447l LFVTVLAVKSRG--IRDNYREATYIGLSVGCSIPTWLVWILSGFVVS-ER-H------RD

Dmel_CG32447 VFIAVLAIKSRG--IRDNYREATYIGLAIGGAIPIWLGWMLCGLAVA-ER-H------KD

Amel_CG32447l VAVACLAVRARG--VRDNNREAAFIGLAVGLSLPIWISSAIGSVAAS-TESD------RE

Cbri_CAE58455 LMALFINMLNRN--IKRNYKETKWLLYSTVGCFFTWVAWITLYLVLG-HE-F------RD

Cele_NP_501400 FMALFISMLNRN--IKRNYKETKWLLYSTVLCFFTWVAWITLYLVLD-HE-F------RD

Rnor_V2R2 LALLCFLTTFVARKLPDNYYEGKCITFGMLVFFIVWISFVPAYLSTK-GKFK------V

Mmus_V2R2 LALLCFATTFVARQLPDNYYEGKCITFGMLVFFIVWISFVPAYLSTK-GKFN------V

Mmus_CasR1 LALLCFLTTFVARQLPDNYYEGKCITFGMLVFFIVWISFVPAYLSTK-GKFK------V

Trub_BAA26126 LACMCFLLAFLARKLPDNFNEARLIAFSMLIFCAVWVAFVPAYISSP-GKYS------T

Spur_mGluR5 LISLCTLYAFKTRNLPENFNEAKYIAFTMYTTCIVWLAFIPLYFGSD--L------KE

Rnor_mGluR1 LIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSN--Y------KI

Rnor_mGluR5 LILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSN--Y------KI

Rnor_mGluR2 LIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTS-SDYR-----VQT

Hsap_mGluR2 LIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTS-SDYR-----VQT

Rnor_mGluR3 LVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTS-SDYR-----VQT

Dmel_Glu LITICTIYAIKTRKIPENFNESKFIGFTMYTTCIIWLAFVPIYFGTG-NSYE-----VQT

Rnor_mGluR6 LMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIFFGTA-QSAEKIY--IQT

Cele_mgl1 LIVLCTTYAVKTRKVPENFNETKFIGFSMYTTCVVWLSWIFFFFGTG-SDFQ-----IQT

####################### #

310 320

======+======+======

Dmel_boss AAIPLGLQASGWAVLVGILIPRTFLIV

Dere_boss AAIPLGLQASGWAVLVGILIPRTFLIV

Dore_boss AAIPLGLQASGWAVLVGILIPRTFLIV

Dpse_boss AAIPLGLQASGWAVLVGILIPRSFLIV

Dvir_boss AAIPLGMQASGWAVLVGILIPRTFLIV

Aaeg_boss AAVSLGLVATALAVLVGVMIPRCFLMV

Agam_boss AAISLGMVATALAVLVGIMIPRCFLMV

Tcas_boss SVLCFGLVSTASVLLATIFVPRTYLMT

Amel_boss TVVSLGIISTAYLIIIGILIPRTYYMV

Mmul_GPRC5B PTLAITLAASGWVFVIFHAIPEIHCTL

Mfas_GPRC5B PTLAITLAASGWVFVIFHAIPEIHCTL

Hsap_GPRC5B PTLAITLAASGWVFVIFHAIPEIHCTL

Ptro_GPRC5B PTLAITLAASGWVFVIFHAIPEIHCTL

Ppyg_GPRC5B PTLAITLTASGWVFVIFHAIPEIHCTL

Btau_GPRC5B PTLAITLVASGWVFVIFHAIPEIHCTI

Cfam_GPRC5B PTLAITLVASGWVFVIFHAIPEIHCTI

Mmus_GPRC5B PTLAITLAASGWVFVIFHAIPEIHYTL

Rnor_GPRC5B PTLAITLVASGWVFVIFHAIPEIHYTL

Ggal_GPRC5B PTLAIALVSSGWVFVIFHAIPEVHCTI

Tnig_GPRC5B PALAIALVAQGWLLLIFHAIPESHICL

Mmus_GPRC5C PTLAIALAANAWTFVLFYVIPEVSQVT

Rnor_GPRC5C PTLAIALAANAWTFVFFYVIPEVSQVT

Btau_GPRC5C PTLAIALATNAWAFVLFYVIPEVSQVT

Xtro_GPRC5C_1 PTLAIALVSNGWAFIFFYIIPEISQLT

Ggal_GPRC5C PTLAIALVSNAYAFILLYVIPEVTHVT

Drer_GPRC5C PTLAIALVSNAWVFLLLHTVPAVCSLS

Xtro_GPRC5C_2 PVLAIALVSNGWVFIVCYFIPEVVEMT

Rnor_GPRC5A TILSTVLVANGWVFLVFYILPEFRQLP

Mmus_GPRC5A TILSTALVANGWVFLAFYILPEFRQLP

Hsap_GPRC5A TILSSALAANGWVFLLAYVSPEFWLLT

Ptro_GPRC5A TILSSALAANGWVFLLAYVSPEFWLLT

Mmul_GPRC5A TILSSALAANGWVFLLAYVSPEFWLLT

Cfam_CPRC5A TVLSSALVANGWVFLLAYAAPEFQLLT

Btau_GPRC5A TILSSALVANGWVFLLAYIAPEFHLLT

Ggal_GPRC5D PVVAIALVSNGWVFLIMYIIPEICFLT

Mmus_GPRC5D AVICIGLVTNAWVFLLIYIIPELSILY

Rnor_GPRC5D AVICIGLVTNAWVFLLLYIIPEMSILY

Hsap_GPRC5D PVVCIALVTNAWVFLLLYIVPELCILY

Ptro_GPRC5D PVVCIALVTNAWVFLLLYIVPELCILY

Btau_GPRC5D PVICIALVTNAWVFLLLYIVPELCILY

Xlae_GPRC5D PVLSIALVANGWVFLMMYMVPELCLMT

Aaeg_CG32447l ACLAFGLVATASTVFLVMFMPKGRQLA

Agam_CG32447l ACLAFGLVATSSTVFLVMFMPKGRQLA

Tcas_CG32447l ACIAFGLVISSALVFLIMFMPKGRQLA

Dmel_CG32447 ACVAFGLVATSATVFLVMFMPKGRQLA

Amel_CG32447l AWLAYGLLATSLLVFLTMFLPKGRQLA

Cbri_CAE58455 TVIVVELIACATILLGFLFGPKIYILL

Cele_NP_501400 TVIVVELVACATILLGFLFGPKIYILL

Rnor_V2R2 AVEIFAILASSYGLLGCIFLPKCFIIL

Mmus_V2R2 AVEIFAILASSYGLLGCLFLPKCFIIL

Mmus_CasR1 AVEIFAILASSYGLLGCLFLPKCFIIL

Trub_BAA26126 LTEIFAILASSYGLLGCIFAPKCYIIL

Spur_mGluR5 IVVCFAVTLSATVTLGCLFFPKTYIIL

Rnor_mGluR1 ITTCFAVSLSVTVALGCMFTPKMYIII

Rnor_mGluR5 ITMCFSVSLSATVALGCMFVPKVYIIL

Rnor_mGluR2 TTMCVSVSLSGSVVLGCLFAPKLHIIL

Hsap_mGluR2 TTMCVSVSLSGSVVLGCLFAPKLHIIL

Rnor_mGluR3 TTMCISVSLSGFVVLGCLFAPKVHIVL

Dmel_Glu TTLCISISLSASVALVCLYSPKVYILV

Rnor_mGluR6 TTLTVSLSLSASVSLGMLYVPKTYVIL

Cele_mgl1 SSLCISISMSANVALACIFSPKLWIIL

######################

FASTA format

>Dmel_boss

VATGLTAAILGLIATLAILVFIVVRISLGDVFEGNPTTSILLLLSLILVFCSFVPYSIEYVNTLCAVRVFIMTLVYCFVF

SLLLCRAVMLASIGSEGGHVNGYIQAVICAFSVVAQVGMSVQLLVVMHVASWLWGLLAYDFALLCCVGALIPSIYRSQRN

YREGILIVIGSVLIMVIWVAWIALSLFGDEWRDAAIPLGLQASGWAVLVGILIPRTFLIV

>Dere_boss

VATGLTAAILGLIATLAILVFIVVRISLGDVFEGNPATSILLLLSLILVFCSFVPFSIEYVNTLCAVRVFIMTLVYCFVF

SLLLCRAVMLASIGSEGGHVNGYIQAVICAFSVVAQVGMSVQLLVVMHVASWLWGLLAYDFALLCCVGALIPSIYRSQRN

YREGILIVIGSVLIMVIWVAWIALSLFGDEWRDAAIPLGLQASGWAVLVGILIPRTFLIV

>Dore_boss

VATGLTAAILGLIATLAILVFIVVRISLGDVFEGNPATSILLLLSLILVFCSFVPFSIEYVNTLCAVRVFIMTLVYCFVF

SLLLCRAVMLASIGSEGGHVNGYIQAVICAFSVVAQVGMSVQLLVVMHVASWLWGLLAYDFALLCCVGALIPSIYRSQRN

YREGILIVIGSVLIMVIWVAWIALSLFGDEWRDAAIPLGLQASGWAVLVGILIPRTFLIV

>Dpse_boss

VATGLTAAILGLIATLAILVFIVVRISVGDVFEGNPVTSILLLLSLILVFCSFVPFSIEYVNTLCAVRVFIMSLVYCFVF

SLLLCRALMLASTGSEGGHVNGYIQAVICAFSVFVQVGMSVQLLVVMHVASWLWGLLSYDFVLLCCVAALIPFIYRSQRN

YREGILIVIGAVLILVIWVAWIVLSLFGDEWRDAAIPLGLQASGWAVLVGILIPRSFLIV

>Dvir_boss

VATGLTAAILGLIATLAILVFIVVRISLGDVFEGNPVTSILLLLSLILVFCSFVPFSMEYVNTLCGVRVFIMTLVYCFVF

SLLLCRAVMLASIGSEGGHVNGYIQAIICVLSVFVQVGMSVQLLVVMHLASWLWGLLAYDFLLLCSLVSLVPFIYRSQRN

YREGILIVIGAVLILIIWSVWIALSMFGDEWRDAAIPLGMQASGWAVLVGILIPRTFLIV

>Aaeg_boss

VAAGLTIASLGILFCLAILIFLIVRVCMDDVLEGNPLSSILLLISLIFQFASFLPFSLEYTNTLCTVKIFLLSVCYCTTF

SLLLCRAIMLASIGSEGGHVNGYLQSVICIFSTLVQLGLSTQLVIVLHASSWFWATIAYDGILLAALIVLSPYIFRSQRN

YREGMLLVTGSILCLVIWTTWIPLCVFGYEWREAAVSLGLVATALAVLVGVMIPRCFLMV

>Agam_boss

VAAGLTVSSLGILLCAAILIFLIVRVCMDDILEGHPLGSILLLISLILQFAAFIPFSLEYTNAHCTVKIFLVSMCYCMTF

SLLLCRAIMLASIGSEGGHINGYIQSVICGFSTLVQLGLSTQLVIVLHANAWFWAVIAYDGVLLVSLIFLAPFIFRSQRN

YREGLLLVTGSVLCLVIWTVWIPLCMFGYEWREAAISLGMVATALAVLVGIMIPRCFLMV

>Tcas_boss

IFAFLSLSLLGVLFCIAILVFLLVSVCRKNVLEGNPVLTILLLFTVMVMFCSIVPLSLE--RSICMARALSITLSFAAAF

SLMLSRSIVLATASKEIGHVAGPVQSFLCLFIFGVQAALSLQVFN------SFIYILSYNIILLLLLLCFCPLIFKSQRN

YREGKYFTFATIITSLLWCFWVPAYLLLGYYKDSVLCFGLVSTASVLLATIFVPRTYLMT

>Amel_boss

IPIFLTVVVCGTFACGAIAVFIIYRFMVEDVLDGNPMLTIVLILANVFTLQTVLPFCIN--ERLNSRKILATTLAFGLDF

SLMLTRAFFLVFS-KGGVHINGHLQGLMVFFMFFVQVAISVMFFALNNHDSVFIALLGYDIFLLITLFVVCFFIFQLPRN

YREGKCFFGTSIGLLIAWAVWLTCFILVEEYRDTVVSLGIISTAYLIIIGILIPRTYYMV

>Mmul_GPRC5B

VVEAVAGAGALITLLLMLILLVRLPFIKEKEKKSPVGLHFLFLLGTLGLFGLTFAFIIQEDETICSVRRFLWGVLFALCF

SCLLSQAWRVRRLVRHGTGPAGWQLVGLALCLMLVQVIIAVEWLVLTVLRDDFVMALIYDMVLLVVTLGLALFTLCFKRW

KLNGAFLLITAFLSVLIWVAWMTMYLFGNVKNDPTLAITLAASGWVFVIFHAIPEIHCTL

>Mfas_GPRC5B

VVEAVAGAGALITLLLMLILLVRLPFIKEKEKKSPVGLHFLFLLGTLGLFGLTFAFIIQEDETICSVRRFLWGVLFALCF

SCLLSQAWRVRRLVRHGTGPAGWQLVGLALCLMLVQVIIAVEWLVLTVLRDDFVMALIYDMVLLVVTLGLALFTLCFKRW

KLNGAFLLITAFLSVLIWVAWMTMYLFGNVKNDPTLAITLAASGWVFVIFHAIPEIHCTL

>Hsap_GPRC5B

VVEAVAGAGALITLLLMLILLVRLPFIKEKEKKSPVGLHFLFLLGTLGLFGLTFAFIIQEDETICSVRRFLWGVLFALCF

SCLLSQAWRVRRLVRHGTGPAGWQLVGLALCLMLVQVIIAVEWLVLTVLRDDFVMALIYDMVLLVVTLGLALFTLCFKRW

KLNGAFLLITAFLSVLIWVAWMTMYLFGNVKNDPTLAITLAASGWVFVIFHAIPEIHCTL

>Ptro_GPRC5B

VVEAVAGAGALITLLLMLILLVRLPFIKEKEKKSPVGLHFLFLLGTLGLFGLTFAFIIQEDETICSVRRFLWGVLFALCF

SCLLSQAWRVRRLVRHGTGPAGWQLVGLALCLMLVQVIIAVEWLVLTVLRDDFVMALIYDMVLLVVTLGLALFTLCFKRW

KLNGAFLLITAFLSVLIWVAWMTMYLFGNVKNDPTLAITLAASGWVFVIFHAIPEIHCTL

>Ppyg_GPRC5B

VVEAVAGAGALITLLLMLILLVRLPFIKEKEKKSPVGLHLLFLLGTLGLFGLTFAFIIQEDETICSVRRFLWGVLFALCF

SCLLSQAWRVRRLVRRGTGPAGWQLVGLALCLMLVQVIIAVEWLVLTVLRDDFVMALIYDMVLLVVTLGLALFTLCFKRW

KLNGAFLLITAFLSVLIWVAWMTMYLFGNVKNDPTLAITLTASGWVFVIFHAIPEIHCTL

>Btau_GPRC5B

VVEAVAGAGALITLLLMLILLVRLPFIKDKEKKDPVGLHFLFLLGTLGLFGLTFAFIIREDETICSVRRFLWGVLFALCF

SCLLSQAWRVRRLVRHGKSPSGWQLVGMALCLMLVQVIIAIEWLVLTVLRDDFAMALIYDMVLLVATLALAFFSLCFKKW

KQNGVCILVTAFLSVLIWVAWMTMYLFGNAEGDPTLAITLVASGWVFVIFHAIPEIHCTI

>Cfam_GPRC5B

VVEAVAGAGALITLLLMLILLVRLPFIKDKEKKDPVGLHFLFLLGTLGLFGLTFAFIIREDETICSVRRFLWGVLFALCF

SCLLSQAWRVRRLVRHGKSPSGWQLVGVALCLMLVQVIIAIEWLVLTVLRDDFVMALIYDMVLLVATLGLALFTLCFKKW

KQNGACILVTAFLSVLIWVAWMTMYLFGNAEGDPTLAITLVASGWVFVIFHAIPEIHCTI

>Mmus_GPRC5B

VVEAVAGAGALITLLLMLILLVRLPFIKDKERKRPVCLHFLFLLGTLGLFGLTFAFIIQMDETICSIRRFLWGVLFALCF

SCLLSQAWRVRRLVRQGTSPASWQLVSLALCLMLVQVIIATEWLVLTVLRDDFVMALIYDMVLLAITLAQSLFTLCFKRW

KVNGAFILVTTFLSALIWVVWMTMYLFGNSLSDPTLAITLAASGWVFVIFHAIPEIHYTL

>Rnor_GPRC5B

VVEAVAGAGALITLLLMLILLVRLPFIKDKERRRPVCLHFLFLLGTLGLFGLTFAFIIRMDETICSIRRFLWGVLFALCF

SCLLSQAWRVRRLVRQGTSPASWQLVSLALCLMLVQVIIATEWLVLTVLRDDFVMALIYDMVLLAITLAQSLFTLCFKRW

KVNGAFILITTFLSVLIWVIWMTMYLFGNSLSDPTLAITLVASGWVFVIFHAIPEIHYTL

>Ggal_GPRC5B

VVEAVAGAGVLTTLLLMLILLVRLPFIKEKEKKSPLGMHFLFLFGTLGLFGLTFAFIIQEDEMVCSTRRFLWGVIFALCF

SCLLAQAWRLRRLVRHGKSPSGWHLAGVAICLMLVQVIIATEWLILTVVRDDFAMALIYVMFLMVFTMGFSLFTLCFKKW

KKNGVCLIITLFFSILIWVAWMTMYLFGNAESDPTLAIALVSSGWVFVIFHAIPEVHCTI

>Tnig_GPRC5B

AVESVAAGGVLIAILLALVLLCRLRHVSEAEKRSGVGPVLLLLLGTLGLFGLSFAYLIEQDESLCLLRRALWGLLFAVCF

SCLLVQGVRLRRLGRERRGPGGCALTGLALGLSAVQGIIAAEWLLLTVLREDFSLACTYVLVLLLAALTAASLALCTRQW

RCNAIWLLVTCLLSLLLWVAWVGFYLYGNDWDHPALAIALVAQGWLLLIFHAIPESHICL

>Mmus_GPRC5C

VSEAVAGAGIITTFVLTIILVASLPFVQDTKKRSLLGTQVFFLLGTLGLFCLVFACVVKPDFSTCASRRFLFGVLFAICF

SCLVAHVLSLNFLTRKNHGPRGWVIFTVALLLTLVEVIINTEWLIITLVRGDFVMALIYVMLLLLTAFLGAWPTLCFKRW

RKHGVFVLLTTVISIAIWVVWIVMYTYGNEQDDPTLAIALAANAWTFVLFYVIPEVSQVT

>Rnor_GPRC5C

VLEAVAGAGIITTFVLTIILVASLPFVQDTKKRSLLGTQVFFLLGTLGLFCLVFACVVKPDFSTCASRRFLFGVLFAICF

SCLIAHTLSLNFLARKNHGPRGWVIFTVALLLTLVEVIINTEWLIITLVRGDFVMALIYVMLLLLAAFLGAWPTLCFKRW

RKHGVFVLLTTATSIAIWVVWIVMYTYGNKQDDPTLAIALAANAWTFVFFYVIPEVSQVT

>Btau_GPRC5C

ILEAVAGAGVVTTFVLTIILVASLPFVQDTKKRSLLGTQVFFLLGTLGLFCLVFACVVKPSFSTCASRRFLFGVLFAICF

SCLVAHVLALHFLVRKNHGPRGWVIFLVALLLSLVEVIINTEWLIITLVRGDFVMALIYVMLLLLCAFSGAWSALCFKRW

RKHGVFILLTTTASIAIWVVWIVMYTYGNRQDDPTLAIALATNAWAFVLFYVIPEVSQVT

>Xtro_GPRC5C_1

VLQAITSAGIVSTFILTIVLVASTPFIQNKKKKSLLGTQVFFLLGTLGIFGLVFDMVVKKDFATCASRRFLFGLLFAICF

ACLWVHGVSLNYLIRRNTQPSGWWIFGLAVCLSLVEAIINTEWLIITIVKTDFVMALIYVMFLILAGFITAWPALCYGHW

RKHAIFILLTLFLSISIWIVWIVMYVYGNVQDDPTLAIALVSNGWAFIFFYIIPEISQLT

>Ggal_GPRC5C

VLEAAASLGAVTSFVLTIVLVASLPFVQDPQKKSLVATQAFFLLGTFGLFCLTFDFIVGPDFSTCTSRRFLFGVLFALCF

SCLLAHAVALNFLARRNRGPRGWVTLAVALLLALVEVIINAEWLIITVARQDFVMALIYVMVLLVAAFGTAWPALCYTRW

RKHGAFILATSGLSMAIWVAWTAMYLYGNQHDDPTLAIALVSNAYAFILLYVIPEVTHVT

>Drer_GPRC5C

VVEAFAAAGLVASLILLIVLLASLPFINSKNWRSSFGLHTVFLIFTFGLFALTFAFIVGKNFATCASRRFLFGVLFAGCF

SCLLMQAVRLNILARRNSGPRGWVWCLGALGLWLVEVVINTEWLIITIVRYDFVMALIYVLNLLLAVVVASVPIMAHKQW

RKDGALILVTGLLSVGIWVAWIVMYVSGNAKDDPTLAIALVSNAWVFLLLHTVPAVCSLS

>Xtro_GPRC5C_2

ILEALAGLGIVCALVLAVIFLALAPSVIRDERKGSLAINFMFLFGVFGLFSLVFAFIIAPNAAVCEVRRFLFGVLFALCF

ACLVAHSVRLNYLVLHNRGPGGGLIFLLAIGLFLVEAVINAEWLLITNVRHDFVTALVYVMFLILASLIVPCPVLCYLPW

KRHGRYIVVTALLSLSIWVTWIVMYVYGNEKDDPVLAIALVSNGWVFIVCYFIPEVVEMT

>Rnor_GPRC5A

ALETLAAVGAVATVALMFALVFLICKVQDSSKRKMLPTQFLFLLGVLGVFGLTFAFIIKLDRATGPTRFFLFGVLFALCF

SCLLAHAFNLIKLVRGRKPLSWLVILSLAVGFSLVQDVIAIEFLVLTMNRTDFVMLLIYVLFLMVLTFVASLLVFCFSGW

KRHGIHICLTSFLSIAIWVAWIILLLIPDIDDDTILSTVLVANGWVFLVFYILPEFRQLP

>Mmus_GPRC5A

ALETLAAVGAVATVACMFALVFLICKVQDSNKRKMLPAQFLFLLGVLGVFGLTFAFIIKLDGATGPTRFFLFGVLFAICF

SCLLAHAFNLIKLVRGRKPLSWLVILSLAVGFSLVQDVIAIEYLVLTMNRTDFVMLLIYVLVLMVLTFFTSFLVFCFSGW

KRHGFHICFTSFLSIAIWVAWIVLLLIPDIDDDTILSTALVANGWVFLAFYILPEFRQLP

>Hsap_GPRC5A

VLETVATAGVVTSVAFMLTLPILVCKVQDSNRRKMLPTQFLFLLGVLGIFGLTFAFIIGLDGSTGPTRFFLFGILFSICF

SCLLAHAVSLTKLVRGRKPLSLLVILGLAVGFSLVQDVIAIEYIVLTMNRTDFVLLLTYVLFLMALTFLMSSFTFCFTGW

KRHGAHIYLTMLLSIAIWVAWITLLMLPDFDDDTILSSALAANGWVFLLAYVSPEFWLLT

>Ptro_GPRC5A

VLETVATAGVVTSVAFMLALPILVCKVQDSNRRKMLPTQFLFLLGVLGIFGLTFAFIIGLDGSTGPTRFFLFGILFSICF

SCLLAHAVSLTQLVRGRKPLSLLVILGLAVGFSLVQDVIAIEYIVLTMNRTDFVLLLIYVLFLMALTFLMSSFTFCFTGW

KRHGAHIYLTMLLSIAIWVAWITLLMLPDFDDDTILSSALAANGWVFLLAYVSPEFWLLT

>Mmul_GPRC5A

VLETLAAAGVVTSVAFMLALPLLVCKVQDSNRRKMLPTQFLFLLGVLGIFGLTFAFIIRLDGSTGPTRFFLFGILFSICF

SCLLAHALNLTQLVRGRKPLSLLVILGLAVGFSLVQDVIAIEYIVLTMNRTDFVLLLIYVLFLMALTFLMSSFTFCFTGW

KRHGAHIYLTMLLSIAIWVAWITLLMLPDFDDDTILSSALAANGWVFLLAYVSPEFWLLT

>Cfam_CPRC5A

VLEAVAAVGAVTSMAFMFALLILICKVQDSNRRKVLPTQFLFLLGVLGIFGLTFAFIIQLDGSTGPTRFFLFGVLFSLCF

SCLLAHAFNLTKLVHGRKPLSLMVMLSLAVGLSLVQDIIAAEYIILTMNRTDFVMLLIYVLSLMALTFLMSCFIFCFIGW

KRHGTHIFLTMLLSIGIWVTWITLLLISTFGDDTVLSSALVANGWVFLLAYAAPEFQLLT

>Btau_GPRC5A

VLEALAGVGAVASVAFMITLLVLICKVQDSNKRKLLPTQFLFLLGVLGIFGLTFAFIITLDGGTGPTRFFLFGVLFALCF

SCLLVHAFNLTKLVRGRQPLSMLVMLGLALGFSLVQDIIAIEYVVLTMNRTDFVMLLIYVLFLMALTFLTASFSFQFTAW

KRHGAHIYLTTILSIAIWVAWITLLLVPTLSDDTILSSALVANGWVFLLAYIAPEFHLLT

>Ggal_GPRC5D

VLESLAAAGVLVTVFLICSLFFLICKVQDNSKRHMISIYFFFLLGILGIFGITFAFIIRSNERIRPTRFFLFGVLFALCF

SCLLIHASNLIRLVRGKKPFSWPVLLLLIVSFALVQVVINIEYLVTMLVK-DFVMLLIYVLFLMALTFLVSIFTFCYKSW

KRHGAHIFVTVLFSIAIWVVWITMLTRGNQSDDPVVAIALVSNGWVFLIMYIIPEICFLT

>Mmus_GPRC5D

VLESLAVIGIVVTILLLLAFLFLMRKVQDCSQWNVLPTQFLFLLAVLGLFGLTFAFIIQLNHQTAPVRYFLFGVLFAICF

SCLLAHASNLVKLVRGRVSFCWTTILFIAIGVSLLQTIIAIEYVTLIMTR-DFVCLLIYVLFLMALTFFVSKATFCCENW

KQHGRLIFATVLVSIIIWVVWISMLLRGNPQDDAVICIGLVTNAWVFLLIYIIPELSILY

>Rnor_GPRC5D

VLESLAVIGIVVTILLLLAFLFLMRRVQDCSQWNVLPTQFLFLLAVLGLFALTFAFIIQLNQQTAPVRYFLFGVLFAICF

SCLLAHASNLVKLVRGRVSFCWTTILFIAIGVSLLQTIIAIEYVTLIMTR-DFVCLLIYVLFLMALTFFVSKATFCCENW

KQHGRLIFATVLVSIIIWVVWISMLMRGNPQDDAVICIGLVTNAWVFLLLYIIPEMSILY

>Hsap_GPRC5D

ILESLAILGIVVTILLLLAFLFLMRKIQDCSQWNVLPTQLLFLLSVLGLFGLAFAFIIELNQQTAPVRYFLFGVLFALCF

SCLLAHASNLVKLVRGCVSFSWTTILCIAIGCSLLQIIIATEYVTLIMTR-DFVVLLVYVLFLMALTFFVSKATFCCENW

KQHGRLIFITVLFSIIIWVVWISMLLRGNPQDDPVVCIALVTNAWVFLLLYIVPELCILY

>Ptro_GPRC5D

ILESLAILGIVVTILLLLAFLFLMRKIQDCSQWNVLPTQLLFLLSVLGLFGLAFAFIIELNQQTAPVRYFLFGVLFALCF

SCLLAHASNLVKLVRGCVSFSWTTILCIAIGCSLLQIIIAIEYVTLIMTR-DFVVLLVYVLFLMALTFFVSKATFCCENW

KQHGRLIFITVLFSIIIWVVWISMLLRGNPQDDPVVCIALVTNAWVFLLLYIVPELCILY

>Btau_GPRC5D

VLESLAAVGIVVTVMLLLAFLFLMRRVQDCAHWNVLPTQFLFLLGVLGLFGLAFAFIIQLNQQTAPIRYFLFGVLFALCF

SCLLAHASNLVKLVRGRASFSWTTILCIAIGVSLLQTIIAIEYVTLIMTR-DFVVLLVYVLFLMALTFFVSKTTFCCENW

KQHGRLIFVTVLVSIIIWVVWISMLMRGNTQDDPVICIALVTNAWVFLLLYIVPELCILY

>Xlae_GPRC5D

VLETLAAAGIVFSIILILALLIMMPRISDPAKRAVSPVQLIFLIGTFGIFGLTFAFIVELTEQTCPTRFFLFGVLFAICF

SCLLAHASKLVRLVRGGHGICWWMMLLMALFLPLVQVVIAILYIVLGLVRSDFVLILIYVFLLMAITFLVSLISLCCKYW

KRHGAHIYVTMFFSIGIWVAWICMLLRGNADDDPVLSIALVANGWVFLMMYMVPELCLMT

>Aaeg_CG32447l

VVPVLVLACLSMIMMAAFEIFVLCKAWRTSPSRRHLFLGQMLLLGLFSCSGLAAVLTINPTILSCATMRFGAGVAFALVF

ASLLVKCVFLISLNGG--YLPAPYQGLLLLFAVLIQVAVGAQWLLTSPPSVELLLSLIYVVFLIIFVAILAIKSRGIRDN

YREATYIGLAVGGIIPIWLGWTLCGLAVADRRDACLAFGLVATASTVFLVMFMPKGRQLA

>Agam_CG32447l

VVPVLVLASLSMLMMAAFEVFVLCKAWRTSPSRRHLFLGQMLLLGLFACSGLAAVLTVNPTVLSCATMRFGAGVAFALVF

ASLLVKCVFLISLNGG--YLPAPYQGLLLLFAVLIQVAVGGQWLLTSPPGVELLLSLIYIVFLIVFVAILAIKSRGIRDN

YREATYIGLAIGGIIPIWLGWTLCGLAVADRRDACLAFGLVATSSTVFLVMFMPKGRQLA

>Tcas_CG32447l

VIPVLTLSAVTMALIIGFEVFVLCKAWRTTPSRRHLFLGQMLLLGLFTCAGLGAVYAAAPTQLTCAVVRFGTGVAYAVVF

ASLLVKCVFLISLNGG--YLPAPYQGLLLLFAILIQVAIGAQWLLTSPPLVDILLSLIYVIFLILFVTVLAVKSRGIRDN

YREATYIGLSVGCSIPTWLVWILSGFVVSERRDACIAFGLVISSALVFLIMFMPKGRQLA

>Dmel_CG32447

VVPVLVLATLTMLMMAAFEIFVLFKAWRTSPSRRHLFLGQMLLLGLFACASLGAIITAQPSLISCGAIRFGVGVAYALVF

AALLVKCVFLISLNGG--YLPAPYQGLLLLFALLIQVAIGGQWLLTQPPEVELLFSLIYIVFLIVFIAVLAIKSRGIRDN

YREATYIGLAIGGAIPIWLGWMLCGLAVAERKDACVAFGLVATSATVFLVMFMPKGRQLA

>Amel_CG32447l

ALPLAALSAATMLLMAGFEVFVLLKARVTAPNRRHLFLGQALLLGLFLLAGLSAAASLSQNPLSCAAFRL-VGLPAALVF

AALLVKCVFLLSLNSG--YLPAPYQALVLGFAVLVQVAIIGQWFYGEPPMVQIVASLGYPGALLVAVACLAVRARGVRDN

NREAAFIGLAVGLSLPIWISSAIGSVAASTEREAWLAYGLLATSLLVFLTMFLPKGRQLA

>Cbri_CAE58455

NYVLLALITVLVVVAVAVLVLVLVKLYLR-VVKGNQSLGISLLIGIIILYSTAFFFVFDPTDSVCRLRVILHGLGYTICF

GVMIAKATQLRNAETLGFHISFWNYWLLLFFIVGVQIALSISWFLEPFMSTEFVVSNFYVMILILMALFINMLNRNIKRN

YKETKWLLYSTVGCFFTWVAWITLYLVLGHERDTVIVVELIACATILLGFLFGPKIYILL

>Cele_NP_501400

NYVLLALITVLVVVAIAVLVLVLVKLYLR-VVKGNQSLGISLLIGIIILYSTAFFFVFDPTDSVCRLRVILHGLGYTICF

GVMIAKATQLRNAETLGFHISFWNYWLLLFFIVGVQIALSISWFLEPFMSTEFVVSNFYVMILIFMALFISMLNRNIKRN

YKETKWLLYSTVLCFFTWVAWITLYLVLDHERDTVIVVELVACATILLGFLFGPKIYILL

>Rnor_V2R2

GYALVILSIFGALVALAVTVVYVIHRHTPLAKANDQELSFLIQMSLVITVLSSILFIGKPYNWTCMARQVTLALGFCLCL

SSILGKTISLFFAYRISKMH-PIFRKLIVLICVVGEIGVCTAYLMLKPPRMIEFLCSIFAFDVLLALLCFLTTFVALPDN

YYEGKCITFGMLVFFIVWISFVPAYLSTKGK-VAVEIFAILASSYGLLGCIFLPKCFIIL

>Mmus_V2R2

GFTLVIISIFGALVVLAVTVVYVIHRHTPLVKANDRELSFLIQMSLGITVLSSMLFIGKPCNWSCKTRQVTLALGFCLCL

SSILGKTVSLFFAYRISIMH-PIFRKLIVLICVVGEIGVCTAYLVLEPPSLIEFLCSIFGFDVLLALLCFATTFVALPDN

YYEGKCITFGMLVFFIVWISFVPAYLSTKGK-VAVEIFAILASSYGLLGCLFLPKCFIIL

>Mmus_CasR1

GFTLVILSIFGALVLLAVTVVYVIHRHTPLVKANDRELSFLIQMSLVITVLSSLLFIGKPCNWSCMARQITLALGFCLCL

SSILGKTISLFFAYRISVMH-PIFRKLIVLICVVGEIGICAAYLVLEPPRMIEFLCSIFGFDVLLALLCFLTTFVALPDN

YYEGKCITFGMLVFFIVWISFVPAYLSTKGK-VAVEIFAILASSYGLLGCLFLPKCFIIL

>Trub_BAA26126

GIALLVVSLIGSFLTCAVALVFFYHRTSPIVRANNSDLSFLLLFSLTLCFLCSLTFISPPSQWSCMLRHTAFGITFVLCI

SCILGKTIVVLMAFRATLWFGPGKQKAIITFSTLVQVVICTVWLVVAPPTPTIAFSLVLGYIGVLACMCFLLAFLALPDN

FNEARLIAFSMLIFCAVWVAFVPAYISSPGK-TLTEIFAILASSYGLLGCIFAPKCYIIL

>Spur_mGluR5

AIAAMCFSCVGILLTVFVTVTFIRHNDTALVKASSRENSYILLAGIYLCFLVTFPFIAKPSTEVCYFRRIGLGLSFCICY

AGLVVRTNRMARILAGSKFLGSTAQVVMTFGVISFEIGIIVATLVLERPAAFGFAAPLG-YDALLISLCTLYAFKTLPEN

FNEAKYIAFTMYTTCIVWLAFIPLYFGSD-LKEIVVCFAVTLSATVTLGCLFFPKTYIIL

>Rnor_mGluR5

PIAAVVFACLGLLATLFVTVIFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSY

SALVTKTNRIARILAGSKFMSACAQLVIAFILICIQLGIIVALFIMEPPDILGVVTPLG-YNGLLILSCTFYAFKTVPAN

FNEAKYIAFTMYTTCIIWLAFVPIYFGSN-YKIITMCFSVSLSATVALGCMFVPKVYIIL

>Rnor_mGluR1

SIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCY

SALVTKTNRIARILAGSKFMSAWAQVIIASILISVQLTLVVTLIIMEPPMPLGVVAPVG-YNGLLIMSCTYYAFKTVPAN

FNEAKYIAFTMYTTCIIWLAFVPIYFGSN-YKIITTCFAVSLSVTVALGCMFTPKMYIII

>Rnor_mGluR2

AVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCY

SALLTKTNRIARIFGGARFISPASQVAICLALISGQLLIVVAWLVVEAPGTASMLGSLA-YNVLLIALCTLYAFKTCPEN

FNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDQTTTMCVSVSLSGSVVLGCLFAPKLHIIL

>Hsap_mGluR2

AVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCY

SALLTKTNRIARIFGGARFISPASQVAICLALISGQLLIVVAWLVVEAPGTASMLGSLA-YNVLLIALCTLYAFKTCPEN

FNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDQTTTMCVSVSLSGSVVLGCLFAPKLHIIL

>Rnor_mGluR3

AIGPVTIACLGFLCTCIVITVFIKHNNTPLVKASGRELCYILLFGVSLSYCMTFFFIAKPSPVICALRRLGLGTSFAICY

SALLTKTNCIARIFDGVKFISPSSQVFICLGLILVQIVMVSVWLILETPGTSSMLISLT-YDVVLVILCTVYAFKTCPEN

FNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDQTTTMCISVSLSGFVVLGCLFAPKVHIVL

>Dmel_Glu

ALIPMAIAIFGIALTSIVIVLFAKNHDTPLVRASGRELSYTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIY

SALLTKTNRISRIFHSASYISPQSQVVITTSLIAIQVLITMIWMVVEPPGTMSFLFSQL-YNMILITICTIYAIKTIPEN

FNESKFIGFTMYTTCIIWLAFVPIYFGTGNSQTTTLCISISLSASVALVCLYSPKVYILV

>Rnor_mGluR6

AALPLLLAVLGIMATTTIMATFMRHNDTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPCAAICAARRLLLGLGTTLSY

SALLTKTNRIYRIFEQGKFISPTSQLVITFGLTSLQVVGVIAWLGAQPPHSLSLIGCLG-YSLLLMVTCTVYAIKAVPET

FNEAKPIGFTMYTTCIIWLAFVPIFFGTAQSQTTTLTVSLSLSASVSLGMLYVPKTYVIL

>Cele_mgl1

SLVPTILAVFGIIATLFVIVVYVIYNETPVVKASGRELSYILLISMIMCYCMTFVLLSKPSAIVCAIKRTGIGFAFSCLY

SAMFVKTNRIFRIFS--TFISPISQVVMTAMLAGVQLIGSLIWLSVVPPGWHHFLYSLA-YDGFLIVLCTTYAVKTVPEN

FNETKFIGFSMYTTCVVWLSWIFFFFGTGSDQTSSLCISISMSANVALACIFSPKLWIIL