Table 2b: Primary haemodynamic and oxygenation variables (mean 6SD, unless otherwise specified)

Experimental arm / Control arm
H0 / H2 / H4 / H6 / H24 / H0 / H2 / H4 / H6 / H24
Mean Blood Pressure -mmHg / 79 618 / 80 623 / 83 620 / 82 614 / 79 621 / 72 614 / 74 613 / 76 618 / 89 615 / 69 627
Central venous pressure -mmHg / 10 66 / 9 65 / 8 64 / 9 64 / 6 64 / 10 65 / 14 65 / 14 66 / 12 65 / 10 66
Heart rate -bpm / 103 622 / 112 626 / 105 621 / 104 619 / 102 620 / 90 617 / 89 618 / 98 619 / 96 628 / 87 646
Glasgow coma score / 13 63 / 13 64 / 13 64 / 13 64 / 14 64 / 11 65 / 11 65 / 11 65 / 11 65 / 12 64
Lactates -mmol/l / 4.0 64.1 / 4.1 64.9 / 4.2 64.4 / 4.0 65.5 / 3.2 62.5 / 3.0 62.2 / 3.1 62.6 / 3.6 62.9 / 2.1 61.7 / 1.5 61.1
PaO2/FiO2-mmHg / 170 689 / 170 6100 / 181 6101 / 198 6113 / 165 694 / 166 692 / 226 6143 / 188 670 / 191 6102 / 198 679
ScvO2-% / 70 620 / 72 617 / 77 614 / 80 65 / 72 611 / 73 67 / 76 68 / 77 611 / 77 610 / 77 67
ScvO2<70% -n (%) / 5 (33.3) / 6 (40) / 5 (33.3) / 4 (26.6) / 3 (23) / 6 (40) / 3 (20) / 2 (13.3) / 2 (13.3) / 2 (14.2)
Masseter-StO2 -% / 79 618 / 78 622 / 81 620 / 82 615 / 75 619 / - / - / - / - / -
Masseter-StO2 <80% -n (%) / 7 (47) / 6 (40) / 4 (26) / 3 (20) / 4 (26)
Deltoid-StO2-% / 70 624 / 69 623 / 79 615 / 78 618 / 62 629 / - / - / - / - / -
Deltoid-StO2 <80% -n (%) / 9 (60) / 7 (47) / 6 (40) / 5 (30) / 8 (52)
Pectoral-StO2-% / 43 633 / 46 633 / 47 633 / 45 636 / 35 634 / - / - / - / - / -
Pectoral-StO2 <80% -n (%) / 9 (60) / 8 (52) / 8 (52) / 7 (47) / 7 (47)
Thenar-StO2-% * / 86 611 / 77 617 / 82 613 / 83 612 / 84 68 / - / - / - / - / -
Thenar-StO2<80% -n / 1 / 2 / 1 / 1 / 1

* 4 patients

Table5: Variation in SOFA score and need for life supportive therapies during the first week post randomization (mean 6SD, unless otherwise specified)

Experimental arm / Control arm
Day 1 / Day 2 / Day 3 / Day 4 / Day 5 / Day 6 / Day 7 / Day 1 / Day 2 / Day 3 / Day 4 / Day 5 / Day 6 / Day 7
SOFA / 7 64 / 5 64 / 4 64 / 4 64 / 4 64 / 4 64 / 4 65 / 8 64 / 7 64 / 7 65 / 7 65 / 6 66 / 5 66 / 5 66
DSOFA>0 vs randomisation-n / - / 2 / 2 / 1 / 1 / 2 / 2 / - / 2 / 3 / 2 / 4 / 2 / 2
Mechanical ventilation – Yes- n (%) / 9 (69) / 8 (67) / 7 (58) / 7 (58) / 7 (58) / 7 (58) / 6 (50) / 13 (93) / 12 (86) / 11 (79) / 11 (79) / 11 (79) / 10 (71) / 9 (69)
Vasopressor therapy- Yes- n (%) / 6 (62) / 4 (33) / 3 (25) / 2 (17) / 2 (17) / 2 (17) / 2 (17) / 10 (66) / 8 (57) / 7 (47) / 6 (40) / 5 (33) / 4 (27) / 3 (20)
Dobutamine- Yes- n (%) / 5 (33) / 0 (0) / 0 (0) / 0 (0) / 0 (0) / 0 (0) / 0 (0) / 1 (7) / 0 (0) / 0 (0) / 0 (0) / 0 (0) / 0 (0) / 0 (0)
Alive- Yes- n (%) / 13 (87) / 12 (80) / 12 (80) / 12 (80) / 12 (80) / 12 (80) / 12 (80) / 14 (93) / 14 (93) / 14 (93) / 14 (93) / 14 (93) / 14 (93) / 13 (87)