Possible Side Effects of Cisplatin, Cyclophosphamide, Etoposide, Methotrexate, Vincristine(Table Version Date: August 28, 2014)

COMMON, SOME MAY BE SERIOUS
In 100 people receiving Cisplatin, Cyclophosphamide, Etoposide, Methotrexate, Vincristine,
more than 20 and up to 100 may have:
  • Nausea, vomiting, loss of appetite, diarrhea, constipation
  • Infection, especially when white blood cell count is low
  • Anemia which may require blood transfusions
  • Bruising, bleeding
  • Kidney damage which may cause swelling, may require dialysis
  • Hearing loss including ringing in ears
  • Hair loss
  • Absence of menstrual period which may decrease the ability to have children
  • Blood in urine
  • Sores in mouth which may cause difficulty swallowing
  • Tiredness
  • Fever, chills
  • Increased risk of sunburn, rash
  • Pain or redness at the site of injection
  • Numbness and tingling of fingers or toes
  • Headache, jaw pain and/or muscle pain
  • Weakness and difficulty walking
  • Swelling of lower legs
  • Nail damage

OCCASIONAL, SOME MAY BE SERIOUS
In 100 people receiving Cisplatin, Cyclophosphamide, Etoposide, Methotrexate, Vincristine,
from 4 to 20 may have:
  • Allergic reaction which may cause rash, low blood pressure, wheezing, shortness of breath, swelling of the face or throat
  • Confusion
  • Difficulty with balance
  • Damage to the bone marrow (irreversible) which may cause infection, bleeding, may require transfusions
  • Loss or absence of sperm which may lead to an inability to father children
  • Stuffy nose
  • Fluid around the heart
  • Damage to the heart, heart failure or heart attack which may cause chest pain, shortness of breath, swelling of ankles, and tiredness
  • Severe skin rash with blisters and peeling which can involve inside of mouth and other parts of the body
  • Liver damage, scarring of the liver or hepatitis which may cause yellowing of eyes and skin, swelling
  • Internal bleeding which may cause belly pain, black tarry stool, blood in vomit
  • A new cancer including cancer of bone marrow (leukemia) resulting from treatment of earlier cancer
  • Seizure
  • Blood clot which may cause swelling, pain, shortness of breath
  • Drooping eyelids
  • Hoarseness

RARE, AND SERIOUS
In 100 people receiving Cisplatin,Cyclophosphamide, Etoposide, Methotrexate, Vincristine,
3 or fewer may have:
  • Swelling of the body including the brain which may cause dizziness, confusion
  • Scarring of the lungs
  • Brain damage which may cause headache, seizure, blindness (also known as Reversible Posterior Leukoencephalopathy Syndrome)

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