The Elderly a Challenge for Appropriate Drug Treatment

European Journal

of Clinical Pharmacology

Volume 64 • Number 3 • March 2008

EDITORIAL COMMENTARIES

The elderly—a challenge for appropriate drug treatment

U. Kfotz 225

Drug-eluting coronary stents: as safe as bare-metal stents, but optimized antiplatelet therapy may further improve clinical outcome

D.Trenk-F.-J. Neumann 227

REVIEW ARTICLE

Clinical use and pharmacological properties of selective COX-2 inhibitors

S. Shi • U. Klotz 233

PHARMACOGENETICS

Distribution of the GNB3 S25C>T polymorphism among Brazilians: impact of population structure

O.D. Vargens ■ L Almendra ■ CJ. Struchiner • G. Suarez-Kurtz 253

Comparison of SLCO1B1 sequence variability among German, Turkish, and African populations

J. Mwinyi ■ K. Kopke ■ M. Schaefer ■ I. Roots ■ T. Gerloff 257

PHARMACOKINETICS AND DISPOSITION

Pharmacokinetics of eslicarbazepine acetate in patients with moderate hepatic impairment

L. Almeida ■ J.H. Potgieter ■ J. Maia ■ MA Potgieter ■ F. Mota ■ P. Soares-da-Silva 267

Inhibition of metoprolol metabolism and potentiation of its effects by paroxetine in routinely treated patients with acute myocardial infarction (AMI)

K. Goryachkina ■ A. Burbello ■ 5. Boldueva ■ S. Babak ■ U. Bergman ■ L Bertilsson 275

Artemisinin and CYP2A6 activity in healthy subjects

S. Asimus-T.N. Hai ■ N.Van Huong -M. Ashton 283

Examining sex-related differences in enteric itraconazole metabolism in healthy adults using grapefruit juice

P.O. Gubbins ■ BJ. Gurley ■ D.K. Williams ■ S.R. Penzak ■ 5.A. McConnefl ■ A.M. Franks ■ M. Saccente 293

PHARMACOEPIDEMIOLOGY AND PRESCRIPTION

Identification of severe potential drug-drug interactions using an Italian genera I-practitioner database

L Magro ■ A. Conforti ■ F. Del Zotti ■ R. Leone ■ M.L lorio ■ I. Meneghelli ■ D. Massignani ■ E. Visona ■ U. Moretti 303

Prevalence and patterns of methylphenidate use in French children and adolescents

A.-L. Kneliwolf ■ J. Deligne ■ F. Chiarotti ■ G.-R. Auleley ■ S. Palmieri ■ C.B. Boisgard ■ P. Panel ■ E. Autret-Leca 311

Rule-based standardised switching of drugs at the interface between primary and tertiary care

S.U. Walk ■ T. Bertsche ■ J. Kaltschmidt ■ M.G. Pruszydlo ■ T. Hoppe-Tichy ■ I.Walter-Sack I • W.E. Haefeli 319

SHORT COMMUNICATION

Pilot study on the influence of liver blood flow and cardiac output on the clearance of propofol in critically ill patients

M.Y.M. Peeters ■ L.P.HJ. Aarts ■ F.A. Boom ■ U. Bras ■ D. Tibboel ■ M.Danhof-CAJ.Knibbe 329

Further articles can be found at Indexed in/abstracted by Current Contents and Index Medicus.

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