Supplementary table 2Main characteristics of Crohn’s disease genetic studies included in the meta-analysis

Surname / Year / Country / Population / Ethnicity / OCTN1 / OCTN2 / IGR2096 / IGR2198 / IGR2230 / TC haplotype
case(MAF)/
control(MAF) / case(MAF)/
control(MAF) / case(MAF)/
control(MAF) / case(MAF)/
control(MAF) / case(MAF)/
control(MAF) / case(TC)/
control(TC)
Tomer / 2009 / America / Children / Caucasian / 83(0.470)/
73(0.356) / 83(0.548)/
73(0.438) / 83(0.482)/
73(0.349) / 83(0.500)/
73 (0.384) / 83(0.560)/
73(0.445) / 83(0.373)/
73(0.301)
Vermeire / 2005 / Belgium / Adult / Caucasian / 461(0.476)/
299(0,460) / 461(0.512)/
300(0.513) / NA / NA / NA / NA
Okazaki / 2008 / Canada / Adult / Caucasian / 207(0.505)/
313(0.398) / 207(0.558)/
313(0.435) / 207(0.490)/
313(0.396) / 207()/
313() / 207(0.556)/
313(0.435) / NA
Waller / 2006 / England / Adult / Caucasian / 492(0.480)/
752(0.410) / 483(0.528)/
750(0.463) / 491(0.474)/
741(0.411) / NA / 494(0.524)/
751(0.461) / NA
Noble / 2005 / Scotland / Adult / Caucasian / 348(0.528)/
259(0.429) / 342(0.564)/
250(0.484) / 341(0.494)/
252(0.419) / 334(0.491)/
256(0.408) / 324(0.548)/
253(0.458) / 330(0.542)/
248(0.423)
Russell / 2006 / Scotland / Children / Mix / NA / NA / 200(0.492)/
256(0.420) / 200(0.477)/
256(0.410) / 200(0.5538)/
256(0.475) / NA
Lappalainen / 2008 / Finland / Adult / Caucasian / 234(0.363)/
190(0.374) / 236(0.396)/
189(0.392) / NA / NA / NA / NA
Török / 2005 / Germany / Adult / Caucasian / 625(0.471)/
1012(0.420) / 625(0.514)/
1012(0.469) / NA / NA / NA / 625(0.470)/
1012(0.420)
Gazouli / 2005 / Greece / Adult / Caucasian / 120(0.250)/
100(0.150) / 120(0.217)/
100(0.140) / NA / NA / NA / 120(0.133)/
100(0.065)
Bene / 2006 / Hungary / Children / Caucasian / 19(0.500)/
49(0.500) / 19(0.658)/
49(0.531) / NA / NA / NA / NA
Talián / 2009 / Hungary / Adult / Caucasian / NA / NA / NA / NA / 200(0.485)/
187(0.446) / NA
Lakner / 2009 / Hungary / Adult / Caucasian / 217(0.454)/
290(0.393) / 217(0.497)/
290(0.460) / 217(0.472)/
290(0.382) / 217(0.459)/
290(0.377) / NA / NA
Csöngei / 2010 / Hungary / Adult / Caucasian / NA / NA / 315(0.465)/
314(0.392) / 315(0.457)/
314(0.389) / NA / NA
Ferraris / 2006 / Italy / Children / NA / 134(0.463)/
160(0.416) / 134(0.526)/
160(0.478) / NA / NA / NA / 134(0.455)/
160(0.413)
Latiano / 2006 / Italy / Adult / Caucasian / NA / NA / 565(0.458)/
357(0.400) / 570(0.467)/
357(0.409) / NA / NA
Palmieri / 2006 / Italy / Adult / Caucasian / 444(0.458)/
611(0.419) / 444(0.534)/
611(0.471) / NA / NA / NA / 444(0.441)/
612(0.360)
Cucchiara / 2007 / Italy / Children / Caucasian / 173(0.471)/
347(0.421) / 172(0.535)/
347(0.471) / 191(0.464)/
347(0.398) / 191(0.453)/
3470.411() / NA / 172(0.448)/
347(0.383)
Leung / 2006 / New Zealand / Adult / Caucasian / 182(0.519)/
188(0.444) / 182(0.552)/
188(0.497) / NA / NA / NA / 182(0.514)/
188(0.428)
de Ridder / 2007 / Netherlands / Adult / NA / 376(0.445)/
293(0.444) / 351(0.479)/
281(0.493) / NA / NA / NA / NA
de Ridder / 2007 / Netherlands / Children / Mix / 76(0.434)/
293(0.444) / 64(0.531)/
281(0.493) / NA / NA / NA / NA
Gaj / 2008 / Poland / Adult / Caucasian / 60(0.483)/
139(0.403) / 60(0.508)/
139(0.500) / NA / NA / NA / NA
Martínez / 2006 / Spain / Adult / Caucasian / 300(0.460)/
342(0.434) / 293(0.452)/
402(0.480) / NA / NA / NA / 256(0.422)/
275(0.396)
Törkvist / 2007 / Sweden / Adult / Mix / 178(0.440)/
142(0.360) / 178(0.466)/
142(0.415) / 178(0.440)/
142(0.338) / 178(0.402)/
142(0.338) / 178(0.463)/
142(0.408) / 178(0.438)/
142(0.356)
Weersma / 2009 / Netherlands / Adult / Caucasian / NA / NA / NA / NA / NA / 1684(0.446)/
1350(0.411)
Babusukumar / 2006 / America / Children / Caucasian / NA / NA / NA / NA / NA / 264(0.466)/
527(0.408)
Newman / 2005 / Canada / Mix / Mix / NA / NA / NA / NA / NA / 732(0.511)/
698(0.407)

NA not available or no such group,MAF minor allele frequency,TCOCTN1/2 TC haplotype frequency