Curriculum Vitae
Min Guo
Department of Cancer Biology
The Scripps Research Institute, Scripps Florida
130 Scripps Way, Jupiter, FL 33458
Ph. (561) 228-3201 Fax. (561) 228-2917
Positions and Education
2010-present Assistant Professor, Department of Cancer Biology, The Scripps Research
Institute (TSRI), Scripps Florida, Jupiter, FL; Department of Molecular Biology, TSRI, La Jolla, CA
Research programs focus on human aminoacyl-tRNA synthetases and their cancer-associated functions
2009- 2010 Senior Research Associate, Department of Molecular Biology, TSRI, La Jolla, CA
2005- 2008 Postdoctoral Research Associate, Department of Molecular Biology, TSRI, La Jolla, CA
Research focused on atomic structures and functional interaction of aminoacyl-tRNA synthetases
2000- 2005 Ph.D., Structural Biology, Department of Molecular and Cell Biology, University of Science and Technology of China (USTC), Hefei, China
1996- 2000 B.S., Biology, University of Science and Technology of China (USTC), Hefei, China
Research
1. Novel functions of human aminoacyl-tRNA synthetases and their dynamic regulation.
2. Chemical and structural basis of aminoacyl-tRNA synthetases
Award
2011 Sidney Kimmel Scholars Award
Presentations
The International Conference of Aminoacyl-tRNA Synthetases, Salt Lake, Utah, 2011
The 2nd Meeting on tRNA Synthetase and Medicine, Hobe Sound, FL, 2010
The 23rd International tRNA Workshop, Aveiro, Portugal, 2010
The Fall Research Symposium of the Scripps Research Institute, La Jolla, CA, 2009
The Hong Kong University of Science and Technology, Hong Kong, China, 2008
The International Conference of Aminoacyl-tRNA Synthetases, Les Pensières, France, 2008
The Fall Research Symposium of the Scripps Research Institute, La Jolla, CA, 2007
University of Science and Technology of China, Hefei, China, 2007
The International Conference of Aminoacyl-tRNA Synthetases, San Diego, CA, 2006
Publications (current as of Mar 2012):
1. Tu X, Wang J, Guo M, Zheng D, Teng M, Niu L, Liu Q, Huang Q, Hao Q. Purification, partial characterization, crystallization and preliminary X-ray diffraction of two cysteine-rich secretory proteins from Naja atra and Trimeresurus stejnegeri venoms, Acta Cryst. D, 2004; 60: 1108-1111
2. Guo M, Teng M, Niu L, Liu Q, Huang Q, Hao Q. Crystal structure of cysteine-rich secretory protein stecrisp reveals the cysteine-rich domain has a K+-channel inhibitor-like fold. J. Biol. Chem., 2005 Apr; 280: 12405-12412
3. Wang D, Guo M, Liang Z, Fan J, Zhu Z, Zang J, Zhu Z, Li X, Teng M, Niu L, Dong Y, and Liu P. Crystal structure of human vacuolar protein sorting protein 29 reveals a phosphodiesterase/nuclease-like fold and two protein-protein interaction sites. J. Biol. Chem., 2005 Jun; 280: 22962 – 22967
4. Wang J, Shen B, Guo M, Lou X, Duan Y, Cheng XP, Teng M, Niu L, Liu Q, Huang Q, Hao Q. Blocking effect and crystal structure of natrin toxin, a cysteine-rich secretory protein from Naja atra venom that targets the BKCa channel. Biochemistry, 2005 Aug 2;44 (30):10145-52
5. Fan J, Wang D, Liang Z, Guo M, Teng M, Niu L. Maize uroporphyrinogen III methyltransferase: overexpression of the functional gene fragments in Escherichia coli and one-step purification. Protein Expr Purif., 2006 Mar;46(1):40-6
6. Li X, Guo M, Fan J, Tang W, Wang D, Ge H, Rong H, Teng M, Niu L, Liu Q, Hao Q. Crystal structure of 3-hydroxyanthranilic acid 3,4-dioxygenase from Sacchromyces cerevisiae: a special subgroup of the type III extradiol dioxygenases. Protein Sci., 2006 Apr;15(4):761-73
7. Guo M, Xu F, Yamada J, Egelhofer T, Gao Y, Hartzog GA, Teng M, Niu L. Core structure of the yeast Spt4-Spt5 Complex: a conserved module for regulation of transcription elongation. Structure, 2008 Nov 12;16:1649-1658
8. Fang P, Wang J, Li X, Guo M, Xing L, Cao X, Zhu Y, Gao Y, Niu L, Teng M. Crystallization and preliminary X-ray analysis of Escherichia coli Rnase G. Acta Cryst. F, 2009 Jun 1; 65:586-8
9. Yang XL, Guo M, Kapoor M, Ewalt KL, Otero FJ, Skene RJ, McRee DE, Schimmel P. Functional and crystal structure analysis of active site adaptations of a potent anti-angiogenic human tRNA synthetase. Structure, 2007 Jul;15(7):793-805
10. Beebe K, Waas W, Druzina Z, Guo M, Schimmel P. A universal plate format for increased throughput of assays that monitor multiple aminoacyl transfer RNA synthetase activities. Anal Biochem., 2007 Sep 1;368(1):111-21
11. Guo M, Ignatov M, Musier-Forsyth K, Schimmel P, Yang XL. Crystal structure of tetrameric form of human lysyl-tRNA synthetase: implications for multisynthetase complex formation. Proc. Natl. Acad. Sci. USA, 2008 Feb 19;105(7):2331-6
12. Schimmel P, Guo M. Ancient tRNA synthetase meets modern structural biology. Structure, 2009 Mar 11;17: 315-7
13. Schimmel P, Guo M. A tipping point for mistranslation and disease. Nature Structure Molecular Biology, 2009 Apr 1;16(4): 348-9
14. Guo M, Chong YE, Beebe K, Shapiro R, Yang XL, Schimmel P. The C-Ala domain brings together editing and aminoacylation functions on one tRNA. Science, 2009 Aug 7; 325;744-7
15. Guo RT, Chong YE, Guo M, Yang XL. Crystal structures and biochemical analyses suggest unique mechanism and role for human GlyRS in Ap4A homeostasis. J. Biol. Chem., 2009 Oct 16; 284(42):28968-76
16. Guo M, Chong YE, Shapiro R, Beebe K, Yang XL, Schimmel P. Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma. Nature, 2009 Dec 10; 462:808-12
17. Zhou Q, Kapoor M, Guo M, Belani R, Xu X, Kiosses WB, Hanan M, Park C, Armour E, Do MH, Nangle LA, Schimmel P, Yang XL. Orthogonal use of a human tRNA synthetase active site to achieve multifunctionality. Nat. Struct. Mol. Biol., 2010 Jan 17; 17:57-61
18. Guo M, Schimmel P, Yang XL. Functional expansion of human tRNA synthetases achieved by structural inventions. FEBS Lett., 2010 Jan 21; 584:434-42
19. Guo M, Shapiro R, Schimmel P, Yang XL. Introduction of a leucine half-zipper engenders multiple high quality crystals of a recalcitrant tRNA synthetase. Acta Cryst. D, 2010 Mar; 66:243-50
20. Guo M, Yang XL, Schimmel P. New functions of tRNA synthetases beyond translation. Nature Reviews Molecular Cell Biology, 2010 Sep;11(9):668-74
21. Guo M, Shapiro R, Morris GM, Yang XL, Schimmel P. Packaging HIV virion components through dynamic equilibria of a human tRNA synthetase. Journal of Physical Chemistry, 2010 Dec;114(49):16273-9
22. Fang P, Zhang HM, Shapiro R, Marshall AG, Schimmel P, Yang XL, Guo M. Structural context for mobilization of a human tRNA synthetase from its cytoplasmic complex. Proc. Natl. Acad. Sci. USA, 2011 May 17;108(20):8239-44
23. Kumar A, Fang P, Park H, Guo M, Nettles KW, Disney MD. A crystal structure of a model of the repeating r(CGG) transcript found in fragile X syndrome. Chembiochem, 2011 Sep;12(14):2140-2
24. He W, Zhang HM, Chong YE, Guo M, Marshall AG, Yang XL. Dispersed disease-causing neomorphic mutations on a single protein promote the same localized conformational opening. Proc. Natl. Acad. Sci. USA, 2011 Jul 26;108(30):12307-12
25. Kumar A, Park H, Fang P, Parkesh R, Guo M, Nettles KW, Disney MD. Myotonic Dystrophy Type 1 RNA Crystal Structures Reveal Heterogeneous 1x1 Nucleotide UU Internal Loop Conformations. Biochemistry, 2011 Nov 15;50(45):9928-35.
26. Jones JE, Slack JL, Fang P, Zhang X, Subramanian V, Causey CP, Coonrod SA, Guo M, Thompson PR. Synthesis and screening of a haloacetamidine containing library to identify PAD4 selective inhibitors. ACS Chem Biol., 2012 Jan 20;7(1):160-5.
27. Guo M, Schimmel P. Structural analyses clarify the complex control of mistranslation by tRNA synthetases. Curr. Opin. Struct. Biology, 2012 Feb; 22(1):119-26.
28. Xu XL, Shi Y, Zhang HM, Marshall AG, Guo M, Kishi S, Yang XL. Unique domain appended to vertebrate tRNA synthetase is essential for vascular development. Nature Communications, 2012 Feb 21; 3:681
29. Sajish M, Zhou Q, Kishi S, Valdez DJ, Kapoor M, Guo M, Kim S, Yang XL. Nuclear Trp-tRNA Synthetase Implicated in Linking IFN-γ Signaling to p53 Activation. Nature Chemical Biology, 2012 [In press]
30. Park MC, Kang T, Jin D, Han JM, Kim SB, Park YC, Cho K, Park YW, Guo M, He W, Yang XL, Paul Schimmel P, Kim S. Secreted Human Gly-tRNA Synthetase Implicated in Defense Against ERK-Activated Tumorigenesis. Proc. Natl. Acad. Sci. USA, 2012 Feb 15. [Epub ahead of print]
31. Wang J, Fang P, Schimmel P, Guo M. Side Chain Independent Recognition of Aminoacyl-Adenylates by the Hint1 Transcription Suppressor. Journal of Physical Chemistry, 2012 Feb 13. [Epub ahead of print]
32. Gonzalez M, Mclaughlin H, Houlden H, Guo M, Tsen LY, Hadjivassilious M, Speziani F, Yang XL, Antonellis A, Reilly MM, Zuchner S. Exome sequencing identifies a loss-of-function mutation in methionyl-tRNA synthetase (MARS) in a family with CMT2. Neurology, 2012 [Submitted]
4