CURRICULUM VITAE

MATHEW NINAN MD, FRCS(C-Th), FETCS

May 3, 2004

PERSONAL DETAILS

Last Name NINAN

First NameMATHEW

Work AddressVanderbilt University Medical Center

Department of Thoracic Surgery

2971 The Vanderbilt Clinic

Nashville, TN 37232-5734

Date of Birth : 4 July 1962

TelephoneWork (615) 322-0064

E-mail

Medical Registration:Tennessee Full License MD0000034573

Pennsylvania Full License MD059 598L

Family: Wife : Annie

Daughter : Rebekah

POSITIONS:

July 2000 to presentAssistant Professor (tenure track), Thoracic Surgery

Surgical Oncologist, Vanderbilt-IngramCancerCenter

Surgical Director, Lung Transplant Program

VanderbiltUniversityMedicalCenter

Nashville, Tennessee

July 2002 to present Master of Science in Clinical Investigation

VanderbiltUniversity

TRAINING

January 1999 to June 2000Senior Registrar and Thoracic Transplantation Fellow, University of Leeds, Leeds, U.K.

July 1995 to November 1998Resident Fellow, Cardiothoracic Surgery

University of PittsburghMedicalCenter

Pittsburgh, Pennsylvania

May 1990 to June 1995Resident, General Surgery

St. Thomas’and Harefield Hospital and The BasildonUniversityHospitals,University of London, U.K.

1982 - 1989J.N. Medical College, KarnatakUniversity, and MedicalCollegeHospital, Trivandrum, Kerala, India

GENERAL THORACIC ONCOLOGY SPECIALIST EXPERIENCE

  • Thoracic oncology surgeon, VanderbiltUniversity, 2000 to 2004. Was responsible for thoracic surgical care of referrals to VanderbiltUniversityHospital and the VanderbiltIngramCancerCenter, responsible for the Division of Thoracic Surgery as the only thoracic surgeon in Year 2003.
  • Special focus on pneumonectomy sparing bronchial and vascular sleeve resections, thoracoscopic lobectomies for early stage lung cancer, minimally invasive esophagectomy.
  • Responsible for establishing the Vanderbilt Lung Volume Reduction Surgery Program, the Photodynamic Therapy Program concentrating on treatment of early stage bronchial and esophageal lesions and the Thoracoscopic Lobectomy program

THORACIC TRANSPLATATION EXPERIENCE

  • Primary Lung Transplant Surgeon of VanderbiltUniversity. Surgical leadership of the program with major operating responsibilities including chairing weekly assessment meetings, chairing protocol sessions, etc. Survival Statistics – 95% operative 30 day survival for the last 24 transplant operations.
  • University of Pittsburgh and University of Leeds: 18 months dedicated thoracic transplantation fellowship training with the transplantation team headed by Dr. Robert Kormos and Dr. Robert Keenan.
  • HarefieldHospital: 6 months training with all transplant operations both recipient and donor) at the busiest thoracic transplant center in Europe, with Professor Sir Magdi Yacoub and team

Board Certifications: Cardiothoracic Surgery, Intercollegiate Board, RoyalCollege of Surgeons 1999

Cardiothoracic Surgery, European Board, 2000

Royal College of Surgeons, UK 1992

OPERATIVE EXPERIENCE

Attending Thoracic Surgeon – VanderbiltUniversityMedicalCenter, Nashville, Tennessee – over 950operative cases in three years

ONGOING CLINICAL RESEARCH PROJECTS

Principal Investigator ECOG THO E5597 – A Phase 3 Chemoprevention Trial of Selenium supplementation in persons with resected Stage 1 Non Small Cell Lung Cancer

Principal Investigator ECOG THO S9900 – A Randomized Phase 3 Trial of Surgery Alone or Surgery plus pre-operative Paclitaxel/Carboplatin in Clinical Stage 1B, 2, and selected 3A Non Small Cell Lung Cancer

Co-Principal Investigator COX2 inhibitors and lung cancers (VCC THO 0055) to the National Institutes of Health (NIH).

Principal Investigator ASCOG THO 0177 Detection of Pleural Micrometastasis in Surgically Treated Non Small Cell Lung Cancer

Principal Investigator : Role of Isoprostanes and Isofurans in Post-operative Acute Lung Injury. Scientific project for the MSCI Program, VanderbiltUniversity.

Principal Investigator : Iron Metabolism in Post-operative Acute Lung Injury. Scientific Project for the GCRC, VanderbiltUniversity.

Two outstanding grant applications to HRSA, DHSS (announcement date July 30, 2004)

Principal Investigator CIOP 12560 “Establishment of a non-heart beating lung donor protocol in a tertiary care hospital: an evidence based approach”. Budget: $1,000,000 over 3 years.

Co-Principal Investigator CIOP 12562 “A multimodality approach to transform and salvage lungs determined to be non-transplantable: a prospective randomized controlled study. Budget: $ 1,000,000 over 3 years

AWARDS AND CITATIONS

Awarded the $ 100,000 Discovery Grant at VanderbiltUniversityMedicalCenter, 2002

Awarded the $ 25,000 GCRC Pilot Grant, VanderbiltUniversityMedicalCenter, 2002

Awarded the $150,000 VanderbiltIngramCancerCenter Lung Cancer Surgery Award, 2000 to 2003.

Resident Award – University of PittsburghMedicalCenter. Award financed a six week transplantation fellowship at Harefield Hospital, U.K. 1997

Best Outgoing Student and First Rank Holder 1988J.N.MedicalCollege, Belgaum, India and Karnatak University, India

First Rank Holder 2 MBBS examination, J.N.MedicalCollege and Karnatak University, India

First Class in all Undergraduate Examinations in MedicalSchool

Pearce Memorial Gold Medal for the Best Outstanding Student, LaidlawMemorialHigh School, Ketti, India 1978

MEMBERSHIPS AND ASSOCIATIONS

Fellow, Intercollegiate Board in Cardiothoracic Surgery

Member, American Thoracic Society

Member, American College of Cardiology

Member, American College of Chest Physicians

Member, International Society of Heart and Lung Transplantation

Fellow, Royal College of Surgeons of Edinburgh

BIBLIOGRAPHY

TEXTBOOK CHAPTERS

Roberts JR, Ninan M. Thoracoscopic Resection of Lung Cancer in Atlas of Cancer. Marka, M (ed) Current Medicine 2002.

Ninan M, Myers J. Revision of the Fontan-Kreutzer procedure to total cavopulmonary connection. Pediatric Cardiac Surgery Annual: 182-5, 1997

Ninan M, Luketich JD. Management of bronchopleural, oesophageal and aortic fistulae of the thoracic cavity. In: Oxford Textbook of Critical Care. Eds. Webb A, Shapiro MJ, Singer M, Suter P, 1997

Ninan M, Venn GE, Goldstraw P. Surgical Management of Bullous Lung Disease. In: Textbook of Thoracic surgery. Ed. Goldstraw P., 429-17, 1995

OTHER BIBLIOGRAPHY

Pierre P. Massion, Peter M. Taflan, Yu Shyr, S. M. Jamshedur Rahman, Pinar Yildiz,

Bashar Shakthour, Mary E. Edgerton, Mathew Ninan, Adriana L. Gonzalez: PIK3CA gene copy number and downstream phosphorylated Akt protein expression are involved in lung tumor development. Accepted for publication Am J Resp Crit Care Med, 2004

Carl R. Schmidt, John L. Tarpley, John R. Roberts, MD, A. Scott Pearson, Mark C. Kelley, MD, Mathew Ninan, R. Daniel Beauchamp, Nipun B. Merchant. Complete Response to Neoadjuvant Chemoradiation Therapy forEsophageal Cancer Does Not Improve Survival. Accepted for publication Annals of Surgical Oncology, 2004

Carsten Schröder, Frank Scholl, Emmanuel Daon, Andrea Goodwin, William H. Frist, John R. Roberts, Karla G. Christian,Aaron P. Milstone, Mathew Ninan, James E. Loyd .Modified bronchial anastomosis technique for lung transplantation,The Annals of Thoracic Surgery, Volume 75, Issue 6; 1697-1704, June 2003

Ninan M, et al. Long term outcome following aortocoronary connection for anomalous left coronary artery arising from the pulmonary artery – a twenty four year experience. J Amer. Coll. Cardiology 31(2) Spl. 190A, 1998

Ninan M et al. Standarized exercise oximetry predicts postpneumonectomy outcome.

Annals of Thoracic Surgery 64:328-333, Aug. 1997

Ninan M, Devita M, et al. Novel critical care strategies following minimally invasive lung reduction surgery. J Pennsylvania Ass. Thorac. Surg 8:122-125, 1997

Devita M, Sirio C, Ninan M, Keenan R. Ethical issues in the delivery of ICU care in a managed care era: lessons learned from minimally lung reduction surgery. Am. J. Res. Crit. Care Med. 155(4): 2(2) 1997

O’Keefe PA, Ninan M et al. Aortic valve replacement with the Jyros bileaflet prosthetic valve: early echocardiographic and radiological evaluation. J. Heart Valve Disease. 4 Suppl. 1: S77-9. July 1995

Ninan M. Minimally Invasive strategies for esophageal cancer staging. J Kerala Chapter Ass. Surg. India 15:207-210, Dec 1995

Ninan M, Hunter S, Parker DJ. Aortobronchial fistulae following aortic valve surgery. J Royal Soc. Med. 87(9):558-9, Sept. 1994

Ninan M, Treasure T. Pericardiectomy using ultrasonic dissector. Annals of Thoracic Surgery 58(1):233-5, July 1994

Ninan M, Treasure T. New strategies for coronary revascularization in the nineties. World J Cardiothoracic. Surg., 15:66-69, Feb 1993

Ninan M. Patterns of injury and surgical management of major hepatic injury in South Kerala, 1991. Dissertation accepted by the University of Kerala in partial fulfillment of the Master of Surgery degree

ABSTRACTS

Roman CD, Ninan M, Roberts JR. Parenchymal Sparing Sleeve Resection in Patients with Poor Pulmonary Function. Submitted to Southern Thoracic Surgical Association Annual Meeting, November 2004.

ACADEMIC PRESENTATIONS

Dummer S, Lazariashvili N, Barnes J, Milstone A, Ninan M. Antifungal Management after lung transplantation: survey of 37 Lung Transplant Centers. Presented to the International Society of Heart and Lung Transplantation Annual Meeting, ViennaAustria, 2003

Simian Virus-40 infection causing nephropathy and renal failure following lung transplantation. Milstone A, Vilchez RA, Geiger X, FogoAB, Ninan M, Dummer S. presented to the International Society of Heart and Lung Transplantation Annual Meeting, Vienna, Austria, 2003

Ninan M et al. Ethical issues in the delivery of ICU care in a managed care era: lessons learned from lung reduction surgery. Presented to the Annual Meeting of the American Thoracic Society. San Francisco 1997

Ninan M, Myers JL, et al. Long term outcome following aortocoronary connection for anomalous left coronary artery from the pulmonary artery – a twenty four year experience. Presented to the Annual Meeting of the American College of Cardiology, Atlanta, Georgia, March 1998

Ninan M. et al. Standardized exercise oximetry predicts postpneumonectomy outcome.

Presented to the Southern Thoracic Surgical Association Annual Meeting at Cancun, Mexico. November 1996

Ninan M, et al. Novel critical issues in minimally invasive lung reduction surgery. Presented to the Annual Conference of the Pennsylvania Association of Thoracic Surgery. Quebec City, Canada, 1997

Ninan M, Ferson P. A new minimally invasive staging protocol for esophageal cancer. Presented to the Pittsburgh Cardiothoracic Surgical Forum, Jan 1996

Ninan M, Hunter S, Parker DJ. Aortobronchial fistulae following aortic valve surgery. Presented to the Royal Society of Medicine, London, May 1994

Ninan M. Minimally invasive lung reduction surgery, the Pittsburgh experience. Presented to the faculty and students, Respiratory Care Program, Western School of Health, Pittsburgh, Pennsylvania, April 1996

Ninan M, Ferson P. Minimally invasive strategies for the treatment of lung cancer. Presented to the faculty and students, Respiratory Care Program, Western School of Health, Pittsburgh, Pennsylvania, May 1997

Ninan M, Thomas PA. Immunosuppressive strategies for heart transplantation. Presented to the Faculty of Surgery, Kerala University, India, April 1989

Ninan M. A strategy for minimally invasive cardiac and thoracic surgery in the next decade. Presented to the Medical Faculty, Medical Trust Hospital, Cochin, India, Nov. 1997

Ninan M. Minimally invasive staging criteria for esophageal cancer – early results.

Presented to the Oncology and Surgical Faculty, Regional Cancer Centre, Trivandrum, India, Nov. 1997

Ninan M, Thomas PA. Surgery for intrahepatic biliary lithiasis. Presented to the Annual Meeting of the Kerala Chapter of the Association of Surgeons of India, Sept. 1989

Ninan M. Outcome of patients after minimally invasive lung reduction surgery, the Pittsburgh experience. Presented to the Surgical Faculty, Medical College Hospital, University of Kerala, India, Nov. 1997

O’Keefe PA, Ninan M, et al. Early results of the Jyros valve. Presented to the Heart Valve Replacement – The Second Sheffield Symposium. Oct. 1994

O’Keefe PA, Ninan M, et al. The Jyros bileaflet prosthetic valve: clinical echocardiographic and radiological evaluation. Presented to the Cardiac Surgical Research Club, Nov. 1994

Roberts JR, Ninan M. Minimally invasive thoracoscopic management of empyema thoracis. Presented to the Annual Conference of the Southern Thoracic Surgical Association, San Antonio, Texas. 8 – 12 November 2001.

MAJOR INTERNATIONAL CONFERENCES ATTENDED

European Society of Cardiothoracic Surgery, October 1994, Amsterdam, The Netherlands.

Brompton Cardiothoracic Conference and Course, organized by Sir Magdi Yacoub, London, England, May 1995

The Toronto General Hospital Cardiac Course, Toronto, Canada, April 1996

Southern Thoracic Surgical Association Annual Conference, Cancun, Mexico, November 1996

Annual Conference of the American Thoracic Society, San Francisco, November 1997

Annual Conference of the PA Association of Thoracic Surgery, Quebec City, Canada, 1997

Annual Conference of the AmericanCollege of Cardiology, Atlanta, GA, March 1998.

Hellenic Lung Cancer Conference, Nicosia, Republic of Cyprus, April 1999.

Thoracic Conference of the University of Padua, Italy, March 2000

Annual conference of the American Association of Thoracic Surgery, Toronto, Canada May 2000

Toronto Thoracic Surgical Conference, Toronto, Canada, May 2001

International Society of Heart and Lung Transplantation, WashingtonD.C., April 2002

Society of Thoracic Surgeons Annual Meeting, 2003

Society of Thoracic Surgeons Annual Meeting, Feb 2004, San Antonio, TX