Table S III-B. Percent API Content in Unstable Formulations with Chemical Potency Below

Table S III-B. Percent API Content in Unstable Formulations with Chemical Potency below Acceptable Limit

Payload (P) / 14 Days (P 1) / 353 Days (P 2) / 596 Days (P 3) / 880 Days (P 4)
Medication / Label / USP / Control / Flight / Control / Flight / Control / Flight / Control / Flight / Control / Flight
Active Substance / (mg) / (%) / % a / ±SD b / % / ±SD / % / ±SD / % / ±SD / % / ±SD / % / ±SD / % / ±SD / % / ±SD / %/100 days c / r2 / %/100 days / r2
Amoxicillin/ / 875 / 90-120 / 116.2 / 0.35 / 116.0 / 0.14 / 100.1 / 0.05 / 102.3 / 0.33 / 97.2 / 0.37 / 88.0 / 0.68 / 96.4 / 0.47 / 87.0 / 0.41 / 2.26 / 0.796 / 3.57 / 0.918
/Clavulante / 125 / 90-120 / 93.3 / 0.59 / 91.0 / 0.79 / 12.0 / 0.43 / 36.7 / 0.33 / 6.60 / 0.16 / 21.1 / 1.10 / 3.3 / 0.31 / 9.1 / 2.07 / 10.1 / 0.732 / 9.37 / 0.906
Ciprofloxacin (SS) / 10.5 / 90-110 / 95.4 / 0.96 / 94.7 / 0.92 / 93.2 / 0.62 / 90.3 / 0.27 / 88.5 / 0.47 / 83.4 / 0.46 / 0.733 / 0.851 / 1.23 / 0.899
Ciprofloxacin (T) / 500 / 90-110 / 104.8 / 0.87 / 101.5 / 0.31 / 92.9 / 0.15 / 92.1 / 1.19 / 91.5 / 0.03 / 90.6 / 0.34 / 90.9 / 0.30 / 84.4 / 0.49 / 1.57 / 0.769 / 1.88 / 0.959
Clotrimazole / 120 / 90-110 / 98.7 / 0.34 / 98.4 / 0.16 / 96.4 / 0.15 / 95.2 / 0.26 / 95.3 / 0.38 / 93.1 / 0.93 / 90.3 / 0.31 / 87.3 / 0.61 / 0.926 / 0.911 / 1.24 / 0.952
Dextroamphetamine / 5 / 93-107 / 98.1 / 0.83 / 98.3 / 0.60 / 98.3 / 1.07 / 89.5 / 1.09 / 97.5 / 0.14 / 88.8 / 1.46 / 87.3 / 0.03 / 84.5 / 0.34 / 1.14 / 0.615 / 1.51 / 0.921
Epinephrine / 1 / 90-115 / 110.5 / 0.23 / 110.0 / 0.21 / 100.3 / 0.30 / 94.0 / 0.10 / 96.5 / 0.75 / 90.8 / 1.14 / 91.7 / 0.60 / 87.2 / 0.50 / 2.15 / 0.972 / 2.58 / 0.886
Fluconazole d / 150 / n/a / 96.3 / 0.51 / 96.0 / 0.27 / 96.0 / 0.09 / 94.2 / 0.39 / 91.7 / 0.40 / 90.2 / 0.69 / 89.9 / 0.84 / 88.2 / 0.60 / 0.808 / 0.869 / 0.952 / 0.958
Furosemide / 20 / 90-110 / 99.1 / 0.71 / 93.9 / 0.54 / 93.6 / 0.42 / 89.9 / 0.42 / 87.9 / 0.16 / 83.2 / 0.11 / 86.2 / 0.63 / 80.2 / 0.69 / 1.56 / 0.961 / 1.67 / 0.968
Levofloxacin d / 500 / n/a / 98.2 / 0.16 / 97.5 / 0.06 / 98.0 / 0.28 / 94.7 / 0.35 / 87.9 / 0.73 / 84.8 / 0.24 / 85.6 / 0.89 / 81.2 / 0.31 / 1.64 / 0.828 / 2.04 / 0.924
Levothyroxine / 0.025 / 90-110 / 92.3 / 0.66 / 88.6 / 0.51 / 90.7 / 0.80 / 86.5 / 0.13 / 83.7 / 0.78 / 75.4 / 0.29 / 75.3 / 0.14 / 72.3 / 0.30 / 2.00 / 0.900 / 2.07 / 0.894
Lidocaine / 100 / 95-105 / 100.4 / 0.72 / 99.6 / 0.59 / 98.7 / 1.14 / 95.6 / 1.68 / 95.3 / 1.18 / 94.0 / 1.45 / 0.550 / 0.860 / 0.651 / 0.999
Metoprolol / 50 / 90-110 / 101.9 / 1.30 / 98.0 / 0.51 / 95.3 / 0.20 / 88.9 / 0.56 / 92.1 / 0.38 / 87.6 / 0.26 / 91.7 / 0.93 / 86.9 / 0.88 / 1.20 / 0.881 / 1.25 / 0.796
Mupirocin / 440 / 90-110 / 98.2 / 0.16 / 99.0 / 0.42 / 94.3 / 0.24 / 89.3 / 0.36 / 87.0 / 0.56 / 82.9 / 0.14 / 1.20 / 0.873 / 1.83 / 0.994
W-norethindrone/ / 100 / 90-110 / 101.3 / 0.74 / 103.4 / 1.80 / 99.1 / 0.77 / 97.8 / 0.40 / 95.7 / 0.44 / 94.6 / 2.59 / 94.9 / 0.22 / 91.0 / 1.44 / 0.791 / 0.973 / 1.43 / 0.998
/P-ethinyl estradiol / 100 / 90-110 / 94.3 / 0.87 / 96.8 / 0.68 / 98.4 / 0.81 / 97.4 / 0.63 / 90.9 / 1.46 / 90.5 / 1.87 / 88.7 / 1.18 / 86.9 / 0.31 / 0.802 / 0.696 / 1.25 / 0.906
phenytoin / 100 / 95-105 / 100.9 / 0.51 / 98.5 / 0.84 / 98.5 / 0.31 / 96.4 / 0.30 / 95.3 / 0.57 / 92.2 / 0.41 / 93.8 / 0.42 / 90.4 / 0.29 / 0.853 / 0.978 / 0.987 / 0.960
Promethazine (T) / 25 / 95-110 / 95.6 / 0.21 / 95.4 / 0.31 / 93.2 / 0.22 / 91.6 / 0.17 / 93.2 / 0.17 / 88.7 / 0.03 / 87.5 / 0.37 / 83.7 / 0.26 / 0.851 / 0.832 / 1.33 / 0.986
Promethazine (SS) / 50 / 95-110 / 99.3 / 0.15 / 97.7 / 0.16 / 97.3 / 0.40 / 92.4 / 0.10 / 95.7 / 0.62 / 89.7 / 0.41 / 93.9 / 0.54 / 84.0 / 0.76 / 0.629 / 0.999 / 1.55 / 0.999
Promethazine (L) / 25 / 95-110 / 103.5 / 1.80 / 100.9 / 0.17 / 95.1 / 0.08 / 93.5 / 0.31 / 92.9 / 0.83 / 91.5 / 0.22 / 91.6 / 0.36 / 87.1 / 0.62 / 1.37 / 0.879 / 1.54 / 0.971
Risedronate d / 35 / n/a / 96.4 / 0.13 / 94.6 / 0.23 / 94.9 / 0.56 / 93.0 / 0.50 / 93.3 / 0.23 / 88.2 / 0.39 / 91.7 / 0.01 / 86.5 / 0.45 / 0.548 / 0.995 / 1.01 / 0.932
Sertraline d / 25 / n/a / 104.8 / 0.09 / 100.8 / 0.23 / 100.3 / 0.54 / 91.7 / 0.45 / 96.0 / 0.61 / 88.1 / 0.63 / 95.6 / 0.23 / 86.9 / 0.45 / 1.12 / 0.921 / 1.62 / 0.895
Silver Sulfadiazine / 250 / 90-110 / 97.5 / 1.33 / 96.0 / 1.00 / 93.5 / 0.28 / 92.6 / 0.51 / 90.5 / 0.36 / 89.8 / 0.61 / 88.3 / 0.15 / 83.9 / 0.05 / 1.08 / 0.991 / 1.37 / 0.965
Temazepam / 15 / 90-110 / 98.9 / 1.35 / 98.8 / 0.21 / 90.9 / 0.38 / 87.6 / 0.08 / 88.1 / 0.67 / 85.4 / 0.20 / 84.2 / 0.14 / 80.8 / 0.91 / 1.67 / 0.972 / 2.01 / 0.936
Sulfamethoxazole/ / 800 / 93-107 / 101.0 / 0.01 / 98.9 / 0.54 / 100.0 / 0.30 / 96.9 / 0.26 / 96.8 / 0.10 / 90.9 / 0.06 / 90.3 / 0.91 / 80.7 / 0.64 / 1.22 / 0.863 / 2.09 / 0.889
/Trimethoprim / 160 / 93-107 / 102.0 / 0.10 / 99.6 / 0.64 / 97.9 / 0.14 / 94.7 / 0.13 / 96.4 / 0.36 / 90.7 / 0.72 / 88.8 / 1.45 / 79.1 / 0.51 / 1.44 / 0.926 / 2.29 / 0.924

a %, Percentage of label content.

b Standard Deviation of Mean.

c %/100 days, rate of degradation.

d No USP method available; Limits were set at 90-110% for these formulations in this study; Numbers in red indicate below lower limit of % chemical content.