Supplemental Table 1. Correlations of age with clinical and pathological features of melanoma by stage.

Table 1. Clinicopathologic features of stage I and II melanoma in patients grouped by decade of age
Age / (years)
Factors / <20 / 20- / 30- / 40- / 50- / 60- / 70- / ≥80 / Total
# of pts / P-value
% Thickness (mm): / <0.0001
0-1.00 / 55.8 / 55.1 / 56.7 / 51.6 / 45.7 / 37.3 / 34.0 / 34.0 / 11,797
1.01-2.00 / 26.0 / 27.8 / 27.0 / 28.4 / 29.4 / 29.8 / 27.7 / 27.7 / 7,262
2.01-4.00 / 14.1 / 13.3 / 12.4 / 14.3 / 17.7 / 22.6 / 24.1 / 24.1 / 4,605
>4.00 / 4.0 / 3.8 / 3.9 / 5.7 / 7.2 / 10.3 / 14.1 / 14.1 / 2,070
Total
number of pts / 446 / 2,121 / 3,901 / 5,091 / 5,292 / 4,790 / 3,128 / 965 / 25,734
% Tumor Ulceration / <0.0001
Absent / 85.0 / 87.5 / 87.1 / 84.6 / 80.9 / 76.0 / 72.8 / 63.5 / 20,750
Present / 15.0 / 12.5 / 12.9 / 15.4 / 19.1 / 24.0 / 27.2 / 36.5 / 4,984
Total
number of pts / 446 / 2,121 / 3,901 / 5,091 / 5,292 / 4,790 / 3,128 / 965 / 25,734
% Mitotic rate (/mm2): / <0.0001
<1 / 29.7 / 33.5 / 35.6 / 31.5 / 28.8 / 23.0 / 17.5 / 16.4 / 2,814
1- / 50.3 / 50.4 / 46.6 / 47.9 / 47.1 / 45.8 / 45.6 / 36.6 / 4,766
5- / 11.9 / 10.6 / 11.9 / 13.0 / 15.1 / 18.1 / 19.1 / 24.2 / 1,568
³10 / 8.1 / 5.5 / 6.0 / 7.6 / 9.1 / 13.0 / 17.8 / 22.8 / 1,085
*Total
number of pts / 185 / 796 / 1509 / 1903 / 2073 / 1924 / 1392 / 451 / 10,233
% Primary site: / <0.0001
Head/neck / 19.1 / 14.6 / 13.5 / 14.1 / 16.3 / 21.9 / 29.1 / 36.7 / 4,814
Upper extremity / 19.3 / 19.1 / 20.4 / 22.0 / 22.3 / 23.5 / 24.4 / 22.3 / 5,693
Trunk / 41.5 / 40.7 / 40.1 / 39.2 / 38.9 / 35.6 / 28.9 / 19.6 / 9,464
Lower extremity / 20.2 / 25.6 / 26.0 / 24.7 / 22.5 / 18.9 / 17.6 / 21.5 / 5,763
Total
number of pts / 446 / 2,121 / 3,901 / 5,091 / 5,292 / 4,790 / 3,128 / 965 / 25,734
% by Gender: / <0.0001
Male / 47.5 / 39.8 / 43.8 / 49.0 / 58.0 / 61.6 / 62.8 / 57.8 / 13,805
Female / 52.5 / 60.2 / 56.2 / 51.0 / 42.0 / 38.4 / 37.2 / 42.2 / 11,929
Total
number of pts / 446 / 2,121 / 3,901 / 5,091 / 5,292 / 4,790 / 3,128 / 965 / 25,734

*Includes only patients with mitotic rate data available in the AJCC database for multivariate analysis.

Supplemental Table 2 Clinicopathologic features of stage III melanoma in grouped by decade of age.
Age / (years)
Factors / <20 / 20- / 30- / 40- / 50- / 60- / 70- / ≥80 / Total
# of pts / P-value
%by Metastatic Nodes: / 0.0467
1 node / 67.4 / 62.3 / 60.2 / 65.8 / 66.9 / 62.3 / 61.5 / 55.0 / 1,471
2-3 nodes / 21.7 / 31.4 / 30.7 / 27.9 / 23.9 / 26.8 / 26.5 / 26.7 / 629
³4 nodes / 10.9 / 6.3 / 9.1 / 6.3 / 9.3 / 11.0 / 11.9 / 18.3 / 213
Total
number of pts / 46 / 175 / 342 / 512 / 507 / 411 / 260 / 60 / 2,313
% Tumor burden / 0.0314
micrometastases / 78.3 / 80.6 / 85.1 / 83.0 / 81.7 / 78.4 / 77.7 / 68.3 / 1,872
macrometastases / 21.7 / 19.4 / 14.9 / 17.0 / 18.3 / 21.7 / 22.3 / 31.7 / 441
Total
number of pts / 46 / 175 / 342 / 512 / 507 / 411 / 260 / 60 / 2313
% Thickness (mm) / <0.0001
0-1.00 / 2.2 / 8.6 / 6.1 / 7.0 / 5.9 / 3.6 / 4.2 / 3.3 / 131
1.01-2.00 / 26.1 / 41.1 / 33.6 / 32.8 / 28.2 / 22.6 / 17.3 / 8.3 / 653
2.01-4.00 / 37.0 / 32.6 / 40.9 / 35.2 / 35.1 / 43.3 / 43.5 / 38.3 / 886
>4.00 / 34.8 / 17.7 / 19.3 / 25.0 / 30.8 / 30.4 / 35.0 / 50.0 / 643
Total
number of pts / 46 / 175 / 342 / 512 / 507 / 411 / 260 / 60 / 2,313
% Tumor Ulceration / <0.0001
Absent / 56.5 / 66.3 / 59.9 / 59.4 / 50.1 / 53.5 / 43.9 / 36.7 / 1,261
Present / 43.5 / 33.7 / 40.1 / 40.6 / 49.9 / 46.5 / 56.2 / 63.3 / 1,052
Total
number of pts / 46 / 175 / 342 / 512 / 507 / 411 / 260 / 60 / 2,313
% Mitotic rate (/mm2) / 0.0214
<1 / 0 / 3.8 / 4.3 / 1.3 / 1.2 / 1.5 / 2.7 / 0 / 16
1- / 62.5 / 54.7 / 58.3 / 51.0 / 51.2 / 47.1 / 36.9 / 37.0 / 383
5- / 18.8 / 28.3 / 22.6 / 29.5 / 21.4 / 31.6 / 25.2 / 40.7 / 206
³10 / 18.8 / 13.2 / 14.8 / 18.1 / 26.2 / 19.9 / 35.1 / 22.2 / 170
*Total
number of pts / 16 / 53 / 115 / 149 / 168 / 136 / 111 / 27 / 775
% Primary site / <0.0001
Head/neck / 32.6 / 16.6 / 12.0 / 13.1 / 12.0 / 16.8 / 16.5 / 20.0 / 337
Upper extremity / 15.2 / 17.7 / 13.5 / 15.6 / 15.8 / 16.1 / 21.5 / 21.7 / 379
Trunk / 34.8 / 38.3 / 46.5 / 47.1 / 43.8 / 36.7 / 33.8 / 18.3 / 955
Lower extremity / 17.4 / 27.4 / 28.1 / 24.2 / 28.4 / 30.4 / 28.1 / 40.0 / 642
Total
number of pts / 46 / 175 / 342 / 512 / 507 / 411 / 260 / 60 / 2,313
% by Gender / <0.0001
Male / 60.9 / 46.3 / 58.5 / 62.9 / 65.1 / 69.8 / 65.4 / 56.7 / 1,452
Female / 39.1 / 53.7 / 41.5 / 37.1 / 34.9 / 30.2 / 34.6 / 43.3 / 861
Total
number of pts / 46 / 175 / 342 / 512 / 507 / 411 / 260 / 60 / 2,313

*Includes only patients with mitotic rate data available in the AJCC database for multivariate analysis.

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