Supplementary Table 1 for Fig. 1

Supplementary Table 1 for Fig. 1.

OP-to-BI
ratio / Exp. No. / Mean life span / Maximum life span / No. of nematodes / Log-rank test
± SE (days old) / ± SE (days old) / (No. of lost worms) / p value
OP (control) / 1 / 12.37 ± 0.49 / 17.23 ± 0.24 / 76 (1)
1:1 / 13.88 ± 0.46 / 19.12 ± 0.38 / 86 (4) / 0.01184
2:3 / 14.03 ± 0.44 / 19.10 ± 0.27 / 98 (2) / 0.00268
3:7 / 14.52 ± 0.49 / 20.29 ± 0.28 / 93 (1) / 0.00011
1:4 / 15.16 ± 0.45 / 19.25 ± 0.28 / 83 (4) / 0.00001
OP (control) / 2 / 13.40 ± 0.44 / 18.20 ± 0.26 / 68 (1)
1:1 / 14.02 ± 0.48 / 18.70 ± 0.25 / 67 (3) / 0.17321
2:3 / 14.41 ± 0.58 / 20.70 ± 0.49 / 68 (1) / 0.01501
3:7 / 14.34 ± 0.52 / 18.83 ± 0.33 / 62 (3) / 0.06154
1:4 / 14.99 ± 0.45 / 19.68 ± 0.40 / 71 (3) / 0.00706
OP (control) / 3 / 13.39 ± 0.45 / 18.05 ± 0.55 / 73 (0)
1:1 / 13.62 ± 0.43 / 17.50 ± 0.30 / 68 (1) / 0.93016
3:7 / 14.46 ± 0.45 / 18.59 ± 0.44 / 71 (0) / 0.10860
1:4 / 14.82 ± 0.49 / 19.77 ± 0.41 / 73 (3) / 0.01125
OP (control) / 4 / 12.81 ± 0.49 / 17.50 ± 0.19 / 71 (0)
1:1 / 14.50 ± 0.50 / 19.14 ± 0.31 / 70 (2) / 0.00375
3:7 / 14.73 ± 0.44 / 19.23 ± 0.27 / 73 (1) / 0.00354
1:4 / 14.68 ± 0.46 / 19.14 ± 0.20 / 72 (1) / 0.00337
OP (control) / 5 / 13.75 ± 0.50 / 18.39 ± 0.20 / 63 (1)
3:7 / 15.25 ± 0.66 / 20.61 ± 0.35 / 59 (1) / 0.00141
1:4 / 15.85 ± 0.49 / 19.94 ± 0.29 / 62 (0) / 0.00099
OP (control) / 6 / 13.50 ± 0.42 / 17.72 ± 0.52 / 59 (1)
3:7 / 16.22 ± 0.49 / 20.94 ± 0.41 / 58 (2) / 0.00004
1:4 / 16.10 ± 0.54 / 21.06 ± 0.38 / 60 (0) / 0.00001

Supplementary Table 2for Fig. 8a.

OP-to-BI
ratio / Exp. No. / Mean life span / Max. life span / No. of nematodes / Log-rank test
± SE (days old) / ± SE (days old) / (No. of lost worms) / p value
OP (control) / 1 / 15.50 ± 0.42 / 19.68 ± 0.18 / 76 (0)
0:10
(whole cell) / 20.55 ± 0.42 / 24.95 ± 0.28 / 75 (3) / 6.26472E-14
1:4
(whole cell) / 17.57 ± 0.48 / 22.23 ± 0.24 / 76 (0) / 1.49111E-05
1:4
(cell wall) / 17.84 ± 0.53 / 22.20 ± 0.30 / 64 (1) / 5.30747E-06
OP (control) / 2 / 13.62 ± 0.53 / 18.90 ± 0.31 / 68 (2)
0:10
(whole cell) / 18.43 ± 0.57 / 24.20 ± 0.47 / 67 (3) / 1.00742E-09
1:4
(whole cell) / 15.75 ± 0.49 / 20.80 ± 0.37 / 69 (1) / 0.00464
1:4
(cell wall) / 16.78 ± 0.51 / 22.10 ± 0.52 / 69 (1) / 2.84866E-05
OP (control) / 3 / 14.30 ± 0.62 / 20.86 ± 0.45 / 70 (0)
0:10
(whole cell) / 18.25 ± 0.71 / 25.50 ± 0.42 / 67 (3) / 7.26630E-06
1:4
(whole cell) / 17.33 ± 0.56 / 22.80 ± 0.58 / 69 (1) / 0.00075
1:4
(cell wall) / 17.35 ± 0.59 / 23.30 ± 0.47 / 68 (2) / 0.00052

Supplementary Table 3for Fig. 8b.

OP-to-BI
ratio / Exp.
No. / Mean life span / Max. life span / No. of nematodes / Log-rank test
± SE (days old) / ± SE (days old) / (No. of lost worms) / p value
OP (control) / 1 / 13.45 ± 0.48 / 18.83 ± 0.47 / 60 (2)
0:10
(whole cell) / 16.20 ± 0.55 / 21.25 ± 0.25 / 54 (8) / 0.00029
0:10 (protoplast) / 16.75 ± 0.47 / 20.83 ± 0.17 / 60 (1) / 0.00001
OP (control) / 2 / 13.98 ± 0.50 / 19.10 ± 0.48 / 66 (4)
0:10
(whole cell) / 16.74 ± 0.67 / 23.61 ± 0.48 / 63 (7) / 1.47589E-04
0:10 (protoplast) / 17.28 ± 0.64 / 23.10 ± 0.37 / 64 (6) / 3.73129E-06
OP (control) / 3 / 14.80 ± 0.54 / 20.77 ± 0.33 / 74 (0)
0:10
(whole cell) / 19.15 ± 0.62 / 24.20 ± 0.21 / 66 (8) / 2.64293E-08
0:10 (protoplast) / 19.61 ± 0.62 / 23.50 ± 0.19 / 54 (18) / 7.62211E-09

Supplementary Table 4for Fig. 9a.

Mutants / Exp. No. / Mean life span / Max. life span / No. of nematodes / Log-rank test
± SE (days old) / ± SE (days old) / (No. of lost worms) / p value
Δpmk-1 OP / 1 / 12.26 ± 0.58 / 17.83 ± 0.44 / 58 (2) / 0.05244
Δpmk-1 BI / 13.27 ± 0.75 / 20.38 ± 0.30 / 53 (7)
Δpmk-1 OP / 2 / 12.65 ± 0.56 / 17.61 ± 0.45 / 62 (1) / 0.06013
Δpmk-1 BI / 12.92 ± 0.78 / 19.75 ± 0.31 / 52 (8)

Supplementary Table 5for Fig. 9b.

Mutants / Exp. No. / Mean life span / Max. life span / No. of nematodes / Log-rank test
± SE (days old) / ± SE (days old) / (No. of lost worms) / p value
Δskn-1 OP / 1 / 15.37 ± 0.53 / 19.86 ± 0.28 / 75 (0) / 0.76058
Δskn-1 BI / 15.60 ± 0.51 / 20.30 ± 0.33 / 68 (6)
Δskn-1 OP / 2 / 12.99 ± 0.34 / 17.57 ± 0.30 / 97 (1) / 0.47597
Δskn-1 BI / 13.49 ± 0.35 / 18.00 ± 0.53 / 82 (17)

Supplementary Table 6for Fig. 9c.

Mutants / Exp. No. / Mean life span / Max. life span / No. of nematodes / Log-rank test
± SE (days old) / ± SE (days old) / (No. of lost worms) / p value
Δvhp-1 OP / 1 / 11.41 ± 0.30 / 14.06 ± 0.24 / 58 (3) / 0.03469
Δvhp-1 BI / 12.39 ± 0.31 / 15.50 ± 0.27 / 56 (4)
Δvhp-1 OP / 2 / 11.28 ± 0.38 / 15.17 ± 0.29 / 59 (1) / 0.01460
Δvhp-1 BI / 12.88 ± 0.32 / 15.94 ± 0.18 / 58 (2)

Supplementary Table 7for Fig. 9d

Mutants / Exp. No. / Mean life span / Max. life span / No. of nematodes / Log-rank test
± SE (days old) / ± SE (days old) / (No. of lost worms) / p value
Δtol-1 OP (control) / 1 / 16.45 ± 0.61 / 22.61 ± 0.56 / 61 (1) / 2.60178E-13
Δtol-1 BI / 25.56 ± 0.97 / 32.63 ± 0.55 / 54 (7)
Δtol-1 OP (control) / 2 / 16.98 ± 0.65 / 22.25 ± 0.25 / 56 (5) / 5.15364E-08
Δtol-1 BI / 22.06 ± 1.03 / 30.38 ± 0.48 / 55 (5)

Supplementary Table 8for Fig. 9e.

Mutants / Exp. No. / Mean life span / Max. life span / No. of nematodes / Log-rank test
± SE (days old) / ± SE (days old) / (No. of lost worms) / p value
Δtir-1 OP / 1 / 18.73 ± 0.80 / 25.75 ± 0.56 / 53 (7) / 0.00102
Δtir-1 BI / 22.33 ± 0.98 / 29.50 ± 0.73 / 41 (19)
Δtir-1 OP / 2 / 17.64 ± 0.70 / 24.06 ± 0.38 / 58 (2) / 0.00861
Δtir-1 BI / 21.29 ± 1.08 / 30.25 ± 0.85 / 28 (32)
Δtir-1 OP / 3 / 17.01 ± 0.81 / 24.38 ± 0.61 / 55 (5) / 2.45191E-05
Δtir-1 BI / 21.97 ± 1.11 / 29.50 ± 0.82 / 38 (22)

Supplementary Table 9for Fig. 10a.

Mutants / Exp. No. / Mean life span / Max. life span / No. of nematodes / Log-rank test
± SE (days old) / ± SE (days old) / (No. of lost worms) / p value
Δdaf-16 OP / 1 / 12.83 ± 0.46 / 16.80 ± 0.15 / 64 (1) / 3.35175E-11
Δdaf-16 BI / 18.20 ± 0.62 / 23.63 ± 0.40 / 56 (7)
Δdaf-16 OP / 2 / 13.48 ± 0.51 / 18.38 ± 0.40 / 56 (4) / 7.81899E-09
Δdaf-16 BI / 19.63 ± 0.95 / 25.33 ± 0.65 / 40 (20)

Supplementary Table 10for Fig. 10b.

Mutants / Exp. No. / Mean life span / Max. life span / No. of nematodes / Log-rank test
± SE (days old) / ± SE (days old) / (No. of lost worms) / p value
Δdaf-2 OP / 1 / 21.56 ± 0.59 / 28.38 ± 0.31 / 104 (1) / 0.45249
Δdaf-2 BI / 22.97 ± 0.48 / 29.43 ± 0.53 / 97 (10)
Δdaf-2 OP / 2 / 25.87 ± 0.85 / 36.10 ± 0.85 / 65 (0) / 0.02491
Δdaf-2 BI / 28.32 ± 1.13 / 39.25 ± 0.67 / 56 (6)

Supplementary Table 11for Fig. 10c.

Mutants / Exp. No. / Mean life span / Max. life span / No. of nematodes / Log-rank test
± SE (days old) / ± SE (days old) / (No. of lost worms) / p value
Δjnk-1 OP / 1 / 15.25 ± 0.58 / 21.06 ± 0.34 / 63 (0) / 2.55585E-08
Δjnk-1 BI / 21.31 ± 0.89 / 29.50 ± 0.57 / 54 (5)
Δjnk-1 OP / 2 / 16.43 ± 0.56 / 21.72 ± 0.46 / 58 (2) / 0.00013
Δjnk-1 BI / 18.64 ± 1.05 / 27.94 ± 0.69 / 57 (3)

Supplementary Table 12for Fig. 10d.

Mutants / Exp. No. / Mean life span / Max. life span / No. of nematodes / Log-rank test
± SE (days old) / ± SE (days old) / (No. of lost worms) / p value
Δaak-2 OP (control) / 1 / 13.54 ± 0.63 / 19.72 ± 0.32 / 57 (3) / 6.12868E-07
Δaak-2 BI / 18.22 ± 0.84 / 24.07 ± 0.43 / 46 (13)
Δaak-2 OP (control) / 2 / 14.83 ± 0.54 / 20.50 ± 0.60 / 57 (4) / 3.52659E-06
Δaak-2 BI / 18.77 ± 0.73 / 24.21 ± 0.18 / 49 (11)

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