Supplementary citations:
Drosophila Dpp plays a role in a plethora of developmental processes, such as dorsoventral patterning of the embryo (Mizutani et al., 2005; O'Connor et al., 2006; Shimmi et al., 2005; Wang and Ferguson, 2005), wing venation (O'Connor et al., 2006; Ralston and Blair, 2005; Sotillos and De Celis, 2005; Sotillos and de Celis, 2006), imaginal disc patterning (Hsiung et al., 2005; Kim et al., 2006; Shen and Dahmann, 2005b), growth of the wing and haltere (Crickmore and Mann, 2006; de Navas et al., 2006; Makhijani et al., 2006; Mohit et al., 2006; Rogulja and Irvine, 2005), morphogenesis of the leg (Joshi et al., 2006; Manjon et al., 2007), development of the eye (Bessa and Casares, 2005; Vrailas and Moses, 2006), egg shell patterning (see Berg, 2005 for review), cytoskeletal remodelling in wing disc cells and follicle cells (Gibson and Perrimon, 2005; Shen and Dahmann, 2005a; Wahlstrom et al., 2006), the development of neurosecretory cells in the brain (de Velasco et al., 2006), the maintenance of germ-line stem cells (reviewed in Lin, 2002), development of the ventral head and proboscis (Stultz et al., 2006; Yasunaga et al., 2006), and even neoplastic tumor formation (Perez-Garijo et al., 2005), (see Parker et al., 2004 for review of the older literature).
Berg, C. A. (2005). The Drosophila shell game: patterning genes and morphological change. Trends Genet 21, 346-55.
Bessa, J. and Casares, F. (2005). Restricted teashirt expression confers eye-specific responsiveness to Dpp and Wg signals during eye specification in Drosophila. Development 132, 5011-20.
Crickmore, M. A. and Mann, R. S. (2006). Hox control of organ size by regulation of morphogen production and mobility. Science 313, 63-8.
de Navas, L. F., Garaulet, D. L. and Sanchez-Herrero, E. (2006). The Ultrabithorax Hox gene of Drosophila controls haltere size by regulating the Dpp pathway. Development 133, 4495-506.
de Velasco, B., Erclik, T., Shy, D., Sclafani, J., Lipshitz, H., McInnes, R. and Hartenstein, V. (2006). Specification and development of the pars intercerebralis and pars lateralis, neuroendocrine command centers in the Drosophila brain. Dev Biol.
Gibson, M. C. and Perrimon, N. (2005). Extrusion and death of DPP/BMP-compromised epithelial cells in the developing Drosophila wing. Science 307, 1785-9.
Hsiung, F., Ramirez-Weber, F. A., Iwaki, D. D. and Kornberg, T. B. (2005). Dependence of Drosophila wing imaginal disc cytonemes on Decapentaplegic. Nature 437, 560-3.
Joshi, M., Buchanan, K. T., Shroff, S. and Orenic, T. V. (2006). Delta and Hairy establish a periodic prepattern that positions sensory bristles in Drosophila legs. Dev Biol 293, 64-76.
Kim, S., Chung, S., Yoon, J., Choi, K. W. and Yim, J. (2006). Ectopic expression of Tollo/Toll-8 antagonizes Dpp signaling and induces cell sorting in the Drosophila wing. Genesis 44, 541-9.
Lin, H. (2002). The stem-cell niche theory: lessons from flies. Nat Rev Genet 3, 931-40.
Makhijani, K., Kalyani, C., Srividya, T. and Shashidhara, L. S. (2006). Modulation of Decapentaplegic gradient during haltere specification in Drosophila. Dev Biol.
Manjon, C., Sanchez-Herrero, E. and Suzanne, M. (2007). Sharp boundaries of Dpp signalling trigger local cell death required for Drosophila leg morphogenesis. Nat Cell Biol 9, 57-63.
Mizutani, C. M., Nie, Q., Wan, F. Y., Zhang, Y. T., Vilmos, P., Sousa-Neves, R., Bier, E., Marsh, J. L. and Lander, A. D. (2005). Formation of the BMP activity gradient in the Drosophila embryo. Dev Cell 8, 915-24.
Mohit, P., Makhijani, K., Madhavi, M. B., Bharathi, V., Lal, A., Sirdesai, G., Reddy, V. R., Ramesh, P., Kannan, R., Dhawan, J. et al. (2006). Modulation of AP and DV signaling pathways by the homeotic gene Ultrabithorax during haltere development in Drosophila. Dev Biol 291, 356-67.
O'Connor, M. B., Umulis, D., Othmer, H. G. and Blair, S. S. (2006). Shaping BMP morphogen gradients in the Drosophila embryo and pupal wing. Development 133, 183-93.
Perez-Garijo, A., Martin, F. A., Struhl, G. and Morata, G. (2005). Dpp signaling and the induction of neoplastic tumors by caspase-inhibited apoptotic cells in Drosophila. Proc Natl Acad Sci U S A 102, 17664-9.
Ralston, A. and Blair, S. S. (2005). Long-range Dpp signaling is regulated to restrict BMP signaling to a crossvein competent zone. Dev Biol 280, 187-200.
Rogulja, D. and Irvine, K. D. (2005). Regulation of cell proliferation by a morphogen gradient. Cell 123, 449-61.
Shen, J. and Dahmann, C. (2005a). Extrusion of cells with inappropriate Dpp signaling from Drosophila wing disc epithelia. Science 307, 1789-90.
Shen, J. and Dahmann, C. (2005b). The role of Dpp signaling in maintaining the Drosophila anteroposterior compartment boundary. Dev Biol 279, 31-43.
Shimmi, O., Umulis, D., Othmer, H. and O'Connor, M. B. (2005). Facilitated transport of a Dpp/Scw heterodimer by Sog/Tsg leads to robust patterning of the Drosophila blastoderm embryo. Cell 120, 873-86.
Sotillos, S. and De Celis, J. F. (2005). Interactions between the Notch, EGFR, and decapentaplegic signaling pathways regulate vein differentiation during Drosophila pupal wing development. Dev Dyn 232, 738-52.
Sotillos, S. and de Celis, J. F. (2006). Regulation of decapentaplegic expression during Drosophila wing veins pupal development. Mech Dev 123, 241-51.
Stultz, B. G., Lee, H., Ramon, K. and Hursh, D. A. (2006). Decapentaplegic head capsule mutations disrupt novel peripodial expression controlling the morphogenesis of the Drosophila ventral head. Dev Biol 296, 329-39.
Vrailas, A. D. and Moses, K. (2006). Smoothened, thickveins and the genetic control of cell cycle and cell fate in the developing Drosophila eye. Mech Dev 123, 151-65.
Wahlstrom, G., Norokorpi, H. L. and Heino, T. I. (2006). Drosophila alpha-actinin in ovarian follicle cells is regulated by EGFR and Dpp signalling and required for cytoskeletal remodelling. Mech Dev.
Wang, Y. C. and Ferguson, E. L. (2005). Spatial bistability of Dpp-receptor interactions during Drosophila dorsal-ventral patterning. Nature 434, 229-34.
Yasunaga, K., Saigo, K. and Kojima, T. (2006). Fate map of the distal portion of Drosophila proboscis as inferred from the expression and mutations of basic patterning genes. Mech Dev 123, 893-906.
Gbb/Scw sequences:
>MmusBMP5
MHWTVFLLRGIVGFLWSGWVQVGYAKGGLGDNHVHSSFIYRRLRNHERREIQREILSILGLPHRPRPFSPGKQASSAPLFMLDLYNAMASEDNPEESEYLVRVSLAGEAKETRKGYPASPNGYAHRLHLPPRTPLTTQSPPLASLHDTNFLNDADMVMSFVNLVERDKDFSHQRRHYKEFRFDLTQIPHGEAVTAAEFRIYKDKGNHRFENETIKISIYQIIKEYTNRDADLFLLDTRKTQALDVGWLVFDITVTSNHWVINPQNNLGLQLCAETGDGRSINVKSAGLVGRHGPQSKQPFMVAFFKASEVLLRSVRAASKRKNQNRNKSNSHQDPSRMPSAGDYNTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGCH
>MmusBMP6
mpglgrraqwlcwwwgllcscgppplrpplpvaaaaaggqllgaggspvraeqpppqssssgflyrrlkthekremqkeilsvlglphrprplhglqqpqppvlppqqqqqqqqqqtareepppgrlksaplfmldlynalsnddeedgasegvgqepgshggasssqlrqpspgaahslnrksllapgpgggaspltsaqdsaflndadmvmsfvnlveydkefsphqrhhkefkfnlsqipegeavtaaefrvykdcvvgsfknqtflisiyqvlqehqhrdsdlflldtrvvwaseegwlefditatsnlwvvtpqhnmglqlsvvtrdglhvnpraaglvgrdgpydkqpfmvaffkvsevhvrttrsassrrrqqsrnrstqsqdvsrgsgssdyngselktackkhelyvsfqdlgwqdwiiapkgyaanycdgecsfplnahmnatnhaivqtlvhlmnpeyvpkpccaptklnaisvlyfddnsnvilkkyrnmvvracgch
>MmusBMP7
mhvrslraaaphsfvalwaplfllrsaladfsldnevhssfihrrlrsqerremqreilsilglphrprphlqgkhnsapmfmldlynamaveesgpdgqgfsypykavfstqgpplaslqdshfltdadmvmsfvnlvehdkeffhpryhhrefrfdlskipegeavtaaefriykdyirerfdnetfqitvyqvlqehsgresdlflldsrtiwaseegwlvfditatsnhwvvnprhnlglqlsvetldgqsinpklagligrhgpqnkqpfmvaffkatevhlrsirstggkqrsqnrsktpknqealrmasvaensssdqrqackkhelyvsfrdlgwqdwiiapegyaayycegecafplnsymnatnhaivqtlvhfinpdtvpkpccaptqlnaisvlyfddssnvilkkyrnmvvracgch
>MmusBMP8
mamrpgplwllglalcalggghgprpphtcpqrrlgarerrdmqreilavlglpgrprpraqpaaarqpasaplfmldlyhamtddddggppqahlgradlvmsfvnmverdrtlgyqephwkefhfdltqipageavtaaefriykepsthplnttlhismfevvqehsnresdlffldlqtlrsgdegwlvlditaasdrwllnhhkdlglrlyvetadghsmdpglagllgrqaprsrqpfmvtffrasqspvrapraarplkrrqpkktnelphpnklpgifddghgsrgrevcrrhelyvsfrdlgwldwviapqgysayycegecafpldscmnatnhailqslvhlmkpdvvpkaccaptklsatsvlyydssnnvilrkhrnmvvkacgch
>AmelGbb
MSPRRLAPLLILGTILAGLTSTAAADRMSGLYVDNGFDQTIVHR
VVSQREKREVEHEILNLLGLPDRPRNTAGRPPQVKRSAPKFLLDIYKNALGEDEDEKP
IGEQQRRAGEFDLTGQDLRAIDQSDVIMTFAAHNHHVAGVRHERGKRLWFDVSEVPPG
EHIIGAELRLYRSMDVKNRRNRGSYMITAYRVLRTEDGTRELQYVDAVNTTTGKEGWL
TLNISESLSHWVNNPDGNKGLYLSVHPADRSVHEMRPEDIGILAFRGDPDKQPFMVGY
FKSSGIRESKVRQKRDARRRKKSESSSLDYRNNPYTDPGTQYNSRTCKIQTLYVSFRD
LKWQDWIIAPDGYDAYYCSGECNFPLNAHMNATNHAIVQTLVHLVSPGKVPKPCCAPT
KLSPISVLYFLDESNVILKKYKNMVVKSCGCH
>NvitGbb
SGLYVDNGYDQTVVHRVITQREKREVEHEILNLLGLPDRPPKHKANSAGPQVKRSAPKFL
LDIYRNGLADEESREHQTEFGLSGQDLRAIDQSDV
IMTFAAHNHHVPSVRHERGKRLWFDVSEVPENEHMINAELRLYRSLDQAKSAKNRGAFT
LTAYRVLRLEDGERELQYIDAVNATAGREGWLSLNVSEALQYWVANPAGNRGLYLSVHPA
DRQVHEMKPEDIGVVGFRGVAERQPFMVAFFKSSG-IRSRAAAAKSRQKRDAKRKKKAEI
SSLDYRSNPYTDPQIQYNSRTCKIQTLYVSFRDLQWQDWIIAPDGYDAYYCSGECNFPLN
AHMNATNHAIVQTLVHLVNPGKVPKPCCAPTKLSPISVLYFLDESNVILKKYKNMVVKSCGCH
>TcasGbb1
MNFVLVLSLVLGEALCWSKAGIYIDNGLNQTVIDREMTTSEKQEMEMEILNLLGLPERPKRVSNSLKRSAPKFLLDIYKSLMEEENEGHSRSERSADLNLSGDEQNAIDESDVIMTFESINHHVSSVRHERGKRLWFNVSEMPIAENVVGAELRIYQKEIHSPKKARNVYTVTVFELVNTDSGERELEYISAVNTTGSFTGWLNLNLTACLPTWVAFPDSNKGLYLSVHPVDKPGREIRPEDIGLITVKGEDETQPFMVAFLKASNHVQPKRSIRDLSSKRRVRKSNYVEMMLSDNPHYGSTCKMYDLYISFKDLKWQDWIIAPAGYSAHYCAGECKFPLNGHMNATNHAIVQTLVHLMYPNKYPKPCCAPTKLTPISVLYFQDDTNVILKKYKKMSVKSCGCH
>TcasGbb2
MKVVVASFVLLLVFREVSTFLKSGIYLDNGFDQTSIGQLGDQQIQLEVLNLLGLPNRPKKINNSVTKSAAKYILDIYNSLMEKIDGHSSRRKRSAGVNLSSEEETAVENSDVIMTFEAIRNSEKKFKRLEKGKKLWFNVSEMSVAEDVISAELKIFQKGAPKRAGNVYAVVVMIEKPGREIRPEEIGLTTSTNPFIVAFLKASTRVQPQRNVRSVSPKQNYVSTMKQYQHGTTCRIHTLYISFKDLKWQDWVIAPEGYAAYYCAGECNFPLTAHMNATKHALVQSLVHLIQPHKFPKPCCAPTELRPIPLVYYLDAGTSNVVLKKYSNMAVKSCGCH
>AgamGbb
mfrkyslcaaaivlyvliglvsstgfyidngvdqtvreksvelherqeieheilellglp
drpnkqhvhpslrksapqfllniyhkfteemnggrrrkryadganlltiaderaigesdv
imsflnkanrhlpkirhhrgghrlwfdtaeidaerdnnqllyaslrmyknrtterpwdai
vrgrqivvrasliggydaakdghrlelvaeqsvpynydgwvelnatqamqrwvvervank
gifvevyyaesprkeilphevglilsnrfgryqpflvgyckgpelvkptaalaggsgtvg
grskrsvrrkagtgtgkrsdrvrnpflerfggggerhkscqiqtlyvsfrdlnwqdwiia
pdgfgaffcfgecnfplnthmnatnhaliqtlvhlmhptrvpkpccaptklnpisvlyhi
ddaninlkkyknmvvkscgcl
>AaegGbb
mnlhillitvvhlvrctgasssgfyidngqgqtvretaitaedrqeieheildllglpdr
pnkehihpslrksapqfllniylkfseeingenrgrrvarnalysnsdlftladqraiee
sdwirtflnkghvnmpkvrhhrygerlvfdtseaasdgalllfaslkvyknlthdylnai
tngrlitirtslikgydsgrnmhemdllaehtlpydyqgwieinatnmmdrwiseslknk
gifvevfytespqkqvrpqnvglilsnkfgryqpflvsyykgrdlvkptphvsrskrsvg
npnqrkkpikktvrprnpllekwaikekscqihtlyvsfrelnwqdwiiapdgfgayfch
gecsfplnthmnatnhaliqtlvhlmhpasvpkpccaptkltpisvlyhiddaninlkky
knmvvkscgcl
>CpipGbb
VVAMITGALILLVVALRGALAVSGIYVDNGVSQTIRQNAITLHDRQEIEHEILDLL
GLPDRPNSKHIHPSLRKSAPQFLLNIYHKQLDAAKGRGRGRRQRDTGSV
YSRSLLTIADERVIEESDVIMTFLNKGHKDLPKIRHRRYGERLWFDTSETSADGA
MQLYASLRIYKNSTIDDWNAITSGRLITVRASLIREYNAKRGEHNLELIAEHTVPYNYEG
WLEINVTDAMDRWMTNRIGNKGIFVDAYYNERPSKNVRPQDFGLILSNKYGRYQPFLVSY
CKGRELVKPTTHNNRSKRSVVKNSPRKAPKKSLKPKNPFLERWTQKEKSCQIHTLYVS
FRDLNWQDWIIAPDGFGAFFCHGDCNFPLNTHMNATNHALIQTLVHLIHPNSVPKPCCAP
TKLNPISVLYHIDDANINLKKYKNMVVKSCGC
>DgriGbb
MLWLLLIISTVPYTQPTQSGIYIDNGKDQTVMQRVLTDDDKLDVSYEILEFLGISDRPLH
HKNHGLSLRKSAPKFLLDVYNRITAEEGLNKNNDHHRSKRDADEEDESEQN
FITDLDKRAIDESDIIMTFLNKRNHNVEEMRHEHGRRLWFDVTNVPGDNYLMMSELRIYQ
NSNEGKWLTTNKQFTVTVYMIQTGGLSQNNLEPLSSVNTTGDYVGWLELNVTEALHDWLT
NAKENHGIYIGAHAINKPDREIKLDDIGLIHHRVKVDDEYQPFMIGFFRGPELIRATAST
THSNQKRTKRSALHQRKKNKSEPSVNPFVDNPIENTRSCQMQTLYIDFKDLGWHDWIIAP
DGYGAFYCSGECNFPLNAHMNATNHAIVQTLVHLLEPKRVPKPCCAPTKLGALPVLYHLN
DENVNLKKYRNMIVKSCGCH
>DvirGbb
RIMTASLVVLPSLWLILIIFTAPHTHCTQSGIYIDNGKDQTVMERVLTDDDKLDV
SHEILEFLGIAARPLHHKSHGLSLRKSAPKFLLDVYYRITAEEGLAIKNKSDHSRS
KRDANESEQNFITDLDKRAIDESDIIMTFLNKRNHNVEEMRHEHGRRLWFDVNN
IPTDNYLMMAELRIYQNSNEGKWTTTNKQFTVTVYMLRSGGSAPNMLEPLSSVNTTGDYV
GWLELNVTEALHDWRVNSNENHGIYIGAHALNKPEREIKLDDIGLIHRRTKVDDENQPFM
IGFFRGPELIKSTSGHSTQKRTKRSTLHQRKKSKS-EPVNPFIENSIENTRSCQMQTLYI
DFKDLGWHDWIIAPEGYGAFYCSGECNFPLNAHMNATNHAIVQTLVHLLEPKRVPKPCCA
PTRLGALPVLYHLNDENVNLKKYRNMIVKSCGCH
>DmojGbb
VQNTMTPSIGVLPTLFAVIFIIFIAPQAESTQSGIYVDNGKDQTVMQRVLTDEDKL
DVSYEILEFLGIADRPMHHRNHGLSLRKSAPKFLLDVYNRITAEEGLTIQSSNE
HSRSKRDLNENEQNFITDLDKRAIDESDIIMTFLNKRNHNVEEMRHEHGRRLWFDV
SNIPNDNYLMMSELRIYQNSNEGKWMTTNKQFTVTVYMIRSSGSSQNTLEPLSSVNTTGD
YVGWLELNVTEALHDWRTNANENHGIYIGAHALNKPDREIKLDDIGLIHRKIKVDDENQP
FMIGFFRGPELIKATASHNAQRRTKRSTLHQRKKSKSEPVNPFAENIVENTRSCQMQT
LYIDFKDLGWHDWIIAPDGYGAFYCSGECNFPLNAHMNATNHAIVQTLVHLIEPKRVPKP
CCAPTRLGALPVLYHLNDENVNLKKYRNMIVKSCGCH
>DwilGbb
SNLRNPSASFYLSPYLIVLILFLPTPSGVGATQSGIYIDNGKDQTIMHRMLSEDDK
LDVSYEILEFLGIAERPMHHNSHQLSLRKSAPKFLLDVYHRITAEEGLGHANQGESGEHN
RRSKRDADLDDDLNDSMEENQNFITDLDKQAIDESDIIMTFLNKRNHNVDELRHEHGRRL
WFDVSNVPSDNSLMMAELRIYQDSNEGKWTTTNKAFTISVYLIGAGTTGQMTMEILSSVN
TTGDFVGWLELNVTEGLHDWLVNGKANHGIYIGAHAVNRPDREVKLDDIGLLIHRKVKLD
DEYQPFMIGFFRGPELIKATAHNNHHRAKRSTLHPRRKKKSESMHPFFDSPSNNSRSC
QMQTLYIDFKDLGWHDWIIAPEGYGAFYCSGECSFPLNAHMNATNHAIVQTLVHLMEPKR
VPKPCCAPTRLGALPVLYHLNDENVNLKKYKNMIVKSCGCH
>DperGbb
SSIRNTSEAVAALASLGLGFVLIIFVSTTPTVIDATQSGIYIDNGKDQTIMHRVLSDDDK
LDVSYEILEFLGIAERPTHHSSHPLSLRKSAPKFLLDVYHRITEEEGLGGGHTDDETVHS
HRSKRNADMSDERNADGEENFITDLDKRAIDESDIIMTFLNKRNHNVEELRHEHGRRLWF
DVSVPSDNYLVMAELRIYQNSNEGKWLTANKQFTITVYSMGLGESGQNTMEALSSVNTTGDYV
GWLELNVTEGLHEWLVHSKENHGIYIGAHAVNRPDREVKLDDVGLIHRKVDDEYQPFMIG
FFRGPELIKTTSHSSHHRSKRSTLHQRKKKKSVPVHPFLDVPIENTRSCQMQTLYIDF
KDLGWHDWIIAPEGYGAFYCSGECNFPLNAHMNATNHAIVQTLVHLLEPKKVPKPCCAPT
RLGALPVLYHLNDENVNLKKYRNMIVKSCGCH
>DpseGbb
fssirntseavaaltslglgfvliifvsttptvidatqsgiyidngkdqtimhrvlsddd
kldvsyeileflgiaerpthhsshqlslrksapkflldvyhriteeeglggghtddetvh
shrskrnadmsdernadgeenfitdldkraidesdiimtflnkrnhnveelrhehgrrlw
fdvskvpsdnylvmaelriyqnsnegkwltankqftitvysmglgesgqntmealssvnt
tgdyvgwlelnvteglhewlvhskenhgiyigahavnrpdrevklddvglihrkvddeyq
pfmigffrgpelikttshsshhrskrstlhqrkkkksvpvhpfldvpientrscqmqtly
idfkdlgwhdwiiapegygafycsgecnfplnahmnatnhaivqtlvhllepkkvpkpcc
aptrlgalpvlyhlndenvnlkkyrnmivkscgch
>DanaGbb
LSHLRNTSEAVAVLASLGLGLVLLVFMATTPIAIEATQSGIYVDNGRDQTIMQRVLSDDD
KLDVSYEILEFLGIADRPTRLSSHQLSLRKSAPKFLLDVYHRITAEEGLAGDQHGDGG
SHRSKRSLDLEEENGES-KNLITDLDKRAIDESDIIMTFLNKRNHNVDELRHEHGRRLWF
DVSNVPVDDYLVMAELRLYQNSNEGKWLTTNKEFTITVYAIGTGTLGQRTMEPLSSVNTT
GDYVGWLEMNVTEGLHEWLIKSKENHGIYIGAHAVNRPDREVKLDDIGLIHRKADDEFQP
FMIGFFRGPELIKTNAHSTHHRSKRSATHQPKRKKPVSTNMNPLQNVPIESTRSCR
MHTLYIDFKDLLWHDWIIAPEGYGAFYCSGECNFPLNAHMNATNHAIVQTLVHLMEPKKV
PKPCCAPTRLGALPVLYHLNDENVNLKKYRNMIVKSCGCH
>DereGbb
MSGLQNTSEAVAVLASLGLGLVLLMFVATTPPAVEATQSGIYIDNGKDQTIMHRVLSEDD
KLDVSYEILEFLGIAERPTHLSSHQLSLRKSAPKFLLDVYHRITAEEGLSEQDEDDSYEH
GHRSRRSVDLEEEEGDQQKNFITDLDKEAIDQSDIIMTFLNKRHHNVDELRHEHGRRLWF
EVSNVPSDNYLVMAELRIYQNANEGKWLTANREFTITVYAIGTGTLGQHTMEPLSSVNTT
GDYVGWLELNVTEGLHEWLVKSKDNHGIYIGAHAVNRPDREVKLDDIGLIHRKVDDEFQP
FMIGFFRGPELIKATAHSSHHRSKRSASHPRKRKKSVSPNNVPLLEPLENTRSCQMQTLY
IDFKDLGWHDWIIAPEGYGAFYCSGECNFPLNAHMNATNHAIVQTLVHLLEPKKVPKPCC
APTRLGALPVLYHLNDENVNLKKYKNMIVKSCGCH
>DyakGbb
MSGLRNTSEAVAVLASLGLGLVLLMFVATTPPAVEATQSGIYIDNGKDQTIMHRVLSEDD
KLDVSYEILEFLGIAERPTHLSSHQLSLRKSAPKFLLDVYHRITAEEGLSDQDEDDSYER
GHRARRSADLEDDEDEHQQKNFITDLDKRAIDESDIIMTFLNKRHHNVDELRHEHGRRLW
FDVSNVPNDNYLVMAELRIYQNANEGKWLTANREFTITVYSIGTGTLGQHTMEPLSSVNT
TGDYVGWLELNVTEGLHEWLVKSKDNHGIYIGAHAVNRPDREVKLDDIGLIHRKVDDEFQ
PFMIGFFRGPELIKATAHSSHHRSKRSASHPRKRKKSVSPNNVPLLEPMESTRSCQMQTL
YIDFKDLGWHDWIIAPEGYGAFYCSGECNFPLNAHMNATNHAIVQTLVHLLEPKKVPKPC
CAPTRLGALPVLYHLNDENVNLKKYRNMIVKSCGCH
>DmelGbb
msglrntseavavlaslglgmvllmfvattppaveatqsgiyidngkdqtimhrvlseddkldvsyeileflgiaerpthlsshqlslrksapkflldvyhritaeeglsdqdedddyerghrsrrsadleedegeqqknfitdldkraidesdiimtflnkrhhnvdelrhehgrrlwfdvsnvpndnylvmaelriyqnanegkwltanreftitvyaigtgtlgqhtmeplssvnttgdyvgwlelnvteglhewlvkskdnhgiyigahavnrpdrevklddiglihrkvddefqpfmigffrgpelikatahsshhrskrsashprkrkksvspnnvpllepmestrscqmqtlyidfkdlgwhdwiiapegygafycsgecnfplnahmnatnhaivqtlvhllepkkvpkpccaptrlgalpvlyhlndenvnlkkyrnmivkscgch
>DgriScw
EQPLAEQFEMLDLLDLGNRPRRLAQPELHNSASKFLLEVYNEINEEQEPQEVLHQRHKRS
MEDDILLTRADRQEIASSNSILTFSSRNRDLGNELDMHITFNTNDVPMDLMLVQAMLR
IYKQPSLQEQRQNLTISVYKKIYSHNQDGGAYRILQSLNTTVNYKGWLEFNLTQTLHTWL
LHRGLQKQRHELRISLGDTKLGALAAGLVPPQELHTNLEPYIVGYFNGPELLVKVQKLRF
KRELHKRKATLAASGYHHMPPPDYYKPPQSCERLNFTVDFKELQMHNWVIAPKKFEAYFC
GGGCNFPLGTKMNATNHAIVQTLMHLKQPHLPKPCCVPTVLGAITILRYLNEDIIDLTKY
QKAVAKECGCH
>DvirScw
LLSSYLGVLGTTYVTGDVNMEPTTLAEQLEMVDLLDLGDRPRRMAQPKQLHTSAT
KFLLEVYNEINEEQEPQEVLQQRHKRSLEDDILVTREDRQEIASCNSILTFSSRLKSLEQ
GEKEEGEINSRQDLHITFNTNDVPVDLTLVQAMLRIYKQPSWQEQRQNFTVSVYRRIHSH
QAFMEDGAPVYRILHSVNTTTHYKGWLEFNLTQTLRAWLLNKSPQRHELRISLGEARVS
ALGAGLVAPQAADSNLEPFIVGYFNGPELLVKVQKLRFKRDLNKRRAMLPPTGHVRPPP
VFKAPQSCERLNFTVDFKELQMHNWVIAPKKFEAYFCGGGCNFPLGTKMNATNHAIVQT
LMHLKQPHLPKPCCVPTVLGAITILRYINEDIIDLTKYQKTVAKECGCH
>DmojScw
ALTTSYVTVDSSVQPALAEQLEMIDLLDLGDRPRRMAQPTELHNSASKFLLEAY
NEISEEQEPQEVLQQRHKRSLDDDILLTREDRKEMASCNSILTFSSRAQSSSSEQDQLDM
HITFNTNDVPVDLMLMQATLRIYKQPSVLEKRQNLTVSVYRTIHSHQQGIEAPPVYRILS
SVNTTAHYKGWLEFNLTRTLRTWLLSRSPERHELRISLGEEAPLTAWHAGLVAPQDIQS
NLQPFIVGYFKGPELLVKVQKLRFKRDLQKRKASQPRPPPPADLYKPPQSCERLNF
TVDFKELQMHNWVIAPKKFEAYFCGGGCNFPLGTKMNATNHAIVQTLMHLKQPHLPKPCC
VPTALGAITILRYINEDIIDLTKYQKTVAKECGCH
>DwilScw
SGTTYITTNPHMNTQVFEERALSQQLEMIDLLDLSDRPRRQAVPNIYNSASKFLLEVYNE
INEDQEPQEVLHQRHKRSLDDDILISEEDRQEIASCNSILTFSSRQKQDLSNDLDLHVT
FNTNDVPMELSLMHAILRIYKEPSSEEQSNNLTVSIYRRLYRSQDAPYRILHSVNTTAQF
KGWLEFNFTQTLRAWLLNKSIQQRHELRISIGDSQLSALGAGLVPPQGSRSNLEPFIVGY
FSGPELLVKIQKLRFKRELQKRKVGAPMRLPPPPAFKPPHSCERLNFTVDFKQLHL
HNDVIAPNKFEAYFCGGGCNFPLGNKMNATNHAIVQTLMHLKQPHLPKPCCVPTVLGSIT
ILRHINEDIFDLTKYQKAVAKECGCH
>DperScw
FLILALASCVMSSTYIDINHHMETPPIYDTRPLSEQMEMIDLLDLGDRPRRQAQPNLHNS
ASKFLLEVYNEINEGQEPEEVLHQRHKRSLDDDILISNEDRQEIASCNSILTFSSRVKPE
DHSNDLDLHITFNTNDVPADLTLVQAMLRVYKQESLVDRRDNVTVSVYRRLDNRPDYSYQ
ILGSVSTTTSHKGWLEFNLTPTLRTWLLGRSLQQRHELRFSIGYSHLSTFAAGLVPPAAS
RSSQEPFIVGYFNGPELLVKIQKLRFKRDLQKRRANSPPQRPPPPPMDLYKPPQSCER
LNFTVDFKELQMHNWVIAPKKFEAYFCGGGCNFPLGTKMNATNHAIVQTLMHLKQPHLPK
PCCVPTVLGSITILRYLSEDIIDLTKYQKSVAKECGCH
>DpseScw
msstyidinhhmetppiydtrplseqmemidlldlgdrprrqaqpnlhnsaskfllevyn
einegqepeevlhqrhkrsldddilisnedrqeiascnsiltfssrvkpedhsneldlhi
tfntndvpadltlvqamlrvykqeslvdrrdnmtvsvyrrldnrpdysyqilgsvnttts
hrgwlefnltptlrtwlfgrslqqrhelrfsigdshlstfaaglvppaasrssqepfivg
yfngpellvkiqklrfkrdlqkrransppqrpppppmdlykppqscerlnftvdfkelqm
hnwviapkkfeayfcgggcnfplgtkmnatnhaivqtlmhlkqphlpkpccvptvlgsit
ilrylsediidltkyqksvakecgch
>DanaScw
MFLLILLTSSVYFVVGTTYVTTNNQAEMPIYQKRPQSEQMEMIDILDLGDRPKRQLSPNL
DNSASKFLLEVYNEINEDQEPKEVLHQRHRRSLDDDILISKEDREEIANCNSILTFSSRI
KPEEVNNELDLHITFNTNDVPVDLTLVQAMLRVYKQPSLVQRRENFTVSIYKRLGDRQDF
SHRILGSVNTTSSYRGWLEFNLTPVLQTWLLSKNFLKRNELRISIGDSQLSTFAAGLVAP
QASRSSLEPFIVGYFNGPELLVKIQKLRFKRDLQKRRANSQPANPHVHPPPPVDLYKPPQ
SCERLNFTVDFKELQMHNWVIAPKKFEAYFCGGGCNFPLGTKMNATNHAIVQTLMHLKQP
HLPKPCCVPTVLGAITILRYLNEDIIDLTKYQKSVAKECGCH
>DereScw
MLNVFLITSLFYAASGTTYVTTNSHIEMPIYQKRPLSEQMEMIDILDLGDRPRRQAEPNL
HNSASKFLLEVYNEISEDQEPKEVLHQRHKRSLDDDILISNEDRQEIASCNSILTFSSRL
KPEELGNELDMHITFNTNDVPVDLSLVQAMLRIYKQPSLVDRRENFTVSVYRKLDNRQDF
SYRILGSVNTTSSQRGWLEFNLTETLRSWLLNKGLQRRNELRISIGDSQLSTFAAGLVTP
QASRSNLEPFIVGYFNGPELLVKVQKLRFKRDLEKRRTGGSAPPPPPPPVDLYRPPQSC
ERLNFTVDFKELHMHNWVIAPKKFEAYFCGGGCNFPLGTKMNATNHAIVQTLMHLKQPHL
PKPCCVPTILGAITILRYLNEDIIDLTKYQKAVAKECGCH
>DyakScw
MFNVFLITSLLYVASGTSYVTTNSHIEMPIYQKRPLSEQMEMIDILDLGDRPRRQAEPNL
HNSASKFLLEVYNEISEDQEPKEVLHQRHKRSLDDDILISNEDRQEIASCNSILTFSSRI
KPEEPDNELDMHITFNTNDVPVDLSLVQAMLRIYKQPSLVDRRENFTVSVYRKLDNRQDF
SYRILGSVNTTTSQRGWLEFNLTETLRTWLLNKGLQRRNELRISIGDSQLSSFAAGLVTP
QTSRSGLEPFIVGYFNGPELLVKIQKLRFKRDLEKRRAGGSPPPPPPPPVDLYRPPQSC
ERLNFTVDFKELHMHNWVIAPKKFEAYFCGGGCNFPLGTKMNATNHAIVQTLMHLKQPHL
PKPCCVPTVLGAITILRYLNEDIIDLTKYQKAVAKECGCH
>DsimScw
MLNVFLITSLFYVASATTYVTTNSHIEMPIYQKRPLSEQMEMIDILDLGDRPRRQAEPNL
HNSASKFLLEVYNEISEDQEPKEVLHQRHKRSLDDDILISNEDRQEIASCNSILTFSSRL
KPEELNNELDMHITFNTNDVPVDLSLVQAMLRIYKQPSLVDRRENFTVSVYRKLDNRQDF
SYRILGSVNTTSSQRGWLEFNLTDTLRSWLLNKGLQRRNELRISIGDSQLSTFAAGLVTP
QASPSSLEPFIVGYFNGPELLVKIQKLRFKRDLEKRRAGGGSPPPPPPPPVDLYRPPQSC
ERLNFTVDFKELHMHNWVIAPKKFEAYFCGGGCNFPLGTKMNATNHAIVQTLMHLKQPHL
PKPCCVPTVLGAITILRYLNEDIIDLTKYQKAVAKECGCH
>DmelScw
mlnvffltslfyaasattyvttnnhiempiyqkrplseqmemidildlgdrprrqaepnlhnsaskfllevyneisedqepkevlhqrhkrsldddilisnedrqeiascnsiltfssrlkpeqldneldmhitfntndvpvdlslvqamlriykqpslvdrranftvsvyrkldnrqdfsyrilgsvnttssqrgwlefnltdtlrywlhnkglqrrnelrisigdsqlstfaaglvtpqasrtslepfivgyfngpellvkiqklrfkrdlekrragggsppppppppvdlyrppqscerlnftvdfkelhmhnwviapkkfeayfcgggcnfplgtkmnatnhaivqtlmhlkqphlpkpccvptvlgaitilrylnediidltkyqkavakecgch
>DsimGbb
msglrntseavavlaslglgmvllmfvattppaveatqsgiyidngkdqtimhrvlseddkldvsyeileflgiaerpthlsshqlslrksapkflldvyhritaeeglsdqdedddyerghrsrrsadleedegeqqknfitdldkraidesdiimtflnkrhhnvdelrhehgrrlwfdvsnvpndnylvmaelriyqnanegkwltanreftitvyaigtgtlgqhtmeplssvnttgdyvgwlelnvteglhewlvkskdnhgiyigahavnrpdrevklddiglihrkvddefqpfmigffrgpelikatahsshhrskrsashprkrkksvspnnvpllepmestrscqmqtlyidfkdlgwhdwiiapegygafycsgecnfplnahmnatnhaivqtlvhllepkkvpkpccaptrlgalpvlyhlndenvnlkkyrnmivkscgch