Supplementary Table I
Data excluded from the meta-analysis
Study / Test / Reason not usedDeery, Anderson, Jacobs, Neale, and Kornberg (2010) / Contingency Naming Test Trial 1 Time* / Trail Making Test A data available and used instead
Contingency Naming Test Trial 2 Time* / Trail Making Test A data available and used instead
Contingency Naming Tests – Errors 4 / Multiple construct (inhibition and mental flexibility)
TEACh - Score Dual Task Total Correct / No other studies to combine this measure with to assess divided attention
TEACh - Sky Search Dual Task Decrement / No other studies to combine this measure with to assess divided attention
TEACh - Sky Search Final Score / No other studies to combine this measure with to assess selective attention
Contingency Naming Tests – Efficiency 4 / Multiple construct (inhibition and mental flexibility)
TEACh - Creature Counting test from – time per switch / Trail Making Test Part B data available and used instead
Hahn et al. (2003) / CMS - Attention/concentration index / Multiple construct (attention and working memory or immediate verbal memory span)
CMS Verbal Recognition / No other recognition measures to combine with
Grooved Pegboard; WASI - Block Design; VMI; VMI Test of Motor Coordination; VMI Test of Visual Perception (combined) / These tests measure various domains; scores for individual tests were not able to be separated out based on the data provided
WASI Matrices with WCST Perseveration Score (combined) / Multiple construct (abstract reasoning and perseveration)
WASI Vocab, Similarities, Test of Language Competence – Making inferences, recreating sentences (combined) / Combined score with multiple constructs
Time to complete TMT parts A and B and perseverative errors from the WCST (combined) / Combined score with multiple constructs
WASI Verbal IQ composite / Used total IQ score
BRIEF – Behaviour Regulation Index / Did not examine behaviour regulation as a domain
BRIEF - Metacognition Index / Did not examine metacognition as a domain
Jacobs, Anderson, Neale, Shield, and Kornberg (2004) / WISC-III Symbol Search or WPPSI-R Animal Pegs / Two tests are not equivalent and the data for each cannot be established from the paper
TEACh – Sky Search Motor Task / Trail Making Test A data available and used instead
Kuni, Banwell, and Till (2012) / BRIEF – Global Executive Composite / No other studies to combine this measure with to assess overall executive functioning
SDMT / Trail Making Test A data available and used instead
SDMT – Oral / Trail Making Test A data available and used instead
TMT – Sq root Parts B - A / Score not routinely used in neuropsychological testing; alternative measure available and used (WCST – Perseverative responding)
WCST – total errors / Multiple construct (problem solving and mental flexibility)
Woodcock JohnsonIII Visual matching / Multiple construct (visual skills, speed of processing information, abstract reasoning)
Woodcock JohnsonIII Rapid Picture Naming / Multiple construct (speed of processing and naming)
WCST – number of categories / Multiple construct (problem solving and mental flexibility)
WASI Vocabulary and Similarities subtests / Used total IQ score
WASI Block Design subtest / Used total IQ score
BRIEF Behaviour Regulation Index / Did not examine behaviour regulation as a domain
BRIEF Metacognition Index / Did not examine metacognition as a domain
Pavone et al. (2010) / Visual Spatial Scale (Test not specified; no reference provided) / The paper does not specify what test this score is derived from
Parrish, Weinstock-Guttman, Smerbeck, Benedict, and Yeh (2013) / Self-report Depression on the BASC-II / Provided parent-report data for internalising symptoms for whole sample rather than sub-sample (n=8) for self-report
Parent-report Depression on the BASC-II / Author provided data on parent-report internalising symptoms for the BASC – this was consistent with the other measures of internalising symptoms provided in other papers and so this was used in its place
Suppiej et al. (2014) / Bell test – accuracy / Test measures neglect – not a construct being examined
Bell test – rapidity / Test measures neglect – not a construct being examined
Corsi Block-Tapping test / No other studies to combine this measure with to assess immediate visual memory span
WISC-III Vocabulary and Similarities subtests / Used total IQ score
WISC-III Block Design subtest / Used total IQ score
Notes: BASC-II – Behaviour Assessment of System for Children 2nd Ed. (Reynolds & Kamphaus, 2004); Bell test (Bisiacchi, Cendron, Gugliotta, Tressoldi, & Vio, 2005); BRIEF – Behaviour Rating Inventory of Executive Function (Gioia, Isquith, Guy, & Kenworthy, 2000); CMS – Children’s Memory Scale (Cohen, 1997); Contingency Naming Test (Anderson, Anderson, Northam, & Taylor, 2000; Taylor, Albo, Phebus, Sachs, & Bierl, 1987); Corsi Block-Tapping Test (Stoppa & Biancardi, 1997); Grooved Pegboard (Matthews & Klove, 1964); SDMT – Symbol Digit Modalities Test (Smith, 1991);TEACh – Test of Everyday Attention for Children (Manly, Anderson, Robertson, & Nimmo-Smith, 1999); Test of Language Competence (Wiig & Secord, 1989); TMT – Trail Making Test (Reitan, 1986); WASI – Wechsler Abbreviated Scale of Intelligence (Wechsler, 1999); WCST – Wisconsin Card Sorting Test (Grant & Berg, 1993; Heaton, Chelune, & Talley, 1993); WISC-III – Wechsler Intelligence Scale for Children – 3rd Edition (Wechsler, 1991); Woodcock Johnson III (Woodcock, McGrew, & Mather, 2001); WPPSI-R – Wechsler Preschool and Primary Scale of Intelligence – Revised (Wechsler, 1989); VMI - Visual Motor Integration (Beery, 1997)
Supplementary Table II
Assessment of publication bias
Neuropsychological domain / Egger’s regression for assessing asymmetryCohort meta-analysis
t / df / pa
IQ / 0.129 / 5 / 0.90
Sustained attention / NA
Mental flexibility / NA / 1 / 0.52
Planning / 0.116 / 2 / 0.92
Idea generation / 2.699 / 2 / 0.11
Processing speed / 0.704 / 5 / 0.51
Verbal memory / NA
Visual memory / NA
Working memory / 1.237 / 2 / 0.34
Immediate verbal memory span / 0.643 / 4 / 0.56
Spelling / 2.757 / 2 / 0.11
Reading / 1.615 / 2 / 0.25
Arithmetic / 0.755 / 2 / 0.53
Internalising / 2.60 / 3 / 0.08
Externalising / 0.323 / 3 / 0.77
Notes. NA – not applicable; not possible to compute due to low number of
studies included in meta-analysis (publication bias can only be assessed where
there are more than 2 studies in a meta-analysis). a two tailed analysis
References for Supplementary Tables
Anderson, P., Anderson, V., Northam, E., & Taylor, H. G. (2000). Standardization of the Contingency Naming Test (CNT) for school-aged children: A measure of reactive flexibility. Clinical Neuropsychological Assessment, 1, 247-273.
Beery, K. E. (1997). The Visual-Motor Integration Test (4th ed.) administration, scoring and teaching manual. Austin, TX: Pro-Ed.
Bisiacchi, P. S., Cendron, M., Gugliotta, M., Tressoldi, P., & Vio, C. (2005). Batteria di Valutazione Neuropsicologica per I'Eta Evolutiva. Trento, Italy: Erickson.
Cohen, M. (1997). Children's Memory Scale (CMS). San Antonio, TX: The Psychological Corporation.
Deery, B., Anderson, V., Jacobs, R., Neale, J., & Kornberg, A. (2010). Childhood MS and ADEM: Investigation and comparison of neurocognitive features in children. Developmental Neuropsychology, 35(5), 506-521.
Gioia, G. A., Isquith, P. K., Guy, S. C., & Kenworthy, L. (2000). Behaviour Rating Inventory of Executive Function professional manual. Odessa, FL: Psychological Assessment Resources Inc.
Grant, D. A., & Berg, E. A. (1993). The Wisconsin Card Sorting Test. San Antonio, TX: The Psychological Corporation.
Hahn, C. D., Miles, B. S., MacGregor, D. L., Blaser, S. I., Banwell, B. L., & Hetherington, C. R. (2003). Neurocognitive outcome after acute disseminated encephalomyelitis. Pediatric Neurology, 29(2), 117-123.
Heaton, R. K., Chelune, G. J., & Talley, J. L. (1993). Wisconsin Card Sorting Test manual. Odessa, TX: Psychological Assessment Resources.
Jacobs, R. K., Anderson, V. A., Neale, J. L., Shield, L. K., & Kornberg, A. J. (2004). Neuropsychological outcome after acute disseminated encephalomyelitis: Impact of age at illness onset. Pediatric Neurology, 31(3), 191-197.
Kuni, B. J., Banwell, B. L., & Till, C. (2012). Cognitive and behavioral outcomes in individuals with a history of acute disseminated encephalomyelitis (ADEM). Developmental Neuropsychology, 37(8), 682-696.
Manly, T., Anderson, V., Robertson, I., & Nimmo-Smith, I. (1999). The test of everyday attention for children. London: Thames Valley Test Company.
Matthews, C. G., & Klove, K. (1964). Instruction manual for the Adult Neuropsychology Test Battery. Madison, Wisc.: University of Wisconsin Medical School.
Parrish, J. B., Weinstock-Guttman, B., Smerbeck, A., Benedict, R. H., & Yeh, E. A. (2013). Fatigue and depression in children with demyelinating disorders. Journal of Child Neurology, 28(6), 713-718.
Pavone, P., Pettoello-Mantovano, M., Le Pira, A., Giardino, I., Pulvirenti, A., Giugno, R., . . . Ruggieri, M. (2010). Acute disseminated encephalomyelitis: A long-term prospective study and meta-analysis. Neuropediatrics, 41(6), 246-255.
Reitan, R. M. (1986). Trail Making Test: Manual for administration and scoring. Tucson, AZ: Reitan Neuropsychology Laboratory.
Reynolds, C. R., & Kamphaus, R. W. (2004). Behavior Assessment System for Children (BASC-2) (2nd ed.). Bloomington, MN: Pearson.
Smith, A. (Ed.). (1991). Symbol Digit Modalities Test (SDMT). Los Angeles, CA: Western Psychological Services.
Stoppa, E., & Biancardi, A. (1997). Il test delle Campanelle modificato: una proposta per lo studio dell'attenzione in eta evolutiva. Psich Inf Adolesc., 64, 73-84.
Suppiej, A., Cainelli, E., Casara, G., Cappellari, A., Nosadini, M., & Sartori, S. (2014). Long-term neurocognitive outcome and quality of life in pediatric acute disseminated encephalomyelitis. Pediatric Neurology, 50(4), 363-367.
Taylor, H. G., Albo, V., Phebus, C., Sachs, B., & Bierl, P. (1987). Postiradiation treatment outcomes for children with Acute Lymphoblastic Leukemia: Clarification of risks. Journal of Pediatric Psychology, 12, 395-411.
Wechsler, D. (1989). Wechsler Preschool and Primary Scale of Intelligence - Revised. San Antonio: Psychological Corporation, Harcourt, Barce, Jovanovich.
Wechsler, D. (1991). Wechsler Intelligence Scale for Children - Third Edition (WISC-III).
Wechsler, D. (1999). Wechsler Abbreviated Scale of Intelligence (WASI). San Antonio, TX: The Psychological Corporation.
Wiig, E. H., & Secord, W. (1989). Test of Language Competence - Expanded edition. San Antonio, TX: The Psychological Corporation.
Woodcock, R. W., McGrew, K. S., & Mather, N. (2001). Woodcock Johnson III NU Tests of cognitive abilities. Chicago, IL: Riverside Publishing.