International Symposium: Mechanisms of neurotrophic factors in health and disease
Salamanca, 14 y 15 de marzo de 2013
Salamanca, March 14-15, 2013
CV
John (Chia-Yang) Lin
PERSONAL STATEMENT
I have a long-standing interest in the interaction between the endocrine, the immune and the nervous systems. My research interest is to develop novel antibody or protein-based therapies to address the pathogenic mechanisms of various human diseases. One area of my therapeutic pursuit is to use receptor agonist antibodies to mimic the neurotrophic factors in the treatment of metabolic disorders and neuropathy. I also investigate the common pathogenic mechanism, e.g. amyloid peptides, in both Alzheimer’s disease and age-related macular degeneration. In addition, my laboratory has recently unveiled major roles of the cytokine interleukin 7 in the pathogenesis of autoimmune diseases such as multiple sclerosis and type 1 diabetes.
Professional Experience
2011 (Dec) – Present, Vice President, Experimental Medicine, Rinat, Pfizer Inc.
-Overseeing the early research portfolio through human Phase 2 clinical studies
-Responsible for novel drug ideas and candidates in neurology, ophthalmology, immunology, cancer, endocrinology and metabolic disorders
2009 (May) – 2011 (Nov), Executive Director, Neuroscience & Endocrinology, Rinat, Pfizer Inc.
2007 (Nov) – 2009 (Apr), Senior Director, Neuroscience & Endocrinology, Rinat, Pfizer Inc.
2006 (Jun) – 2007 (Oct), Director, Neuro-degeneration & Neuro-endocrinology, Rinat, Pfizer Inc.
2006 (Jan –May), Director, Neurology and Neuro-endocrinology, Rinat Neuroscience Corp.
2005-2006, Associate Director, Biology, Rinat Neuroscience Corp.
2002-2004, Scientist/ Senior Scientist, Rinat Neuroscience Corp.
1999–2001, Postdoctoral fellow, Genentech Inc.
Education
1992-1998, PhD, Program in Biological and Biomedical Sciences,
Harvard University.
Thesis advisor: Dr. Constance L. Cepko, Professor in Genetics, HHMI
1985-1992, MD, College of Medicine,
National Taiwan University.
Publications
-Research Articles-
Li-Fen Lee, Kathryn Logronio, Guang Huan Tu, Wenwu Zhai, Irene Ni, Li Mei, Jeanette Dilley, Jessica Yu, Arvind Rajpal, Colleen Brown, Charles Appah, Sherman Michael Chin, Bora Han, Timothy Affolter, John C. Lin. Anti-IL-7Ra reverses established type 1 diabetes in NOD mice by modulating effector T cell function. Proceedings of National Academy of Sciences USA 2012 July 31: 109(31):12674-9. PMID# 22733769
~~ This paper was highlighted in the Jul 31 issue of PNAS with an accompanying commentary “IL-7 receptor alpha blockade, an off switch for autoreactive T cells” by Tobias Boettler and Matthias von Herrath; and also highlighted in Nature Review Drug Discovery (Aug 2012) 11:599.~~
Sherry L. La Porte, Sangeetha S. Bollini, Tom Lanz, Yasmina N. Abdiche, Alexander S. Rusnak, Wei-Hsien Ho, Dione Kobayashi, Ons Harrabi, Danielle Pappas, Erene W. Mina, Anthony J. Millici, Thomas T. Kawabe, Kelly Bale, John C. Lin & Jaume Pons. Structural basis of C-terminal beta-amyloid peptide binding by the antibody ponezumab for the treatment of Alzheimer’s disease. Journal of Molecular Biology 2012 Aug 24; 421(4-5):525-36. PMID# 22197375
Gary B. Freeman, John C. Lin, Jaume Pons, and Nancy Raha. 39-Week toxicity and toxicokinetic study of ponezumab (PF-04360365) in cynomolgus monkeys with 12-week recovery period. Journal of Alzheimer’s Disease 2012, 28(3):531-41. PMID# 22045481
Hong Liang, Javier Chaparro-Riggers, Pavel Strop, Tao Geng, Janette E. Sutton, Daniel Tsai, Lanfang Bai, Yasmina Abdiche, Jeanette Dilley, Jessica Yu, Si Wu, S. Michael Chin, Nicole A. Lee, Andrea Rossi, John C. Lin, Arvind Rajpal, Jaume Pons, and David Shelton (2011) PCSK9 antagonism and statin additively reduce LDL-cholesterol in hypercholesterolemic non-human primates. Journal of Pharmacology and Experimental Therapeutics 2012 Feb; 340(2):228-36. PMID# 22019884
Li-Fen Lee, Robert Axtell, Guang Huan Tu, Kathryn Logronio, Jeanette Dilley, Jessica Yu, Mathias Rickert, Bora Han, Winston Evering, Brigit A. de Jong, Joep Killestein, Chris H. Polman, Lawrence Steinman and John C. Lin (2011) IL-7 promotes TH1 cell development and serum levels predict clinical response to Interferon-b in multiple sclerosis. Science Translational Medicine 2011 Jul 27;3(93):93ra68. PMID#21795588 ~~ This paper was highlighted in the Aug 16, 2011 issue of SciBX (Science-Business eXchange, co-published by Nature and BioCentury). ~~
Jin-dong Ding, Lincoln V. Johnson, Rolf Herrmann, Sina Farsiu, Stephanie G. Smith, Brian Mace, Patrick Sullivan, Jeffrey A. Jamison, Una Kelly, Ons Harrabi, Sangeetha Subbaoro Bollini, Dione Kobayashi, Ted Johnson, Bing Kuang, Jaume Pons, John C. Lin#, Catherine Bowes Rickman# ( #corresponding authors) (2011) Anti-amyloid immunotherapy protects against RPE damage and loss of visual function in an age-related macular degeneration model. Proceedings of National Academy of Sciences USA 2011 Jul 12;108(28):E279-87. [Epub 2011 Jun 20]. PMID#21690377
~~ This paper was highlighted in the Jul 27 issue of SciBX (Science-Business eXchange, co-published by Nature and BioCentury) and also highlighted in the Sep 8 issue of Nature Biotechnology (2011) 29:809. ~~
Zarife Sahenk, Gloria Galloway, Chris Edwards, Vinod Malik, Brian K. Kaspar, Amy Eagle, Brent Yetter, Alison Forgie, David Tsao, and John C. Lin (2010) TrkB and TrkC agonist antibodies improve function, electrophysiologic and pathologic features in Trembler J mice. Experimental Neurology 2010 Aug 224(2):495-506, [Epub ahead of print, 2010 May 27] PMID#20553714
John C. Lin, David Tsao, Paul Barras, Raul A. Bastarrachea, Bob Boyd, Rodnie Rosete, Joyce Chou, Hua Long, Alison Forgie, Jeanette Dilley, Jennifer Stratton, Yasmina Abdiche, Carlos Garcia, David L. Sloane, Anthony G. Comuzzie and Arnon Rosenthal (2008) Appetite enhancement and weight gain by peripheral administration of trkB agonists in non-human primates. PLoS ONE. 2008 Apr 2;3(4):e1900. PMID#18382675 ~~ This collaborative work with Southwest Primate Research Center was highlighted in the article “Today’s Lab Rats of Obesity: Furry Couch Potatoes” by Andrew Pollack, New York Time (Feb 19, 2011). ~~
David Tsao, Heather Koenig Thomsen, Joyce Chou, Jennifer Stratton, Michael Hagen, Carole Loo, Carlos Garcia, David L. Sloane, Arnon Rosenthal and John C. Lin, (2008)
TrkB agonists ameliorate obesity and associated metabolic conditions in mice. Endocrinology 2008 Mar;149(3):1038-48. [Epub ahead of print, 2007 Dec 6] PMID#18063676
Jindong Ding, John Lin, Brian E. Mace, Rolf Herrmann, Patrick Sullivan and Catherine Bowes Rickman, (2008) Targeting age-related macular degeneration with Alzheimer’s disease based immunotherapies: Anti-amyloid- antibodies attenuate pathologies in an age-related macular degeneration mouse model. Vision Research, 2008 Feb;48(3):339-45. [Epub ahead of print, 2007 Sep 19] PMID #17888483
Rocio Ruiz, John Lin, Alison Forgie, Davide Foletti, David Shelton, Arnon Rosenthal and Lucia Tabares (2005) Treatment with TrkC agonist antibodies delays disease progression in neuromuscular degeneration (nmd) mice. Human Molecular Genetics 14(13):1825-37. [Epub ahead of print, 2005 May 25] PMID#15888478
John C. Lin, Wei-Hsien Ho, Austin Gurney and Arnon Rosenthal (2003) The netrin-G1 ligand NGL-1 promotes the outgrowth of thalamocortical axons. Nature Neuroscience. 2003 Dec;6(12):1270-6. [Epub ahead of print, 2003 Nov 02] PMID#14595443
John C. Lin, Li, C. and Constance L. Cepko (2001) The external granule layer of the developing chick cerebellum generates both granule cells and cells of the isthmus and rostral hindbrain. Journal of Neuroscience 21(1): 159-168. PMID # 11150332
John C. Lin and Constance L. Cepko (1999). Biphasic dispersion of clones containing Purkinje cells and glia in the developing chick cerebellum. Developmental Biology 211(2):177-197. PMID #10395781
John C. Lin and Constance L. Cepko (1998). Granule cell raphes and the parasagittal domains of Purkinje cells: Complementary patterns in the developing chick cerebellum. Journal of Neuroscience 18(22): 9342-9353. PMID#9801373
-Review Articles-
John C. Lin and Arnon Rosenthal (2003) Molecular mechanisms controlling the development of catecholaminergic neurons. Seminars in Cell and Developmental Biology 14(3) pp. 175-180. PMID #12948352
Constance L. Cepko, Elizabeth Ryder, Jeff Golden, Shawn Fields-Berry and John C. Lin (2000) Lineage analysis with retroviral vectors. Methods in Enzymology. Vol. 327, pp.118-45. Academic Press, San Diego. PMID#11044979
Constance L. Cepko, Elizabeth Ryder, Christopher Austin, Jeff Golden, Shawn Fields-Berry and John C. Lin (1998). Lineage analysis using retroviral vectors. “METHODS: A Companion to Methods in Enzymology" Vol. 14, pp393-406. Academic Press, San Diego. PMID #9608510
-Book Chapters-
Arnon Rosenthal and John C. Lin (2011) Modulation of Neurotrophin Signaling by Monoclonal Antibodies
In “Neurotrophic Factors”, (Bruce D. Carter and Gary R. Lewin eds.) Handbook of Experimental Pharmacology (HEP) series, Springer Verlag, Berlin
Arnon Rosenthal and John C. Lin (2010) Dopaminergic Differentiation
In “Developmental Neurobiology” (Greg Lemke ed.). Academic Press / Elsevier, Oxford.
Arnon Rosenthal and John Lin (2009) Cell Type Specification: Neuronal Cell Subtype Specification: Dopaminergic Differentiation (MS number: 1037)
In “Encyclopedia of Neuroscience” (Larry Squire, Tom Albright, Floyd Bloom, Fred Gage and Nick Spitzer eds.). Elsevier, Oxford.
Constance L. Cepko, Jeff A. Golden, Francis G. Szele and John C. Lin (1997) Lineage analysis in the vertebrate central nervous system.
In "Molecular and Cellular Approaches to Neural Development" (W.M. Cowan, T.M. Jessell, and S.L. Zipursky, eds.). Oxford University Press, London.
- Manuscripts under review or in preparation –
Erene W. Mina, Terence Park, Alison Forgie, Sawsan Youssef, Joyce Chou, Kathryn Logronio, Li-fen Lee, Jay Perera and John C. Lin. High-fat diet induced peripheral expression of a-Synuclein contributes to obesity-associated inflammatory response and impaired glucose homeostasis. Endocrinology (in revision)
Hua Long, Joyce Chou, Sawsan Youssef, Li-Fen Lee, Jay Perera and John C. Lin. Glucagon-like peptide 1 (GLP-1) receptor agonists attenuate the disease progression in experimental autoimmune encephalomyelitis. (in preparation)
- Selected Meeting Abstracts –
Kay D Rittenhouse, Theodore R. Johnson, Venkata Doppalapudi, John Lin (2012) Catabolism and Pharmacokinetics of Protein Drugs in the Eye. (Tracking Number: 12-S-878-ARVO) ARVO, May 6-10, 2012 Fort Lauderdale, FL.
D. Todd, M. Wall, I. Gowers, S. Penrose, G. Wishart, G. McAllister, R. Bürli, M. Lamers, J. Turney, R. Grishanin, R. Gimeno, J. Paulsen, J. Lin, G. Flynn, D. F. Fischer, A. Kiselyov, J. Wityak, J. Bard (2012) Advancing TrkB Modulation Toward Huntington’s Disease Therapeutics: Time to Get Off the Beaten Trk. The 7th Annual Huntington’s Disease Therapeutics Conference. Feb 27-Mar 1, 2012. Palm Springs, CA.
Jeffy P. Jimenez, Maj-Linda Selenica, David Morgan, John Lin, Norma A. Alcantar.
(2010) Changing the Kinetics of Amyloid Beta Plaques Formation: Implications for Alzheimer’s Disease Immunotherapy. Biophysical Society 54th Annual Meeting, Feb 23, San Francisco, CA
Wenlin Li, Sangeetha Subbarao, Hendrik Neubert, Theodore Johnson, John Lin, Scott Fountain, Bing Kuang (2009) Development of a Sensitive, High-throughput Immunoaffinity-LC-Tandem Mass Spectrometry Method for Quantification of Amyloid ß Peptides in Biological Matrices. The 2009 AAPS National Biotechnology Conference, June 21-24, Seattle
Erene W. Mina, Thushara J. Perera, Zhe Chen, Joyce Chou and John C. Lin (2009) Novel roles of alpha-Synuclein in energy and glucose homeostasis. The 69th Scientific Session of American Diabetes Association, June 5-9, New Orleans
Una Kelly, Erene Mina, John Lin, Greg Hageman, Vadim Arshavsky, Haixiang Jiang, Michael Frank, Catherine Bowes Rickman, (2008) Investigation of the Interactions between Complement Factor H, C3b, and Amyloid β.
The Association for Research in Vision and Ophthalmology / ARVO
Patents Issued:
Title: Antagonist IL7 Receptor Antibodies and Method of Use
United States Patent: 8,298,535
Issued: October 30, 2012
Lin; C.-Y. (Palo Alto, CA), Lee; L.-F. (Palo Alto, CA), and Zhai; W. (Redwood City, CA)
Assignee: Rinat Neuroscience Corp. (South San Francisco, CA)
Appl. No.: 13/033,491
Filed: February 23, 2011
Title: Methods for Treating Obesity by Administering a TrkB Antagonist
United States Patent: 7,935,342
Issued: May 3, 2011
Inventors: Lin; John Chia-Yang (Palo Alto, CA), Rosenthal; Arnon (Woodside, CA)
Assignee: Rinat Neuroscience Corp. (South San Francisco, CA)
Appl. No.: 12/278,182
Filed: January 29, 2007
PCT Filed: January 29, 2007
PCT No.: PCT/IB2007/000264
371(c)(1),(2),(4) Date: February 03, 2009
PCT Pub. No.: WO2007/088479
PCT Pub. Date: August 09, 2007
Title: Promotion of Axonal Regeneration by NGL-1
United States Patent: 7,544,659
Issued: June 9, 2009
Inventors: Lin; Chia-Yang (Mountain View, CA), Rosenthal; Arnon (Woodside, CA)
Assignee: Rinat Neuroscience Corp. (South San Francisco, CA)
Appl. No.: 10/917,905
Filed: August 13, 2004
Patent Applications:
Siebel, S., Pascua; E, Lin; C-Y. and Chaparro-Riggers; J.
Pfizer Inc.
Human Growth Hormone Receptor Antagonist Antibodies and Method of Use Thereof
U.S. Provisional Patent Application, filed Dec, 2011
Lin; C.-Y., Long; H., Chou J.
Pfizer Inc.
Glucagon-like Peptide-1 Receptor (GLP-1R) Agonists for Treating Autoimmune Disorders
U.S. Provisional Patent Application (Serial No. 61237654), filed Aug 27, 2009
Lin, C.-Y., Zhai, W., Chaparro-Riggers, J., Stratton, J., Grishanin, R.
Pfizer Inc.
TrkB Agonist Antibodies and Their Use
U.S. Provisional Patent Application, filed Jan 30, 2009
Lin , C.-Y.
Pfizer Inc.
Method for Treating Age-related Macular Degeneration
U.S. Provisional Patent Application, Mar 2007
Published as WO2008/110885
Lin, C.-Y., Stratton J. and Rosenthal, A
Rinat Neuroscience Corp.
Method for Treating Human Cachexia and Anorexia
U.S. Provisional Patent Application; Feb 2006
Professional Awards:
2007 William E. Upjohn Prize, the Pfizer Inc. corporate-level award in recognition of special accomplishment of Innovation.
Grant Review Committee and Advisory board
CHDI (Cure Huntington’s Disease Initiative), Neurotrophin Working Group meeting April 18, 2012, in New York, NY
Michael J. Fox Foundation for Parkinson’s Research, New York, NY
Grant Review Committees,
- 2011 Therapeutics Development Initiative, Industry-track
- 2009 Therapeutics Development Initiative, Industry-track
- 2008 Therapeutics Development Initiative, Academic-track
- 2007 Target Validation program
- 2007 Therapeutics Development Initiative
Scientific Advisory Board,
4th GTCbio, Diabetes Drug Discovery Conference, March 7-8, 2011, Philadelphia, PA
Scientific Advisory Board,
5th GTCbio, Diabetes Drug Discovery and Development Conference, April, 2012, Boston, MA
Ad hoc Referee for Peer-review Journals:
Nature Neuroscience
NN-A35278A-Z (Dec 2011)
NN-R37530 (Aug 2011)
NN-BC36334 (May 2011)
NN-A35278 (Feb 2011)
NN-A26839 (Jan 2009)
NN-A24674-T (May 2008)
NN-BC22454 (Apr 2008)
NN-A21606 (May 2007)
NN-A14344-T (Apr 2005)
NN-BC10516A (Jun 2004)
NN-A10431A (Mar 2004)
Annals of Neurology
ANA-12-1664 (Nov 2012)
Genes and Immunity
2011-GENE-269 (Jan 2012)
Investigative Ophthalmology & Visual Science
IOVS-12-10763 (Aug 2012)
Trends in Neuroscience
British J. Cancer
Developmental Biology
Experimental Brain Research
Regulatory Peptide
FUNDACIÓN RAMÓN ARECES