Table 1S. [3H]Nisoxetine binding to the norepinephrine transporter in food- and cocaine-reinforced animals following 30 days involuntary abstinence from operant responding. The cocaine group is subdivided to show data from animals that were or were not re-exposed to a single session of cocaine reinforcement following abstinence.

Brain region / No re-exposure to reinforcers / Single re-exposure to reinforcers
Food control (N=1-2) / Cocaine (N=4) / Food control (N=4) / Cocaine (N=4)
Dorsal noradrenergic bundle
Prefrontal cortex
Medial / 9.4 / * / 12.1 / ± 2.8 / 15.9 / ± 2.9 / 13.6 / ± 2.3
Orbital / 7.8 / * / 11.6 / ± 2.8 / 14.3 / ± 3.5 / 11.3 / ± 3.5
Dorsolateral / 7.6 / * / 11.7 / ± 3.1 / 15.3 / ± 3.7 / 12.5 / ± 3.3
Anterior cingulate / 8.7 / * / 12.6 / ± 2.2 / 15.0 / ± 2.9 / 14.9 / ± 3.1
Insula / 5.1 / ± 1.1 / 17.6 / ± 3.2 / 11.3 / ± 1.0 / 21.6 / ± 3.0
Caudate / 2.4 / ± 0.4 / 10.3 / ± 1.5 / 9.8 / ± 2.6 / 11.4 / ± 1.0
Putamen / 2.4 / ± 0.8 / 9.7 / ± 1.7 / 9.3 / ± 2.5 / 11.2 / ± 1.0
Nucleus accumbens core / 7.3 / ± 1.5 / 17.7 / ± 1.8 / 12.7 / ± 4.1 / 16.1 / ± 2.0
Septum / 9.0 / ± 5.8 / 26.0 / ± 3.4 / 17.4 / ± 3.0 / 29.5 / ± 6.1
Basolateral amygdala / 13.0 / ± 0.5 / 19.6 / ± 1.5 / 13.7 / ± 3.1 / 24.8 / ± 5.8
CA1 / 2.3 / * / 11.4 / ± 3.3 / 6.5 / ± 1.0 / 10.4 / ± 2.9
Dentate / 4.9 / ± 0.5 / 17.5 / ± 0.9 / 8.4 / ± 4.8 / 15.8 / ± 4.3
Subicular complex / 3.8 / ± 2.6 / 12.3 / ± 3.3 / 6.5 / ± 2.2 / 12.4 / ± 2.1
Entorhinal cortex / 6.9 / ± 2.9 / 14.4 / ± 2.5 / 11.2 / ± 1.1 / 16.4 / ± 4.9
Dorsal Raphe / 55.8 / ± 6.8 / 167.3 / ± 10.5 / 72.0 / ± 7.1 / 175.4 / ± 13.9
Ventral noradrenergic bundle
Nucleus accumbens shell / 11.1 / ± 2.0 / 51.3 / ± 7.1 / 32.0 / ± 3.4 / 40.4 / ± 8.2
Bed nucleus of stria terminalis
Laterodorsal / 60.5 / ± 46.7 / 50.8 / ± 8.4 / 70.2 / ± 10.1 / 75.3 / ± 16.0
Medial / 30.2 / ± 9.0 / 33.4 / ± 3.3 / 38.2 / ± 5.3 / 42.2 / ± 6.1
Lateral / 38.1 / ± 12.6 / 31.5 / ± 4.8 / 38.9 / ± 4.8 / 39.0 / ± 3.6
Ventral / 52.5 / ± 7.8 / 56.1 / ± 5.8 / 62.1 / ± 4.9 / 62.9 / ± 6.7
Central amygdala / 45.7 / ± 1.2 / 41.3 / ± 6.8 / 54.5 / ± 7.8 / 47.0 / ± 2.6
Medial preoptic area / 27.8 / ± 2.0 / 27.5 / ± 2.2 / 28.4 / ± 5.4 / 35.6 / ± 2.9
Lateral preoptic area / 44.5 / ± 6.4 / 42.8 / ± 3.7 / 41.9 / ± 4.6 / 45.0 / ± 3.7
Dorsomedial hypothalamus / 31.6 / ± 0.5 / 42.5 / ± 6.5 / 48.1 / ± 7.0 / 40.5 / ± 4.5
Lateral hypothalamus / 27.1 / ± 4.9 / 35.6 / ± 5.6 / 32.7 / ± 3.2 / 33.7 / ± 5.1
Paraventricular nucleus / 69.9 / ± 0.5 / 75.9 / ± 6.9 / 74.7 / ± 6.5 / 71.7 / ± 3.0
Values expressed as fmol/mg wet weight tissue. * N=1