Curriculum Vitae
David Dunbar Ivy MD
Professor of Pediatrics Phone: 720-777-6820
Section of Cardiology Fax: 720-777-7290
University of Colorado
Children’s Hospital Colorado
13123 East 16thAvenue, Box 100
Aurora, CO 80045
Education
1980-1984 Bachelor of Science
Davidson College, Davidson, North Carolina
1984-1988 Doctorate of Medicine
Tulane Medical School, New Orleans, Louisiana
1988-1991 Pediatrics Residency Program
Children’s Hospital Colorado
University of Colorado School of Medicine, Aurora, CO
1991-1994 Pediatric Cardiology Fellowship
Children’s Hospital Colorado
University of Colorado School of Medicine, Aurora, CO
Academic Appointments
1994-1996 Instructor of Pediatrics
University of Colorado School of Medicine, Aurora, CO
1996-2001 Assistant Professor of Pediatrics
University of Colorado School of Medicine
2001-2007 Associate Professor of Pediatrics
University of Colorado School of Medicine
2007-present Professor of Pediatrics with Tenure
University of Colorado School of Medicine
Professional Positions
1994-Present Pediatric Cardiologist, Section of Cardiology
Children’s Hospital Colorado, Aurora, Colorado
1996-Present Director of Pediatric Pulmonary Hypertension Program
Children’s Hospital Colorado, Aurora, Colorado
2003-Present Chief, Section of Cardiology
Children’s Hospital Colorado, Aurora, Colorado
University of Colorado School of Medicine
Honors, Special Recognition and Awards
1993 Fellows Basic Research, The Society For Pediatric Research
1995 Research paper 1st place, Frontiers in Cardiology Conference
2001 Children’s Choice Award, Pulmonary Hypertension Program
2003 Selby’s Endowed Chair of Pediatric Cardiology
2007 Award of Tenure, University of Colorado
2005-2008 5280 Magazine Top Docs
2010-2016 5280 Magazine Top Docs
2008 Heart Who Cares Award, Children’s Hospital Heart Institute
2011-2012 Patient Perception Award / Overall Top Performer
PRC National Excellence in Healthcare Awards
2016 CHCO NRC Patient Satisfaction Award
Board Membership in Professional Organizations
2005-2013 Scientific Leadership Council, Pulmonary Hypertension Association
2011-2014 Board of Trustees, Pulmonary Hypertension Association
2011-present Board, Pediatric Congenital Heart Association
2014-present Board, Chairman Association of Pediatric Pulmonary Hypertension
Society Membership
American College of Cardiology, Fellow
American Academy of Pediatrics, Fellow
American College of Chest Physicians, Fellow
American Heart Association, Fellow
Pediatric Cardiac Intensive Care Society
Pulmonary Hypertension Association
American Physiological Society
Society For Pediatric Research
Association for European Paediatric Cardiology
Pulmonary Vascular Research Institute
Association for Pediatric Pulmonary Hypertension
Major Committee and Service Responsibilities
Local
1999-2000 Blood Utilization Review Committee, TCH
1999-2002 Search Committee, Cardiac ICU Director, TCH
2001 Graduate Medical Education
Internal review of Nuclear Medicine and Cardiac Electrophysiology
2000-2002 Nominating Committee for The Children’s Hospital,
2003-2004 Imagine the Miracles, The Children’s Hospital Foundation
2005-2006 Search Committee, Chief Adult Cardiology, UC SOM
2010-2012 Data Safety and Monitoring Board: “Effect of Statin Therapy
on Disease Progression in Children with ADPKD”,
Melissa Cadnapaphornchai, M.D., PI
2011-2013 Executive Planning Committee, Denver American Heart Association Ball
2013-2014 Search Committee Chair, Chief Pediatric Pulmonology, UC SOM
2013-2015 Inpatient Efficiency, Children’s Hospital Colorado
National/International
2004 NICHD Supplemental U01 Grant Review
2005-2008 Society for Pediatric Research Young Investigator Award Committee
2006-11,-15 American College of Cardiology, abstract reviewer
2007 Society of Pediatric Research, abstract reviewer
2009-2010 NIH NHLBI Loan Repayment Program L30
2009-2012 Gilead Research Scholars Grant Review Board
2010 Guidelines for Pediatric Cardiology Training Programs
2010 Pulmonary Hypertension Academic Research Consortium
2011 NIH Workshop: Improving Outcomes in Pulmonary Hypertension
2011-2013 American Heart Association, National Program Planning Committee
2012 Cardiovascular Medical Research and Education Fund, Program Grant Review Committee
2013 Congressionally Directed Medical Research Program
Department of Defense Grant Reviewer
Licensure and board certification
1993-present Medical license, Colorado
2010-present Medical license, Wyoming
1991 Diplomate, American Board of Pediatrics
1994 Diplomate, Pediatric Cardiology, American Board of Pediatrics
2015 Diplomate, American Heart Association
Review and referee work
Circulation
Journal of the American College of Cardiology
American Journal of Cardiology
American Journal of Physiology
British Journal of Pharmacology
Biology of the Neonate
Biology of Perinatal Medicine
Critical Care Medicine
Pediatric Pulmonology
Catheterization and Cardiovascular Diagnosis
Pediatric Research
Annals of Thoracic Surgery
American Journal of Respiratory and Critical Care Medicine
Journal of Pediatrics
Pediatrics
European Respiratory Journal
Journal of Applied Physiology
Circulation Journal Japan
Journal of Infection and Public Health
Chest
Journal of Critical Care
Advances in Pulmonary Hypertension
American Journal of Cardiovascular Drugs
Frontiers in Pediatric Cardiology
Editorial Board
2002-2004 Topic Editor, Pulmonary Circulation Journal Club American Thoracic Society
2005-present Congenital Heart Disease: Clinical Studies from Fetus to Adulthood
2011-present Advances in Pulmonary Hypertension, Pulmonary Hypertension Association
2011-present Frontiers in Pediatric Cardiology
Administrative Positions
1996-2001 Fellowship Director, Pediatric Cardiology
1997-present Director, Pediatric Pulmonary Hypertension Program
2003-present Chief, Pediatric Cardiology
2006-2007 Interim Director, Cardiac ICU
Teaching
2001-2003 Physiology 5000, Clinical Correlates / First year medical students
1994-present Pediatrics 7000, Third year medical students
1994-present Core Lecture Series, Pediatric residents
1996-2001 Fellowship Director
1994-present Direct pediatric resident teaching and supervision
1994-present Direct cardiology fellow teaching and supervision
Mentoring
Medical Student Research Mentor
2016-2017 Karel Breeman
Cardiac MRI in determination of ventricular vascular coupling in children with pulmonary hypertension, University of Groningen, Netherlands
Pediatric Resident Research Mentor
1998-2000 Conrad Epting, MD
1999-2002 Kirsten Bourke, MD
2002-2004 Eric Austin, MD
Pediatric Cardiology Fellow Research Mentor
2002-2004 Dennis Chang, MD 2002-2004
2002-2003 Bibhuti Das, MD
2004-2007 Anna Bernus, MD
2005-2008 Jane Nydam, MD
2014-present Rick Friesen, MD
Pediatric Faculty Pulmonary Hypertension Mentor
2003-2004 Dong Seok Lee, MD, PhD
2010-2012 Shinichi Takatsuki, MD
2013 Erika Harder, MD
2013-present Scott Auerbach, MD
2013-present Uyen Truong, MD
2013-present Pei-Ni Jone
Master’s Advisor
2000-2003 Craig Weinberg, MS 2000-2003
Ultrasound evaluation of the pulmonary vascular resistance, input impedance, and right ventricular power in children with pulmonary hypertension
2007-2008 Alex Barker, MS
Wall stress as determined by cardiac MRI in patients with pulmonary arterial hypertension
2011-2012 Nick Hobson, MS
Utility of single beat measurement of ventricular vascular coupling in children with pulmonary arterial hypertension
2015-2016 Michal Schafer
4D Flow in children with pulmonary hypertension
PhD Advisor
2014-2015 Shawna Burgett
Mechanics of the proximal pulmonary artery in pulmonary hypertension
University of Colorado. Department of Bioengineering
2015-2017 Willemijn Zijlstra, University of Groningen, Netherlands
2016-2017 Michal Schafer
4D Flow in children with pulmonary hypertension
Grant Support
Active Grants
Office of Pediatric Therapeutics, Food and Drug Administration
Title: Investigation of Actigraphy, an Exercise Measurement Device, as a Novel, Well-defined, Reliable, Feasible, Easy to Use, and Non-Invasive Study Endpoint to Facilitate Pediatric Pulmonary Arterial Hypertension Trials and Drug Development
Funding: FDA Total Period 2016-2018
PI: Dunbar Ivy, MD Role: Principal-Investigator
% effort: 2.0 calendar
R01 National Institutes of Health
Title: Clinical and mechanistic role of HDGF in pulmonary hypertension
Funding: NIH / NHLBI (R01HL135114) Total Period 2017-2022
PI: Allen Everett, MD Role: Co-Investigator
% effort: 0.6 calendar
R01 National Institutes of Health
Title: Functional and Biological Phenotyping of Pediatric Pulmonary Hypertension
Funding: NIH / NHLBI (R01 HL114753) Total Period 2012-2017
PI: Robin Shandas, PhD Role: Co-Investigator
% effort: 0.6 calendar
R24 National Institutes of Health
Title: National Biological Sample and Data Repository for PAH
Funding: NIH / NHLBI (R24 HL105333) Total Period 2012-2017
PI: Bill Nichols, MD Role: Co-Investigator
% effort: 0.3 calendar
U01 National Institutes of Health
Title: Data Fusion: A Sustainable, Scalable, Open Source Registry Advancing Pulmonary Vascular Disease Research
Funding: NIH / NHLBI (U01HL121518) Total Period 2014-2018
PI: Steve Abman, MD / Ken Mandl, MD Role: Co-Investigator
% effort: 1.2 calendar
Completed Grants
American Heart Association Fellowship Award
Title: Role of Endothelin in Perinatal Pulmonary Hypertension
Funding: AHA of Colorado (CF-035-93) Total Period 1993-1994
PI: Dunbar Ivy, MD Role: PI
% effort: 75%
Bugher Physician Scientist Training Program
Title: Endothelin in the Fetal Pulmonary Circulation
Funding: Bugher Physician Scientist Program Total Period 1994-1996
PI: Dunbar Ivy, MD Role: PI
% effort: 75%
Clinical Research Center, The Children’s Hospital of Denver
Title: Use of Intravascular Ultrasound in Pediatric Pulmonary Hypertension
Funding: The Children’s Hospital of Denver Total Period 1995-1997
PI: Dunbar Ivy, MD Role: PI
% effort: 25%
Children’s Hospital Research Institute Career Development Award
Title: Endothelin in the Perinatal Pulmonary Circulation
Funding: The Children’s Hospital of Denver Total Period 1996-1998
PI: Dunbar Ivy, MD Role: PI
% effort: 50%
March of Dimes Basil O’Connor Starter Scholar Award
Title: Role of Endothelin in Perinatal Pulmonary Hypertension
Funding: March of Dimes Total Period 1997-1999
PI: Dunbar Ivy, MD Role: PI
% effort: 75%
American Heart Association
Title: Role of the Endothelin B Receptor in a Model of Pulmonary Hypertension
Funding: AHA, Desert/Mountain (9951441Z) Total Period 1999-2001
PI: Dunbar Ivy, MD Role: PI
% effort: 75%
K-08 National Institutes of Health
Title: Role of Endothelin in Perinatal Pulmonary Vasoregulation
Funding: NIH / NHLBI (K08 HL03823) Total Period 1999-2003
PI: Dunbar Ivy, MD Role: PI
% effort: 75%
R01 National Institutes of Health
Title: Noninvasive Assessment of Pediatric Pulmonary Hypertension
Funding: NIH / NHLBI (R01 HL067393) Total Period 2001-2006
PI: Robin Shandas, PhD Role: Co-Investigator
% effort: 5%
R38 US Department of Health and Human Services
Title: Infant Heart Transplantation from Non-Heart-Beating Donors: A Strategy to Reduce Waiting Mortality
Funding: USDHHS (R38 OTO) Total Period 2003-2006
PI: Mark Boucek, MD Role: Co-Investigator
% effort: 10%
U01 NIH/NHLBI Clinical Proteomics Programs
Title: Clinical Proteomics Program in Lung Disease
Funding: NIH / NHLBI (U01 HL081335) Total Period 2005-2009
PI: Frank Accurso, MD Role: Co-Investigator
% effort: 3%
National Institutes of Health 2006-2009
Title: Sildenafil in Treatment of Sickle Cell Disease Associated Pulmonary Hypertension
Funding: NIH / NHLBI (HHSN268200617185C) Total Period 2006-2009
PI: David Badesch, MD Role: Co-Investigator
% effort: 3%
RC1 National Institutes of Health / NHLBI ARRA Challenge Grant
Title: Identification and validation of quantifiable biomarkers of vasodilator therapeutic response in children with IPAH
Funding: NIH / NHLBI (RC1HL099786) Total Period 2009-2011
PI: Allan Everett, MD Role: Co-Investigator
% effort: 3%
P50 Specialized Centers of Clinically Oriented Research (SCCOR)
Title: Lung Vascular Disease in Infants and Children: Mechanisms and Treatment
Funding: NIH/NHLBI (P50 HL084923) Total Period 2006-2011
PI: Kurt Stenmark, MD Role: Co-Investigator
% effort: 10%
Bibliography
Peer Reviewed Publications
1. Humpl T, Berger RM, Austin ED, Fasnacht Boillat MS, Bonnet D, Ivy DD, Zuk M, Beghetti M, Schulze-Neick I. Treatment initiation in paediatric pulmonary hypertension: insights from a multinational registry. Cardiol Young. 2016 PMID: 27995825
2. Patel SS, Fernie JC, Taylor AL, Ivy DD, Rausch CM. Evaluation of predictive models for six-minute walk test among children with pulmonary hypertension.International Journal of Cardiology.2016 PMID: 27838122
3. Clopton RG, Friesen R, Partrick D, Wilson N, Jaggers J, Ivy DD, Schwartz LI, Ing RJ. The Anesthetic Challenges of Lung Biopsy-Associated Intrathoracic Hemorrhage in a Child With Suprasystemic Pulmonary Hypertension. Semin Cardiothorac Vasc Anesth. 2016 PMID: 27815350
4. Takatsuki S, Nakayama T, Ikehara S, Matsuura H, Ivy DD, Saji T.
Pulmonary Arterial Capacitance Index Is a Strong Predictor for Adverse Outcome in Children with Idiopathic and Heritable Pulmonary Arterial Hypertension. J Pediatr. 2016 PMID: 27810156
5. Abman SH, Ivy DD, Archer SL, Wilson K; AHA/ATS Joint Guidelines for Pediatric Pulmonary Hypertension Committee. Executive Summary of the American Heart Association and American Thoracic Society Joint Guidelines for Pediatric Pulmonary Hypertension. Am J Respir Crit Care Med. 2016;194(7):898-906. PMID: 27689707.
6. HumplT, BarstRJ, Berger RMF, Moore DJ, Fasnacht Boillat MS, Zuk M, Beghetti M, SchulzeNeickI for the TOPP Investigators. Treatment initiation in Pediatric Pulmonary Hypertension – A glance at current international practice pattern. Cardiology in the Young. 2016 PMID:
7. Kheyfets VO, Dunning J, Truong U, Ivy D, Hunter K, Shandas R. A 0-D Model and Protocol for Simulating Patient Specific Pulmonary Hemodynamics from Limited Clinical Data. J Biomech Eng. 2016 Dec 1;138(12) PMID: 27684888.
8. Burkett DA, Slorach C, Patel SS, Redington AN, Ivy DD, Mertens L, Younoszai AK, Friedberg MK. Impact of Pulmonary Hemodynamics and Ventricular Interdependence on Left Ventricular Diastolic Function in Children With Pulmonary Hypertension.Circ Cardiovasc Imaging. 2016;9(9). PMID: 27581953
9. Schäfer M, Ivy DD, Barker AJ, Kheyfets V, Shandas R, Abman SH, Hunter KS, Truong U. Characterization of CMR-derived haemodynamic data in children with pulmonary arterial hypertension. Eur Heart J Cardiovasc Imaging. 2016. PMID: 27444679
10. Ivy D. Pulmonary Hypertension in Children. Cardiology Clinics. 2016;34(3):451-72. PMID: 27443141
11. Yang J, Nies MK, Fu Z, Damico R, Korley FK, Hassoun PM, Ivy DD, Austin ED, Everett AD. Hepatoma Derived Growth Factor Predicts Disease Severity and Survival in Pulmonary Artery Hypertension. Am J Respir Crit Care Med. 2016 Nov 15;194(10):1264-1272 PMID: 27254543
12. Zijlstra WM, Douwes JM, Ploegstra MJ, Krishnan U, Roofthooft MT, Hillege HL, Ivy DD, Rosenzweig EB, Berger RM. Clinical classification in pediatric pulmonary arterial hypertension associated with congenital heart disease. Pulmonary Circulation. 2016;6(3):302-312 PMID: 27683607
13. Hauck A, Guo R, Ivy DD, Younoszai A.Tricuspid annular plane systolic excursion is preserved in young patients with pulmonary hypertension except when associated with repaired congenital heart disease.Eur Heart J Cardiovasc Imaging. 2016. PMID: 27099276
14. Ploegstra MJ, Ivy DD, Wheeler JG, Brand M, Beghetti M, Rosenzweig EB, Humpl T, Iriart X, Rouzic EM, Bonnet D, Berger RM. Growth in children with pulmonary arterial hypertension: a longitudinal retrospective multiregistry study. Lancet Respir Med. 2016; 4(4):281-90. PMID: 26994897
15. Douwes JM, Humpl T, Bonnet D, Beghetti M, Ivy DD, Berger RMF, on behalf of the TOPP Investigators. Acute Vasodilator Response in Pediatric Pulmonary Arterial Hypertension: Current Clinical Practice from the TOPP Registry. J Am Coll Cardiol. 2016;67:1312–23. PMID: 26988953
16. Beghetti M, Berger RM, Ivy DD, Bonnet D, Humpl T. To "Cath" or Not in Pediatric Pulmonary Hypertension? J Am Coll Cardiol. 2016 Mar 1;67(8):1010-1. PMID: 26916495
17. Kim JS, McSweeney J, Lee J, Ivy D. Pediatric Cardiac Intensive Care Society 2014 Consensus Statement: Pharmacotherapies in Cardiac Critical Care Pulmonary Hypertension. Pediatr Crit Care Med. 2016 Mar;17(3 Suppl 1):S89-S100. PMID: 26945333
18. Jone PN, Patel SS, Cassidy C, Ivy DD. Three-dimensional Echocardiography of Right Ventricular Function Correlates with Severity of Pediatric Pulmonary Hypertension. Congenit Heart Dis. 2016;11:562–569 PubMed PMID: 26899626.