2
Table S3. P. aeruginosa genes displaying >2-fold altered expression during growth with cyclamate as sulfur source, relative to growth with sulfate as sulfur source ( p<0.05). Positive values of fold change represent genes showing higher expression during growth with cyclamate (i.e. in the absence of sulfate), negative values show higher expression during growth with sulfate.
Gene Name / Fold Change / Synonyms / Description / FunctionPA0183_atsA_at / 32.95 / arylsulfatase / Carbon compound catabolism; Central intermediary metabolism
PA0184_at / 41.30 / atsC / probable ATP-binding component of ABC transporter / Transport of small molecules
PA0185_at / 16.18 / atsB / probable permease of ABC transporter / Membrane proteins; Transport of small molecules
PA0186_at / 24.03 / atsR / probable binding protein component of ABC transporter / Transport of small molecules
PA0187_at / 3.76 / hypothetical protein / Hypothetical, unclassified, unknown
PA0192_at / 25.42 / probable TonB-dependent receptor / Membrane proteins; Transport of small molecules
PA0193_at / 42.40 / hypothetical protein / Hypothetical, unclassified, unknown; Putative enzymes
PA0194_at / 26.92 / hypothetical protein / Hypothetical, unclassified, unknown; Putative enzymes
PA0197_at / 38.60 / hypothetical protein / Transport of small molecules
PA0198_exbB1_at / 55.97 / transport protein ExbB / Transport of small molecules
PA0199_exbD1_at / 35.72 / transport protein ExbD / Transport of small molecules
PA0213_at / 2.26 / mdcG / hypothetical protein / Carbon compound catabolism
PA0280_cysA_at / 3.33 / sulfate transport protein CysA / Transport of small molecules
PA0281_cysW_at / 3.23 / sulfate transport protein CysW / Membrane proteins; Transport of small molecules
PA0282_cysT_at / 3.22 / sulfate transport protein CysT / Membrane proteins; Transport of small molecules
PA0283_sbp_at / 3.10 / sulfate-binding protein precursor / Transport of small molecules
PA0284_at / 2.56 / hypothetical protein / Hypothetical, unclassified, unknown
PA0502_at / 2.43 / bioH / probable biotin biosynthesis protein bioH / Biosynthesis of cofactors, prosthetic groups and carriers
PA0504_bioD_at / 2.48 / dethiobiotin synthase / Biosynthesis of cofactors, prosthetic groups and carriers
PA1249_aprA_at / 3.63 / alkaline metalloproteinase precursor / Secreted factors (toxins, enzymes, alginate)
PA1317_cyoA_at / 3.42 / cytochrome o ubiquinol oxidase subunit II / Energy metabolism
PA1318_cyoB_at / 2.26 / cytochrome o ubiquinol oxidase subunit I / Energy metabolism
PA1319_cyoC_at / 2.81 / cytochrome o ubiquinol oxidase subunit III / Energy metabolism
PA1320_cyoD_at / 3.37 / cytochrome o ubiquinol oxidase subunit IV / Energy metabolism
PA1321_cyoE_at / 2.18 / cytochrome o ubiquinol oxidase protein CyoE / Energy metabolism
PA1747_at / 2.28 / hypothetical protein / Hypothetical, unclassified, unknown
PA2030_at / 6.75 / hypothetical protein / Hypothetical, unclassified, unknown
PA2031_i_at / 6.08 / hypothetical protein / Hypothetical, unclassified, unknown
PA2050_at / 7.36 / probable sigma-70 factor, ECF subfamily / Transcriptional regulators
PA2051_at / 9.91 / probable transmembrane sensor / Membrane proteins; Transcriptional regulators
PA2057_at / 2.30 / hypothetical protein / Hypothetical, unclassified, unknown
PA2062_at / 4.98 / probable pyridoxal-phosphate dependent enzyme / Putative enzymes
PA2063_at / 2.85 / hypothetical protein / Hypothetical, unclassified, unknown
PA2070_at / 2.61 / hypothetical protein / Hypothetical, unclassified, unknown; Membrane proteins
PA2083_at / 4.39 / probable ring-hydroxylating dioxygenase subunit / Carbon compound catabolism
PA2084_at / 7.87 / asnB; yucB / probable asparagine synthetase / Amino acid biosynthesis and metabolism
PA2085_at / 11.08 / probable ring-hydroxylating dioxygenase small subunit / Carbon compound catabolism
PA2086_at / 13.53 / probable epoxide hydrolase / Carbon compound catabolism
PA2087_at / 12.16 / hypothetical protein / Hypothetical, unclassified, unknown
PA2088_at / 13.07 / hypothetical protein / Hypothetical, unclassified, unknown
PA2089_at / 7.71 / hypothetical protein / Hypothetical, unclassified, unknown
PA2090_at / 9.87 / hypothetical protein / Hypothetical, unclassified, unknown
PA2091_at / 8.44 / hypothetical protein / Hypothetical, unclassified, unknown; Membrane proteins
PA2092_at / 12.03 / probable MFS transporter / Membrane proteins; Transport of small molecules
PA2093_at / 9.73 / probable sigma-70 factor, ECF subfamily / Transcriptional regulators
PA2094_at / 4.04 / probable transmembrane sensor / Membrane proteins; Transcriptional regulators
PA2095_at / 3.48 / hypothetical protein / Hypothetical, unclassified, unknown
PA2202_at / 4.26 / probable amino acid permease / Membrane proteins; Transport of small molecules
PA2203_at / 4.22 / probable amino acid permease / Membrane proteins; Transport of small molecules
PA2204_at / 3.57 / probable binding protein component of ABC transporter / Transport of small molecules
PA2289_at / 3.71 / conserved hypothetical protein / Hypothetical, unclassified, unknown
PA2290_gcd_at / 4.13 / glucose dehydrogenase / Carbon compound catabolism; Energy metabolism
PA2292_at / 13.41 / hypothetical protein / Hypothetical, unclassified, unknown
PA2293_at / 20.70 / hypothetical protein / Hypothetical, unclassified, unknown
PA2294_at / 22.32 / probable ATP-binding component of ABC transporter / Transport of small molecules
PA2295_at / 35.52 / probable permease of ABC transporter / Membrane proteins; Transport of small molecules
PA2296_at / 44.80 / hypothetical protein / Hypothetical, unclassified, unknown
PA2297_at / 18.52 / probable ferredoxin / Energy metabolism
PA2298_at / 14.83 / probable oxidoreductase / Putative enzymes
PA2299_at / 19.46 / probable transcriptional regulator / Transcriptional regulators
PA2306_at / 9.15 / conserved hypothetical protein / Hypothetical, unclassified, unknown; Membrane proteins
PA2307_at / 15.12 / probable permease of ABC transporter / Membrane proteins; Transport of small molecules
PA2308_at / 15.43 / probable ATP-binding component of ABC transporter / Transport of small molecules
PA2309_at / 11.83 / hypothetical protein / Hypothetical, unclassified, unknown
PA2310_at / 10.81 / hypothetical protein / Putative enzymes
PA2311_r_at / 2.42 / hypothetical protein / Hypothetical, unclassified, unknown
PA2312_at / 5.66 / probable transcriptional regulator / Transcriptional regulators
PA2313_at / 3.62 / hypothetical protein / Hypothetical, unclassified, unknown; Membrane proteins
PA2324_at / 26.10 / hypothetical protein / Putative enzymes
PA2325_at / 14.64 / hypothetical protein / Putative enzymes
PA2326_at / 11.14 / hypothetical protein / Putative enzymes
PA2333_at / 2.04 / probable sulfatase / Putative enzymes
PA2335_at / 3.26 / optO / probable TonB-dependent receptor / Transport of small molecules
PA2336_at / 6.28 / hypothetical protein / Hypothetical, unclassified, unknown
PA2346_at / 24.30 / conserved hypothetical protein / Putative enzymes
PA2347_at / 34.83 / hypothetical protein / Putative enzymes
PA2348_at / 46.96 / conserved hypothetical protein / Putative enzymes
PA2349_at / 36.85 / conserved hypothetical protein / Hypothetical, unclassified, unknown
PA2350_at / 19.24 / probable ATP-binding component of ABC transporter / Transport of small molecules
PA2351_at / 10.54 / probable permease of ABC transporter / Membrane proteins; Transport of small molecules
PA2354_at / 16.04 / probable transcriptional regulator / Transcriptional regulators
PA2355_at / 22.58 / msuC / probable FMNH2-dependent monooxygenase / Putative enzymes
PA2356_msuD_at / 18.44 / methanesulfonate sulfonatase MsuD / Carbon compound catabolism
PA2357_msuE_at / 17.80 / NADH-dependent FMN reductase MsuE / Central intermediary metabolism; Carbon compound catabolism
PA2358_at / 4.72 / hypothetical protein / Hypothetical, unclassified, unknown
PA2359_at / 6.10 / probable transcriptional regulator / Transcriptional regulators
PA2594_at / 4.24 / conserved hypothetical protein / Hypothetical, unclassified, unknown
PA2596_at / 6.99 / conserved hypothetical protein / Hypothetical, unclassified, unknown
PA2597_at / 4.16 / hypothetical protein / Putative enzymes
PA2598_at / 4.28 / hypothetical protein / Hypothetical, unclassified, unknown
PA2599_at / 3.77 / conserved hypothetical protein / Hypothetical, unclassified, unknown
PA2600_at / 3.00 / hypothetical protein / Hypothetical, unclassified, unknown
PA2602_at / 3.10 / hypothetical protein / Hypothetical, unclassified, unknown
PA2603_at / 4.28 / probable thiosulfate sulfurtransferase / Putative enzymes
PA2693_at / 3.03 / vdlD / conserved hypothetical protein / Hypothetical, unclassified, unknown
PA2786_at / 3.12 / hypothetical protein / Hypothetical, unclassified, unknown
PA3186_oprB_s_at / 2.54 / outer membrane porin OprB precursor / Transport of small molecules
PA3441_at / 5.09 / ssuF / probable molybdopterin-binding protein / Transport of small molecules
PA3442_at / 4.13 / ssuB ycbE / probable ATP-binding component of ABC transporter / Transport of small molecules
PA3443_at / 3.92 / ssuC ycbM / probable permease of ABC transporter / Membrane proteins; Transport of small molecules
PA3444_at / 2.96 / ssuD / conserved hypothetical protein / Putative enzymes
PA3445_at / 2.99 / conserved hypothetical protein / Hypothetical, unclassified, unknown
PA3446_at / 2.61 / ssuE / conserved hypothetical protein / Hypothetical, unclassified, unknown
PA3447_at / 13.47 / probable ATP-binding component of ABC transporter / Transport of small molecules
PA3448_at / 14.59 / ygaM / probable permease of ABC transporter / Membrane proteins; Transport of small molecules
PA3449_at / 9.05 / conserved hypothetical protein / Hypothetical, unclassified, unknown
PA3450_at / 3.11 / lsfA / probable antioxidant protein / Adaptation, protection
PA3892_at / 2.02 / conserved hypothetical protein / Hypothetical, unclassified, unknown
PA3931_at / 3.00 / conserved hypothetical protein / Hypothetical, unclassified, unknown
PA3932_at / 4.63 / probable transcriptional regulator / Transcriptional regulators
PA3933_at / 2.84 / betT3 / probable choline transporter / Membrane proteins; Transport of small molecules
PA3935_tauD_at / 2.87 / taurine dioxygenase / Carbon compound catabolism
PA3936_at / 3.29 / tauC / probable permease of ABC taurine transporter / Membrane proteins; Transport of small molecules
PA3937_at / 4.00 / tauB / probable ATP-binding component of ABC taurine transporter / Transport of small molecules
PA3938_at / 4.46 / tauA / probable periplasmic taurine-binding protein precursor / Transport of small molecules
PA3939_at / 3.98 / hypothetical protein / Hypothetical, unclassified, unknown
PA3954_at / 20.21 / hypothetical protein / Hypothetical, unclassified, unknown
PA4033_at / 3.52 / hypothetical protein / Hypothetical, unclassified, unknown
PA4034_aqpZ_at / 2.41 / bniP / aquaporin Z / Membrane proteins; Transport of small molecules
PA4191_at / 5.48 / probable iron/ascorbate oxidoreductase / Putative enzymes
PA4192_at / 4.98 / probable ATP-binding component of ABC transporter / Transport of small molecules
PA4193_at / 4.94 / probable permease of ABC transporter / Membrane proteins; Transport of small molecules
PA4194_at / 5.38 / probable permease of ABC transporter / Transport of small molecules; Membrane proteins
PA4195_at / 4.94 / probable binding protein component of ABC transporter / Transport of small molecules
PA4613_katB_at / 3.22 / catalase / Adaptation, protection
PA5030_at / 2.92 / ynfM / probable MFS transporter / Transport of small molecules; Membrane proteins
PA5101_at / 2.74 / hypothetical protein / Hypothetical, unclassified, unknown
PA5102_at / 3.97 / hypothetical protein / Hypothetical, unclassified, unknown; Membrane proteins
PA5103_at / 2.99 / hypothetical protein / Hypothetical, unclassified, unknown
PA5429_aspA_at / 5.45 / aspartate ammonia-lyase / Amino acid biosynthesis and metabolism
PA5446_i_at / 2.02 / hypothetical protein / Hypothetical, unclassified, unknown
PA5519_at / 2.10 / conserved hypothetical protein / Hypothetical, unclassified, unknown
PA0024_hemF_at / -2.36 / coproporphyrinogen III oxidase, aerobic / Biosynthesis of cofactors, prosthetic groups and carriers
PA0026_at / -2.41 / hypothetical protein / Hypothetical, unclassified, unknown
PA0049_at / -2.18 / hypothetical protein / Hypothetical, unclassified, unknown
PA0126_at / -2.08 / hypothetical protein / Hypothetical, unclassified, unknown
PA0295_at / -3.82 / probable periplasmic polyamine binding protein / Transport of small molecules
PA0403_pyrR_at / -2.52 / transcriptional regulator PyrR / Nucleotide biosynthesis and metabolism; Transcriptional regulators
PA0408_pilG_at / -3.21 / twitching motility protein PilG / Chemotaxis; Two-component regulatory systems; Motility & Attachment
PA0409_pilH_at / -3.44 / twitching motility protein PilH / Chemotaxis; Two-component regulatory systems; Motility & Attachment
PA0410_pilI_at / -2.72 / twitching motility protein PilI / Motility & Attachment; Chemotaxis
PA0411_pilJ_at / -2.16 / twitching motility protein PilJ / Motility & Attachment; Chemotaxis
PA0459_at / -2.97 / clpC / probable ClpA/B protease ATP binding subunit / Translation, post-translational modification, degradation
PA0509_nirN_at / -2.85 / probable c-type cytochrome / Energy metabolism; Biosynthesis of cofactors, prosthetic groups and carriers
PA0510_at / -3.13 / nirE / probable uroporphyrin-III c-methyltransferase / Energy metabolism; Biosynthesis of cofactors, prosthetic groups and carriers
PA0511_nirJ_at / -3.94 / heme d1 biosynthesis protein NirJ / Biosynthesis of cofactors, prosthetic groups and carriers; Energy metabolism
PA0512_at / -5.43 / nirH / conserved hypothetical protein / Energy metabolism; Hypothetical, unclassified, unknown; Biosynthesis of cofactors, prosthetic groups and carriers
PA0513_at / -6.54 / nirG / probable transcriptional regulator / Energy metabolism; Transcriptional regulators; Biosynthesis of cofactors, prosthetic groups and carriers
PA0514_nirL_at / -5.24 / heme d1 biosynthesis protein NirL / Energy metabolism; Hypothetical, unclassified, unknown; Biosynthesis of cofactors, prosthetic groups and carriers
PA0515_at / -9.90 / nirD / probable transcriptional regulator / Energy metabolism; Transcriptional regulators; Biosynthesis of cofactors, prosthetic groups and carriers
PA0516_nirF_at / -6.80 / heme d1 biosynthesis protein NirF / Biosynthesis of cofactors, prosthetic groups and carriers; Energy metabolism
PA0517_nirC_at / -9.35 / probable c-type cytochrome precursor / Biosynthesis of cofactors, prosthetic groups and carriers; Energy metabolism
PA0518_nirM_at / -9.01 / cytochrome c-551 precursor / Biosynthesis of cofactors, prosthetic groups and carriers; Energy metabolism
PA0519_nirS_at / -10.07 / nitrite reductase precursor / Energy metabolism
PA0672_at / -3.48 / pigA / hypothetical protein / Hypothetical, unclassified, unknown
PA0745_at / -2.24 / probable enoyl-CoA hydratase/isomerase / Putative enzymes
PA0746_at / -2.62 / probable acyl-CoA dehydrogenase / Putative enzymes
PA0779_at / -2.69 / probable ATP-dependent protease / Putative enzymes
PA0795_prpC_at / -2.13 / citrate synthase 2 / Carbon compound catabolism; Central intermediary metabolism
PA0802_i_at / -2.11 / hypothetical protein / Hypothetical, unclassified, unknown; Membrane proteins
PA0835_pta_at / -2.75 / phosphate acetyltransferase / Carbon compound catabolism
PA0836_at / -2.99 / ackA tdcD / probable acetate kinase / Putative enzymes
PA0852_cpbD_at / -2.48 / chitin-binding protein CbpD precursor / Secreted factors (toxins, enzymes, alginate)
PA0958_oprD_at / -2.11 / outer membrane porin protein OprD precursor / Transport of small molecules
PA1070_braG_at / -3.48 / branched-chain amino acid transport protein BraG / Transport of small molecules
PA1071_braF_at / -3.33 / branched-chain amino acid transport protein BraF / Transport of small molecules
PA1072_braE_at / -4.57 / branched-chain amino acid transport protein BraE / Membrane proteins; Transport of small molecules
PA1073_braD_at / -4.03 / branched-chain amino acid transport protein BraD / Membrane proteins
PA1074_braC_at / -3.22 / branched-chain amino acid transport protein BraC / Transport of small molecules
PA1123_at / -2.82 / hypothetical protein / Hypothetical, unclassified, unknown
PA1168_at / -3.40 / hypothetical protein / Hypothetical, unclassified, unknown