PCBC Cardiac Workshop Tentative Agenda (As of 4-17-2017)

PCBC Cardiac Workshop Tentative Agenda (as of 4-17-2017)

Sunday April 23rd, 2017

All day – Arrival from SFO or SJC to Sheraton, Palo Alto, CA

Monday April 24th, 2017

All day – Attend Stanford Drug Discovery Conference (optional for PCBC Cardiac Workshop Investigators)

6:30 pm - Dinner at Dan Gordon’s in downtown Palo Alto (640 Emerson St, Palo Alto, CA 94301)

Tuesday April 25th, 2017

8:00 am – Shuttle transportation from Sheraton Palo Alto to Lokey Stem Cell Research Building, Room G1161, 265 Campus Drive, Stanford, CA 94305. Meet at the front of hotel for pick up.

8:25 am – Breakfast (Lokey Stem Cell Research Building, Room G1161)

8:45 am– Welcome/Introduction (Joe Wu)

8:50 am - Summary of PCBC Programs and Focused Workshop Series (Denis Buxton – via Skype)

8:55 am - Introduction to PCBC Workshop on Cardiac Precision Medicine (Sean Wu)

Description of challenges to address and brief highlight workshop agenda

Precision Medicine for Treating Myopathies

9:00 am - CRISPR/Cas9 based therapy for Duchene’s Muscular Dystrophy (Eric Olson, UTSW)

9:25 am - Stem cell and large animal models of RBM20-mutation mediated dilated cardiomyopathy (Tim Nelson, Mayo Clinic)

9:50 am - Coffee Break

Cardiac Tissue Engineering for Precision Medicine

10:00 am - Regenerative approaches to post-MI heart failure using engineered cardiac patch (Jay Zhang, University of Alabama, Birmingham)

10:25 am - Engineering microphysiological systems from single cell to 3D tissue (Beth Pruitt, Stanford)

10:50 am - Vascular regeneration with reprogrammed cells and engineered stem cells (Young-sup Yoon, Emory)

11:15 am - Coffee Break

Stem Cell-based Cardiac Regenerative Biology

11:30 am - Congenital dilated cardiomyopathy patient-derived iPSCs for identifying a new causal gene - implications for adult heart failure (Charles Hong, Vanderbilt University)

11:55 am - Critical polyploidy in human cardiomyocytes (Jay Schneider, UT Southwestern)

12:20 pm - Lunch and Team Basketball Competition (Lokey Stem Cell Research Building, Room 1161)

Stem/Progenitor Cell-based Vascular Disease Modeling

1:55 pm - Vascular tissue engineering for ischemic peripheral artery disease (Ngan Huang, Stanford)

2:20 pm – hiPSC-based models of aortic malformation (Yibin Qyang, Yale)

2:45 pm - Coffee Break

Stem Cell Modeling of Cardiac Metabolism and Toxicity

3:00 pm – Probing cardiomyocyte maturation mechanisms using in vivo Cas9 somatic mutagenesis (William Pu, Boston Children’s)

3:25 pm - hiPSC-CM as a platform for understanding the genetic susceptibility for doxorubicin-induced cardiotoxicity - (Dan Bernstein, Stanford)

3:50 pm – Coffee Break

High Throughput Approaches to Cardiac Precision Medicine

4:00 pm – Precise small molecule screening for LMNA-related Dilated Cardiomyopathy (Nazish Sayed/Joe Wu Lab, Stanford)

4:25 pm - RNAi-based target discovery for heart failure and arrhythmia (Mark Mercola, Stanford)

4:50 pm – Wrap Up Discussion (all participants)

5:30 pm – Reserved shuttle to dinner at Il Fornaio (520 Cowper St.) in downtown Palo Alto

Wednesday April 26th, 2017

Return to airport – Individual ground transportation arrangements

Participants:

Investigators:

Dan Bernstein (Stanford)

Charles Hong (Vanderbilt)

Ngan Huang (Stanford)

Mark Mercola (Stanford)

Tim Nelson (Mayo Clinic)

Eric Olson (UT Southwestern)

Beth Pruitt (Stanford)

William Pu (Boston Children’s/Harvard)

Yibin Qyang (Yale)

Nazish Sayad (J Wu Lab) (Stanford)

Jay Schneider (UT Southwestern)

Joseph Wu (Stanford)

Sean Wu (Stanford)

Young-sup Yoon (Emory)

Jay Zhang (University of Alabama, Birmingham)

Trainees:

Seongho Bae (Yoon Lab) (Emory)

Haodong Chen (J Wu Lab) (Stanford)

Jared Churko (J Wu Lab) (Stanford)

Alison Schroer (Pruitt Lab) (Stanford) alisonschroer2gmail.com

Gaspard Pardon (Pruitt Lab) (Stanford)

Guang Li (S Wu Lab) (Stanford)

Matthew Ellis (Qyang Lab) (Yale)

Sharon Paige (S Wu Lab) (Stanford)

Vassilios Bezzerides (Pu Lab) (Boston Children’s)

Kenneth Tan (Conklin Lab) (Gladstone/UCSF)

Additional PCBC Attendees:

Masataka Yokoyama (Rafii Lab) (Cornell)

Hannele Ruohola-Baker (U of Wash)

Stefan Jovinge (Van Andel Institute/Spectrum Health)

Administrative Coordinators:

Hana Lee, MS (Associate Director, Stanford Cardiovascular Institute)

David Preston (Program Manager, Stanford Cardiovascular Institute)

Some useful information:

Sheraton Palo Alto: Lokey Stem Cell Building:

625 El Camino Real Blvd Room G1161

Palo Alto, CA 94301 265 Campus Dr.

800-325-3535 Stanford, CA 94305

Sean Wu:

Lokey Stem Cell Building, Room G1120A

265 Campus Drive, Stanford, CA 94305

617-980-1671 (cell)

Internet Access Code:

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