Supplementary Table 3: Univariate Cox Regression Analysis of PS.8 in Different Subgroups

Supplementary Table 3: Univariate Cox regression analysis of PS.8 in different subgroups

Subgroup / p-value / Hazard ratio / Confidence interval (95%)
Whole validation set / OS (n=149) / <0.001 / 0.69 / 1.35 - 2.13
TTT (n=105) / <0.001 / 1.79 / 1.49 - 2.17
Untreated patients / OS (n=107) / 0.002 / 1.72 / 1.23 - 2.38
TTT (n=78) / <0.001 / 1.85 / 1.45 - 2.38
Relapsed patients / OS (n=33) / 0.04 / 1.45 / 1.02 - 2.04
TTT (n=26) / 0.005 / 1.59 / 1.15 - 2.17
Binet A patients / OS (n=52) / 0.14 / 1.72 / 0.83 - 3.57
TTT (n=45) / 0.01 / 2.08 / 1.16 - 3.7
Newly diagnosed patients / OS (n=59) / 0.02 / 2.04 / 1.15 - 3.57
TTT (n=35) / 0.003 / 1.92 / 1.28 - 2.94
Favorable risk patients1 / OS (n=59) / 0.2 / 1.45 / 0.85 - 2.5
TTT (n=42) / 0.009 / 2 / 1.23 - 3.33
Unfavorable risk patients2 / OS (n=74) / 0.01 / 1.43 / 1.06 - 1.89
TTT (n=51) / <0.001 / 1.52 / 1.19 - 1.96
CD 19 sorted subgroup / OS (n=53) / 0.024 / 1.56 / 1.06 - 2.33
TTT (n=35) / 0.002 / 1.92 / 1.28 - 2.86
CD 19 unsorted subgroup / OS (n=96) / <0.001 / 1.85 / 1.35 - 2.56
TTT (n=70) / <0.001 / 2.17 / 1.67 - 2.86
Peripheral blood subgroup / OS (n=95) / <0.001 / 1.82 / 1.35 - 2.5
TTT (n=72) / <0.001 / 2.04 / 1.59 - 2.63
Bone marrow subgroup / OS (n=54) / 0.004 / 1.67 / 1.18 - 2.38
TTT (n=33) / 0.012 / 1.56 / 1.11 - 2.22

HR: Hazard ratio; CI: Confidence interval

The HR of PS.8 is given for a unit change

1 Favorable risk: No del 11q or 17p and no unmutated IGVHstatus

2 Unvavorable risk: Del 17p or 11q or unmutated IGVHstatus