MIAMI-DADE COUNTY PUBLIC SCHOOLS
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BIOLOGY I Course Code: 200031001
TOPIC XXII: MOLECULAR GENETICS - RNA and Protein Synthesis / Pacing / DateTraditional 5 days / 03-10-17 to 03-17-17
Block 2.5 days / 03-10-17 to 03-17-17
UNIT 6 TEST / 03-17-17 to 03-31-17
ESSENTIAL CONTENT / OBJECTIVES / INSTRUCTIONAL TOOLS
A. RNA Synthesis: Transcription (16.3, 16.5)
1. Role in the cell
2. Comparing RNA and DNA
3. Functions of RNA (types)
4. Codons (mRNA; Start and Stop)
B. Protein Synthesis: Translation (16.5)
1. Ribosomes (rRNA; “P” and “A” sites)
2. Amino Acids (tRNA; Anticodon)
3. Codon table
4. Translation
5. Gene Expression
C. Types of Mutations: (16.4)
1. Types
a. Point
b. Frameshift
c. Chromosomal
2. Effects
a. Harmful (16.8)
b. Beneficial
c. Variation
d. Neutral / · Summarize the process of transcription.
· Identify the different types of RNA (mRNA, tRNA, and rRNA) and explain the structure and function of each. **
· Demonstrate how specific code sequences are translated into traits through protein synthesis.
· Trace the information flow from DNA to a protein.
· Students will explain the basic processes of transcription and/or translation, and their roles in the expression of genes.
· Describe how amino acids are coded.
· Identify that certain chromosomal mutations can lead to human disorders such as sickle-cell disease.
· List possible mutagens and distinguish between chemical and physical mutagens.
· Differentiate the cellular processes of DNA replication, transcription, and/or translation (ALD)
· Students will explain how gene and chromosomal mutations may or may not result in a phenotypic change.
· Relate that mutation and genetic recombination increase genetic variation. (ALD) / Core Text Book: Ch.13
Vocabulary:
DNA, RNA, Transcription, Messenger RNA, Ribosomal RNA, Transfer RNA, Translation Codon, Anticodon, Ribosome, Amino Acid, Polypeptide, Protein, Nucleotide, Helix, Base pairing, Hydrogen bonding, Peptide Bond, RNA splicing, RNA polymerase
Technology:
1. HHMI: Translation (Basic Detail)
2. Interactive Art: Transcription and Translation
3. Art Review: Point Mutations
4. Data Analysis: Complicated Operon
5. NOVA: RNAi
6. DNA tube: Detailed Explanation of mRNA Translation
7. NOVA: Cracking the Code of Life
8. Bozeman Podcast: Mutations
9. Edgenuity
10. Packet 20 RNA L.16.3
SC.912.L.16.5 / RNA and Protein Synthesis
Standard: SC.912.L.16.3 / / Video / · How a Specific Sequence in a DNA Molecule is Replicated to Create an Identical Copy of Itself / · The Cell Cycle: Replication
· The Cell Cycle and DNA / · Introduction: DNA Replication
Standard: SC.912.L.16.4 / / Video / · Mutation
· DNA Mutations
· Genetic Disease
/ Image / · DNA sequence; nature of mutation
· Base pairing errors; generation of mutations
· Base substitution mutation
· Insertion and deletion mutations
Standard: SC.912.L.16.5 / / Video / · The Central Dogma: RNA and Transcription
· The Central Dogma: Translation and the Code
· What Is RNA?
· RNA Polymerase and Transcription
· Simulating the Process of Transcription With Models
· Exceptions to the Rules of Transcription / · Closing Remarks: Transcription of DNA to Messenger RNA
· Gene Expression DNA and RNA
· Review of the Processes of Transcription and Translation of mRNA
· The Standard Deviants School Biology: RNA: Introduction
· Translation / · The mRNA Template
· What is the Role of RNA?
· How Does RNA Know Where to Start Coding From a DNA Molecule?
· Introduction: Translation and Protein Synthesis
· Degenerate Code System
· The Process of Protein Synthesis
· Translating the Message into Protein
Standard: SC.912.L.16.5 / / Image / · Cell with ribosomes highlighted
Standard: SC.912.L.16.8 / / Video / · DNA and the Genetics of Cancer
· Defining Cancer
Standard: SC.912.L.16.9 / / Video / · Gene Expression Overview
· Amino Acid and the Language of Life
Standard: HE.912.C.1.7 / / Video / · The Role of Genes
· Mendel's Laws of Inheritance
· Inheritance Patterns
· Heredity: How Our Parents' Genes Affect Us
· Basic Facts About Cancer
· Obesity
· Diabetes / · Hunting Down the Genes Involved in Disease
· DNA and the Genetics of Cancer
· Genetic Disease
· Families and Genetic Disease
· Genetic Case Study: Addison's Disease
· Cystic Fibrosis / · Risk Factors for Heart Disease
· DNA Screening
· High & Low Risks for Cancer
· High & Low Risks for Cardiovascular Disease
· High & Low Risks for Diabetes
/ Audio / · Is Tone Deafness Hereditary?
· Can Your Grandfather's Diet Shorten Your Life?
/ Video / · Science Behind the News: Influenza & Flu Vaccines
· Georgia Tech Chemist Designs Molecules That May Stop or Slow Effects of Alzheimer's
· NIH Discovers Key to Sickle Cell Cure
· California Funds Stem Cell Research and Pushes for Quick Results
· For Mixed Race Patients, Few Bone Marrow Donors
· Animals, Injected with Human Genes, Are Possible Source of Transplantable Organs
· Stem Cells Provide Hope for Heart Failure Patients
· New Research May Help People Increase Their Lifespans
·
/ Image / · Pick Your Poison: Cobra Venom Shows Therapeutic Promise
Division of Academics – Department of Science Page 5 of 5
Third Nine Weeks
MIAMI-DADE COUNTY PUBLIC SCHOOLS
Learning Goals
BIOLOGY I Course Code: 200031001
SC.912.L16.3: Describe the basic process of DNA replication and how it relates to the transmission and conservation of the genetic information. ( Cognitive Complexity: Level 3: Strategic Thinking & Complex Reasoning)SC.912.L16.5: Explain the basic processes of transcription and translation and how they result in the expression of genes. ( Cognitive Complexity: Level 3: Strategic Thinking & Complex Reasoning )
Scale / Learning Progression / Sample Progress Monitoring and Assessment Activities
Score/Step 5.0 / ð I am able to distinguish among the cellular processes of DNA replication, transcription, and translation. / Using a given DNA nucleotide sequence, trace the pathway from replication to transcription and translation.
Identify the corresponding protein sequence that will form based on the original DNA nucleotide sequence and what could occur if the original DNA sequence was changed in any way.
Score/Step 4.0 / ð I am able to differentiate the cellular processes of DNA replication, transcription, and translation. / Create a diagram demonstrating the processes of DNA replication, transcription and translation. Include descriptions of each process and how they differ from one another.
Score/Step 3.0 Target
(Learning Goal) / ð I am able to differentiate the cellular processes of DNA replication, transcription, and translation. / Given a diagram of the processes of DNA replication, transcription and translation, identify the correct sequence of each process.
Score/Step 2.0 / ð I am able to choose the correct cellular process of DNA replication. / Given a diagram of the components of DNA replication, identify the correct sequence of replication.
Score/Step 1.0 / ð I am able to understand that every organism has hereditary information stored in DNA that get passed on from one generation to another.
Division of Academics – Department of Science Page 5 of 5
Third Nine Weeks