CURRICULUM VITAE
Name and family name / Vaidutis KučinskasDate of birth / January 27, 1947
Scientific degree and titles / Ph.D., Dr. Habil., Professor
Higher Education
University / Year of graduation / Qualification obtained
Vilnius University / 1982 / mathematics
Vilnius University / 1970 / biology (genetics)
Graduate studies
University / Title of thesis / Date / Degree obtained
Vilnius University / “Population genetics analysis of allergic diseases” / 1974 / Ph.D. (biology – genetics)
Habilitation
University / Title of thesis / Date / Degree obtained
Center of Medical Genetics, Medical Acad. Sci. of the USSR, Moscow, USSR / “Genetic process in contemporary Lithuanian population” / 1987 / Dr. Habil. (genetics)
Work experience
Lithuania
Year (from/to) / Workplace / Position
2012- present / Department of Human and Medical Genetics (Vilnius University) / Professor, Chief Research Fellow
2012 -present / The Centre for Medical Genetics (Vilnius University Hospital Santariškių klinikos) / Consultant professor, medical geneticist
2002-2012 / Department of Human and Medical Genetics (Vilnius University) / Chairman, Professor
2002-2012 / The Centre for Medical Genetics (Vilnius University Hospital Santariškių klinikos) / Director, medical geneticist
1991–2002 / Center of Human Genetics (Vilnius University) / Chairman, Professor
1991–2002 / Vilnius University Hospital (Vilnius) / Director, Professor
1985–1990 / Department of Medical Genetics (Vilnius);
Research Institute of Mother and Child Care (Vilnius) / Director of the Dept. of Medical Genetics
1977–1985 / Research Inst. of Exp. and Clin. Medicine (Vilnius) / Director of the Lab. of Medical Genetics
1970–1977 / Vilnius Republican Hospital / Director of the Genetic Counseling Office
Scientific and teaching activities
Scientific interests / Teaching activity (courses offered)
Diversity of the human genome and genetic processes in human populations.
Diagnostics and research of inherited diseases by application of biotechnological assays.
mt-DNA, Y chromosome and nuclear DNA polymorphism in human populations. / Human Molecular Genetics,
Human Genome Analysis,
Basic Genetics and Genomics
Visiting positions
Place / Duration / Years
ESHG/LSHG courses for laboratory medical geneticists: Translating genomics into the clinics / 1 week / 2009
Institute of Genetics, National Yang-Ming University, Taiwan / 2 months / 2002
8th European School of Medical Genetics, Genoa, Italy / 1 week / 1995
Institute of Ophthalmology, Dept. Of Molecular Genetics, University College London, UK / 5 months / 1994
Medical genetics department of Umeå University (Umeå, Sweden) / 4 months / 1993
First EC course for mutation-detection and characterization in ophthalmic-genetic diseases, Lübeck, Germany / 1week / 1993
National Cancer Institute, Frederick National Laboratory for Cancer Research, Laboratory of Viral Carcinogenesis (Frederick, MD, USA) / 6 months / 1992
Department of Human genetics and – WHO associated center (Budapest, Hungary) / 1 month / 1990
Central physician development center of Moscow (Moscow, USSR) / 4 months / 1971–1972
Medical Institute of Postgraduate Training (Moscow) / 4 months / 1971–1972
Faculty of Medicine of Vilnius University / 2 months / 1970
Main publications during last 5 years
Textbooks, encyclopaedias
1. Vaidutis Kučinskas, Pranė Stankevičienė, Biologija. Vadovėlis XI-XII klasei. Organizmų požymių paveldėjimas ir genų technologijos. – Kaunas: Šviesa, 2013, 240 p., ISBN 9785430061395 ((in Lithuanian).
2. Vaidutis Kučinskas, Fundamentals of Genetics and Genomics (Genetikos ir genomikos pagrindai). Vilnius: Vilniaus University, Vilniaus University Press. – 2012. 296 p. ISBN 978-609-459-090-0. (in Lithuanian).
3. Kučinskas V. Genetic family counseling (Genetinis šeimų konsultavimas). // Obstetrics and gynecology practice (Akušerija ir ginekologija šeimos gydytojo praktikoje). Second edition, p. 135-155 / Drąsutienė G (ed.). // Vilnius : Vaistų žinios, 2010, p. 800 (in Lithuanian).
4. Andrejevaitė V., Ašoklis R., Aranauskas R., Blažienė A., Bylaitė M., Butrimienė I., Dadonienė J., Drąsutienė G., Jankevičius F., Jatužis D., Jurgutis A., Kasiulevičius V., Kiverytė S., Kučinskas V. et. al. Family medicine (Šeimos medicina) / Vilnius: National medicine training centre (Nac. med. mokymo centras), 2009, p. 576 (in Lithuanian).
5. Drąsutienė, Gražina Stanislava, Ališauskas, Jonas, Arlauskienė, Audronė, Benušienė, Eglė, Bumbulienė, Žana, Daunoravičius, Ričardas, Domža, Bronius, Drazdienė, Nijolė, Jatužienė, Diana, Klimas, Vytautas, Krikštopaitytė, Rita, Kučinskas, Vaidutis, Mačiulienė, Kornelija, Mečėjus, Gediminas, Petraitienė, Vida, Ramašauskaitė, Diana, Raugalė, Algimantas, Obstetrics and gynecology practice guide (Akušerijos ir ginekologijos praktikos vadovas) / Vilnius: Vilnius University Press, 2008, p. 542 (in Lithuanian).
Studies
1. Sergio Giannattasio, Antonella Bobba, Paolo Lattanzio, Vaidutis Kučinskas, Ersilia Marra. Genotypic Heterogeneity of the Molecular Basis of Cystic Fibrosis: The Paradigm of Lithuanian Population Genetic Testing (Chapter 5). Cystic Fibrosis: Etiology, Diagnosis and Treatments, (Genetics – Research and Issues Series), Editor: Paul N.Leatte, 2009, Nova Science Publishers, Inc., p. 113-127, ISBN 978-1-60741-833-7.
Articles in Scientific Journals
Articles in Journals from the master list of ISI
1. Čiuladaitė Ž, Burnytė B, Vansevičiūtė D, Dagytė E, Kučinskas V, Utkus A. Clinical, cytogenetic and molecular study of a case of ring chromosome 10. Mol Cytogenet [Internet]. 2015 Apr 21 [cited 2015 May 5]; Vol 8. no 29; 6 p. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411697/.
2. Preikšaitienė E, Krasovskaja N, Utkus A, Kasnauskienė J, Meškienė R, Paulauskienė I, Valevičienė N, Kučinskas V. R368X mutation in MID1 among recurrent mutations in patients with X-linked Opitz G/BBB syndrome. Clinical Dysmorphology. – 2015, vol. 24, no. 1, p. 7-12.
3. Bulik-Sullivan BK, Loh P-R, Finucane HK, Ripke S, Yang J, Schizophrenia Working Group of the Psychiatric Genomics Consortium, et al. LD Score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat Genet. 2015 Mar;47(3):291–5. Preiksaitiene E., Caro A., Benušienė E., Oltra S., Orellana C., Morkūnienė A., et al. A novel missense mutation in the NSDHL gene identified in a Lithuanian family by targeted next-generation sequencing causes CK syndrome. Am J Med Genet A [Internet]. 2015 Apr 21 [cited 2015 May 20]; vol. 21. 7 p. Available from: http://onlinelibrary.wiley.com/doi/10.1002/ajmg.a.36999/abstract.
4. Gusev A, Hong Lee S, Trynka V, Finucane H, Bjarni J,... Kučinskas V, Kučinskienė ZA et. al., Partitioning Heritability of Regulatory and Cell-Type-Specific Variants across 11 Common Diseases. The American Journal of Human Genetics 95, p. 535–552, November 6, 2014.
5. Liaugaudiene O, Benusiene E, Domarkiene I, Ambrozaityte L, Kučinskas V. X-linked ichthyosis: Differential diagnosis of low maternal oestriol level. J Obstet Gynaecol. 2014 Nov;34(8):737-739.
6. Čiuladaitė Ž., Eglė Preikšaitienė, Algirdas Utkus, Vaidutis Kučinskas, Relatives with Opposite Chromosome Constitutions, rec(10)dup(10p)inv(10)(p15.1q26.12) and rec(10)dup(10q)inv(10)(p15.1q26.12), due to a Familial Pericentric Inversion. Cytogenet Genome Res 2014; 144; p. 109-113. Publisched online: November 15, 2014.
7. Lazaridis I., Patterson N., Mittnik A., Renaud G., Mallick S., Kirsanow K.,….Kučinskas V., Uktverytė I. et al. Ancient human genomes suggest three ancestral populations for present-day Europeans. Nature: international weekly journal of science, vol. 513, no. 7518, p. 409-413, ISSN 0028-0836 2014.
8. Ripke S., Benjamin M. Neale, Aiden Corvin, James T. R. Walters, Kai-How Farh,...Vaidutis Kučinskas et. al. (Schizophrenia Working Group of the Psychiatric Genomics Consortium), Biological insights from 108 schizophrenia-associated genetic loci. Nature, vol. 511, 24 July 2014, p. 421-427, ISSN : 0028-0836, EISSN : 1476-4687.
9. Knappskog S., Gansmo L. B., Dibirova K., Metspalu A., Cybulski C., Peterlongo P.,...Kučinskas V., ... Dörk T., Balanovsky O., Lønning P. E., Population distribution and ancestry of the cancer protective MDM2 SNP 285 (rs117039649). Oncotarget, 2014, vol. 5, No. 18, p. 8223-8234. Online ISSN: 1949-2553.
10. Preikšaitienė E., Alma Molytė, Juratė Kasnauskienė, Živilė Čiuladaitė, Algirdas Utkus, Philippos C. Patsalis, Vaidutis Kučinskas, Considering specific clinical features as evidence of pathogenic copy number variants. Journal of Applied Genetics, Published online: 18 February 2014, ISSN: 1234-1983 (Print) 2190-3883 (Online).
11. Ginevičienė V., Audronė Jakaitienė, Linas Tubelis, Vaidutis Kučinskas, Variation in the ACE, PPARGC1A and PPARA genes in Lithuanian football players. European Journal of Sport Science, 2014, vol. 14, Suppl 1, S289-295.
12. Čiuladaitė Ž, Aušra Matulevičienė, Aušra Bandanskytė, Andrius Brazaitis, Jūratė Kasnauskienė, Vaidutis Kučinskas, Familiar Distal Monosomy 5pl5.3-pter With Trisomy 12q24.2-qter Resulting in Neurodevelopmental Delay and Dysmorphic Features. Journal of Child Neurology, 2014, Mar; 29(3), p. 399-405.
13. Kashevarova AA, Lyudmila P. Nazarenko, Nikolay A. Skryabin, Olga A. Salyukova, Nataliya N. Chechetkina, Ekaterina N. Tolmacheva, Elena A. Sazhenova, Pamela Magini, Claudio Graziano, Giovanni Romeo, Vaidutis Kučinskas, Igor N. Lebedev, Array CGH analysis of a cohort of Russian patients with intellectual disability. Gene, vol. 536, Iss. 1, 15 February 2014, p.145–150.
14. Matulevičienė A, Preikšaitienė E, Linkevičienė L, Radavičius M, Molytė A, Utkus A, Kučinskas V. Heterogeneity of oral clefts in relation to associated congenital anomalies. Medicina (Kaunas). 2013;49(2):61-6.
15. Kasnauskiene J, Ciuladaite Z, Preiksaitiene E, Utkus A, Peciulyte A, Kučinskas V. A new single gene deletion on 2q34: ERBB4 is associated with intellectual disability. Am J Med Genet A. 2013 Jun;161(6):1487-90.
16. Esko T, Mezzavilla M, Nelis M, Borel C, Debniak T, Jakkula E, Julia A, Karachanak S, Khrunin A, Kisfali P, Krulisova V, Aušrelé Kučinskiené Z, Rehnström K, Traglia M, Nikitina-Zake L, Zimprich F, Antonarakis SE, Estivill X, Glavač D, Gut I, Klovins J, Krawczak M, Kučinskas V, Lathrop M, Macek M, Marsal S, Meitinger T, Melegh B, Limborska S, Lubinski J, Paolotie A, Schreiber S, Toncheva D, Toniolo D, Wichmann HE, Zimprich A, Metspalu M, Gasparini P, Metspalu A, D'Adamo P. Genetic characterization of northeastern Italian population isolates in the context of broader European genetic diversity. Eur J Hum Genet. 2013 Jun;21(6):659-65. doi: 10.1038/ejhg.2012.229. Epub 2012 Dec 19.
17. Ciuladaite Z, Matuleviciene A, Bandanskyte A, Brazaitis A, Kasnauskiene J, Kučinskas V. Familial Distal Monosomy 5p15.3-pter With Trisomy 12q24.2-qter Resulting in Neurodevelopmental Delay and Dysmorphic Features. J Child Neurol. 2013 Jan 22.
18. Kučinskas V, Uktverytė I. Genetic variation and genomic origin of Lithuanians. IFEH 12th World Congress on Environmental Health Vilnius, Lithuania 22-27 May 2012. Medimond Publisher proceedings, 2012 (ISBN-978-88-7587-664-7).
19. Esko T, Mezzavilla M, Nelis M, Borel C, Debniak T, Jakkula E, Julia A, Karachanak S, Khrunin A, Kisfali P, Krulisova V, Aušrelé Kučinskiené Z, Rehnström K, Traglia M, Nikitina-Zake L, Zimprich F, Antonarakis SE, Estivill X, Glavač D, Gut I, Klovins J, Krawczak M, Kučinskas V, Lathrop M, Macek M, Marsal S, Meitinger T, Melegh B, Limborska S, Lubinski J, Paolotie A, Schreiber S, Toncheva D, Toniolo D, Wichmann HE, Zimprich A, Metspalu M, Gasparini P, Metspalu A, D'Adamo P. Genetic characterization of northeastern Italian population isolates in the context of broader European genetic diversity. Eur J Hum Genet. 2012 Dec 19. doi: 10.1038/ejhg.2012.229. [Epub ahead of print]
20. Mendizabal I, Lao O, Marigorta UM, Wollstein A, Gusmão L, Ferak V, Ioana M, Jordanova A, Kaneva R, Kouvatsi A, Kučinskas V, Makukh H, Metspalu A, Netea MG, de Pablo R, Pamjav H, Radojkovic D, Rolleston SJ, Sertic J, Macek M Jr, Comas D, Kayser M. Reconstructing the Population History of European Romani from Genome-wide Data. Curr Biol. 2012 Dec 18;22(24):2342-9. doi: 10.1016/j.cub.2012.10.039. Epub 2012 Dec 6.
21. Kasnauskiene J, Cimbalistiene L, Utkus A, Ciuladaite Z, Preiksaitiene E, Pečiulytė A, Kučinskas V. Two new de novo interstitial duplications covering 2p14-p22.1: clinical and molecular analysis. Cytogenet Genome Res. 2013;139(1):52-8. doi: 10.1159/000342544. Epub 2012 Oct 2.
22. Preiksaitiene E, Kasnauskiene J, Ciuladaite Z, Tumiene B, Patsalis PC, Kučinskas V. Clinical and molecular characterization of a second case of 7p22.1 microduplication. Am J Med Genet A. 2012 May;158A(5):1200-3. doi: 10.1002/ajmg.a.35300. Epub 2012 Apr 11.
23. Kasnauskienė J, Čiuladaitė Ž, Preikšaitienė E, Matulevičienė A, Alexandrou A, Koumbaris G, Sismani C, Pepalytė I, Patsalis PC, Kučinskas V. A single gene deletion on 4q28.3: PCDH18 – A new candidate gene for intellectual disability? European Journal of Medical Genetics vol.55, No. 4, April 2012, p. 274-277, ISSN 1769-7212.
24. Preikšaitienė E, Männik K, Dirsė V, Utkus A, Čiuladaitė Ž, Kasnauskienė J, Kurg A, Kučinskas A. A novel de novo 1.8 Mb microdeletion of 17q21.33 associatedwith intellectual disability and dysmorphic features. European Journal of Medical Genetics (2012)1-4 ISSN 1769-7212.
25. Ginevičienė V, Jakaitienė A, Tubelis L, Kučinskas V. Variation in the ACE, PPARGC1A and PPARA genes in Lithuanian footbal players. European Journal of Sport Science, 2012, p. 1-7, iFirst article, ISSN 1746-1391.
26. Ginevičienė V, Pranculis A, Jakaitienė A, Milašius K, Kučinskas V.. Genetic Variation of the Human ACE and ACTN3 Genes and Their Association with Functional Muscle Properties in Lithuanian Elite Athletes, Medicina, (Kaunas) 2011, t.47, nr.5, p. 284-290, ISSN 1010-660X.
27. Ciuladaitė Z, Kasnauskienė J, Cimbalistienė L, Preikšaitienė E, Patsalis PC, Kučinskas V. Mental retardation and autism associated with recurrent 16p11.2 microdeletion: incomplete penetrance and variable expressivity. J Appl Genet. 2011 Nov;52(4):443-9..
28. Dirsė V, Šliužas V, Čiuladaitė Ž, Aleksiūnienė B, Kučinskas V. Subtelomeric fluorescence in situ hybridization in clinical cytogenetics: results of analysis of Lithuanian patients, Biologija, Vol. 57, No. 1, p. 8–14, Lietuvos mokslų akademija, 2011, ISSN: 1392-0146.
29. Kasnauskiene J, Cimbalistiene L, Ciuladaite Z, Preiksaitiene E, Kučinskienė ZA, Hettinger JA, Sismani C, Patsalis PC, Kučinskas V. De novo 5q35.5 duplication with clinical presentation of Sotos syndrome. Am J Med Genet A. 2011 Oct;155A(10):2501-7.
30. Nikopensius T, Kempa I, Ambrozaitytė L, Jagomägi T, Saag M, Matulevičienė A, Utkus A, Krjutškov K, Tammekivi V, Piekuse L, Akota I, Barkane B, Krumina A, Klovins J, Lace B, Kučinskas V, Metspalu A. Variation in FGF1, FOXE1, and TIMP2 genes is associated with nonsyndromic cleft lip with or without cleft palate. Birth Defects Research (Part A) 91:218_225 (2011).
31. Ginevičienė V, Pranckevičienė E, Milašius K, Kučinskas V. Gene variants related to the power performance of the Lithuanian athletes. Central European Journal of Biology 2011;6(1), p.48–57, ISSN: 1895104X.
32. Skirton H, Lewis C, Kent A, Coviello DA, Bloch-Zupan A, Darpoux FC, Cornel M, DeLozier C, Farndon P, Goetz P, Hodgson S, Houge G, Hulten M, Kosztolanyi G, Kučinskas V, Ozcelik T, Sequeiros J, Soller M, Tranebjaerg L. Genetic education and the challenge of genomic medicine: development of core competences to support preparation of health professionals in Europe. Eur J Hum Genet, Sep;18(9), p. 972-7, 2010.
33. Nikopensius T, Ambrozaitytė L, Ludwig KU, Birnbaum S, Jagomägi T, Saag M, Matulevičienė A, Linkevičienė L, Herms S, Knapp M, Hoffmann P, Nöthen MM, Metspalu A, Kučinskas V, Mangold E. Replication of Novel Susceptibility Locus for Nonsyndromic Cleft Lip with or without Cleft Palate on Chromosome 8q24 in Estonian and Lithuanian Patients American Journal of Medical Genetics Part A.2009, vol. 149A, no. 11. ISSN1552-4825 p. 2551-2553.