Zhi Liu

Selected Publications

1.  Li N, Park M, Zhao M, Hilario-Vargas J, McInnes DM, Prisayanh PS, Liu Z, Diaz LA. The Thomsen-Friedenreich antigen-binding lectin jacalin interacts with desmoglein-1 and abrogates the pathogtenicity of pemphigus foliaceus autoantibodies in vivo. J Invest Dermatol. 2010 July 15.

  1. Li N, Zhao M, Wang J, Liu Z, Diaz LA. Involvement of the apoptotic mechanism in pemphigus foliaceus autoimmune injury of the skin. J Immunol. 2009 Jan 1;182(1):711-7.

3.  Li Z, Garantziotis S, Jia W, Potts E, Lalani S, Liu Z, He Y-W, Foster WM, Hollingsworth JW. The extracellular matrix protein mindin regulates trafficking of murine eosinophils into the airspace. J Leuko Biol. 2009(85):124-131.

4.  Liu Z, Sui W, Zhao M, Li Z, Li N, Thresher R, Giudice GJ, Fairley JA, Sitaru C, Zillikens D, Ning G, Marinkovich P, Diaz LA. Subepidermal blistering induced by human autoantibodies to BP180 requires innate immune players in a humanized bullous pemphigoid mouse model. J. Autoimmune. 2008;31:331-338.

5.  Berkowitz P, Chua M, Liu Z, Diaz LA, Rubenstein DS. Autoantibodies in the autoimmune disease pemphigus foliaceus induce blistering via p38 mitogen-activated protein kinase-dependent signaling in the skin. Am J Pathol. 2008 Dec;173(6):1628-36.

6.  Chen M, Doostan A, Bandyopadhyay P, Remington J, Wang X, Hou Y, Liu Z, Woodley DT. The cartilage matrix protein subdomanin of type VII collagen is pathogenic for epidermolysis bullosa acquisita. Am J Pathol. 2007(170):2009-2018.

  1. Kaufmann WK, Nevis KR, Qu P, Ibrahim JG, Zhou T, Zhou Y, Simpson DA, Helms-Deaton J, Cordeiro-Stone M, Moore DT, Thomas NE, Hao H, Liu Z, Shields JM, Scott GA, Sharpless NE. Defective cell cycle checkpoint functions in melanoma are associated with altered patterns of gene expression. J Invest Dermatol. 2007(128):175-187.

8.  Nelson KC, Zhao M, Schroeder PR, Li N, Westel RA, Diaz LA, Liu Z. Role of different pathways of the complement cascade in experimental bullous pemphigoid. J. Clin. Invest. 2006;116:2892-2900.

9.  Zhao M, Trimbeger ME, Li N, Diaz LA, Shapiro SD, Liu Z. Role of FcRs in animal model of autoimmune bullous pemphigoid. J. Immunol. 2006;177:3398-3405.

10.  Liu Z, Zhao M, Li N, Diaz LA, Mayadas TN. Differential roles for beta2 integrins in experimental autoimmune bullous pemphigoid. Blood. 2006;107:1063-1069.

  1. Woodley DT, Ram R, Doostan A, Bandyopadhyay P, Huang Y, Remington J, Hou Y, Keene DR, Liu Z, Chen M. Induction of epidermolysis bullosa acquisita in mice by passive transfer of autoantibodies from patients. J. Invest. Dermatol. 2006;126:1323-1330.
  2. Berkowitz P, Hu P, Warren S, Liu Z, Diaz LA, Rubenstein DS. p38MAPK inhibition prevents disease in pemphigus vulgaris mice. Proc. Natl. Acad. Sci. U.S.A. 2006;103:12855-12860.
  3. Liu Z, Li N, Diaz LA, Shipley JM, Senior RM, Werb Z. Synergy between a plasminogen cascade and MMP-9 in autoimmune disease. J. Clin. Invest. 2005;115:879-887.

14.  Woodley DT, Chang C, Saadat P, Ram R, Liu Z, Chen M. Evidence that Anti-Type VII Collagen Antibodies Are Pathogenic and Responsible for the Clinical, Histological, and Immunological Features of Epidermolysis Bullosa Acquisita. J. Invest. Dermatol. 2005;124:958-964.

15.  Berkowitz P, Hu P, Liu Z, Diaz LA, Enghild JJ, Chua MP, Rubenstein DS. Desmosome signaling. Inhibition of p38MAPK prevents pemphigus vulgaris IgG-induced cytoskeleton reorganization. J Biol Chem. 2005;280:23778-23784.

16.  Li N, Zhao M, Hilario-Vargas J, Prisayanh P, Warren S, Diaz LA, Roopenian DC, Liu Z. Complete FcRn dependence for intravenous Ig therapy in autoimmune skin blistering diseases. J. Clin. Invest. 2005;115:3440-3450.

  1. Xiao H, Heeringa P, Hu P, Liu Z, Zhao M, Aratami Y, Maeda NN, Falk RJ, Jennette JC. Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vesculitis in mice. J. Clin. Invest. 2002;110:955-963.
  2. Arteaga LA, Prisayanh P, Warren SJP, Liu Z, Diaz LA, Lin M, The Cooperative Group of Fogo Selvagem Research. A subset of pemphigus foliaceus patients exhibits pathogenic autoantibodies against both desmoglein-1 and desmoglein-3. J. Invest. Dermatol. 2002;118:806-811.

19.  Chen R, Fairley AJ, Zhao M-L, Giudice GJ, Zillikens D, Diaz LA, Liu Z. Macrophages, but not T and B lymphocytes, are critical for subepidermal blister formation in experimental bullous pemphigoid: macrophage-mediated neutrophil infiltration depends on mast cell activation. J. Immunol. 2002;169:3987-3992.

  1. Chen R, Zhou X, Diaz LA, Werb Z, Liu Z. Mast cells play a key role in neutrophil recruitment in experimental bullous pemphigoid. J. Clin. Invest. 2001;108:1151-1158.
  2. Liu Z, Zhou X, Shapiro SD, Shipley JM, Twining SS, Diaz LA, Senior RM, Werb Z. The serpin alpha1-proteinase inhibitor is a critical substrate for gelatinase B/MMP-9 in vivo. Cell 2000;102:647-655.
  3. Betsuyaku T, Shipley JM, Liu Z, Senior RM. Neutrophil emigration in the lungs, peritoneum, and skin does nor require gelatinase B. Am. J. Respir. Cell Mol. Biol. 1999;20:1303-1309.

23.  Ding X, Diaz LA, Fairley JA, Giudice GJ, Liu Z. The anti-desmoglein 1 autoantibodies in pemphigus vulgaris sera are pathogenic. J. Invest. Dermatol. 1999;112:739-743.

24.  Liu Z, Shipley JM, Vu TH, Zhou X, Diaz LA, Werb Z, Senior RM. Gelatinase B-deficient mice are resistant to experimental bullous pemphigoid. J. Exp. Med. 1998;188:475-482.

  1. Liu Z, Giudice GJ, Zhou X, Swartz SJ, Troy JL, Fairley JA, Till GO, Diaz LA. A major role for neutrophils in experimental bullous pemphigoid. J. Clin. Invest. 1997;100:1256-1263.
  2. Zillikens D, Rose PA, Balding SD, Olague-Marchan M, Mascaro JM Jr, Liu Z, Diaz LA, Giudice GJ. Tight clustering of extracellular BP180 epitopes recognized by bullous pemphigoid autoantibodies. J. Invest. Derm. 1997;109:573-579.

27.  Zillikens D, Mascaro JM, Rose PA, Liu Z, Ewing SM, Caux F, Hoffmann RG, Diaz LA, Giudice GJ. A highly sensitive enzyme-linked immunosorbent assay for the detection of circulating anti-BP180 autoantibodies in patients with bullous pemphigoid. J. Invest. Dermatol. 1997;109:679-683.

  1. España A, Diaz LA, Giudice GJ, Fairley JA, Till GO, Liu Z. Mechanisms of acantholysis in pemphigus foliaceus. Clin. Immunol. Immunopath. 1997;85:83-89.
  2. Mascaró JM, España A, Liu Z, Ding X, Swartz SJ, Fairley JA, Diaz LA. Mechanisms of acantholysis in pemphigus vulgaris: role of IgG valence. Clin. Immunol. Immunopath. 1997;85: 90-96.
  3. Liu Z, Roopenian DC, Zhou X, Diaz LA, Sedmak DD, Anderson CL. Beta2-microglobulin-deficient mice are resistant to bullous pemphigoid. J. Exp. Med. 1997;186:777-783.
  4. Liu Z, Haas AL, Diaz LA, Conrad CA, Giudice GJ. Characterization of a novel keratinocyte ubiquitin carrier protein. J. Biol. Chem. 1996;271:2817-2822.
  5. Zillikens D, Kawahara Y, Ishiko A, Shimizu H, Mayer J, Rank CV, Liu Z, Giudice GJ, Tran HH, Marinkovich MP, Brocker EB, Hashimoto T. A novel subepidermal blistering disease with autoantibodies to a 200-kDa antigen of the basement membrane zone. J. Invest. Dermatol. 1996;106:1333-1338.
  6. Liu Z, Giudice GJ, Swartz SJ, Fairley JA, Till GO, Troy JL, Diaz LA. The role of complement in experimental bullous pemphigoid. J. Clin. Invest. 1995;95:1539-1544.

34.  Liu Z, Diaz LA, Swartz SJ, Fairley JA, Troy JL, Giudice GJ. Molecular mapping of a pathogenically relevant BP180 epitope associated with experimentally induced murine bullous pemphigoid. J. Immunol. 1995;155:5449-5454.

  1. Liu Z, Diaz LA, Giudice GJ. Autoimmune response against the bullous pemphigoid 180 autoantigen. Dermatology 1994;189:34-37.
  2. Giudice GJ, Emery DJ, Zelickson B, Anhalt GJ, Liu Z, Diaz LA. Bullous pemphigoid and herpes gestationis autoantibodies recognize a common non-collagenous site on the BP180 ectodomain. J. Immunol. 1993;151:5742-5750.
  3. Liu Z, Diaz LA, Troy JL, Taylor AF, Emery DE, Fairley JA, Giudice GJ. A passive transfer model of the organ-specific autoimmune disease, bullous pemphigoid, using antibodies generated against the hemidesmosomal antigen, BP180. J. Clin. Invest. 1993;92:2480-2488.
  4. Liu Z, Diaz LA, Haas AL, Giudice GJ. cDNA cloning of a novel human ubiquitin carrier protein. An antigenic domain specifically recognized by endemic pemphigus foliaceus autoantibodies is encoded in a secondary reading frame of this human epidermal transcript. J. Biol. Chem. 1992;267:5829-5835.
  5. Liu Z, Fan M-K, Tsui C. In Vitro transformation of cultured cells of Daucus Carota by Agrobacterium Tumefaciens strain C58. Science (China) 1987;37:1013-1018.