Supplementary table S1. Comparison of clinical features between methicillin-sensitive S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA)

No. (%) of subjects / P-value*

1  MSSA

(n =25) /

2  MRSA

(n =34)
General information
Male / 13 (52.0) / 17 (50.0) / 0.879
Age† / 41.528.7 / 50.726.3 / 0.207
Underlying Disease
Diabetes mellitus / 5 (20.0) / 12 (35.3) / 0.200
Hypertension / 8 (32.0) / 11 (32.4) / 0.977
Pulmonary disease / 2 (8.0) / 4 (11.8) / 1
Renal disease / 2 (8.0) / 6 (17.6) / 0.447
Liver disease / 2 (8.0) / 2 (5.9) / 1
Malignancy / 5 (20.0) / 3 (8.8) / 0.265
Current infection‡ / 5 (20.0) / 8 (23.5) / 0.747
Immunosupressant use / 3 (12.0) / 1 (2.9) / 0.302
Recent antibiotic use / 3 (12.0) / 8 (23.5) / 0.325
Ocular history
Contact lens / 1 (4.0) / 1 (2.9) / 1
Ocular trauma / 4 (16.0) / 4 (11.8) / 0.711
Ocular surface disease / 15 (60.0) / 22 (64.7) / 0.712
Surgery history / 11 (44.0) / 16 (47.1) / 0.816
HA factors§ / 17 (68.0) / 22 (64.7) / 0.792
Diagnosis
Lid disorder / 2 (8.0) / 6 (17.6) / 0.447
Conjunctivitis / 6 (24.0) / 7 (20.6) / 0.755
Keratitis / 11 (44.0) / 18 (52.9) / 0.497
Endophthalmitis / 2 (8.0) / 0 / 0.172
Wound infection / 4 (16.0) / 3 (8.8) / 0.443
Outcome
Outpatient treatment, cured / 11 (44.0) / 15 (44.1) / 0.993
Hospitalization, cured / 13 (52.0) / 15 (44.1) / 0.549
MSSA, methicillin-sensitive S. aureus ; MRSA, methicillin-resistant S. aureus ; HA, healthcare-associated
*Fisher’s exact test instead of Pearson’s chi-square test was performed when any expected count was less than 5 by statistical analysis.
†Independent-samples t’ test was used
‡Infection other than ocular infection such as pneumonia
§HA factors included specimens (S. aureus culture) after 48 hours of admission; history of hospitalization, long-term care facility within one year, under dialysis; living in healthcare facility; permanent indwelling catheter; a known positive culture for S, aureus before; history of surgery in one year.


Supplementary table S2. Antibiotic susceptibility* of methicillin-sensitive S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA) isolates for ocular infections.

Antibiotics / No. (%) of subjects / P-value†
MSSA (n = 25) / MRSA (n = 34)
Clindamycin / 24 (96.0) / 2 (5.9) / < 0.001
Erythromycin / 23 (92.0) / 2 (5.9) / < 0.001
Cefoxitin / 25 (100) / 0 (0) / < 0.001
Penicillin / 2 (8.0) / 0 (0) / 0.175
Trimethoprim/Sulfamethoxazole / 25 (100) / 26 (76.5) / 0.016
Teicoplanin / 25 (100) / 34 (100) / 1
Vancomycin / 25 (100) / 34 (100) / 1
Ciprofloxacin / 25 (100) / 22 (64.7) / 0.001
Levofloxacin / 25 (100) / 23 (67.6) / 0.001
Gatifloxacin / 25 (100) / 25 (73.5) / 0.007
Moxifloxacin / 25 (100) / 26 (76.5) / 0.016
MSSA, methicillin-sensitive S. aureus ; MRSA, methicillin-resistant S. aureus ;
* Intermediate interpreted as resistant; the susceptibility to fluoroquinolones were tested by E test, and others were tested by disk diffusion method.
†Fisher’s exact test instead of Pearson’s chi-square test was performed when any expected count was less than 5 by statistical analysis.