Robert Brown
Statement of Research Interest
My interest in zoonotic diseases began at the University of Michigan. I had a desire to use my math and computer skills developed studying astrophysics at Columbia University in a way that more directly impacted the well being of those around me.
I found a research position there with Professor Alfred Hero. In his lab I helped develop a correlation based screening process to analyze time-course human gene expression data of individuals inoculated with various viruses. In addition to learning statistical techniques and being introduced to gene expression data, I was exposed to many different ways people are researching infectious diseases and the myriad of questions surrounding how they spread, evolve and affect different people in different ways.
Since starting at UCLA last September, I have further narrowed my research interests to better understanding the effects of ecological factors on virus evolution, especially in understanding zoonotic diseases. These diseases account for many of the emerging pathogens. However, what drives zoonosis is understudied and poorly understood. Since beginning my PhD, I have chosen lab rotations that I believe are giving me a strong background for research in this area.
With Professor Lake, my first rotation, I have learned how to search online genetic databases and how to perform various forms of phylogenetic analysis in order to better understand endosymbiotic and whole genome duplication events. Currently, I am working with Professor Novembre analyzing rare variant based coalescent models used for population genetics, gaining insights into how researchers estimate population sizes as well as mutation and growth rates based on genomic data. In understanding virus evolution and adaptation, this background will be invaluable. My final rotation will be with Professor Lloyd-Smith who is an expert in the field of zoonotic diseases. I have chosen to rotate with him last so that I will have the strongest possible base as I entered the lab in which I hope to remain.
In addition to lab work and core bioinformatics classes, I have discussed the various required classes with Professor Novembre and we have decided that the following would best prepare me to research in my field of interest: Deterministic Modeling (Biomath201), Stochastic Models in Biology (Biomath M203), Theoretical Genetic Modeling (Biomath 207A), Statistical Theory (Stat 200B) Mathematical Ecology (OBEE C219), and Structure Function and Evolution in Biological Systems (Biomath 202).
The academic classes, seminars, and mentorship opportunities that are a part of the SIB Training Grant would be invaluable towards research in a multifaceted topic such as zoonosis. Through the training grant I am confident I would be able to make the connections and to build the background knowledge that would allow me to become a truly effective researcher in this field.