The World Health Organization Defines Waldenstrom S Macroglobulinemia (WM) As

Supplementary Table 1. Phenotypic profile of the mature B-cell compartment in newly-diagnosed patients with an IgM monoclonal gammopathy distributed according to diagnosis.

IgM MGUS
(n=68) / Smoldering WM
(n=76) / Symptomatic WM
(n=100) / P.-value
CD19 / 100 / 100 / 100 / -
+dim / 2% / 8% / 16% / .006
+ / 98% / 92% / 84%
CD5 / 10 (0 - 100) / 5 (0 - 100) / 5 (0 - 100) / .4
- / 86% / 94% / 94% / .5
-/+ / 7% / 3% / 2%
+ / 7% / 3% / 4%
CD10 / 0 / 6 (0 - 100) / 1 (0 - 100) / .1
- / 100% / 94% / 98% / .3
-/+ / 0% / 5% / 1%
+ / 0% / 1% / 1%
CD11b / 4 (0 - 100) / 4 (0 -100) / 1 (0 - 47) / .6
- / 94% / 95% / 98% / .8
-/+ / 3% / 3% / 2%
+ / 3% / 2% / 0%
CD11c / 2 (0 - 30) / 6 (0 - 100) / 7 (0 - 100) / .4
- / 89% / 89% / 89% / .7
-/+ / 11% / 9% / 8%
+ / 0% / 2% / 3%
CD20 / 100 / 100 / 100 / -
+dim / 0% / 6% / 6% / .2
+ / 100% / 94% / 94%
CD22 / 69 (4 - 100) / 92 (5 - 100) / 88 (2 - 100) / <.001
+dim / 14% / 76% / 72% / <.001
+dim / + / 54% / 15% / 17%
+ / 32% / 9% / 11%
CD23 / 12 (0 - 70) / 4 (0 - 51) / 5 (0 - 100) / <.001
- / 60% / 86% / 89% / <.001
-/+ / 40% / 14% / 9%
+ / 0% / 2% / 2%
CD24 / 78 (0 - 100) / 89 (0 - 100) / 90 (0 - 100) / .1
- / 6% / 5% / 2% / .07
-/+ / 41% / 13% / 17%
+ / 53% / 82% / 81%
CD25 / 61 (0 - 100) / 88 (0 - 100) / 90 (0 - 100) / <.001
- / 3% / 3% / 1% / <.001
-/+ / 85% / 27% / 33%
+ / 12% / 70% / 66%
CD27 / 39 (0 - 90) / 56 (0 - 100) / 58 (0 - 100) / .01
- / 2% / 17% / 9% / <.001
-/+ / 98% / 56% / 66%
+ / 0% / 27% / 25%
CD38 / 12 (0 - 100) / 19 (0 - 100) / 21 (0 - 100) / .2
- / 82% / 65% / 70% / .06
-/+ / 10% / 23% / 15%
+ / 8% / 12% / 15%
CD45 / 100 / 100 / 100 / -
+ / 100% / 100% / 100% / -
CD45RA / 100 / 100 / 100 / -
+ / 100% / 100% / 100% / -
CD45RO / 2 (0 - 40) / 2 (0 - 50) / 6 (0 - 64) / .3
- / 94% / 95% / 87% / .4
-/+ / 6% / 5% / 13%
CD56 / 0 (0 - 11) / 1 (0 - 43) / 0 (0 - 2) / .1
- / 98% / 95% / 99% / .4
-/+ / 2% / 5% / 1%
CD103 / 0 / 0 / 0 / -
- / 0% / 0% / 0% / -
CD138 / 0 / 0 / 0 / -
- / 0% / 0% / 0% / -
BCL2 / 100 / 100 / 100 / -
+ / 100% / 100% / 98% / -
FMC7 / 50 (0 - 100) / 62 (0 - 100) / 55 (0 - 100) / .3
- / 2% / 18% / 14% / .003
-/+ / 76% / 48% / 62%
+ / 22% / 34% / 34%
HLA-DR / 100 (90 - 100) / 87 (25 - 100) / 84 (30 - 100) / .008
-/+ / 3% / 26% / 31% / .006
+ / 97% / 74% / 69%
SmIgM / 88 (23 - 100) / 95 (34 - 100) / 97 (40 - 100) / .002
-/+ / 87% / 39% / 16% / <.001
+ / 13% / 61% / 84%

Results expressed as median percentage of positive cells for a given marker; the percentage of cases showing distinct patterns of expression of each marker is shown below individual markers.

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