Association of Plaque-Type Alzheimer Disease Pathologies with Abnormal Lipid Metabolism

Matsuzaki et al. (S1)

Table e-3. Multivariate-adjusted odd ratios (ORs) and 95% confidence intervals (CIs) for presence of neuritic plaques (CERAD score 1–3 vs 0) according to lipid profile level in subjects without Alzheimer-type dementia (n = 121)
Model 1 / Model 2 / Model 3
OR / (95%CI) / P value / OR / (95%CI) / P value / OR / (95%CI) / P value
TC / (>5.80 vs. ≤5.80 mmol/L) / 7.2 / (2.2, 24.1) / 0.001 / 8.7 / (2.4, 32.1) / 0.001 / 20.3 / (3.8, 109.3) / 0.0005
LDLC / (>4.02 vs. ≤4.02 mmol/L) / 6.2 / (1.8, 21.3) / 0.004 / 6.6 / (1.8, 23.9) / 0.004 / 9.0 / (2.0, 0.6) / 0.004
HDLC / (≤1.04 vs. >1.04 mmol/L) / 4.3 / (1.4, 13.1) / 0.009 / 3.9 / (1.3, 12.3) / 0.02 / 2.3 / (0.7, 8.0) / 0.19
TG / (>1.56 vs. ≤1.56 mmol/L) / 2.9 / (1.0, 8.2) / 0.05 / 3.6 / (1.1, 11.5) / 0.03 / 3.2 / (0.9, 11.8) / 0.08
TC/HDLC / (>5.10 vs. ≤5.10) / 9.7 / (2.4, 39.5) / 0.001 / 8.0 / (1.9, 34.5) / 0.005 / 11.0 / (2.0, 61.2) / 0.006
LDLC/HDLC / (>3.48 vs. ≤3.48) / 6.3 / (1.8, 22.4) / 0.004 / 6.2 / (1.6, 24.2) / 0.008 / 6.1 / (1.2, 30.5) / 0.03
non-HDLC / (>4.61 vs. ≤4.61 mmol/L) / 10.0 / (2.7, 37.4) / 0.001 / 10.1 / (2.5, 40.3) / 0.001 / 13.2 / (2.7, 63.9) / 0.001
Model 1 was adjusted for age and sex. Model 2 was adjusted for age, sex, systolic blood pressure, fasting blood glucose, fasting insulin, body mass index, current smoking, regular exercise and cerebrovascular disease. Model 3 was adjusted for age, sex, systolic blood pressure, fasting blood glucose, fasting insulin, body mass index, current smoking, regular exercise, cerebrovascular disease and APOEε4 carrier.