“Cytokine suppression of MDS progression through miRNA haploinsufficiency”

February 29, 2016

12:00-1:00 PM

Austrian Auditorium, CRB

Aly Karsan, MD

Professor of Pathology and Laboratory Medicine

University of British Columbia

Target Audience

This program has been designed for physicians, fellows, residents, and researchers in the medical specialties of pathology.

Series Educational Objectives

After completing this activity, participants should be able to:

·  Enhance knowledge practice and competence of anatomical pathology diagnosis

·  Enhance knowledge, practice and competence of clinical laboratory testing

·  Enhance knowledge, practice, and competence of transfusion medicine

·  Review new and upcoming therapies to improve clinical management and care of patients

·  Apply knowledge of the pathological basis of disease to improve clinical management and care of patients

Session Educational Objectives

After completing this activity, participants should be able to:

·  Explain the role of microRNAs on chromosome 5q in myelodysplastic syndrome pathology

·  Describe the effect of cytokines in myelodysplastic syndrome progression

Accreditation

Physicians: The Perelman School of Medicine at the University of Pennsylvania is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Designation of Credit

Physicians: The Perelman School of Medicine at the University of Pennsylvania designates this live activity for a maximum of 1 AMA PRA Category 1 Credit ™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Acknowledgement of Commercial Support* NONE

For more information, please contact

Laurie Baker

215-898-2021

Disclosure of Relevant Financial Relationships and Unapproved Uses of Products

It is policy at the Perelman School of Medicine at the University of Pennsylvania and the Hospital of the University of Pennsylvania, Department of Nursing Education, Innovation and Professional Development for individuals who are in a position to control the content of an educational activity to disclose to the learners all relevant financial relationships that they have with any commercial interest that provide products or services that may be relevant to the content of this continuing education activity. For this purpose we consider relationships of the person involved to include financial relationships of a spouse or partner.

The intent of this policy is to ensure that Penn CME/CNE certified activities promote quality and safety, are effective in improving medical practice, are based on valid content, and are independent of control from commercial interests and free of commercial bias. Peer review of all content was conducted for all faculty presentations whose disclosure information was found to contain relationships that created a conflict of interest relevant to the topic of their presentation. In addition, all faculty were instructed to provide balanced, scientifically rigorous and evidence-based presentations.

The staff in the Office of CME at the Perelman School of Medicine at the University of Pennsylvania, Mila Kostic, CHCP, FACEHP, Director of CME, Zalman Agus, MD, Senior peer reviewer and Patricia A. Smith, MSN, RN-BC, Nursing professional development specialist of the HUP Department of Nursing Innovation and Development have disclosed that they have no relevant financial relationships with any commercial interests related to the content of this educational activity.

The following individuals have disclosed that they have no relevant financial relationships with any commercial interests related to the content of this educational activity:

Planning Committee Member Name

Taku Kambayashi, MD, PHD / Kathleen Montone, MD

Presenter Name

ALY KARSAN, MD

The following individuals have reported the listed relevant financial relationships with commercial interests related to the content of this educational activity.

Planning Committee Member Name Name of Commercial Interest Relationship

Warren S. Pear, MD, PHD Pfizer, Amgen, Johnson & Johnson Stock/Shareholder

Presenter Name Name of Commercial Interest Relationship

Relevant financial relationships are those relationships in which the individual benefits by receiving a salary, royalty, intellectual property rights, consulting fee, honoraria, ownership interest (e.g., stocks, stock options or other ownership interest, excluding diversified mutual funds), or other financial benefit. Financial benefits are usually associated with roles such as employment, management position, independent contractor (including contracted research), consulting, speaking and teaching, membership on advisory committees or review panels, board membership, and other activities from which remuneration is received or expected

Disclosure of Unapproved Uses of Products

Presenter name Product Investigational and/or Off-label Use