Supplementary Table 3 Univariate analysis for overall survival and disease-free survival

Overall Survival / Disease-Free Survival
Factor / HR / 95% CI / P value / HR / 95% CI / P value
Model 1
Age / 1.08 / 1.02-1.15 / 0.011 / 1.01 / 0.99-1.03 / 0.394
Sex / 0.28 / 0.11-0.72 / 0.008 / 0.67 / 0.44-1.02 / 0.067
Histologic differentiation
Moderately / 4.04 / 1.13-14.45 / 0.032 / 4.03 / 2.20-7.37 / <.001
Poorly / 10.86 / 2.91-40.44 / <.001 / 6.37 / 0.44-1.02 / <.001
Whole tumor size, cm
>2 to 3 / 3.64 / 0.36-36.47 / 0.271 / 1.06 / 0.56-1.99 / 0.860
>3 to 5 / 17.28 / 1.77-168.44 / 0.014 / 3.12 / 1.69-5.74 / <.001
5 / 7.66 / 0.39-151.44 / 0.151 / 2.46 / 0.79-7.71 / 0.12
Model 2
Age / 1.07 / 1.01-1.14 / 0.014 / 1.01 / 0.99-1.03 / 0.397
Sex / 0.38 / 0.14-1.02 / 0.055 / 0.80 / 0.52-1.22 / 0.298
Histologic differentiation
Moderately / 3.51 / 0.80-15.33 / 0.095 / 3.70 / 2.01-6.82 / <.001
Poorly / 7.88 / 1.60-38.7 / 0.011 / 5.07 / 2.23-11.50 / <.001
Solid tumor size, cm
>2 to 3 / 3.75 / 0.85-16.46 / 0.080 / 1.90 / 1.09-3.29 / 0.023
>3 to 5 / 9.42 / 2.36-37.59 / 0.002 / 4.68 / 2.59-8.47 / <.001
>5 / 4.90 / 0.35-68.77 / 0.2382 / 3.83 / 0.92-15.96 / 0.065
Model 3
Age / 1.07 / 1.01-1.13 / 0.021 / 1.01 / 0.99-1.03 / 0.493
Sex / 0.23 / 0.08-0.63 / 0.004 / 0.67 / 0.44-1.01 / 0.058
Histologic differentiation
Moderately / 2.96 / 0.84-10.39 / 0.09 / 3.75 / 2.03-6.91 / <.001
Poorly / 7.76 / 2.11-28.51 / 0.002 / 5.63 / 2.48-12.78 / <.001
Whole tumor size, cm
>2 to 3 / 3.74 / 0.37-37.62 / 0.263 / 1.03 / 0.55-1.93 / 0.928
>3 to 5 / 14.42 / 1.42-146.65 / 0.024 / 2.86 / 1.53-5.33 / 0.001
>5 / 6.36 / 0.31-128.73 / 0.228 / 2.13 / 0.66-6.88 / 0.205
SUVmax / 1.04 / 1.02-1.06 / <.001 / 1.02 / 1.00-1.04 / 0.066
Model 4
Age / 1.06 / 1.01-1.12 / 0.032 / 1.01 / 0.986-1.031 / 0.464
Sex / 0.29 / 0.10-0.83 / 0.020 / 0.79 / 0.511-1.206 / 0.269
Histologic differentiation
Moderately / 2.69 / 0.61-11.89 / 0.191 / 3.53 / 1.90-6.55 / <.001
Poorly / 6.19 / 1.23-31.17 / 0.027 / 4.71 / 2.05-10.84 / <.001
Solid tumor size, cm
>2 to 3 / 3.50 / 0.76-16.12 / 0.108 / 1.84 / 1.06-3.20 / 0.030
>3 to 5 / 6.87 / 1.6-29.49 / 0.01 / 4.32 / 2.31-8.06 / <.001
>5 / 3.30 / 0.21-53.04 / 0.4 / 3.34 / 0.78-14.25 / 0.104
SUVmax / 1.04 / 1.02-1.06 / <.001 / 1.01 / 0.99-1.03 / 0.234
Model 5
Age / 1.07 / 1.011-1.13 / 0.019 / 1.01 / 0.99-1.04 / 0.332
Sex / 0.24 / 0.09-0.66 / 0.006 / 0.69 / 0.45-1.05 / 0.08
Histologic differentiation
Moderately / 2.66 / 0.84-8.46 / 0.097 / 2.45 / 1.26-4.75 / 0.008
Poorly / 6.35 / 1.85-21.83 / 0.003 / 3.32 / 1.36-8.09 / 0.009
Whole tumor size, cm
>2 to 3 / 3.36 / 0.34-33.27 / 0.301 / 0.79 / 0.42-1.48 / 0.456
>3 to 5 / 11.36 / 1.02-126.85 / 0.048 / 1.90 / 1.00-3.60 / 0.049
>5 / 5.03 / 0.24-105.21 / 0.298 / 1.35 / 0.41-4.49 / 0.626
SUVmax / 1.04 / 1.02-1.06 / <.001 / 1.02 / 1.99-1.04 / 0.172
TDR / 0.99 / 0.97-1.01 / 0.411 / 0.98 / 0.97-0.99 / 0.001

Note – Numbers in bold are statistically significant at P < .05. HR, hazard ratio; CI, confidence interval; OS, overall survival; DFS, disease-free survival; TDR, tumor shadow disappearance rate; SUVmax, maximum standardized uptake value