Supplementary Table 2. Characteristics of glioblastoma cases and controls

Variable / Number of cases (%) (n=852) / Number of controls (%) (n=8,520) / OR (95% CI)* / p-value
Age (years)*
0-9 / 4 (0.5) / 40 (0.5) / - / -
10-19 / 5 (0.6) / 50 (0.6) / - / -
20-29 / 5 (0.6) / 50 (0.6) / - / -
30-39 / 20 (2.4) / 200 (2.4) / - / -
40-49 / 79 (9.3) / 790 (9.3) / - / -
50-59 / 220 (25.8) / 2,200 (25.8) / - / -
60-69 / 285 (33.5) / 2,850 (33.5) / - / -
70-79 / 198 (23.2) / 1,980 (23.2) / - / -
80-90 / 36 (4.2) / 360 (4.2)
Sex*
Men / 462 (54.2) / 4,620 (54.2) / - / -
Women / 390 (45.8) / 3,900 (45.8) / - / -
BMI (kg/m2)
< 18.5 / 5 (0.6) / 90 (1.1) / 0.55 (0.22-1.37) / 0.198
18.5-24.9 / 257 (30.2) / 2,549 (29.9) / 1.00 (referent) / -
25-29.9 / 311 (36.5) / 2,809 (33.0) / 1.10 (0.92-1.31) / 0.287
≥30.0 / 149 (17.5) / 1,568 (18.4) / 0.94 (0.76-1.17) / 0.600
Unknown / 130 (15.3) / 1,504 (17.7) / 0.82 (0.65-1.05) / 0.111
Smoking status
Never smoker / 436 (51.2) / 4,005 (47.0) / 1.00 (referent) / -
Current smoker / 137 (16.1) / 1,426 (16.74) / 0.88 (0.71-1.08) / 0.204
Past smoker / 210 (24.7) / 2,276 (26.7) / 0.84 (0.70-1.01) / 0.056
Unknown / 69 (8.1) / 813 (9.5) / 0.74 (0.55-1.00) / 0.049
Cardiovascular comorbidities or conditions
Stroke/TIA / 32 (3.8) / 375 (4.4) / 0.84 (0.58-1.23) / 0.369
Hypertension / 250 (29.3) / 2,476 (29.1) / 1.02 (0.86-1.20) / 0.853
CHF / 9 (1.1) / 150 (1.8) / 0.59 (0.30-1.16) / 0.126
Arrhythmia / 35 (4.1) / 492 (5.8) / 0.69 (0.49-0.99) / 0.042
IHD / 81 (9.5) / 889 (10.4) / 0.89 (0.70-1.15) / 0.374
MI / 23 (2.7) / 333 (3.9) / 0.67 (0.44-1.04) / 0.075
Renal failure / 19 (2.2) / 211 (2.5) / 0.90 (0.56-1.45) / 0.656
Diabetes / 48 (5.6) / 667 (7.8) / 0.70 (0.52-0.95) / 0.021
Dyslipidemia / 86 (10.1) / 969 (11.4) / 0.87 (0.68-1.10) / 0.239

* Matching variables: age, sex, general practice, and number of years of active history in the database.

BMI: Body Mass Index; TIA: transient ischemic attack; CHF: congestive heart failure; IHD: ischemic heart disease; MI: myocardial infarction, OR: Odds ratio.