Online Resource1. Characteristics of the Subjects

Online Resource1. Characteristics of the subjects

Article title:Alpha and beta cell abnormalities in haemoglobin A1c-defined prediabetes and type 2 diabetes.

Journal name: Acta Diabetologica.

Author names:Salvatore Calanna, Roberto Scicali, Antonino Di Pino, Filip Krag Knop, Salvatore Piro, Agata Maria Rabuazzo, Francesco Purrello*.

*Corresponding author,Department of Clinical and Molecular Biomedicine, University of Catania, Catania, Italy,

Controls

F/M / Age
(years) / BMI (kg/m2) / HbA1c
(%) / HbA1c (mmol/mol) / WC
(cm) / FPG
(mmol/l) / HOMA-IR / 2h post-OGTT glucose (mmol/l)
Subject 1 / M / 46 / 26.9 / 5.6 / 37.7 / 106 / 5.4 / 1.5 / 5.2
Subject 2 / F / 49 / 22.5 / 5.6 / 37.7 / 80 / 5.0 / 0.9 / 6.3
Subject 3 / M / 49 / 31.6 / 5.6 / 37.7 / 107.5 / 4.7 / 1.2 / 7.1
Subject 4 / F / 46 / 26.4 / 4.9 / 30.1 / 99.5 / 4.2 / 0.7 / 6.3
Subject 5 / F / 53 / 35.8 / 5.6 / 37.7 / 116 / 4.6 / 1.4 / 7.3
Subject 6 / F / 42 / 29.1 / 5.5 / 36.6 / 89 / 4.5 / 1.1 / 5.4
Subject 7 / M / 58 / 35.2 / 5.2 / 33.3 / 106 / 4.6 / 0.9 / 7.4
Subject 8 / F / 41 / 24.2 / 5.6 / 37.7 / 82 / 5.0 / 1.3 / 5.4
Subject 9 / F / 53 / 34.9 / 5.5 / 36.6 / 108 / 4.8 / 1.2 / 5.6
Subject 10 / M / 56 / 29.4 / 5.6 / 37.7 / 104 / 4.6 / 3.3 / 4.8

BMI, body mass index; FPG, fasting plasma glucose; HbA1c, glycated haemoglobin A1c; OGTT, oral glucose tolerance test; WC, waist circumference.

Subjects with HbA1c-defined prediabetes

F/M / Age
(years) / BMI (kg/m2) / HbA1c
(%) / HbA1c (mmol/mol) / WC
(cm) / FPG
(mmol/l) / HOMA-IR / 2h post-OGTT glucose (mmol/l)
Subject 1 / M / 29 / 30.1 / 5.9 / 41.0 / 100 / 5.3 / 5.2 / 7.3
Subject 2 / M / 50 / 31.2 / 5.8 / 39.9 / 103 / 5.8 / 2.0 / 6.5
Subject 3 / M / 47 / 24.8 / 6.3 / 45.4 / 98 / 5.9 / 1.9 / 10.6
Subject 4 / M / 55 / 34.7 / 6 / 42.1 / 112 / 5.2 / 2.8 / 8.1
Subject 5 / F / 52 / 31.8 / 6.2 / 44.3 / 90 / 4.6 / 1.0 / 7.6
Subject 6 / M / 55 / 33.2 / 5.9 / 41.0 / 102 / 5.2 / 1.7 / 8.9
Subject 7 / F / 52 / 31.4 / 6.1 / 43.2 / 104 / 4.7 / 1.4 / 5.2
Subject 8 / F / 61 / 26.2 / 6.4 / 46.4 / 91 / 6.2 / 3.6 / 10.8
Subject 9 / M / 54 / 26.1 / 5.7 / 38.8 / 95 / 4.5 / 1.3 / 5.9
Subject 10 / M / 46 / 33.3 / 6 / 42.1 / 115 / 4.8 / 2.4 / 5.8

BMI, body mass index; FPG, fasting plasma glucose; HbA1c, glycated haemoglobin A1c; OGTT, oral glucose tolerance test; WC, waist circumference.

Subjects with HbA1c-defined type 2 diabetes

F/M / Age
(years) / BMI (kg/m2) / HbA1c
(%) / HbA1c (mmol/mol) / WC
(cm) / FPG
(mmol/l) / HOMA-IR / 2h post-OGTT glucose (mmol/l)
Subject 1 / M / 49 / 27.2 / 6.5 / 47.5 / 91 / 6.2 / 0.7 / 14.0
Subject 2 / F / 53 / 28.6 / 6.5 / 47.5 / 99 / 7.2 / 2.1 / 12.7
Subject 3 / F / 52 / 32.0 / 6.8 / 50.8 / 97 / 5.6 / 2.0 / 9.2
Subject 4 / M / 54 / 29.9 / 7.5 / 58.5 / 110 / 8.8 / 9.1 / 13.0
Subject 5 / M / 59 / 24.6 / 7.9 / 62.8 / 90.5 / 7.1 / 2.2 / 12.2
Subject 6 / M / 56 / 37.4 / 6.5 / 47.5 / 125 / 6.6 / 8.4 / 12.8
Subject 7 / M / 46 / 30.3 / 7.2 / 55.2 / 110 / 6.0 / 2.7 / 11.3
Subject 8 / F / 62 / 33.2 / 6.7 / 49.7 / 115 / 4.8 / 1.1 / 12.4

BMI, body mass index; FPG, fasting plasma glucose; HbA1c, glycated haemoglobin A1c; OGTT, oral glucose tolerance test; WC, waist circumference.