Burden of Crohn S Disease in Europe and the US, 2000 2013

Burden of Crohn’s disease in Europe and the US, 2000–2013

Supplementary material (inclusion and exclusion criteria; search terms)

Inclusion criteria

Types of studies: All studies that provide estimates of prevalence, incidence and mortality of CD in adult and paediatric subjects were included. Study designs included systematic reviews, registries, observational studies, longitudinal studies and interventional studies.

For studies assessing economic burden we included direct costs, indirect costs, cost-effectiveness studies, resource use, cost drivers, cost of illness, productivity losses/gains and activity impairment/disability evaluation. For studies assessing humanistic burden we included quantitative and qualitative studies that assessed the impact of CD on a patient’s health-related quality of life (HRQoL).

Interventions: The search was not restricted by interventions.

Outcomes: The search was not restricted by outcome measures.

Countries: US, EU5 (France, Germany, Italy, Spain, UK)

Economic parameters: Direct and indirect costs, productivity, resource use, cost-effectiveness, cost of illness, activity impairment/disability

Humanistic parameters: health-related quality of life, activities of daily living

Secondary outcomes:None

Adverse events:None

Types of study:Systematic reviews, registries, observational studies, longitudinal studies and interventional studies

Types of publication: All

Exclusion criteria

Non-English language publications

Search terms for economic publications

Crohn disease/

(crohn$ adj3 disease).tw.

(enteritisregionalis or regional enteritis or regional enterocolitis).tw.

Enteritis, Granulomatous.tw.

Ileitis, Terminal.tw.

Ileocolitis.tw.

morbus crohn.tw.

Ileitis, Regional.tw.

enteritis/

(inflammatory bowel disease$1 or IBD or crohn).tw.

economic burden.tw.

cost effectiveness analys$.ti,ab.

cost benefit analys$.ti,ab.

costanalys$.ti,ab.

cost utility analys$.ti,ab.

(utilit$ adj2 (value$1 or cost$1 or health)).ti,ab.

(cba or cea or cua).tw.

economics.tw.

(burdenadj2 (disease or illness)).tw.

"cost benefit analysis"/ or "health care cost"/ or "cost"/ or "drug cost"/ or "hospital cost"/ or "cost of illness"/ or "hospitalization cost"/

Absenteeism/

productivity/

activity impairment.tw.

“Activities of Daily Living"/

disability.tw.

exp Disability Evaluation/

((direct or indirect) adj4 cost).tw.

((work or employment or education or school) adj productivity).tw.

United Kingdom/

(UK or United kingdom or Britain or GB or Great Britain or Wales or Scotland or England or Northern Ireland).ti,ab.

United States/

(US or USA or United States or United States of America or America).ti,ab.

Germany/

(Germany or Berlin).ti,ab.

Italy/

(Italy or Sicily or Rome).ti,ab.

Spain/

France/

(France or Paris).ti,ab.

Europe/

(english language and humans)

Search terms for quality of life publications

Crohn disease/

(crohn$ adj3 disease).tw.

(enteritisregionalis or regional enteritis or regional enterocolitis).tw.

Enteritis, Granulomatous.tw.

Ileitis, Terminal.tw.

Ileocolitis.tw.

morbus crohn.tw.

Ileitis, Regional.tw.

enteritis/

(inflammatory bowel disease$1 or IBD or crohn).tw.

exp "quality of life"/

quality of life.ti.

(hql or hrql).ti,ab.

health related quality of life.ti,ab.

quality of life index.ti,ab.

economicevaluation.ti,ab.

quality adjusted life year$.ti,ab.

(qaly$ or qald$ or qale$).ti,ab.

qwb.tw.

quality of well being.tw.

quality of wellbeing.tw.

(hui or hui 2 or hui2 or hui 3 or hui3).ti,ab.

(time trade off or time tradeoff or tto).ti,ab.

(utilit$ adj2 (value$1 or cost$1 or health)).ti,ab.

health state$1.ti,ab.

(hye or healthy year$1 equivalent$).ti,ab.

standard gamble$.ti,ab.

discrete choice experiment$.ti,ab.

(euroqol or euroquol or EQ 5D or eq5d).ti,ab.

*pain assessment/

visualanalog$ scale$.ti,ab.

*visual analog scale/

(sf 36 or sf36 or sf thirtysix or sf thirty six or short form 36 or short form thirty six or short form thirty-six or short form 36).ti,ab.

(sf6 or sf 6 or short form 6 or shortform 6 or sf six or sfsix or short form six or short form six).ti,ab.