Supplementary Table 7. Logistic Regression Analysis for Correlation of Clinicopathological

Supplementary Table 7. Logistic regression analysis for correlation of clinicopathological characteristics and molecular alterations with PD-L1 expression on tumor cells for 50% cutoff

Predictors of PD-L1 expression for 2 vs. 0-1 / OR / 95% confidence interval / P
Male / 0.67 / 0.27-1.66 / 0.385
Age / 1.07 / 1.01-1.21 / 0.013
Smoking (≥10 PPY) / 2.62 / 0.50-13.59 / 0.252
Size / 0.99 / 0.71-1.39 / 0.967
T stage (pT2-4 vs. pT1) / 1.27 / 0.42-3.87 / 0.677
Nodal stage (pN1-2 vs. pN0) / 0.96 / 0.28-3.36 / 0.952
Histologic subtype (solid vs. non-solid) / 5.23 / 1.85-14.89 / 0.002
Nuclear grade (2 vs. 0-1) / 2.48 / 1.02-6.05 / 0.045
Lymphatic invasion (present vs. absent) / 1.30 / 0.85-1.98 / 0.227
Vascular invasion (present vs. absent) / 1.55 / 0.61-3.95 / 0.361
CD8+ TILs (2-3 vs. 0-1) / 4.75 / 1.76-12.78 / 0.002
CD8 stroma (10% vs 10%) / 3.29 / 1.31-8.26 / 0.011
T-bet TILs (2-3 vs 0-1) / 1.29 / 0.35-4.78 / 0.705
T-bet stroma (5% vs 5%) / 0.56 / 0.17-1.90 / 0.353
KRASmutations (vs. SNaPshot wild-type) / 1.41 / 0.55-3.78 / 0.473
EGFRmutations (vs. SNaPshot wild-type) / 0.46 / 0.08-2.62 / 0.382
ALKrearrangements (vs. SNaPshot wild-type) / 1.84 / 0.08-43.21 / 0.704
Other alterations (vs. SNaPshot wild-type) / 0.58 / 0.09-3.55 / 0.554

Notes: Histologic subtype was dichotomized into solid vs. non-solid predominant pattern. Nuclear grade was dichotomized into grades 2 vs. 0-1. CD8+ and T-bet+ tumor infiltrating lymphocytes (TILs) were dichotomized into values 2-3 vs. 0-1, representing high or low TILs, respectively. CD8+ and T-bet+ lymphocytes in the tumor stroma were dichotomized using 10% and 5% cut-offs, respectively. Bold values indicate statistical significance at p<0.05.

Abbreviations: PPY, pack per year; OR, odds ratio; TILs, tumor infiltrating lymphocytes; stroma, lymphocytes in the tumor stroma