Supplementary Material

Figure S1 PC2 vs PC3 scores plot for LC-MS results

Table S1 Statistically significant concentration changes as a result of MBP treatment for compounds detected by GC-MS(A). Single and double symbols denote respectively 95% and 99% significance levels of the observed EAE effects (– denotes decrease, + denotes increase).

name / HMDB ID / Pubchem CID / early stage EAE / full stage
EAE / EAE progression
(R)-3-Hydroxybutyric acid / HMDB00011 / 92135 / + / +
(S)-3,4-Dihydroxybutyric acid / HMDB00337 / 150929
2,4-Dihydroxybutanoic acid / HMDB00360 / 192742
2-Hydroxy-3-methylbutyric acid / HMDB00407 / 853180
2-Hydroxybutyric acid / HMDB00008 / 11266 / + / +
3-Hydroxyisovaleric acid / HMDB00754 / 69362
3-Hydroxymethylglutaric acid / HMDB00355 / 1662 / -
Acetoacetic acid / HMDB00060 / 96 / + / +
Ascorbic acid / HMDB00044 / 644104
Cholesterol / HMDB00067 / 5997 / + / +
Citric acid / HMDB00094 / 311 / -
Creatinine / HMDB00562 / 588
D-Fructose / HMDB00660 / 439709
D-Glucose / HMDB00122 / 5793 / -
D-Mannose / HMDB00169 / 18950 / + / +
D-Ribose / HMDB00283 / 5779
Dihydrouracil / HMDB00076 / 649 / + / +
Erythritol / HMDB02994 / 8998 / - / - / -
Erythronic acid / HMDB00613 / 439535 / -
Gluconic acid / HMDB00625 / 10690 / - / -
Glyceric acid / HMDB00139 / 439194 / -
Glycerol / HMDB00131 / 753 / - / -
Glycerol 3-phosphate / HMDB00126 / 439162
Glycolic acid / HMDB00115 / 757
Hydroxypropionic acid / HMDB00700 / 68152 / - / -
Hypoxanthine / HMDB00157 / 790
Inosine / HMDB00195 / 6021
Isocitric acid / HMDB00193 / 1198
L-Arabinose / HMDB00646 / 439195
L-Lactic acid / HMDB00190 / 107689
Myoinositol / HMDB00211 / 892 / - / -
Oleic acid / HMDB00207 / 965
Oxalic acid / HMDB02329 / 971 / +
Palmitic acid / HMDB00220 / 985
Pantothenic acid / HMDB00210 / 6613 / -
Pectin / HMDB03402 / Not Available / - / - / -
Pelargonic acid / HMDB00847 / 8158
Phosphate / HMDB01429 / 1061 / + / +
Pseudouridine / HMDB00767 / 15047 / + / +
Pyruvic acid / HMDB00243 / 1060 / +
Salicylic acid / HMDB01895 / 338
Stearic acid / HMDB00827 / 5281
Sucrose / HMDB00258 / 5988
Uracil / HMDB00300 / 1174 / + / +
Urea / HMDB00294 / 1176 / - / +
Uric acid / HMDB00289 / 1175 / + / +