Frankel CV Page 20
Wayne N. Frankel, Ph.D.
The Jackson Laboratory, Bar Harbor, ME 04609
Phone: 207-288-6354 • Fax: 207-288-6757
Email:
Curriculum Vitae
Personal
Date of birth: November 24, 1960
Marital status: Married (to Verity Letts, Ph.D.). One child (b. 1996).
Citizenship: USA
Home address: 74 Ledgelawn Avenue, Bar Harbor, ME 04609.
Education
1982 B.A. (Biology), The University of Pennsylvania, Philadelphia, PA
1984 M.S. (Genetics), Albert Einstein College of Medicine, Bronx, NY
1987 Ph.D. (Genetics), Albert Einstein College of Medicine, Bronx, NY
Awards and Honors
1982-1987 Scholarship, Immunology & Immunooncology Training Fellowship, Albert Einstein College of Medicine
1987-1990 Leukemia Society of America Fellowship
1990-1993 Leukemia Society of America Special Fellowship
1994-1997 Klingenstein Fellowship in the Neurosciences
Research Positions
1982-1987 Graduate Student, Department of Genetics, Albert Einstein College of Medicine (advisor: T. V. Rajan)
1987-1991 Postdoctoral Fellow, Tufts University School of Medicine
(mentor: John M. Coffin).
1992 Assistant Professor, The Jackson Laboratory, Bar Harbor, ME
1995-2002 Associate Professor, The Jackson Laboratory, Bar Harbor, ME
2002-present Professor, The Jackson Laboratory, Bar Harbor, ME
Professional Activities
Editorial and Advisory Board Service
1994-present Editorial Board, Mammalian Genome
1995-2003 Scientific Advisory Board, Digital Gene Technologies, La Jolla, CA
1996-1997 Editorial Board, Genomics
1997-2005 Associate Editor, Genomics
1997-1998 Secretariat, International Mammalian Genome Society
2000-2002 Editor-in-Chief, Gene Expression Patterns
2001-2005 Member, Faculty of 1000, Animal Genetics section
2002-present Editorial Board, Genes, Brains and Behavior
2005-2008 Founding Editor-in-Chief, PLoS Genetics (Public Library of Science)
2005-2009 Scientific Advisory Board, The EuroHear Consortium
2007-2008 Editorial Board, Epilepsia
2008-2013 Member, Board of Scientific Counselors, NIH - NIDCD
2009-present Advisory Board Faculty of 1000 Reports.
Specific Extramural Grant Review and Planning Groups:
1993 NICHD Special Review Committee Study Section
1994, 1998 NIA Special Review Committee Study Section
1995 NIAAA Special Review Committee Study Section
1995 NIDCD Special Review Committee Study Section
1996, 1999 Temporary Member, Mammalian Genetics Study Section
NIMH, Special Review Committee Study Section
1998 NCI Advisory, Preclinical Models for Cancer Workgroup, Mouse Genomics and Genetics
1998 NCI Review Board, Intramural Program
1998 NIH Advisory, Priority Setting for Mouse Genomics/Genetics Workshop
1998 Ad Hoc Reviewer, ALTX-3 Study Section
1999-2000 Proposed Member (still not chartered), NIH BDCN-4 Study Section
1999 Princeton Mouse Genome Sequencing Meeting
1999 Temporary Member, NIH Biol-1 Study Section
1999 NIH/NINDS Advisory, Future Genetic Strategies for Epilepsy Workshop
1999 Genetics in the New Millennium: Directions for the Future, Bar Harbor
2000 NIH Advisory, Priority Setting Mouse Genomics/Genetics Follow-up
2000 NIMH Advisory, Setting Priorities for Phenotyping the Mouse Nervous System and Behavior
2000 Genetics in the New Millennium: A Neuroscience Prospective, Bar Harbor
2001 NIH/NINDS Advisory, Models for Epilepsy and Epileptogenesis, Bethesda
2001 NINDS Special Review Committee, Innovations in Translational Epilepsy Research Study Section
2001 Mouse Analysis Working Group Meeting (Mouse Genome Sequence Consortium), Whitehead Institute Genome Center, Cambridge, MA
2001 Chair, Mouse Sequencing Liaison Group (NHGRI-based committee to improve and maintain communication between the genome sequencing centers and the mouse research community)
2001 Reviewer, Quality of Life Integrated Projects in Functional Genomics Relating to Human Health (grant solicitation from European Commission)
2001 Reviewer, NIH/NINDS Gene Discovery Panel (RFA), Reviewer
2001 Ad Hoc Reviewer, NIH Social Sciences, Nursing, Epidemiology and Methods (SNEM) Integrated Review Group, SNEM-2
2002-2007 Scientific Reviewer, CURE (Citizens United for Research in Epilepsy)
2002 Ad Hoc Reviewer, NIH/CSR Special Review Committee for Mammalian Genetics
2003 Ad Hoc Reviewer, Veterans Administration, NEUD subpanel
2003 Reviewer, NIH/NINDS Special Review Committee Brain Disorders in the Developing World: Research Across the Lifespan (ZNS1 SRB-H 01)
2003 Subcommittee Member, Medical Research Council, Review of the MRC Mammalian Genetics Unit, Harwell, Oxford, UK
2004 Reviewer, NIH/NINDS Special Review Committee Model Validation for Antiepileptogenic and Resistant Epilepsy Therapies
2005 Panel Reviewer, Genome Canada Competition III. Montreal
2006 Reviewer, NIH/NINDS Neuroscience Blueprint Interdisciplinary Center Core Grant (RFA)
2006 Ad Hoc Reviewer, NIH Clinical Neuroplasticity and Neurotransmitters Study Section
2006 Ad Hoc Reviewer, NIH Genetics of Health and Disease Study Section
2006 Ad Hoc Reviewer, NIH/NINDS Workshop, Model Development in Epileptogenesis and Therapy-Resistant Epilepsy and Models of Geriatric Epilepsy
2007 Panel Reviewer, Genome Canada International Scientific Review Committee (ISRC) for Competition III. Vanouver, BC.
2007 Ad Hoc Reviewer, NIH Molecular, Cellular, and Developmental Neuroscience Study Section
2009 Ad Hoc Reviewer, Genetics IRG, Challenge grants
Institutional Service
1992-1993 Reinstated/Organized Genetics Interest Group (Weekly Journal Club)
1992-93; 06-07 Training and Education Committee
1993-95; 98-99 Scientific Advisory Committee
1995 Genetic Resources
1995-1997 Staff (Faculty) Recruiting
1998-1999 Courses and Meetings
1998-2000 TJL Mutagenesis/Physiogenomics Service (Staff Supervisor)
1998-2005 Research Grants Committee
1999-2001 Director Search Committee
2000-01; 05-09 Faculty Recruiting Committee
2001 Staff Recruiting Subcommittee, Biophysics
2003-2006 Director of Research Search Committee
2003-present Promotions Committee
2005-2006 Chair, TJL Neuroscience Recruitment Planning Group
2005-2008 University of Maine/TJL Functional Genomics Ph.D. Program Recruiting Committee
2008-present Scientific Director Postdoctoral Training
2008-present Postdoctoral Training Committee, Chair
2009-present Predoctoral steering committee
Current NIH Research Support
1993-present Principal Investigator, R01 NS31348-017, Genetics of Epilepsy in Murine Systems (last renewed in 2009, 5 yrs). $320,000 direct costs
2006-present Principal Investigator, T32 NS051112, Training in Mouse Neurogenetics (two postdoctoral slots)
2008-present Principal Investigator, R01 NS061971-02, Genetic Regulation of Complex Neurological Disease, (5 yrs) $250,000 direct costs - modular
2009-2011 Principal Investigator, R01 NS061971-02Z, Genetic Regulation of Complex Neurological Disease, ARRA competing revision, $175,000 direct costs
Conference Organization
1994 Organizer (with A. Messer, R. Reeves, B. Tempel), Workshop in Mouse Molecular Neurogenetics, Bar Harbor
1995 Organizer (with A. Chakravarti, S. Ghosh, N. Schork), Biology and Genetics of Complex Mammalian Traits, Bar Harbor
1996 Organizer (with K. Herrup, J. Noebels, A. Silva), 2nd Biennial Workshop in Mouse Molecular Neurogenetics, Bar Harbor
1996 Organizer (with multiple others), Knockouts and Mutants: Genetically Dissecting Brain & Behavior, San Diego (sponsored by Elsevier)
1999 Organizer (with S. Ackerman, M. MacDonald, G. Sutcliffe), 3rd Biennial Workshop in Mouse Molecular. Neurogenetics, Bar Harbor
2002 Organizer, 4th Biennial Workshop in Mouse Molecular Neurogenetics, Bar Harbor
2004 Organizer 5th Biennial JAX Neurogenetics Conference (formerly Workshop in Mouse Molecular. Neurogenetics), Bar Harbor
Teaching Experience
1985 Medical Genetics Instructor, Albert Einstein College of Medicine
1989 Infectious Diseases Instructor, Tufts University School of Medicine
1992-93 Lecturer, Short Course in Medical and Experimental Mammalian Genetics
1995-2000 Lecturer, Short Course in Medical and Experimental Mammalian Genetics
1995-96, 98 Lecturer, Grad-level Genetics Course, Tufts University School of Medicine
1996 Lecturer, Short Course: Modern Genetics for Neuroscientists (held at Winter Conference for Brain Research), Snowmass, CO
1996 Lecturer, Society for Neurosciences Annual Meeting Short Course: What's wrong with my mouse?
1997 Director, Grad-Level Course, Experimental Genetics of the Laboratory Mouse: Genetics, Development and the Brain, The Jackson Laboratory
1997 Lecturer, Grad-Level Genetics Course, Albert Einstein College of Medicine
Invited Seminars and Platform Presentations
1996 Invited Speaker, “Genetics of epilepsy in mice,” Winter Conference for Brain Research, Snowmass (January)
1996 Platform Speaker, Klingenstein Fellows Annual Meeting, Banbury Center, Cold Spring Harbor (April)
1996 Invited Speaker, Workshop on Behavioral Phenotypes of Inbred Strains of Mice, NIH, Bethesda (April)
1996 Invited Speaker, “Genetics of epilepsy in mice...as of May 30th, 1996,” 10th International Workshop, Molecular Genetics of the Mouse, Spa, Belgium (June)
1997 Invited Seminar, “Genetics of epilepsy in mice,” Cornell Medical School (February)
1997 Invited Seminar, “Genetics of epilepsy in mice,” Department of Human Genetics, University of Florida, Gainesville (February)
1997 Invited Seminar, “Gene hunting (and finding) in mouse models for epilepsy and other neurological disorders, " Albert Einstein College of Medicine, Department of Molecular Genetics, Bronx (December)
1998 Platform Speaker, “Gene hunting in new and old mouse models of epilepsy” at Epilepsy Research Foundation: Workshop on the Use of Animal Models for Elucidating the Molecular Basis of Epilepsy, Oxford, UK (September)
1998 Invited Seminar, “Gene discovery for uncovering molecular mechanisms of neurological disorders” at Department of Biophysics and Physiology, University of Iowa (October)
1998 Platform Speaker, “Gene discovery using mouse models: Overview and strategies of positional cloning for neurological traits” at Knockouts and Mutants: Genetically Dissecting Brain and Behavior (sponsored by Brain Research Interactive) San Diego (November)
1998 Platform Speaker, “The mouse stargazer gene encodes a candidate g subunit for neuronal calcium channels," at 1998 Annual Meeting of the Society for Neurosciences, Los Angeles (November)
1998 Invited Seminar, “Gene hunting in simple and complex mouse models for epilepsy,” at Parke-Davis Mouse Genetics Laboratory, Alameda (April)
1999 Platform Speaker, “Fidgetin – a novel AAA ATPase disrupted in fidget mutant mice,” at Cellular Functions of AAA Proteins, Salk Institute, La Jolla (April)
1999 Invited Seminar and Lecture, "Positional cloning mouse genes: a-stargazin and a-fidgetin and a-voiding complex traits?" and “Complex traits in mouse, NHGRI, Bethesda (May)
1999 Platform Speaker, “In search of seizure susceptibility genes: QTLs vs Mutagenesis,” at Mouse Initiatives: Advanced Functional Genomics, The Jackson Laboratory, Bar Harbor (July)
2000 Platform Speaker, “Electroconvulsive screens for mouse strains and mutants,” at Mouse Behavioral Phenotyping, Banbury Center, Lloyd Harbor (August)
2000 Platform Speaker, “Production and screening of mouse neurological mutants: The Jackson Laboratory's Neuroscience Mutagenesis Facility,” at Mutagenesis of the Mouse Genome, University of Georgia, Athens (GA) September
2000 Invited Seminar, "Mutation screens for epilepsy and other neurological disorders in mice" Center for Neurobiology and Behavior, University of Pennsylvania, Philadelphia (November)
2000 Invited Special Speaker, "Mutation screens for epilepsy and other neurological disorders in mice" The Fourth Annual Einstein Postdoctoral Symposium, Albert Einstein College of Medicine, Bronx (December)
2001 Invited Seminar, "Mutation screens for epilepsy and other neurological disorders in mice" Eccles Center for Human Genetics, University of Utah, Salt Lake City (February)
2001 Invited Seminar, "Mutation screens for epilepsy and other neurological disorders in mice" Department of Biochemistry, George Washington University School of Medicine, Washington, DC (February)
2001 Invited Speaker, "Mutation screens for epilepsy and other neurological disorders in mice" at Genetic Basis of Neurological and Behavioral Disorders (sponsored by The Klingenstein Fund), Cold Spring Harbor Laboratory, Cold Spring Harbor (March)
2001 Invited Seminar, "Mutation screens for epilepsy and other neurological disorders in mice" Program in Genetics, Tufts University School of Medicine, Boston (April)
2001 Invited Speaker, "The effects of natural variants on detection and mapping of novel seizure mutations in mutagenesis screens" at Identification of Genes Underlying ENU-Induced Mutant Phenotypes, McLaughlin Research Institute, Great Falls (July)
2001 Platform Speaker, "Mutation screens for epilepsy and other neurological disorders in mice" at Mouse Genome Initiatives III, The Jackson Laboratory, Bar Harbor (August)
2001 Invited Speaker, “QTLs meets mutagenesis in Bar Harbor,” IBANGS Annual Meeting (International Behavioral and Neuronal Genetics Society), San Diego (November)
2001 Platform Speaker, “Electroconvulsive thresholds and antiepileptic drug responses for mouse mutants and strains” at Society for Neuroscience Annual Meeting, San Diego (November)
2001 Participant, “New mouse behavioral phenotyping assays and mutagenesis for brain and behavior phenotypes, Half Moon Bay (December)
2002 Invited Seminar, “Mutation screens for seizure and other neurological disorders in mice,” Duke University Department of Neurobiology, Durham (January)
2002 Invited Participant, “International Mouse Mutagenesis Consortium” discussion meeting, London (February)
2002 Invited Speaker, “Electroconvulsive thresholds and antiepileptic drug response in mouse mutants and strains” in Nurturing the Genome: A Festschrift for Benson E. Ginsburg, University of Connecticut, Storrs (June)
2002 Invited Speaker, “Progress in the JAX Neuroscience Mutagenesis Facility as it approaches its 2nd birthday” in Workshop on ENU Mutagenesis: Planning for Saturation, Chantilly, VA (July)
2002 Invited Speaker, “Mouse sequencing and mutations” in Mouse Initiatives IV: Comparative Genomic Approaches to the Analysis of Gene Function and Human Disease, Bar Harbor, ME (August)
2002 Invited Seminar, “Progress in mutagenesis screens for new models of epilepsy and other neurological disorders in mice,” Tufts University Department of Molecular Biology and Microbiology, Boston (September)
2002 Invited Speaker, “Seizure genetics in mice” in Neurogenetics of Childhood Epilepsy (Symposium at Annual Meeting of American Society of Human Genetics, Baltimore, MD (October)
2002 Platform Speaker, “Mutant mice with a low electroconvulsive threshold have a spontaneous deletion that includes the Kcnq2 and Chrna4 genes” at Society for Neuroscience Annual Meeting, Orlando, FL (November)
2002 Invited Participant, “Beyond the beginning: the future of genomics II. NHGRI-sponsored conference at Airlie Conference Center (November)
2003 Invited Speaker, “Screening and characterization of epilepsy related and other neurological mutations in mice” in Molecular Basis of CNS Disorders, Bonn, Germany (February)
2003 Platform Speaker, “Spike-wave seizures in the stargazer allelic series,” in Spring Epilepsy Research Conference, Grand Cayman, CI (April)
2003 Invited Speaker, “New genetically-defined and readily-testable models for epilepsy and for therapy resistance in mice,” Division of Neurology, University of Pennsylvania, Philadelphia (September)
2003 Platform Speaker, “Stateside ENU: overview of neuro-mutagenesis centers funded by the NIH,” The mouse as an instrument for hearing research, Bar Harbor (September)
2003 Invited Speaker, “Evolving the electroconvulsive test as a forward-genetic screen for epilepsy research in mice” in Phenotype screens for mice developing an integrated platform; Eumorphia Annual Meeting, Slough/London, UK (October)
2003 Invited Speaker, “Forward genetics approaches to new mouse models for epilepsy research and therapy resistance,” Wellcome Trust Center for Human Genetics, Oxford, UK (December)
2004 Invited Speaker, “Effect of genetic background on induced and spontaneous mouse models for epilepsy” in joint plenary session of Human Genome Sequence Variation and the Inherited Basis of Common Disease and Natural Variation and Quantitative Genetics in Model Organisms, Keystone Symposia, Breckenridge (January)
2004 Invited Speaker, “Neurological mutations and modeling for epilepsy and other brain disorders in mice," Vermont Genetics Network Third Annual Retreat, Burlington (August)
2004 Invited Speaker, “Genetic studies of new epilepsy mutations and models in mice”, University of Tennessee Neuroscience Institute, Memphis (October)
2005 Invited Speaker, “Genetic studies of epilepsy in mice: Complexities of simple traits” in Distinguished Scientist Seminar Series at Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee (March)