Course on
MOLECULAR ASPECTS of HEMATOLOGICAL DISORDERS
June 7-8, 2016
Vs 160603
The postgraduate school Molecular Medicine (MolMed) presents this course for the 3rd time, together with the department of Hematology of the Erasmus MC in close collaboration with the department of Cell Biology and investigators in the field of Hematology of other UMCs in Holland, Belgium and Germany.
This workshop provides a unique opportunity for investigators in the field to be updated on the latest developments in molecular biology of leukemic and pre-leukemic disorders. Investigators from Erasmus MC, Radboud University Medical Center, University Medical Center Groningen, Sanquin Research and Landsteiner Laboratory Amsterdam Medical Centre, Free University of Amsterdam, Ghent University and University of Münster, will present their most recent work.
The following themes will be central in the first two days of the course:
· Hematopoietic stem cells and development
· Preleukemic disorders
· Hematopoietic stem cells and support
· Myeloid malignancies and chromatin modifications
· Malignant Hematopoiesis in Xenotransplant models
· Lymphoid malignancies
· Leukemia: molecular and epigenetics
Location
The meeting will be held on Tuesday, 7th of June, and Wednesday 8th of June, in Congress Centre Engels, at Stationsplein 45, conveniently located nearby Rotterdam Central Station.
Speakers
We are proud to announce as keynote speakers: Marc Mansour, University College London, Great Britain; Douglas Higgs from the University of Oxford, Great Britain; Hugues de Thé from University Paris Diderot, France; Ido Amit from Weizmann Institute of Science Rehovot, Israel; Tessa Holyoake from University of Glasgow, Great Britain; Ivo Touw from ErasmusMC Rotterdam, The Netherlands; Pieter van Vlierberghe from Ghent University, Belgium; and Rebekka Schneider-Kramann from University Hospital RWTH Aachen, Germany. In addition, a selection of PhD Students and Postdocs from the participating research groups will present and discuss their latest work. Frank van Vliet will be pleased to answer organizational questions (010-704 3518 or 06-5474 6408;).
We are looking forward to meet you during the course!
Ruud Delwel, Dept. of Hematology, Erasmus MC;
Frank van Vliet, MolMed/Erasmus MC;
First Day, Tuesday 7 June 2016, Congress Centre Engels, Claus Room (‘Claus zaal’), 2nd floorMolecular aspects of hematological disorders
Theme: The bone marrow niche in malignancy
Moderators: Roland Kuiper and Marcel Spaargaren
Time / Speaker/participants / Title
8.45-9.15 / Registration and coffee
Short talks
9.15-9.30
9.30-9.45
9.45-10.05 / Zhen Ping,
ErasmusMC, Rotterdam
Si Chen,
ErasmusMC, Rotterdam
Richard Groen,
VUmc, Amsterdam / Deconstructing niche contributions to leukemogenesis in Shwachman –Diamond syndrome
Niche abnormalities in the pathogenesis of MDS
Identification of candidate targets for anti-myeloma compounds with enhanced activity in the context of tumor-stromal interactions
10.05-10.35 / KEYNOTE LECTURE:
Ivo Touw,
Rotterdam, The Netherlands / Genomic evolution of severe congenital neutropenia
10.35-11.00 / Coffee Break
Theme: Hematopoiesis
Moderators: Edo Vellenga and Peter Valk
Time / Speaker/participants / Title
Short talks
11.00-11.15
11.15-11.30
11.30-11.50
11.50-12.10 / Johannes Jung,
UMCG, Groningen
Seka Lazare,
UMCG, Groningen
Hein Schepers,
UMCG, Groningen
Emma de Pater,
Erasmus MC, Rotterdam / The role of Cbx proteins in human hematopoiesis
Changes in HSC transcriptome with age
CITED2 cooperates with low PU.1 and DNMT3A to maintain self-renewal in hematopoietic stem cells
Gpr56: A novel molecule involved in hematopoietic stem cell generation
12.10-12.40 / KEYNOTE LECTURE:
Tessa Holyoake,
Glasgow, Great Britain / Chronic myeloid leukaemia stem cells – from omics to therapy
12.40-13.40 / Lunch
Theme: Malignant Erythropoiesis
Moderators: Frank Grosveld and Marieke von Lindern
Time / Speaker/participants / Title
Short talks
13.40-13.55
13.55-14.10 / Steven Heshusius,
Sanquin Amsterdam
Guillaume Giraud,
ErasmusMC, Rotterdam / The role of Klf1 in erythropoiesis
The LDB1 complex FLI(-1)es to leukemia genes enhancers during erythroleukemia
14.10-14.50 / KEYNOTE LECTURE:
Douglas Higgs,
Oxford, Great Britain / An odd way to discover a tumour suppressor
14.50-15.10 / Coffee Break
Theme: Acute Myeloid Leukemia I
Moderators: Gerald de Haan and Sjaak Philipsen
Time / Speaker/participants / Title
Short talks
15.10-15.25
15.25-15.40
15.40-15.55 / Han Verhagen,
VUmc, Amsterdam
Anne Marneth,
Radboud University, Nijmegen
Tamas Csikos,
VUmc, Amsterdam / IGFBP7 induces differentiation and eradication of acute myeloid leukemia (stem) cells
Abnormal intragenic transcriptional activation in MLL-AF9 and KAT6A-CREBBP acute myeloid leukemia
A CRISPR-Cre-LoxP hybrid approach allows for both instant allele removal and homozygote mutant identification
15.55-16.35 / KEYNOTE LECTURE:
Hugues de Thé,
Paris, France / PML nuclear bodies, unexpected effectors of APL cure
18.00 / Dinner at Restaurant Tai Wu, Mauritsweg 24-26, 010-433 0818
Second Day, Wednesday 8th June 2016, Congress Centre Engels, Claus Room, 2nd floor
Molecular aspects of hematological disorders
Theme: Lymphoblastic leukemia I
Moderators: Linda Smit and JJ Schuringa
Time / Speaker/participants / Title
Short talks
8.30-8.45
8.45-9.00
9.00-9.15
9.15-9.30 / Leonie Smeenk,
ErasmusMC, Rotterdam
Miriam Butler,
Radboud University, Nijmegen
Kaat Durinck,
CMGG, Ghent
Filip Matthijssens,
CMGG, Ghent / Molecular role of the PAX5-ETV6 oncoprotein in promoting Bcell acute lymphoblastic leukemia
CRISPR/Cas9 Based Kinome Screen Identifies Novel Targets that Determine Sensitivity for Asparinase Therapy in Acute Lymphoblastic Leukemia
Characterization of the Notch-dependent mRNA/miRNA network that controls human gamma-delta development
Oncogenic functions of RUNX2 in leukemia
9.30-10.00 / KEYNOTE LECTURE:
Pieter van Vlierberghe,
CMGG, Ghent / Understanding sensitivity towards LSD1 inhibition in hematological malignancies
10.00-10.20 / Coffee Break
Theme: Lymphoblastic Leukemia II
Moderators: Frank Rosenbauer and Hein Schepers
Time / Speaker/participants / Title
Short talks
10.20-10.35
10.35-10.50
10.50-11.05
11.05-11.25 / Rene Marke, Radboud University, Nijmegen
Jiangyan Yu,
Radboud University, Nijmegen
Kirsten-Cante-Barrett,
ErasmusMC, Rotterdam
Jules Meijerink,
ErasmusMC, Rotterdam / Tumor suppressor genes BTG1 and IKZF1 cooperate in leukemia development and glucorticoid resistance
Genetic architecture of relapsed pediatric B-cell precursor acute lymphoblastic leukemia is related to the intensity of upfront protocols
Human T-cell development signatures reveals the T-cell commitment checkpoint and relevance for T-ALL
Determining the mutational landscape of T-cell acute lymphoblastic leukemia reveals NR3C1 deletions and activating mutations in IL7R signaling as cause of steroid resistance
11.25-12.00 / KEYNOTE LECTURE:
Ido Amit,
Rehovot, Israel / The power of one: Immunology in the age of single cell genomics
12.00-13.00 / Lunch
Theme: Acute Myeloid Leukemia and Myelodysplastic Syndrome
Moderators: Pieter van Vlierberghe and Richard Groen
Time / Speaker/participants / Title
Short talks
13.00-13.15
13.15-13.30
13.30-13.45 / Hendrik Folkerts,
UMCG, Groningen
Josi Fischer,
UKM Münster
Bauke de Boer,
UMCG, Groningen / The role of autophagy in AML
The role of PU.1 in granulocyte activation
Unraveling plasma membrane protein composition in leukemia
13.45-14.15 / KEYNOTE LECTURE:
Rebekka Schneider-Kramann, Aachen, Germany / Molecular link between genetic abnormalities in MDS, activation of the innate immune system, and ineffective hematopoiesis
14.15-14.35 / Coffee Break
Theme: Epigenetics and leukemia
Moderators: Ivo Touw and Frank van Leeuwen
Time / Speaker/participants / Title
Short talks
14.35-14.55
14.55-15.10
15.10-15.25
15.25-15.40 / Henny Maat,
UMCG, Groningen
Petros Kolovos,
ErasmusMC, Rotterdam
Melinda Czeh,
UKM, Münster
Marten Hansen,
Sanquin Amsterdam / Identification of USP7 as a targetable deubiquitinating enzyme the non-canonical PRC1.1 complex
T2C identifies the interactome and compartmentalization of genomic regions at a resolution below 1Kb
A DNA methylation checkpoint in the development of dendritic cells
Megakaryopoiesis from iPS: a model system to study Gray Platelet Syndrome
15.40-16.15 / KEYNOTE LECTURE:
Marc Mansour,
London, Great Britain / Finding NEMOs - Neomorphic Enhancer Mutations of Oncogenes - in T-ALL
Course fees
This course is generously sponsored by:
-Stichting Leukemie Rotterdam (‘Foundation Leukemia’);
-Daniel den Hoed Foundation.
Because of this sponsoring, we could lower the course fee for non-commercial participants (i.e. PI’s, postdocs, graduate students, technicians), including lunches, coffee, tea and dinner at Restaurant Tai Wu to €75.
This is a flat fee for everyone including all speakers and MolMed-members. Only invited keynote speakers receive a 100% discount and pay €0.
Invoice
After your registration you will receive an INVOICE per snail mail. Late participants can also pay in cash upon signing in at the start of the course.
Cancellation
The fees mentioned apply to the full 2-day course. There is no discount when attending only part of the course. Cancellation is possible up to one week before the start of the course. Later cancellation will not be accepted, but you are allowed to send a substitute.
Commercial participants & sponsors
Companies are invited to inquire about participation and sponsoring options.