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CURRICULUM VITAE
Name: Pavel Klein, M.B., B.Chir.
Address: 9 Watchwater Way
Rockville, MD 20850
Telephone: 301-424-1658
E-mail:
EDUCATION
1977 B.A., Oxford University
1980 M.B., B.Chir., Cambridge University
1983 M.A., Oxford University
POSTDOCTORAL TRAINING
1981-82 House Officer, General Surgery & Internal Medicine, William Harvey Hospital, Ashford, UK
1982-83 Senior House Officer, Neurology & Geriatrics/Neurology, University College Hospital, London, UK
1983 Fellow in Clinical Neuropharmacology, University College Hospital, London, UK
1983-85 European Exchange Fellowship in Clinical Medicine: Respiratory Medicine, Cardiology & Internal Medicine
§ 1983-84 Guy’s Hospital, London UK
§ 1984-85 University Hospital, Hamburg Germany
1986 Neurology Research Assistant, University of Virginia, Charlottesville, VA
1986-89 Resident in Neurology, University of Virginia, Charlottesville, VA
1989-90 Fellowship in EEG/Epilepsy, University of Virginia, Charlottesville VA
1995-97 Fellowship in Neuroendocrinology, Beth Israel Deaconess Medical Center, Boston, MA
1997-98 Fellowship in Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA
EMPLOYMENT HISTORY
1990-94 Private Practice, Neurology, Chattanooga, TN
1995-98 Attending Physician, Beth Israel Deaconess Medical Center, Boston, MA
1999-8/2003 Attending Physician, Georgetown University Medical Center,
Washington, D.C.
9/2003-present Director, Mid-Atlantic Epilepsy and Sleep Center, L.L.C.
7/2008-present Associate Professor, Neurology and Pediatrics, Children’s National
Medical Center, The George Washington University, Washington, D.C.
LICENSURE AND CERTIFICATION
1990 American Board of Psychiatry and Neurology
1992 American Board of Psychiatry and Neurology with added qualifications in Clinical Neurophysiology
2000 Diplomate, American Board of Sleep Medicine
1990 Georgia License Registration
1991 Tennessee License Registration
1995 Massachusetts License Registration
1998 Maryland License Registration
1998 Virginia License Registration
1998 District of Columbia License Registration
AWARDS AND HONORS
1974 Open Exhibition, University College, Oxford
1975 Plumbton Mynor Scholarship, University College, Oxford
1983 European Exchange Fellowship in Clinical Medicine, Guy’s Hospital, London,
UK
PROFESSIONAL SOCIETIES
1986- American Academy of Neurology
1992- American EEG Society
1999- American Academy of Sleep Medicine
1999- American Epilepsy Society
ACADEMIC APPOINTMENTS AND AFFILIATIONS
1995-99 Instructor in Neurology, Harvard Medical School, Boston, MA
1999-03 Assistant Professor, Georgetown University Hospital, Washington, DC
1999-03 Director, Epilepsy Center, Georgetown University Hospital, Washington, DC
1999-03 Director, Clinical Neurophysiology Laboratory, Georgetown University
Hospital, Washington, D.C.
1999-03 Director, Neuroendocrinology Unit, Georgetown University Hospital,
Washington, DC
2008- Adjunct Associate Professor, Neurology and Pediatrics, Children’s National
Medical Center, The George Washington University, Washington, D.C.
HOSPITAL APPOINTMENTS
1995-99 Attending Neurologist, Beth Israel Deaconess Medical Center, Boston, MA
1999-03 Attending Neurologist, Georgetown University Hospital, Washington, DC
2003- Attending Neurologist, Holy Cross Hospital, Silver Spring, MD
PROFESSIONAL ACTIVITIES
Peer Review and Editorial Activities
Ad hoc reviewer for Annals of Neurology, Neurology, Epilepsia, Epilepsy and Behavior, Brain Research, Neuroendocrinology, Steroid, CNS Drugs.
Ad hoc grant reviewer
CURE Epilepsy: 2009,
NIH (NINDS) 2014, 2016
Invited Lectures/symposia
Symposia:
2002: Co-Founder, Neuroendocrine Special Interest Group, American Epilepsy Society
2002-2008: Co-organizer and Co-chair of annual Neuroendocrine SIG meetings at annual AES meetings.
2006: Co-organizer, NIH workshop: Biomarkers of epileptogenesis.
2011: Co-Founder, Private Practice Epilepsy, Special Interest Group, American Epilepsy Society.
2011-: Co-organizer and Co-chair, annual Private Practice Epilepsy Special Interest Group meetings at annual AES meetings.
Lectures:
2002: Stress and Epilepsy. Presentation, neuroendocrinology special interest
group meeting, Annual Meeting of the American Epilepsy Society (AES), 2002.
2005: Hormonal Influences on circadian seizure fluctuation. Presentation,
neuroendocrinology special interest group meeting, Annual Meeting of the AES.
2006: Biomarkers of epileptogenesis: NIH workshop.
2007: Hormonal influences and treatments in adolescents with epilepsy. Special
symposium, “Professionals in Epilepsy”. Annual Meeting of the AES, 2007.
2004, 2007-2009: Lecturer/panel discussant, TopScholar Symposium at the
Annual Meeting of the AES
2011-2014: Epilepsy Research in Private Practice. Presentation, Annual Meeting
of the American Epilepsy Society.
2002-2015: Numerous neurology grand rounds, seminars and lectures at local,
national and international academic institutions and community hospitals including, among others:
National Institutes of Health, Georgetown University Hospital, George Washington University Hospital, Bethesda Naval Hospital, Walter Reed Army Hospital, Howard University, Virginia Commonwealth University, Richmond, VA, University of Michigan, Ann Arbor, MI, New York, Boston, Seattle, San Francisco, Cleveland, Pittsburgh, Oslo University, Norway, Toronto, Canada, Brussels, Belgium, Charles University, Prague, Czech Republic.
National level committee activities
1999-2005: Member, Task force, women’s issues in epilepsy, American Epilepsy Society
2006-2009: Member, Investigator’s workshop committee, American Epilepsy Society
2009-2011: Member, Clinical Practice Committee, American Epilepsy Society
2009-2012: Member, Health Reform Task Force, American Epilepsy Society
2010-2012: Member, AES annual meeting Science Program Committee, American Epilepsy Society
2010-2014: Member, AES Treatment Committee, American Epilepsy Society
2012-current: Member, AES Treatment Committee, Devices American Epilepsy Society
2010-current: Member, American Academy of Neurology Neuroendocrine Research Award Subcommittee
2010-2012: Member, Development Committee, American Society of Experimental NeuroTherapeutics
2012-current: Member, Corporate Advisory Committee, American Epilepsy Society
2011-current: Co-founder and Co-Chair, Consortium of Private Epilepsy Centers of North America
PUBLICATIONS
1. Klein P, Lees A, Stern G. Consequences of chronic 5-hydroxytryptophan in parkinsonian instability of gait and balance and other neurological disorders. Advances in Neurology 1986; 45:603-604.
2. Klein P, Rubinstein L. Benign symptomatic glial cysts of the pineal gland. Journal of Neurology, Neurosurgery, and Psychiatry 1988; 52:991-995.
3. Klein P, Haley EC, Wooten GF, Vandenberg SR. Focal cerebral infarctions associated with perivascular tumor infiltrates in carcinomatous leptomeningeal metastases. Arch Neurol 1989; 46:1149-1151.
4. Klein P. Cerebellar ataxia. Archives of Neurology 1989; 46:1166.
5. Klein P, Zientek G, Vandenberg SR, Lothman EW. Primary CNS lymphoma: Lymphomatous meningitis presenting as a cauda equina lesion in an AIDS patient. Canadian Journal of Neurological Science 1990; 17:329-331.
6. Larner JM, Kersch CR, Constable WC, Klein P, Ferguson R, Short R, Jane JA. Phase I/II trial of arterial 5FU infusion for patients with glioblastoma. Journal of Clinical Oncology 1991; 14:514-518.
7. Klein P, Oertel J. Depression associated with pontine vascular malformation. Biological Psychiatry 1997; 42:519-521.
8. Herzog AG, Klein P, Ransil BJ. Three patterns of catamenial epilepsy. Epilepsia 1997;38:1082-1088.
9. Klein P, Herzog AG. Emerging applications of hormonal therapy of paroxysmal central nervous system disorders. Expert Opinion on Investigational Drugs 1997;6(10):1337-1349.
10. Herzog AG, Klein P, Jacobs AR. Testosterone versus testosterone and testolactone in treating reproductive and sexual dysfunction in men with epilepsy and hypogonadism. Neurology 1998; 50:782-784.
11. Silveira DC, Liu Z, de LaCalle S, Jun L, Klein P, Holmes GL, Herzog AG. Activation of the locus coreruleus following amygdaloid kindling. Epilepsia 1998; 39(12):1261-1264.
12. Klein P, Herzog AG. Hormonal Effects on Epilepsy in Women. Epilepsia 1998; 39 (Suppl 8):S9-S16.
13. Klein P, Herzog AG, Versi E. Mood and the menopause. Br J Ob Gyn 1999; 106:1-4.
14. Silveira DC, Klein P, Liu Z, Holmes GL, Elmquist J, de LaCalle S, Herzog AG. Asymmetric activation of hypothalamic neurons with unilateral amygdaloid seizures in female rats. Epilepsia 2000;41:34-42.
15. Klein P, Pezzullo JC, Serje A. Premature ovarian failure in women with epilepsy. Epilepsia 2001;42:1584-1590.
16. Klein P, Clark L, Pezzullo JC. Onset of Epilepsy at the time of menarche. Neurology 2003;60:495-7.
17. Herzog AG, Coleman AE, Jacobs AR, Klein P, Friedman MN, Drislane FW,
Schomer DL. Relationship of sexual function to the laterality and reproductive
hormone levels in women with temporolimbic epilepsy. Epilepsy Behav 2003;4:407-
13.
18. Herzog AG, Coleman AE, Jacobs AR, Klein P, Friedman MN, Drislane FW, Ransil
BJ, Schomer DL. Interictal EEG discharges, reproductive hormones and menstrual
disorders in epilepsy. Ann Neurol 2003;54:625-37.
19. Sahoo S, Klein P. Maternal Complex partial seizure associated with fetal distress.
Arch Neurol 2005;62:1304-05.
20. Klein P, Sahoo S. Effect of ACTH-induced hypercortisolemia on EEG in patients
with stress-related epilepsy. Epilepsy Behav 2005;6:187-190.
21. Klein P, van Passell-Clark L. Effect of stress related to the 9/11/2001 terror attack on
seizures in patients with epilepsy. Neurology 2005;64:1815-16.
22. Thorneycroft I, Klein P, Simon J. Impact of antiepileptic drug therapy on steroidal
contraceptive efficacy. Epilepsy Behav 2006; 9:31-39.
23. Klein P, Janousek J, Barber A, Weissberger R. Ketogenic diet treatment in adults
with refractory epilepsy. Epilepsy Behav. 2010;19:575-9.
24. Klein P, Herr D, Pearl PL, et.al. Results of phase II safety and feasibility study of
treatment with levetiracetam for prevention of posttraumatic epilepsy. Arch Neurol
2012; 69:1290-95.
25. Klein P, Herr D, Pearl PL, et.al. Results of phase II pharmacokinetic study of
levetiracetam for prevention of posttraumatic epilepsy. Epi Behav 2012; 24:
457-61.
26. Janousek J, Barber A, Goldman L, Klein P. Obesity in adults with epilepsy. Epi
Behav 2013;28:391-394.
27. Pearl PL, Herr D,…Klein P. Results of phase II levetiracetam trial following
acute head injury in children at risk for post-traumatic epilepsy. Epilepsia 2013;
54: (9):e135-7. doi: 10.1111/epi.12326. Epub 2013 Jul 22.
28. Klein P, Mathews GC. Antiepileptic drugs and neurocognitive development,
Editorial. Neurology 2014; 82:194-195.
29. Klein P, Tyrlikova I, Mathews GC. Dietary treatment of refractory epilepsy in
Adults. Neurology 2014; 83:1978-85.
30. Tomson T, Klein P. Fine-tuning risk assessment with antiepileptic drug use in
pregnancy. Editorial. Neurology 2015; 83:339-341.
31. Lee D, Kalu U, Halford J, Biton V, Cloyd J, Klein P, ...Tolbert D. Intravenous
carbamazepine as short- term replacement therapy for oral carbamazepine in adults
with epilepsy: Pooled tolerability results from two open-label trials. Epilepsia 2015;
32. Klein P, Schiemann J, Sperling M, Whitesides J, Liang W, Stalvey T, Brandt C,
Kwan P. A randomized, double-blind, placebo- controlled, multicenter, parallel-
group study to evaluate the efficacy and safety of adjunctive brivaracetam in adult
patients with uncontrolled partial-onset seizures. Epilepsia 2015;56:1890-1898; doi:
10.1111/epi.13212. Epub 2015 Oct 16.
33. Klein P, Tyrlikova, I, Brazdil I, Rektor P. Brivaracetam for the treatment of
epilepsy. Expert Opinion Pharmacoterhapy. 2016; Jan 13:1-13 [Epub ahead of print].
34. Klein P, Biton V, Dilley D, Barnes M, Schiemann J, Lu S. Safety and tolerability of
adjunctive brivaracetam as intravenous infusion or bolus in patients with epilepsy.
Epilepsia 2016; 57:1130-38.
35. Ben-Menachem E, Mameniskiene R, Quarato PP, Klein P, Gamage J, Schiemann J,
Johnson ME, Whitesides J, McDonough B, Eckhardt K. Efficacy and safety of
brivaracetam for partial-onset seizures in 3 pooled clinical studies.
Neurology 2016; 87:314-323.Published ahead of print Jun2 22,2016.
REVIEWS & CHAPTERS
1. Klein P, Herzog AG. Endocrine Aspects of Partial Epilepsy. In: Schachter SC and Schomer DL, eds. The Comprehensive Management and Treatment of Epilepsy. Academic Press, San Diego 1997, Chapter 12, pp. 207-232.
2. Klein P, Herzog AG. Endocrine Aspects of Epilepsy. In: Pretel S, Knigge KM, and Prasad A, eds. MCH and Seizures: Neuromolecular and Neuroendocrine Aspects. Research Signpost, India 1997, pp. 111-139.
3. Herzog AG, Klein P. Hormonal Therapy. In: Sperling M. Medical Management of Epilepsy. Marcel Dekker 1998.
4. Klein P, Herzog AG. Hormones and Epilepsy. In: Schmidt S and Schachter SC, eds. Epilepsy: Problem Solving in Clinical Practice. Martin Dunitz Ltd., London 2000, Chapter 32, pp 413-434.
5. Klein P. Exacerbation of seizures in a young woman. In: Schmidt D, Schachter SC, eds. 110 Puzzling Cases of Epilepsy. Martin Dunitz Ltd., London 2001, Chapter 61, pp 237-241.
6. Klein P, Janousek J. Impact of Neuroendocrine Factors in Seizure Genesis and Treatment. In: Rho JM, Cavazzos JE, eds. Epilepsy: Scientific Foundations of Clinical Management. Marcel Dekker 2004. Revised, second edition, 2009.
7. Klein P. Mood and the Menopause. In: Studd J, ed. The management of the menopause. The Parthenon Publishing Group, Lancaster (UK) 2003.
8. Klein P, Schomer D. Effect of Ovarian Hormones on the Nervous System. In Kaplan P, ed. Neurologic Disease in Women. Martin Dunitz Ltd., London 2005.
9. Klein P, Janousek J. Hormones and antiepileptic drugs. In: Bui E, Klein AM, eds. Women with Epilepsy. Cambridge University Press, Cambridge (UK), 2013.
10. Tyrlikova I, Klein P. Ketogenic diet treatment in adults with refractory epilepsy. In:
Watson RR, Preedy V, eds. Bioactive Nutriceuticals and Dietary Supplements in
Neurological and Brain Disease: Prevention and Therapy. Elsevier, 2014.
11. Klein P. Status epilepticus. In: Koubeissi MZ, Azar N, eds. Epilepsy Board Review: A Comprehensive Guide. Springer Science +Business Media, 2016; in press.
RECENT ABSTRACTS
1. Klein P, Jacobs AR, Herzog AG. A comparison of testosterone versus testosterone and testolactone in the treatment of reproductive/sexual dysfunction in men with epilepsy and hypogonadism. Neurology 1996; 46:177.
2. Herzog AG, Klein P. Three patterns of catamenial epilepsy. Epilepsia 1996; 37:83.
3. Klein P, Silveira DC, Liu Z, Holmes GL, Elmquist J, de LaCalle S, Herzig AG. Asymmetric activation of hypothalamic neurons with unilateral amygdaloid seizures in male rats. European Journal of Neurology 1997; 4:S14.
4. Silveira DC, Liu Z, LaCalle S, Lu J, Klein P, Holmes GL, Herzog AG. Locus coeruleus fos-immunoreactivity following amygdala-kindled generalized seizures. Epilepsia 1997;38:186.
5. Joseph J, Klein P, Kleefield J. Vasospasm neuroradiology and pathology. J Neurol Exp Neuropathol 1997.
6. Herzog AG, Klein P, Jacobs AR, Coleman AC, Drislane FW, Schomer DL. Abnormal interictal prolactin elevations particularly among men and women with complex partial seizures of right temporal origin. Epilepsia 1997; 38:48.
7. Herzog AG, Coleman AE, Jacobs AR, Klein P et al. Menstrual Disorders, reproductive endocrine dysfunction and interictal discharge frequency in women with temprolimbic epilepsy. Neurology 1999; 52;(Suppl 2) A2:24.
8. Klein P. Effect of stress on localization-related epilepsy. Epilepsia 2000, 41; (Suppl. 7):S112).
9. Serje A, Klein P. Premature Ovarian Failure in women with epilepsy. Epilepsia 2000, 41;(Suppl.7):S 198.
10. Herzog AG, Coleman AE, Jacobs AR, Klein P, et al. Acute hypothalamopituitary dysfunction following interictal unilateral temporal epileptiform discharges in women with epilepsy. Epilepsia 2000, 41; (Suppl. 7):S 167.
11. Cantero, J, Klein P. Treatment of Exacerbation of partial seizures during perimenarche with natural progesterone. Epilepsia 2001;42 (Suppl 7) 290.
12. Sahoo S, Klein P. Effect of adrenocorticotropic hormone (ACTH)-induced acute hypercortisolemia on EEG in patients with stress-related epilepsy. Epilepsia 2001;42 (Suppl 7) 115.
13. Klein P. Onset of epilepsy at the time of menarche. Epilepsia 2001;42 (Suppl 7) 291.
14. Clark L, Klein P. Seizure occurrence in relationship to the 9/11 terrorist attack among patients with epilepsy in the Washing, DC area. Epilepsia 2002; 43 (Suppl 7) 298.