Page 3 of 14

CURRICULUM VITAE

Name: Pavel Klein, M.B., B.Chir.

Address: 9 Watchwater Way

Rockville, MD 20850

Telephone: 301-424-1658

E-mail:

EDUCATION

1977  B.A., Oxford University

1980  M.B., B.Chir., Cambridge University

1983  M.A., Oxford University

POSTDOCTORAL TRAINING

1981-82  House Officer, General Surgery & Internal Medicine, William Harvey Hospital, Ashford, UK

1982-83  Senior House Officer, Neurology & Geriatrics/Neurology, University College Hospital, London, UK

1983  Fellow in Clinical Neuropharmacology, University College Hospital, London, UK

1983-85  European Exchange Fellowship in Clinical Medicine: Respiratory Medicine, Cardiology & Internal Medicine

§  1983-84 Guy’s Hospital, London UK

§  1984-85 University Hospital, Hamburg Germany

1986  Neurology Research Assistant, University of Virginia, Charlottesville, VA

1986-89  Resident in Neurology, University of Virginia, Charlottesville, VA

1989-90  Fellowship in EEG/Epilepsy, University of Virginia, Charlottesville VA

1995-97  Fellowship in Neuroendocrinology, Beth Israel Deaconess Medical Center, Boston, MA

1997-98  Fellowship in Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA

EMPLOYMENT HISTORY

1990-94  Private Practice, Neurology, Chattanooga, TN

1995-98  Attending Physician, Beth Israel Deaconess Medical Center, Boston, MA

1999-8/2003 Attending Physician, Georgetown University Medical Center,

Washington, D.C.

9/2003-present Director, Mid-Atlantic Epilepsy and Sleep Center, L.L.C.

7/2008-present Associate Professor, Neurology and Pediatrics, Children’s National

Medical Center, The George Washington University, Washington, D.C.

LICENSURE AND CERTIFICATION

1990  American Board of Psychiatry and Neurology

1992 American Board of Psychiatry and Neurology with added qualifications in Clinical Neurophysiology

2000 Diplomate, American Board of Sleep Medicine

1990  Georgia License Registration

1991  Tennessee License Registration

1995  Massachusetts License Registration

1998  Maryland License Registration

1998  Virginia License Registration

1998  District of Columbia License Registration

AWARDS AND HONORS

1974  Open Exhibition, University College, Oxford

1975  Plumbton Mynor Scholarship, University College, Oxford

1983 European Exchange Fellowship in Clinical Medicine, Guy’s Hospital, London,

UK

PROFESSIONAL SOCIETIES

1986- American Academy of Neurology

1992-  American EEG Society

1999-  American Academy of Sleep Medicine

1999-  American Epilepsy Society

ACADEMIC APPOINTMENTS AND AFFILIATIONS

1995-99  Instructor in Neurology, Harvard Medical School, Boston, MA

1999-03 Assistant Professor, Georgetown University Hospital, Washington, DC

1999-03 Director, Epilepsy Center, Georgetown University Hospital, Washington, DC

1999-03 Director, Clinical Neurophysiology Laboratory, Georgetown University

Hospital, Washington, D.C.

1999-03  Director, Neuroendocrinology Unit, Georgetown University Hospital,

Washington, DC

2008- Adjunct Associate Professor, Neurology and Pediatrics, Children’s National

Medical Center, The George Washington University, Washington, D.C.

HOSPITAL APPOINTMENTS

1995-99 Attending Neurologist, Beth Israel Deaconess Medical Center, Boston, MA

1999-03 Attending Neurologist, Georgetown University Hospital, Washington, DC

2003- Attending Neurologist, Holy Cross Hospital, Silver Spring, MD

PROFESSIONAL ACTIVITIES

Peer Review and Editorial Activities

Ad hoc reviewer for Annals of Neurology, Neurology, Epilepsia, Epilepsy and Behavior, Brain Research, Neuroendocrinology, Steroid, CNS Drugs.

Ad hoc grant reviewer

CURE Epilepsy: 2009,

NIH (NINDS) 2014, 2016

Invited Lectures/symposia

Symposia:

2002: Co-Founder, Neuroendocrine Special Interest Group, American Epilepsy Society

2002-2008: Co-organizer and Co-chair of annual Neuroendocrine SIG meetings at annual AES meetings.

2006: Co-organizer, NIH workshop: Biomarkers of epileptogenesis.

2011: Co-Founder, Private Practice Epilepsy, Special Interest Group, American Epilepsy Society.

2011-: Co-organizer and Co-chair, annual Private Practice Epilepsy Special Interest Group meetings at annual AES meetings.

Lectures:

2002: Stress and Epilepsy. Presentation, neuroendocrinology special interest

group meeting, Annual Meeting of the American Epilepsy Society (AES), 2002.

2005: Hormonal Influences on circadian seizure fluctuation. Presentation,

neuroendocrinology special interest group meeting, Annual Meeting of the AES.

2006: Biomarkers of epileptogenesis: NIH workshop.

2007: Hormonal influences and treatments in adolescents with epilepsy. Special

symposium, “Professionals in Epilepsy”. Annual Meeting of the AES, 2007.

2004, 2007-2009: Lecturer/panel discussant, TopScholar Symposium at the

Annual Meeting of the AES

2011-2014: Epilepsy Research in Private Practice. Presentation, Annual Meeting

of the American Epilepsy Society.

2002-2015: Numerous neurology grand rounds, seminars and lectures at local,

national and international academic institutions and community hospitals including, among others:

National Institutes of Health, Georgetown University Hospital, George Washington University Hospital, Bethesda Naval Hospital, Walter Reed Army Hospital, Howard University, Virginia Commonwealth University, Richmond, VA, University of Michigan, Ann Arbor, MI, New York, Boston, Seattle, San Francisco, Cleveland, Pittsburgh, Oslo University, Norway, Toronto, Canada, Brussels, Belgium, Charles University, Prague, Czech Republic.

National level committee activities

1999-2005: Member, Task force, women’s issues in epilepsy, American Epilepsy Society

2006-2009: Member, Investigator’s workshop committee, American Epilepsy Society

2009-2011: Member, Clinical Practice Committee, American Epilepsy Society

2009-2012: Member, Health Reform Task Force, American Epilepsy Society

2010-2012: Member, AES annual meeting Science Program Committee, American Epilepsy Society

2010-2014: Member, AES Treatment Committee, American Epilepsy Society

2012-current: Member, AES Treatment Committee, Devices American Epilepsy Society

2010-current: Member, American Academy of Neurology Neuroendocrine Research Award Subcommittee

2010-2012: Member, Development Committee, American Society of Experimental NeuroTherapeutics

2012-current: Member, Corporate Advisory Committee, American Epilepsy Society

2011-current: Co-founder and Co-Chair, Consortium of Private Epilepsy Centers of North America

PUBLICATIONS

1.  Klein P, Lees A, Stern G. Consequences of chronic 5-hydroxytryptophan in parkinsonian instability of gait and balance and other neurological disorders. Advances in Neurology 1986; 45:603-604.

2.  Klein P, Rubinstein L. Benign symptomatic glial cysts of the pineal gland. Journal of Neurology, Neurosurgery, and Psychiatry 1988; 52:991-995.

3.  Klein P, Haley EC, Wooten GF, Vandenberg SR. Focal cerebral infarctions associated with perivascular tumor infiltrates in carcinomatous leptomeningeal metastases. Arch Neurol 1989; 46:1149-1151.

4.  Klein P. Cerebellar ataxia. Archives of Neurology 1989; 46:1166.

5.  Klein P, Zientek G, Vandenberg SR, Lothman EW. Primary CNS lymphoma: Lymphomatous meningitis presenting as a cauda equina lesion in an AIDS patient. Canadian Journal of Neurological Science 1990; 17:329-331.

6.  Larner JM, Kersch CR, Constable WC, Klein P, Ferguson R, Short R, Jane JA. Phase I/II trial of arterial 5FU infusion for patients with glioblastoma. Journal of Clinical Oncology 1991; 14:514-518.

7.  Klein P, Oertel J. Depression associated with pontine vascular malformation. Biological Psychiatry 1997; 42:519-521.

8.  Herzog AG, Klein P, Ransil BJ. Three patterns of catamenial epilepsy. Epilepsia 1997;38:1082-1088.

9.  Klein P, Herzog AG. Emerging applications of hormonal therapy of paroxysmal central nervous system disorders. Expert Opinion on Investigational Drugs 1997;6(10):1337-1349.

10.  Herzog AG, Klein P, Jacobs AR. Testosterone versus testosterone and testolactone in treating reproductive and sexual dysfunction in men with epilepsy and hypogonadism. Neurology 1998; 50:782-784.

11.  Silveira DC, Liu Z, de LaCalle S, Jun L, Klein P, Holmes GL, Herzog AG. Activation of the locus coreruleus following amygdaloid kindling. Epilepsia 1998; 39(12):1261-1264.

12.  Klein P, Herzog AG. Hormonal Effects on Epilepsy in Women. Epilepsia 1998; 39 (Suppl 8):S9-S16.

13.  Klein P, Herzog AG, Versi E. Mood and the menopause. Br J Ob Gyn 1999; 106:1-4.

14.  Silveira DC, Klein P, Liu Z, Holmes GL, Elmquist J, de LaCalle S, Herzog AG. Asymmetric activation of hypothalamic neurons with unilateral amygdaloid seizures in female rats. Epilepsia 2000;41:34-42.

15.  Klein P, Pezzullo JC, Serje A. Premature ovarian failure in women with epilepsy. Epilepsia 2001;42:1584-1590.

16.  Klein P, Clark L, Pezzullo JC. Onset of Epilepsy at the time of menarche. Neurology 2003;60:495-7.

17. Herzog AG, Coleman AE, Jacobs AR, Klein P, Friedman MN, Drislane FW,

Schomer DL. Relationship of sexual function to the laterality and reproductive

hormone levels in women with temporolimbic epilepsy. Epilepsy Behav 2003;4:407-

13.

18. Herzog AG, Coleman AE, Jacobs AR, Klein P, Friedman MN, Drislane FW, Ransil

BJ, Schomer DL. Interictal EEG discharges, reproductive hormones and menstrual

disorders in epilepsy. Ann Neurol 2003;54:625-37.

19. Sahoo S, Klein P. Maternal Complex partial seizure associated with fetal distress.

Arch Neurol 2005;62:1304-05.

20. Klein P, Sahoo S. Effect of ACTH-induced hypercortisolemia on EEG in patients

with stress-related epilepsy. Epilepsy Behav 2005;6:187-190.

21. Klein P, van Passell-Clark L. Effect of stress related to the 9/11/2001 terror attack on

seizures in patients with epilepsy. Neurology 2005;64:1815-16.

22. Thorneycroft I, Klein P, Simon J. Impact of antiepileptic drug therapy on steroidal

contraceptive efficacy. Epilepsy Behav 2006; 9:31-39.

23. Klein P, Janousek J, Barber A, Weissberger R. Ketogenic diet treatment in adults

with refractory epilepsy. Epilepsy Behav. 2010;19:575-9.

24. Klein P, Herr D, Pearl PL, et.al. Results of phase II safety and feasibility study of

treatment with levetiracetam for prevention of posttraumatic epilepsy. Arch Neurol

2012; 69:1290-95.

25. Klein P, Herr D, Pearl PL, et.al. Results of phase II pharmacokinetic study of

levetiracetam for prevention of posttraumatic epilepsy. Epi Behav 2012; 24:

457-61.

26. Janousek J, Barber A, Goldman L, Klein P. Obesity in adults with epilepsy. Epi

Behav 2013;28:391-394.

27. Pearl PL, Herr D,…Klein P. Results of phase II levetiracetam trial following

acute head injury in children at risk for post-traumatic epilepsy. Epilepsia 2013;

54: (9):e135-7. doi: 10.1111/epi.12326. Epub 2013 Jul 22.

28. Klein P, Mathews GC. Antiepileptic drugs and neurocognitive development,

Editorial. Neurology 2014; 82:194-195.

29. Klein P, Tyrlikova I, Mathews GC. Dietary treatment of refractory epilepsy in

Adults. Neurology 2014; 83:1978-85.

30. Tomson T, Klein P. Fine-tuning risk assessment with antiepileptic drug use in

pregnancy. Editorial. Neurology 2015; 83:339-341.

31. Lee D, Kalu U, Halford J, Biton V, Cloyd J, Klein P, ...Tolbert D. Intravenous

carbamazepine as short- term replacement therapy for oral carbamazepine in adults

with epilepsy: Pooled tolerability results from two open-label trials. Epilepsia 2015;

32. Klein P, Schiemann J, Sperling M, Whitesides J, Liang W, Stalvey T, Brandt C,

Kwan P. A randomized, double-blind, placebo- controlled, multicenter, parallel-

group study to evaluate the efficacy and safety of adjunctive brivaracetam in adult

patients with uncontrolled partial-onset seizures. Epilepsia 2015;56:1890-1898; doi:

10.1111/epi.13212. Epub 2015 Oct 16.

33. Klein P, Tyrlikova, I, Brazdil I, Rektor P. Brivaracetam for the treatment of

epilepsy. Expert Opinion Pharmacoterhapy. 2016; Jan 13:1-13 [Epub ahead of print].

34. Klein P, Biton V, Dilley D, Barnes M, Schiemann J, Lu S. Safety and tolerability of

adjunctive brivaracetam as intravenous infusion or bolus in patients with epilepsy.

Epilepsia 2016; 57:1130-38.

35. Ben-Menachem E, Mameniskiene R, Quarato PP, Klein P, Gamage J, Schiemann J,

Johnson ME, Whitesides J, McDonough B, Eckhardt K. Efficacy and safety of

brivaracetam for partial-onset seizures in 3 pooled clinical studies.

Neurology 2016; 87:314-323.Published ahead of print Jun2 22,2016.

REVIEWS & CHAPTERS

1.  Klein P, Herzog AG. Endocrine Aspects of Partial Epilepsy. In: Schachter SC and Schomer DL, eds. The Comprehensive Management and Treatment of Epilepsy. Academic Press, San Diego 1997, Chapter 12, pp. 207-232.

2.  Klein P, Herzog AG. Endocrine Aspects of Epilepsy. In: Pretel S, Knigge KM, and Prasad A, eds. MCH and Seizures: Neuromolecular and Neuroendocrine Aspects. Research Signpost, India 1997, pp. 111-139.

3.  Herzog AG, Klein P. Hormonal Therapy. In: Sperling M. Medical Management of Epilepsy. Marcel Dekker 1998.

4.  Klein P, Herzog AG. Hormones and Epilepsy. In: Schmidt S and Schachter SC, eds. Epilepsy: Problem Solving in Clinical Practice. Martin Dunitz Ltd., London 2000, Chapter 32, pp 413-434.

5.  Klein P. Exacerbation of seizures in a young woman. In: Schmidt D, Schachter SC, eds. 110 Puzzling Cases of Epilepsy. Martin Dunitz Ltd., London 2001, Chapter 61, pp 237-241.

6.  Klein P, Janousek J. Impact of Neuroendocrine Factors in Seizure Genesis and Treatment. In: Rho JM, Cavazzos JE, eds. Epilepsy: Scientific Foundations of Clinical Management. Marcel Dekker 2004. Revised, second edition, 2009.

7.  Klein P. Mood and the Menopause. In: Studd J, ed. The management of the menopause. The Parthenon Publishing Group, Lancaster (UK) 2003.

8.  Klein P, Schomer D. Effect of Ovarian Hormones on the Nervous System. In Kaplan P, ed. Neurologic Disease in Women. Martin Dunitz Ltd., London 2005.

9.  Klein P, Janousek J. Hormones and antiepileptic drugs. In: Bui E, Klein AM, eds. Women with Epilepsy. Cambridge University Press, Cambridge (UK), 2013.

10.  Tyrlikova I, Klein P. Ketogenic diet treatment in adults with refractory epilepsy. In:

Watson RR, Preedy V, eds. Bioactive Nutriceuticals and Dietary Supplements in

Neurological and Brain Disease: Prevention and Therapy. Elsevier, 2014.

11.  Klein P. Status epilepticus. In: Koubeissi MZ, Azar N, eds. Epilepsy Board Review: A Comprehensive Guide. Springer Science +Business Media, 2016; in press.

RECENT ABSTRACTS

1.  Klein P, Jacobs AR, Herzog AG. A comparison of testosterone versus testosterone and testolactone in the treatment of reproductive/sexual dysfunction in men with epilepsy and hypogonadism. Neurology 1996; 46:177.

2.  Herzog AG, Klein P. Three patterns of catamenial epilepsy. Epilepsia 1996; 37:83.

3.  Klein P, Silveira DC, Liu Z, Holmes GL, Elmquist J, de LaCalle S, Herzig AG. Asymmetric activation of hypothalamic neurons with unilateral amygdaloid seizures in male rats. European Journal of Neurology 1997; 4:S14.

4.  Silveira DC, Liu Z, LaCalle S, Lu J, Klein P, Holmes GL, Herzog AG. Locus coeruleus fos-immunoreactivity following amygdala-kindled generalized seizures. Epilepsia 1997;38:186.

5.  Joseph J, Klein P, Kleefield J. Vasospasm neuroradiology and pathology. J Neurol Exp Neuropathol 1997.

6.  Herzog AG, Klein P, Jacobs AR, Coleman AC, Drislane FW, Schomer DL. Abnormal interictal prolactin elevations particularly among men and women with complex partial seizures of right temporal origin. Epilepsia 1997; 38:48.

7.  Herzog AG, Coleman AE, Jacobs AR, Klein P et al. Menstrual Disorders, reproductive endocrine dysfunction and interictal discharge frequency in women with temprolimbic epilepsy. Neurology 1999; 52;(Suppl 2) A2:24.

8.  Klein P. Effect of stress on localization-related epilepsy. Epilepsia 2000, 41; (Suppl. 7):S112).

9.  Serje A, Klein P. Premature Ovarian Failure in women with epilepsy. Epilepsia 2000, 41;(Suppl.7):S 198.

10.  Herzog AG, Coleman AE, Jacobs AR, Klein P, et al. Acute hypothalamopituitary dysfunction following interictal unilateral temporal epileptiform discharges in women with epilepsy. Epilepsia 2000, 41; (Suppl. 7):S 167.

11.  Cantero, J, Klein P. Treatment of Exacerbation of partial seizures during perimenarche with natural progesterone. Epilepsia 2001;42 (Suppl 7) 290.

12.  Sahoo S, Klein P. Effect of adrenocorticotropic hormone (ACTH)-induced acute hypercortisolemia on EEG in patients with stress-related epilepsy. Epilepsia 2001;42 (Suppl 7) 115.

13.  Klein P. Onset of epilepsy at the time of menarche. Epilepsia 2001;42 (Suppl 7) 291.

14.  Clark L, Klein P. Seizure occurrence in relationship to the 9/11 terrorist attack among patients with epilepsy in the Washing, DC area. Epilepsia 2002; 43 (Suppl 7) 298.