Supplementary Table 5. Cox Regression Analysis of Overall Survival for Elderly Patient Cohort (N=23,229)

Univariate analysis / Multivariate analysisa
Variable / HR / 95% CI / p-value / HR / 95% CI / p-value
Age / 1.03 / 1.02-1.03 / <.001 / 1.02 / 1.01-1.02 / <.001
Female vs. male / 0.83 / 0.80-0.85 / <.001 / 0.83 / 0.80-0.85 / <.001
White vs. non-white / 1.14 / 1.09-1.20 / <.001 / 1.14 / 1.08-1.19 / <.001
Academic vs. non-academic / 0.90 / 0.87-0.93 / <.001 / 0.94 / 0.91-0.97 / <.001
Private vs. non-private insurance / 0.99 / 0.95-1.04 / .77 / NS / NS / NS
Median income (≥$48,000 vs. <$48,000) / 0.93 / 0.90-0.95 / <.001 / 0.95 / 0.92-0.98 / <.001
County location (metropolitan vs. non-metropolitan) / 0.91 / 0.88-0.94 / <.001 / 0.92 / 0.88-0.96 / <.001
Clinical stage IIIB vs. stage IIIA / 1.13 / 1.10-1.17 / <.001 / 1.16 / 1.13-1.20 / <.001
Distance to closest facilityb / 0.99 / 0.98-1.00 / .05 / 0.98 / 0.97-0.99 / .002
Charlson-Deyo score (1 vs. 0) / 1.12 / 1.09-1.15 / <.001 / 1.10 / 1.06-1.13 / <.001
CRT vs. RT alone / 0.63 / 0.61-0.65 / <.001 / 0.66 / 0.64-0.68 / <.001
Single-agent CRT vs. RT alone / 0.83 / 0.78-0.88 / <.001 / 0.84 / 0.78-0.90 / <.001
Multi-agent CRT vs. RT alone / 0.61 / 0.59-0.63 / <.001 / 0.64 / 0.61-0.66 / <.001
Multi-agent vs. single-agent chemotherapyc / 0.74 / 0.70-0.79 / <.001 / 0.76 / 0.71-0.81 / <.001
Days to start of radiationd / 1.00 / 1.00-1.00 / <.001 / 1.00 / 1.00-1.00 / <.001

aAdjusted HR derived from the multivariate Cox regression model that takes into account all confounders with p<.10 on univariate analysis.

blog of distance (miles) used for analysis.

cin 18,206 patients that received CRT only.

dHR from univariate analysis is 0.997 (0.997-0.998) and from multivariate analysis is 0.998 (0.997-0.998)

CI, confidence interval; CRT, chemoradiation; HR, hazard ratio; NS, p-value>.10 on univariate analysis; RT, radiation therapy.