Abridged CV:
Updated Mar 2010
Name: / Prof CB (Tiaan) BrinkRank: / · Full Professor in Pharmacology
· Programme manager for the development and presentation of a Web-based distance learning Honours B.Sc. and CPD Programme in Pharmacology
Tel no: / +27 18 299 2234
E-mail: /
Qualifications: / · B. Pharm. (1989 – PU for CHE)
· M.Sc. in pharmacology (1991 – PU for CHE)
· Ph.D. in pharmacology (1998 – PU for CHE)
Experience (teaching and otherwise): /
Teaching
20 years tertiary teaching experience:· Pre-graduate B. Pharm. Students:
- Cardiovascular Pharmacology
- Rhino and Broncho Pharmacology
- Sexology for the Pharmacist
· Post-graduate (Hons. B.Sc. in Pharmacology)
- Cardiovascular Pharmacology
- Evidence-Based Medicine
· Programme manager of a distance-learning, Web-based Honours B.Sc. Programme in Pharmacology (1997 - ).
· Secretary of the Teaching Section of the International Union of Basic and Clinical Pharmacology - IUPHAR (2006 - ); IOSP Councillor for Africa.
Research
Field of Expertise in ResearchMolecular and signal transductional pharmacology, with specific application to the investigation of the biomolecular basis of the action of drugs used for the treatment of anxiety and stress disorders.
· Postdoctoral studies in signal-transductional molecular pharmacology at the Dept. of Pharmacology, University of Michigan from July 1998 until June 1999, under Dr. Richard. R. Neubig.
· Supervised several postgraduate, research-related M.Sc. and Ph.D. studies
· Established and headed the central Laboratory for Applied Molecular Biology (LAMB) at the North-West University (2000 - 2009).
· Editor and peer-reviewer for several international scientific journals.
Professional
The following reflect activity in the pharmacy profession· Vice-President of the South African Society for Basic and Clinical Pharmacology (www.sapharmacol.co.za)
· Steering Committee of the 17th World Congress of Pharmacology (WCP2014 - www.iuphar2014.org) and of ‘Pharmacology for Africa’ initiative (PharfA - www.iuphar-Africa.org).
· Registration at the South African Pharmacy Board as pharmacist since 1992 (no. 0011827 – P01419).
· Member of the Academy of Pharmaceutical Sciences of the Pharmaceutical Society of South Africa – APSSA (2003 - 2008)
· Between 1992 and 2003 ad hoc locum work as pharmacist was done in several community pharmacies (± 10) in South Africa, as well as in Medi-Clinic private hospital.
Research area: / · Field of Expertise in Research
Molecular and signal transductional pharmacology, with specific application to the investigation of the biomolecular basis of the action of drugs used for the treatment of anxiety and stress disorders.
Publications (past 3 years) /
Accepted / submitted
· Mokoena ML, Harvey, BH, Oliver DW & Brink CB*. (2010) The modulating effects of acute and chronic inhaled ozone on the antidepressant-like effects of imipramine and on associated parameters of oxidative stress in various brain regions of the rat. Metabolic Brain Disease, (accepted – in press).· Liebenberg N, Brand L, Harvey BH & Brink CB*. (2010) Antidepressant-like properties of phosphodiesterase type 5 inhibitors in a genetic rat model of depression. Behavioural Pharmacology (provisionally accepted).
· Mokoena ML, Brink CB, Harvey BH & Oliver DW*. (2010) Appraisal of ozone as biologically active molecule and experimental tool in biomedical sciences. Medical Chemistry Research, (submitted).
Published
· Liebenberg N, Wegener G, Harvey BH & Brink CB*. (2010) Investigating the role of protein kinase-G in the antidepressant-like response of sildenafil in combination with muscarinic acetylcholine receptor antagonism. Behavioural Brain Research, 209:137-141. (http://dx.doi.org/10.1016/j.bbr.2010.01.032)· Brink CB*. (2009) Major depression and models for new generations effective antidepressants. Scientific contributions, series H: Inaugural speeches no. 232. North-West University : Potchefstroom. 23 p.; ISBN: 978-1-86822-582-8.
· Brink CB*, Pretorius, A, Van Niekerk BPJ, Oliver, DW & Venter, DP. (2008) Studies on cellular resilience and adaptation following acute and repetitive exposure to ozone in cultured human epithelial (HeLa) cells. Redox Report, 13(2):87-100.
· Brink CB*, Clapton HC, Eagar, BE & Harvey, BH. (2008) Appearance of antidepressant-like effect by sildenafil in rats after central muscarinic receptor blockade. Evidence from behavioural and neuro-receptor studies. Journal of Neural Transmission, 115(1):117-125 (Epub 07 Sep 2007).
· Brink CB, Harvey BH, Brand L. (2006) Tianeptine: a novel atypical antidepressant that may provide new insights into the biomolecular basis of depression. Recent Patents on CNS Drug Discovery, 1:29-41 (invited article for inaugural issue).
Current projects: / The following are current research projects:
· The behavioural and neuromodulatory effects of phosphodiesterase type 5 inhibitors in a genetic animal model of depression.
· The modulating effects of acute and chronic inhaled ozone on the antidepressant-like and central neuromodulatory effects of imipramine in rat.
· The effect of early-life exposure of rats to antidepressants on behaviour in adulthood.
Collaborations: / · Research collaboration with Prof Gregers Wegener of the University of Aarhus in Denmark.
· Involvement in several committees of the University, including the Ethics Committee.
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Abridged CV: Prof CB Brink