Sari Izenwasser, Ph.D.
Research Professor
Psychiatry and Behavioral Sciences
Office Phone: (305) 243-2032 FAX: (305) 243-5475
Education
1980 B.A. (High Honors) Psychology
Florida International University, Miami,. FL
1983 M.A. Experimental/Physiological Psychology
Boston University, Boston, MA
1987 Ph.D. Experimental/Physiological Psychology
Boston University, Boston, MA
Professional Experience
1993-1997 Senior Staff Fellow
Psychobiology Section
National Institute on Drug Abuse, National Institutes of Health
1996-1998 Adjunct Assistant Professor
Department of Pharmaceutical Sciences
University of Maryland School of Pharmacy
1997-2001 Research Associate Professor
Department of Neurology
University of Miami School of Medicine
2001-2004 Research Associate Professor
Department of Psychiatry and Behavioral Sciences
University of Miami School of Medicine
2004-present Research Professor
Department of Psychiatry and Behavioral Sciences
University of Miami School of Medicine
Publications
Books and Monographs
1. Izenwasser, S. The role of the dopamine transporter in cocaine abuse. Review Article, Neurotoxicity Research, 6:379-384, 2004.
2. Mash, D.C., Kramer, L.C. and Izenwasser, S. Dopamine transporter mRNA in human brain: distribution and regulatory effects in autopsy studies of cocaine abusers. In: Cerebral Signal Transduction: From First to Fourth Messengers, (M.E.A. Reith, ed.) Humana Press, pp. 401-417, 2000.
3. Izenwasser, S. Basic pharmacological mechanisms of cocaine. In: Cocaine abuse: Basic determinants, clinical applications, and policy. (S. Higgins and J.L. Katz, eds.) Academic Press, pp.1-20, 1998.
4. Adams, J.U., Izenwasser, S., Kramer, T.H., Stevens, C.W., Tiseo, P.J., and Unterwald, E.M. Mechanisms of sensitization. Presentation in symposium entitled: Tolerance and sensitization to opioids and cocaine. NIDA Research Monograph, Problems of Drug Dependence, 140, 69-73 1993.
5. Izenwasser, S. and Kornetsky, C. Brain-stimulation reward: A method for assessing the neurochemical bases of drug-induced euphoria. In: Drugs of Abuse and Neurobiology (ed. R.R. Watson), CRC Press, Boca Raton, FL, pp. 1-22,1992.
Scientific Articles in Reviewed Journals
1. Rhoden, J.B., Bouvet, M., Izenwasser, S., Wade, D., Lomenzo, S.A., and Trudell, M.L. Structure-activity studies of 3’-4’-dichloro-meperidine analogues at dopamine and serotonin transporters, Bioorganic and Medicinal Chemistry Letters, 13:5623-5634, 2005.
2. Lomenzo, S.A., Rhoden, J.B., Izenwasser, S., Wade, D., Katz, J.L., Kopajtic, T., Trudell, M.L. Synthesis and biological evaluation of meperidine analogues at monoamine transporters, J. Med. Chem., 48:1336-1343, 2005.
3. Collins, S.L., Wade, D., Ledon, J., and Izenwasser, S. Neurochemical alterations produced by daily nicotine exposure in periadolescent vs. adult male rats, Eur. J. Pharmacology, 502:75-85, 2004.
4. Collins, S.L., Montano, R., and Izenwasser, S. Nicotine treatment produces persistent increases in amphetamine-stimulated locomotor activity in periadolescent male but not female or adult male rats. Developmental Brain Research, 153:175-187, 2004.
5. Di Benedetto, M., Feliciani, D., D’Addario, C., Izenwasser, S., Candeletti, S., and Romualdi, P. Effects of the selective norepinephrine uptake inhibitor nisoxetine on prodynorphin gene expression in rat CNS. Molecular Brain Research, 127:115-120, 2004.
6. Collins, S.L. and Izenwasser, S. Chronic nicotine differentially alters cocaine-induced locomotor activity in adolescent vs. adult male and female rats. Neuropharmacology, 46: 349-362, 2004.
7. D’Addario, C., Di Benedetto, M., Izenwasser, S., Candeletti, S., Romualdi, P. Differential time course of the effects of kappa-opioid agonist treatment on dynorphin A and on kappa-opioid receptor density, J. Molecular Neuroscience, 24:307-314, 2004.
8. Cheng, J., Xu, L., Stevens, E.D., Izenwasser, S., Wade D., and Trudell, M.L. Stereoselective synthesis of conformationally constrained tropane analogues: 6-Chloro-2,5-diazatetracyclo [8.5.0.02,13.04,9]pentadeca-4,6,8-triene-11-one and 6-Chloro-2,7-diazatetracyclo-[8.5.0.02,13.04,9] pentadeca-4,6,8-triene-11-one, J. Heterocyclic Chem. 41:569-574, 2004.
9. Platt, D.M., Rowlett, J.K., Izenwasser, S., and Spealman, R.D. Opioid partial agonist effects of 3-O-methylnaltrexone in rhesus monkeys, J. Pharmacol. Exp. Ther., 308:1030-1039, 2004.
10. Di Benedetto, M., D’Addario, C., Collins, S., Izenwasser, S., Candeletti, S., and Romualdi, P. Role of serotonin on cocaine mediated effects on prodynorphin gene expression in the rat brain, J. Molecular Neuroscience, 22:213-222, 2004.
11. Xu, L., Kulkarni, S., Izenwasser, S., Katz, J.L., Kopajtic, T., Lomenzo, S.A., Newman, A.H. and Trudell, M.L. Synthesis and monoamine transporter binding of 2-(diarylmethoxymethyl)-3 beta-aryltropane derivatives. J. Med. Chem., 47:1676-1682, 2004.
12. Cheng, J., Izenwasser, S., Zhang, C., Zhang, S., Wade, D., and Trudell, M.L. Synthesis and nicotinic acetylcholine receptor binding affinities of 2- and 3-isoxazolyl-8-azabicyclo[3.2.1]octanes. Bioorganic and Medicinal Chemistry Letters, 14:1775-1778, 2004.
13. Winfield, L., Chunming, Z., Reid, C., Stevens, E., Izenwasser, S., Wade, D., and Trudell, M.L. Synthesis, lipophilicity and structure of 2,5-disubstituted 1, 3, 5-dithiazine derivatives, J. Heterocyclic Chemistry, 40, 827-832, 2003.
14. Bradley, A.L., Izenwasser, S., Wade, D., Cararas, S., and Trudell, M.L. Synthesis of dopamine transporter selective 3-{2-(Diarylmethoxy]ethylidene)}-8-alkylaryl-8-azabicyclo[3.2.1]octanes. Bioorganic & Medicinal Chemistry Letters, 13:629-632, 2003.
15. Mash, D.C., Ouyang, Q., Pablo, J., Basile, M., Izenwasser, S., Lieberman, A., and Perrin, R. Cocaine abusers have an overexpression of a-synuclein in dopamine neurons. J. Neurosci., 23:2564-71; 2003.
16. Izenwasser, S. and French, D. Tolerance and sensitization to cocaine are mediated via independent mechanisms. Pharmacol. Biochem. Behav., 73:877-882, 2002.
17. Collins, S.L. and Izenwasser, S. Cocaine differentially alters behavior and neurochemistry in periadolescent vs. adult rats. Dev. Brain Res., 138:27-34, 2002.
18. Bradley, A.L., Izenwasser, S., Wade, D., Klein-Stevens, C., Zhu, N., and Trudell, M.L. Synthesis and dopamine transporter binding affinities of 3a-benzyl-8-(diarylmethoxyethyl)-8-azabicyclo[3.2.1]octanes, Bioorganic & Medicinal Chemistry Letters, 12:2387-2390, 2002.
19. Collins, S.L., Kunko, P.M., Ladenheim, B., Cadet, J.-L., Carroll, F.I., and Izenwasser, S. Chronic cocaine increases k-opioid receptor density: lack of effect by selective dopamine uptake inhibitors. Synapse, 45:153-158, 2002.
20. Cheng, J., Zhang, C., Stevens, E.D., Izenwasser, S., Wade, D., Chen, S., Paul, D., and Trudell, M.L. Synthesis and biological evaluation at nicotinic acetylcholine receptors of N-arylalkyl- and N-aryl-7-azabicyclo[2.2.1]heptanes. J. Med. Chem., 45:3041-3047, 2002.
21. Winfield, L., Izenwasser, S., Wade, D., and Trudell, M.L. Synthesis and dopamine transporter binding affinity of 2,6-dioxopiperazine analogues of GBR 12909. Med. Chem. Res., 11:102-115, 2002.
22. Mash, D.C., Pablo, J., Ouyang, Q., Hearn, W.L., and Izenwasser, S. Dopamine transport function is elevated in cocaine users. J. Neurochem., 81: 292-300, 2002.
23. Schenk, S. and Izenwasser, S. Pretreatment with methylphenidate sensitizes rats to the reinforcing effects of cocaine. Pharmacol. Biochem. Behav., 72:651-657, 2002.
24. Xu, L., Izenwasser, S., Katz, J.L., Kopajtic, T., Klein-Stevens, C., Zhu, N., Lomenzo, S.A., Winfield, L., and Trudell, M.L. Synthesis and biological evaluation of 2-substituted 3b-tolyltropane derivatives at dopamine, serotonin, and norepinephrine transporters. J. Med. Chem., 45:1203-1210, 2002.
25. Collins, S.L., D’Addario, C., Romualdi, P., Candeletti, S., and Izenwasser, S. Regulation of dynorphin gene expression by kappa-opioid agonist treatment. NeuroReport, 13:107-109, 2002.
26. Collins, S.L., D’Addario, C., and Izenwasser, S. Effects of kappa opioid receptor agonists on long-term cocaine use and dopamine neurotransmission, Eur. J. Pharmacol., 426:25-34, 2001.
27. Collins, S.L., Gerdes, R.M., D'Addario, C. and Izenwasser, S. Kappa opioid agonists alter dopamine markers and cocaine-stimulated locomotor activity. Beh. Pharmacol., 12:237-246, 2001.
28. Barrett, A.C., Morgan, D., Izenwasser, S. and Picker, M.J. Cocaine-like discriminative stimulus effects and [3H]dopamine uptake inhibition produced by selected partial opioid agonists. Beh. Pharmacol., 12:225-235, 2001.
29. Cheng, J., Izenwasser, S., Wade, D., and Trudell, M.L. Synthesis and nicotinic acrtylcholine receptor binding affinity of exo- and endo-2-(pyridinyloxymethyl)-7-azabicyclo[2.2.1]heptanes. Med. Chem. Res., 10:356-365, 2001.
30. Newman, A.H., Robarge, M.J., Howard, I.M., Wittkopp, S.L., George, C., Kopajtic, T., Izenwasser, S., and Katz, J.L. Structure-activity relationships at monoamine transporters and muscarinic receptors for N-substituted-3-(3'-chloro-, 4'-chloro-, and 4',4' '-dichloro-substituted-diphenyl)methoxytropanes. J. Med. Chem., 44:633-640, 2001.
31. Romualdi, P., D'Addario, C., Ferri, S., Cox, B.M., and Izenwasser, S. Chronic GBR 12909 administration differentially alters prodynorphin gene expression compared to cocaine. Eur. J. Pharmacol., 413:207-212, 2001.
32. Mash, D.C., Staley, J.K., Izenwasser, S., Basile, M., and Ruttenber, A.J. Serotonin transporters upregulate with chronic cocaine abuse. J. Chemical Neuroanatomy, 20:271 – 280, 2000.
33. Katz, J.L., Izenwasser, S., and Terry, P. Relationships among dopamine transporter affinities and cocaine-like discriminative stimulus effects. Psychopharmacol., 148: 90-98, 2000.
34. Robarge, M.J., Agoston, G.E., Izenwasser, S., Kopajtic, T., George, C., Katz, J.L., and Newman, A.H. Highly selective chiral N-substituted 3a-[bis(4'-fluorophenyl)methoxy] tropane analogues for the dopamine transporter: Synthesis and comparative molecular field analysis. J. Med. Chem., 43:1085-93, 2000.
35. Mufson E.J.,. Deecher D.C., Basile M., Izenwasser S., and Mash, D.C. Galanin receptor plasticity within the nucleus basalis in early Alzheimer’s Disease: an in vitro autoradiographic analysis. Neuropharmacol., 39:1404-1412, 2000.
36. Katz, J.L., Izenwasser, S., Kline, R.H., Allen, A.C., and Newman, A.H. Novel 3a-diphenylmethoxytropane analogs: Selective dopamine uptake inhibitors with behavioral effects distinct from those of cocaine, J. Pharmacol. Exp. Ther., 288:302-315, 1999.
37. Izenwasser, S., French, D., Carroll, F.I., and Kunko, P.M. Continuous infusion of selective dopamine uptake inhibitors or cocaine produces time-dependent changes in rat locomotor activity. Behavioural Brain Research, 99:201-208, 1999.
38. Izenwasser, S., Coy, A., Ladenheim, B., Loeloff, R.J., Cadet, J.L., and French, D. Chronic methylphenidate alters locomotor activity and dopamine transporters differently from cocaine. Eur. J. Pharmacol., 373:187-193, 1999.
39. Izenwasser, S., Staley, J.K., Cohn, S., and Mash, D.C. Characterization of kappa1-opioid receptor binding in human insular cortex. Life Sciences, 65:857-862, 1999.
40. Newman, A.H., Izenwasser, S., Robarge, M.J., and Kline, R.H. CoMFA Study of Novel Phenyl Ring-Substituted 3a-(Diphenylmethoxy)tropane Analogues at the Dopamine Transporter. J. Med. Chem., 42: 3502-3509, 1999.
41. Husbands, S.M., Izenwasser, S., Kopajtic, T. , Bowen, W.D., Vilner, B.J., Katz, J.L., and Newman, A.H. Structure-activity relationships at the monoamine transporters and s receptors for a novel series of 9-[3-(cis-3,5-dimethyl-1-piperazinyl)propyl]carbazole (rimcazole) analogs. J. Med. Chem., 42: 4446-4455, 1999.
42. Lomenzo, S.A., Izenwasser, S., Gerdes, R.M., Katz, J.L., Kopajtic, T., and Trudell, M.L. Synthesis, dopamine and serotonin transporter binding affinities of novel analogues of meperidine. Bioorganic & Medicinal Chemistry Letters, 9:3273-6, 1999.
43. Izenwasser, S., Thompson-Montgomery, D., Deben, S.E., Chowdhury, I.N., and Werling, L.L. Modulation of amphetamine-stimulated (transporter-mediated) dopamine release by sigma2 receptor agonists and antagonists. Eur. J. Pharmacol., 346:189-196, 1998.
44. Kunko, P.M., French, D., and Izenwasser, S. Alterations in locomotor activity during chronic cocaine administration: Effect on dopamine receptors and interaction with opioids. J. Pharmacol. Exp. Ther., 285:277-284, 1998.
45. Zhang, C., Izenwasser, S. Katz, J.L., Terry, P., and Trudell, M.L. Synthesis and dopamine transporter affinity of the four stereoisomers of (±)-2-methoxycarbonyl-7-methyl-3-phenyl-7-azabicyclo[2.2.1]heptane. J. Med. Chem., 41: 2430-2435, 1998.
46. Lomenzo, S.A., Izenwasser, S., Katz, J.L., and Trudell, M.L. The effects of alkyl substituents at the 6-position of cocaine analogues on dopamine transporter binding affinity and dopamine uptake inhibition. Med. Chem. Res., 8:35-42,1998.
47. Izenwasser, S., Acri, J.B., Kunko, P.M., and Shippenberg, T. Repeated treatment with the selective kappa opioid agonist U-69593 produces a marked depletion of dopamine D2 receptors, Synapse. 30:275-283,1998.
48. Kline, R.H., Izenwasser, S., Katz, J.L., Joseph, D.B., Bowen, W.D., and Newman, A.H. 3’-Chloro-3-(diphenylmethoxy)tropane but not 4’- Chloro-3a -(diphenylmethoxy)tropane produces a cocaine-like behavioral profile. J. Med. Chem., 40:851-857, 1997.
49. Katz, J.L., Newman, A.H., and Izenwasser, S. Relations between heterogeneity of dopamine transporter binding and function and the behavioral pharmacology of cocaine, Pharmacology, Biochemistry and Behavior. 57:505-512, 1997.
50. Xu, L., Kelkar, S.V., Lomenzo, S.A., Izenwasser, S., Katz, J.L., Kline, R.H., and Trudell, M.L. Synthesis, dopamine transporter affinity, dopamine uptake inhibition and locomotor stimulant activity of 2-substituted-3b-phenyltropane derivatives. J. Med. Chem., 40:858-863, 1997.
51. Kunko, P.M., Loeloff, R.J., and Izenwasser, S. Chronic administration of the selective dopamine uptake inhibitor GBR 12909, but not cocaine, produces marked decreases in dopamine transporter density. Naunyn-Schmiedeberg’s Arch. Pharmacol., 356:562-569, 1997.
52. Agoston, G.E., Wu, J.H., Izenwasser, S., George, C., Katz, J., Kline, R.H., and Newman, A.H. Novel N-substituted 4’,4”-difluoro-3a-(diphenylmethoxy)tropane analogs: Selective ligands for the dopamine transporter. J. Med. Chem., 40:4329-4339, 1997.
53. Husbands, S.M., Izenwasser, S., Loeloff, R.J., Katz, J.L., Bowen, W.D., Vilner, B.J., and Newman, A.H. Isothiocyanate derivatives of 9-[3-cis-3,5-dimethyl-(1-piperazinyl)propyl] carbazole (Rimcazole): Irreversible ligands for the dopamine transporter. J. Med. Chem., 40:4340-4346, 1997.
54. Lomenzo, S.A., Izenwasser, S., Katz, J.L., Terry, P., Zhu, N., Klein, C.L., and Trudell, M.L. Synthesis, structure, dopamine transporter affinity and dopamine uptake inhibition of novel 6-alkyl-3-benzyl-2-(methoxycarbonylmethyl)-tropane derivatives. J. Med. Chem., 40: 4406-4414, 1997.
55. Agoston, G.E., Vaughan, R., Lever, J.R., Izenwasser, S., Terry, P.D., Newman, A.H. A novel photoaffinity label for the dopamine transporter based on N-substituted-4’,4’-difluoro-3a-(diphenylmethoxy)tropane. Bioorganic & Medicinal Chemistry Letters, 7:3027-3032, 1997.
56. Izenwasser, S., Newman, A.H., Cox, B.M., and Katz, J.L. The cocaine-like behavioral effects of meperidine are mediated by activity at the dopamine transporter. Eur. J. Pharmacol., 297:9-17, 1996.
57. Izenwasser, S., Heller, B. and Cox, B.M. Continuous cocaine administration enhances µ- but not d-opioid receptor-mediated inhibition of adenylyl cyclase activity in rat nucleus accumbens. Eur. J. Pharmacol., 297:187-191, 1996.
58. Aronson, B., Enmon, J.L., Izenwasser, S., Katz, J.L., Kelkar, S.V., Luo, L., Nolan, S.P., and Trudell, M.L. Synthesis and ligand binding at cocaine receptors of 6-(2b-carbomethoxy-3b -phenyltropane) transition metal complexes. J. Med. Chem., 39:1560-1563, 1996.
59. Newman, A.H., Shah, J.H., Izenwasser, S., Heller, B., Mattson, M.V., and Tortella, F.C. Highly selective s1 ligands based on dextromethorphan. Med. Chem. Res., 6:102-117, 1996.
60. Shah, J.H., Kline, R.H., Geter-Douglass, B., Izenwasser, S., Witkin, J.M., and Newman, A.H. (±)-3-Cinnamyl(4’-N,N-dimethylamino)benzazepine analogs: Novel dopamine D1 receptor antagonists. J. Med. Chem., 39:3423-3428, 1996.
61. Romualdi, P., Donatini, A., Izenwasser, S., Cox, B.M., and Ferri, S. Chronic intracerebroventricular cocaine differentially affects prodynorphin gene expression in rat hypothalamus and caudate putamen. Mol. Brain Res., 40:153-156, 1996.
62. Chen, Z., Izenwasser, S., Katz, J.L., Zhu, N., Klein, C.L., and Trudell, M.L. Synthesis and dopamine transporter affinity of 2-(methoxycarbonyl)-9-methyl-3-phenyl-9-azabicyclo[3.3.1]nonane derivatives. J. Med. Chem., 39:4744-4749, 1996.
63. Izenwasser, S. and Cote, T.E. Inhibition of adenylyl cyclase activity by a homogeneous population of dopamine D2 receptors: Selective blockade by antisera directed against G i1 and/or Gi2. J. Neurochem., 64:1614-1621, 1995.