Unprecedented anticancer activity of organorhenium sulfonato and carboxylato complexes against hormone-dependent MCF-7 and hormone-independent triple-negative MDA-MB-231 breast cancer cells

Paul T. Wilder1, David J. Weber1*, Angela Winstead2, Sabreea Parnell2, Tiara V. Hinton2, Monet Stevenson2, Dipak Giri2, Samira Azemati2, Pola Olczak2, Brent V. Powell2, Tijesunimi Odebode2, Solomon Tadesse2, Yongchao Zhang2, Saroj K. Pramanik3, James M. Wachira3, Sujan Ghimire2, Pumtiwitt McCarthy2, Alexis Barfield4, Hirendra N. Banerjee4, Chao Chen5, James A. Golen5, Arnold L. Rheingold5, Jeanette A. Krause6, Douglas M. Ho7, Peter Y. Zavalij8, Roosevelt Shaw2, Santosh K. Mandal2*

1Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA

2Department of Chemistry, Morgan State University, Baltimore, MD, USA

3Department of Biology, Morgan State University, Baltimore, MD, USA

4Department of Natural, Pharmacy and Health Sciences, Elizabeth City State University – University of North Carolina, Elizabeth City, NC, USA

5Department of Chemistry, University of California, San Diego, CA, USA

6Department of Chemistry, University of Cincinnati, Cincinnati, Ohio, USA

7Princeton University, Department of Chemistry, Princeton, NJ, USA

8Department of Chemistry and Biochemistry, University of Maryland, College Park, MD, USA

*Corresponding author

E-mail: (SKM)

SUPPLEMENTARY MATERIAL

S1 Table. Change in fluorescence intensity after 72-h treatment of MCF-7 and MDA-MB-231 breast cancer cells with various concentrations of the organorhenium sulfonato and carboxylate complexes

Structures TOS(1-8) Series / MCF 7A Estrogen Receptor(+) Breast Cancer Cell Line / MDA-MB231 Estrogen (-) Breast Cancer Cell Line / MCF 10A Normal Breast Cell line
Structures 1NS(1-8)Series / MCF 7A Estrogen Receptor(+) Breast Cancer Cell Line / MDA-MB231 Estrogen (-) Breast Cancer Cell Line / MCF 10A Normal Breast Cell line

INS1 / /

INS2 / / /

INS3 / / /

INS4 / / /

INS5

INS6 / / /

INS7 / / /

INS8
Structures 2NS(1-8) Series / MCF 7A Estrogen Receptor(+) Breast Cancer Cell Line / MDA-MB231 Estrogen (-) Breast Cancer Cell Line / MCF 10A Normal Breast Cell line

2NS1 / / /

2NS2 / / /

2NS3 / / /

2NS4 / / /

2NS5 / / /

2NS6 / / /

2NS7 / / /

2NS8 / / /
Structures PIC(1-8) Series / MCF 7A Estrogen Receptor(+) Breast Cancer Cell Line / MDA-MB231 Estrogen (-) Breast Cancer Cell Line / MCF 10A Normal Breast Cell line
Structures NIC(1-8) Series / MCF 7A Estrogen Receptor(+) Breast Cancer Cell Line / MDA-MB231 Estrogen (-) Breast Cancer Cell Line / MCF 10A Normal Breast Cell line
Structures
TP(1-8)Series / MCF 7A Estrogen Receptor(+) Breast Cancer Cell Line / MDA-MB231 Estrogen (-) Breast Cancer Cell Line / MCF 10A Normal Breast Cell line

TP2 / / /

TP3 / / /

TP4 / / /

TP5 / / /

TP6 / / /

TP7 / / /

TP8 / / /
Structures ASP(1-9) Series / MCF 7A Estrogen Receptor(+) Breast Cancer Cell Line / MDA-MB231 Estrogen (-) Breast Cancer Cell Line / MCF 10A Normal Breast Cell line
Structures FN(1-8) Series / MCF 7A Estrogen Receptor(+) Breast Cancer Cell Line / MDA-MB231 Estrogen (-) Breast Cancer Cell Line / MCF 10A Normal Breast Cell line

FN1 / / /

FN2 / / /

FN3 / / /

FN4 / / /

FN5 / / /

FN6 / / /

FN7 /

FN8 / / /
Structures IB(1-8) Series / MCF 7A Estrogen Receptor(+) Breast Cancer Cell Line / MDA-MB231 Estrogen (-) Breast Cancer Cell Line / MCF 10A Normal Breast Cell line

IB1 / / /

IB2 / / /

IB3 / / /

IB4 / / /

IB5 / / /

IB6 / / /

IB7 / /
Structures MF(1-8) Series / MCF 7A Estrogen Receptor(+) Breast Cancer Cell Line / MDA-MB231 Estrogen (-) Breast Cancer Cell Line / MCF 10A Normal Breast Cell line

MF1 / /

MF2 / / /

MF3 / / /

MF4 / /

MF5 / / /

MF6 / /

MF7 / /

MF8 / / /
Structures TF(1-8) Series / MCF 7A Estrogen Receptor(+) Breast Cancer Cell Line / MDA-MB231 Estrogen (-) Breast Cancer Cell Line / MCF 10A Normal Breast Cell line

TF1 / / /

TF2 / / /

TF3 / / /

TF4 / /

TF6 / / /

TF7 /

TF8 / / /
Structures NP(1-8) Series / MCF 7A Estrogen Receptor(+) Breast Cancer Cell Line / MDA-MB231 Estrogen (-) Breast Cancer Cell Line / MCF 10A Normal Breast Cell line

NP1 / /

NP2 / /

NP3 / / /

NP4 / /

NP5 / /

NP6 /

NP7 / /

NP8 / /