Name______
Biol 207 Biology of Cancer
Exam 2 (75 points)
Spring 2004
Be sure to write your name on your exam, SCANTRON and blue book. Please write your answers to part I directly on the exam, to part II on the SCANTRON in #2 pencil, and to part III in the blue books.
I. Briefly define the following terms (3 pts. each)
a. chronic myeloid leukemia—
b. epidermal growth factor (EGF) receptor—
c. astrocytoma—
d. hereditary non-polyposis colon cancer (HNPCC)--
e. orchiectomy--
f. myeloma—
II. Multiple choice. Select the one best answer (3 points each) and fill in the appropriate box on the SCANTRONS provided using a #2 pencil.
1. Which of the following molecules are not involved in cell-cell adhesion?
a. cadherins
b. integrins
c. cyclins
d. selectins
2. Cells growing in culture which are behaving more like cancer cells would display all of the following properties except
a. reduced need for growth factors
b. immortalization
c. anchorage independent
d. contact inhibition
3. Hematopoetic (blood forming) cells that are susceptible to cancer are
a. red blood cells
b. platelets
c. stem cells
d. glial cells
4. Small proteins discovered by Dr. Judah Folkman that act as inhibitors of blood vessel proliferation are
a. ras and RB
b. endostatin and angiostatin
c. cyclin and cyclin-dependent kinase
d. PDGF and VEGF
5. An imaging method that incorporates X-ray data into computer generated images for diagnostic testing
a. PET scan
b. MRI
c. CT
d. colonoscopy
6. Procedure for the treatment of colon cancer where a segment of the large intestine containing a tumor and some healthy tissue is removed and the ends are rejoined
a. MRI
b. colonoscopy
c. surgical resection
d. stereotactic biopsy
7. Which of the following individuals would not be at increased risk of lung cancer?
a. asbestos worker
b. smoker
c. homeowner with radon levels greater than 4 pCi/l
d. person with Krohn's disease
8. A grade 4 brain tumor
a. is not able to spread to other parts of the central nervous system
b. is usually surgical removed
c. displays necrosis (dead cells) when biopsied
d. would be associated with a good prognosis for recovery
9. The PSA test
a. identifies a marker protein highly correlated with prostate cancer
b. is used in the diagnosis of lung cancer
c. tests for angiogenesis of brain tumors
d. is used to identify a hormone associate with testicular cancer
10. The tumor suppressor gene altered in families with familial adenopolyposis coli (FAP) is
a. MSH2
b. APC
c. p53
d. cadherin
11. Avastin, a promising new drug for the treatment of late stage colon cancer, inhibits the binding of vascular endothelial growth factor, which stimulates growth of blood vessels. This type is drug is called
a. an anti-angiogenesis inhibitor
b. a metalloproteinase inhibitor
c. a cell cycle arrest factor
d. a blood thinner
12. A test for blood in the stool that is used for the detection of colon cancer
a. PSA test
b. hemoccult test
c. PET scan
d. colonoscopy
13. A critical protein found in mitochondria that determines whether cells undergo programmed cell death
a. ras
b. RB
c. bcl-2
d. VEGF
14. Which of the following is not involved in regulation of the cell cycle?
a. RB
b. cyclins
c. cyclin-dependent kinases (cdks)
d. endostatin
15. A blood test for hCGH (human Chorionic Gonadotrophin) is used for detecting and monitering
a. prostate cancer
b. testicular cancer
c. colon cancer
d. Hodgkin's lymphoma
16. (Bonus question) An example of an oncoprotein which is a transcription factor that regulates the expression of genes important for growth is
a. fos
b. bcl-2
c. ras
d. src
3. Answer any 2 of the following questions in the blue books provided (12 pts.). Clearly indicate the questions you want counted or only your first two answers will be graded.
a. Briefly describe the process involved in a bone marrow transplant and how it is used to treat leukemias.
b. Two major ideas presented by Roger King with regard to the preferential sites of metastasis pertain to the "first-pass" organ and the seed and soil concept. Briefly describe these two hypotheses and explain how each might explain the sites of secondary tumors for breast, prostate, or colon cancers.
c. For any two of the following biological processes, contrast how that process works in normal cells as compared to cancer cells. For full credit, give examples of specific proteins that are altered in the process in cancer cells.
· Binding of growth factors
· Entry/exit from G0 of cell cycle
· Activation of genes that promote growth
· Copying the ends of chromosomes
· Invasion of blood vessels
· Repair of damage to DNA
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